결핵성 흉막염과 악성 흉수의 감별진단에 있어서 흉수 IFN-$\gamma$ 측정의 유용성

김명선,양성은,지현숙,김우성,김원동,Kim, Myung-Sun,Yang, Sung-Eun,Chi, Hyun-Sook,Kim, Woo-Sung,Kim, Won-Dong 대한결핵및호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.2

연구배경: 결핵성 흉막염과 악성 흉수는 임상증상, 징후와 흉수내 백혈구 세포조성, 생화학적 검사로 감별하기 어렵고 미생물학적 검사와 세포진 또는 조직검사에 의해서도 확실히 진단하기 어렵다. 이런 문제 때문에 최근들어 결핵성 흉막염을 interleukin-2 (IL-2), interferon-$\gamma$(IFN-$\gamma$), tumor necrosis factor-$\alpha$(TNF-$\alpha$) 같은 면역 매개물질들을 이용하여 진단하려는 시도들이 있어 왔다. 결핵균에 대한 면역반응으로 주로 $Th_1$ 세포에 의해 분비되는 IFN-$\gamma$는 결핵성 흉막염에서 제 1형 반응이 거의 일어나지 않는 악성 흉수 보다 휠씬 높게 측정되므로 흉수내 IFN-$\gamma$ 수치의 차를 이용하여 두 질환을 감별할 수 있다. 이에 저자들은 흉수 IFN-$\gamma$의 진단적 가치를 ADA, CEA와 비교하여 보고 한국인에서의 민감도와 특이도를 알아보았다. 방 법: 결핵성 흉막염 40예, 악성 흉수 42예를 대상으로 흉수의 세포 조성, 생화학 검사와 IFN-$\gamma$, ADA, CEA 수치를 측정하였다. 결 과: 흉수내 IFN-$\gamma$와 ADA는 결핵성 흉막염에서 악성 흉수 보다 유의하게 높았고, CEA는 악성 흉수에서 결핵성 흉막염보다 유의하게 높았다. 결핵성 흉막염에서 IFN-$\gamma$는 민감도 0.97, 특이도 1.0을 나타내었고 ADA는 만감도 0.87, 특이도 0.97을 나타내었다. 악성 흉수에서 CEA는 민감도 0.67, 특이도 1.0을 나타내었다. ADA 활성도와 IFN-$\gamma$ 수치 사이에는 유의한 상관관계가 없었다. 결 론: IFN-$\gamma$는 결핵성 흉막염과 악성 흉수 감별에 매우 예민하고 특이적인 양상을 보이기 때문에 경제적인 검사는 아니나 결핵성 흉막염의 진단에 유용한 검사방법으로 사용될 수 있을 것으로 사료되었다. Background: It is sometimes difficult to differentiate tuberculous pleural effusion from malignant pleural effusion by clinical symptoms, signs, by routine tests of pleural fluid, and by pathologic studies. And recently, it was discovered that cytokines such as IL-2, IFN-$\gamma$, TNF-$\alpha$ are elevated in tuberculous pleural fluid, and there have been several attempts to diagnose tuberculous pleural effusion by using these immunological mediators. There are several studies regarding the diagnostic value of IFN-$\gamma$, and there are two studies in Korea. But the diagnostic values of IFN-$\gamma$ in these studies were slightly lower than those in other countries. To compare the diagnostic value of IFN-$\gamma$ with those of CEA and ADA, and to determine the sensitivity and specificity of IFN-$\gamma$ in Korean, we mesured IFN-$\gamma$, CEA level and ADA activity in pleural effusions. Methods: ADA activity, IFN-$\gamma$ level and CEA level as well as cell count, differential count, and biochemical assays such as protein content and lactate dehydrogenase were measured in 40 cases of tuberculous pleuritis and 42 cases of malignant pleural effusion. Results: Tuberculous pleural fluid showed higher levels of IFN-$\gamma$ and ADA ($832.6{\pm}357.2$ pg/ml and $82.5{\pm}25.9$ U/L, respectively) than those of malignant pleural effusion ($2.6{\pm}8.0$ pg/ml and $19.2{\pm}10.9$ U/L, respectively) (p<0.01). Malignant pleural effusions showed higher median value (102.2 ng/ml) than tubercalous pleural effusions (1.8 ng/ml) (p<0.01). The sensitivities of IFN-$\gamma$, ADA, CEA were 0.97, 0.87, 0.67 and the specificities of IFN-$\gamma$, ADA, CEA were 1.0, 0.97, 1.0, respectively. There was no significant correlation between ADA activity and IFN-$\gamma$ level. Conclusion: This study showed that IFN-$\gamma$ test would be a very useful clinical test for differential diagnosis of tuberculous pleuritis and malignant pleural effusion because it is very sensitive and specific, although it is an expensive test.

초음파 유도하 중재술을 이용한 견관절 통증의 치료

김명선,문은선,Kim, Myung-Sun,Moon, Eun-Sun 대한정형외과초음파학회 2011 대한정형외과 초음파학회지 Vol.4 No.1

견관절 통증의 치료를 위해 시행되는 초음파 유도하 중재술은 견관절 통증의 치료에 매우 안전하고 유용하며, 그 방법들도 통증을 유발하는 원인 질환에 따라 다양하다. 본 종설에서는 견관절 주위에서 시행될 수 있는 초음파 유도하 중재술의 여러 활용 방법에 대해 설명하고자 하였다. Ultrasound-guided intervention is very safe and useful for the treatment of shoulder pain. Injection techniques vary according to the diseases causing shoulder pains. This review tried to describe various methods of the ultrasoundguided intervention around the shoulder joint.

통배추김치에 관한 연구 - 대구지역을 중심으로 담그는 방법과 기호에 관한 실태조사 -

김명선,한재숙 ( Myung Sun Kim,Jae Sook Han ) 한국식품조리과학회 1995 한국식품조리과학회지 Vol.11 No.1

The purpose of this study was to investigate the method of making whole Chinese cabbage Kimchi, the family`s taste in Kimchi and the reason for disliking the taste of Kimchi in the Taegu area The results were as follows; 1) Most housewives learned the method of making the Kimchi from their mothers. Method was as follows; First, scatter salt on the whole Chinese cabbage. and soak that for 3∼6 hours. After, wash the whole Chinese cabbage 3 times. Then, add red pepper powder, garlic, ginger and salted fermented anchovy as basic seasoning. Be sure to, mix the red pepper powder and salted fermented anchovy until they taste hot and salty. Store the whole Chinese cabbage until they ferment. Afterwards store the whole Chinese cabbage in the refrigerator. 2) It was the whole Chinese cabbage Kimchi that most family members preferred. 3) Among the family members, the old age group preferred newly made Kimchi because of the cool and fresh taste. The adult group preferred fresh taste, also smell and peculiar taste of the seasoning were important. The adolescent group preferred fresh taste and sour taste. 4) It shows that most of the family likes Kimchi, and among the family members, about 25% of the sons and daughters dislike Kimchi. And it shows that all family members dislike salty taste. 5) The older housewives` Kimchi was preferred over the younger housewives` Kimchi.

남녀 대학생의 식행동에 관한 연구(2) - 경제적 환경을 중심으로 -

김명선 ( Myung Sun Kim ) 한국식품조리과학회 2005 한국식품조리과학회지 Vol.21 No.2

The purposes of this study were to determine what kinds of food university students had, how often they were eating out and how much they consumed. A questionnaire survey was conducted on 597 university students (male : 40.9%, female : 59.1%). The students who spent under 200 thousand won per month had regular meals at breakfast, lunch and dinner. The students with personal monthly spending over 300 thousand won, both male and female, ate out more than others. The female students had more protein foods than the male students. Consumption of milk and milk products increased with rising monthly spending for female students. Regardless of monthly spending, the male students ate seaweeds low in 1-2 time per a week. Consumption of rice decreased with rising monthly spending for male and female students.

도자기 축제의 방문만족 요인에 관한 한중간 비교연구 -한국 이천 세계도자비엔날레 및 중국 경덕진(景德鎭) 도자박람회를 대상으로-

김명선 ( Myung Sun Kim ) 경기대학교 관광종합연구소 2010 여가관광연구 Vol.15 No.-

일제강점기 기존 건물을 전용한 군청사의 개축 및 증축 양상

김명선(Kim, Myung-Sun) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.7

이 연구의 목적은 기존건물을 전용하는 군청사는 어느 정도 차지하는지, 전용한 군청사의 건축적 특성은 무엇인지, 군청사 기능에 맞게 증개축하는 경우 그 양상을 고찰하는 것이다. 군청사 관련 디지털 도면자료, 해제와 더불어 조선총독부와 각 도 사이에 오고간 문서와 신문·잡지의 기사·도면·사진 등을 발굴·분석하는 문헌연구방법을 사용한다. 군청사로 전용된 건 물은 조선과 대한제국의 지방관립시설, 대한제국기 군청사, 용도를 알 수 없는 건물로 나뉜다. 전용 건물을 군청사의 위상과 기능에 적합하게 개축할 때는 방을 구획하는 벽을 털어내 큰 방을 만들고 접수대를 놓아 직원의 업무공간과 민원인의 대기공 간으로 구분했고, 증축은 전면 중앙에 작은 돌출현관을 내달고 간단한 양식 목조의 부속가를 본가의 뒤나 옆에 신축하고 외부연결복도로 이었다. 전용 군청사가 전체 군의 약 30%로 많고 전국에 걸쳐 있었는데, 그 57%가 나중에 신축되는데 절반 은 1930년대 전반기 신축되고 이후 급감한다. The purpose of this study is to investigate that which Goon office buildings were reused from existing buildings and to identify remodeling and extension ways of the reused to match Goon's administration work. This study used literature research method, i.e., analysing the digital images, the annotation, and the official documents between the Japanese government-general of Korea and To(道), and articles of newspapers and journals. The reused were governmental offices of Joseon(朝鮮) dynasty, existing Goon office buildings of Korean empire government and old buildings with unknown purposes. They were remodelled and extended to match Goon's administration work. Common remodelling was making large space with desks for civil petitions and projecting an small entrance from the center of main building's facade. Common extension was constructing accessory buildings with simple wooden structure, locating them to back or side of the reused, and connecting them through external corridor. As many as 30% of 218 Goon office buildings were reused. About 57% of them were replaced as new office buildings, however the number of the new was rapidly decreased after mid 1930s.

지석영의 『신학신설』 (1891)에서 근대적 주거 문제

김명선(Kim, Myung-Sun) 한국산학기술학회 2008 한국산학기술학회논문지 Vol.9 No.3

지석영이 1891년 저술한 『신학신설』은 우리나라 최초의 본격적인 개인위생서로 주거위생에 관해 내용도 담고 있다. 주거관련 내용은 ‘광(빛),’ ‘공기,’ ‘듸기(地氣)’ 항에서 등장하는데, 주거의 일조 및 채광, 통풍 및 환기, 주거지의 건조하고 신선한 공기와 토질 등이다. 근대적 위생론이 형성되기 시작한 1891년이라는 매우 이른 시기에 저술되었기 때문에 전통적인 ‘양생’ 개념에 의지하여 서술되었지만, 빛, 공기, 물, 열 등 주거위생에 중요한 환경조건을 처음으로 제시하고 건조, 정결, 토질 등 주거지의 위생조건을 자세히 다루었다. 이 책은 1890년대 중반 이후 민간신문, 잡지, 학회지, 교과용도서 등에서 본격적으로 전개된 근대적 주거담론의 기본적인 인식구조와 서술방식을 선취했으며, 근대적 주거의 필수조건으로 위생조건을 구체적으로 서술하여 일반인들을 계몽하고자 했다는 점에서 중요하다. Ji, Syok-young wrote a book named Sinhaksinseol(新學新說) in 1891, one of the first hygiene books in Korea. There were the conditions of modern housing like lighting, ventilation and dry and fresh air of a housing site in the contents of the book. Because the book was written when the modern hygiene theory had just been accepted, traditional concept of 'Yangseng(養生),' but it dealt the main environmental conditions of hygienic housing at first, which makes it the leader of modern housing discourses through the newspapers, magazines, academic journals or textbooks from 1890s mid to 1910.

고등여학교 가사과목 교과용도서의 주거지식(1908-1914)

김명선(Kim, Myung-Sun) 한국산학기술학회 2010 한국산학기술학회논문지 Vol.11 No.7

1907년 현공렴이 발행한 가정학 분야 책 『漢文家政學』, 『新編家政學』, 『新撰家政學』은 1908년 한국정부에서 인가된 후 1912-1914년에 걸쳐 조선총독부에서 불인가될 때까지 고등여학교 가사과목 교과용도서로 사용되었다. 그 안에는 주택에 관한 근대적 지식이 포함되어 있었다. 이는 당시 다른 과목의 교과용도서나 신문·잡지·학회지 등에 등 장하는 주거지식과 마찬가지로 위생에 초점을 맞추고 있지만, 구성은 좀 더 체계적이다. 이 세 책 모두 일본에서 발 간된 下田歌子의 『新選家政學』(1900)을 편역한 것으로, 당시 일본에서 가족건강을 위해 주거위생의 책임을 여성에게 부과하려 한 근대가정학 분야의 움직임이 반영되어 있다. 이 지식은 여성의 사회진출보다는 가정 내 주부의 역할에 고착하고 세세한 방법을 가르치는데 치중했다. 그들이 배운 주거지식은 주부로서 주거위생의 인식과 실천을 독려하기 위한 방법론이었다. 새로운 주거지식을 접한 여학생들이 그 지식을 심화하거나 실천할 여지도 거의 없었다. Three books of home economics were published in Korea 1907 and approved as textbooks for women's education by Korean government from 1908 to 1910 and by the Choseon Government-General from 1912 to 1914. The textbooks contained modern knowledge about housing which was focused on hygine matters and most systematic among the knowledge of that time. The original book of the three was Sinsen Gajunhak(新 選家政學) by Shimoda Yutako published in Japan 1990 after her surveying western home economics knowledge. It means the modern housing knowledge educated in Korea around 1910 was affected by Western modern thinking in home economics field that gave the responsibility of housing cleanness for family members' health to housewives. So the knowledge even made the educated women to practice their learning only as wives, which was still traditional.

서울, 경기지역의 더덕에 대한 인지도 및 이용실태 조사

김명선 ( Myung Sun Kim ),오옥희 ( Ok Hee Oh ) 대한가정학회 2008 Family and Environment Research Vol.46 No.3

일제강점기 도청사ㆍ부청사 건립의 배경과 성격

김명선(Kim Myung-Sun),박정대(Park Jung-Dae) 대한건축학회 2008 대한건축학회논문집 Vol.24 No.2

During the period of colonial Choson, there were a total of 13 To (道) government office buildings, and as few as 12 and as many as 22 Pu (府) government buildings. In the beginning of that period, To and Pu government buildings were mainly housed in pre-existing facilities that had initially been constructed as Togwanchalbu (道觀察府) or the Japanese Lisachung (日本理事廳), as well as other types of facilities. Eight out of the nine newly established Pu's in the 1930's continued to make use of pre-existing buildings. It was towards the latter half of the 1920's that To and Pu offices began to be newly constructed. In the case of To offices, even earlier cases of new construction existed. The main reasons that spurred these particularly early new constructions were the relocation of a To office building to a different city; the relocation of the To government building within the same city; or the loss of a facility due to fire. Additionally, for both To's and Pu's, there were a few instances where older, pre-existing buildings were enlarged or remodeled for continued use. The five main reasons to invest in new construction were, 1) the relocation of a To government building or the new designation of a Pu; 2) the deterioration of a facility or subsequent lack of space due to an increase in activities and employees; 3) the loss of a building due to a fire; 4) the subsequent off-center location of a Pu due to the relocation or growth of the town's administration district; or 5) the desire to provide a building that fittingly reflects the prestige and dignity that a To or Pu was believed to possess. Among these five reasons, the second demonstrated the most need for the new construction of To and Pu government buildings. Many To and Pu officers simultaneously requested that the Choson Government-General grant them permits for new construction, but insufficient funds prevented their demands from easily being met. For this reason, some To and Pu officers would apply for a building permit while also donating funds or land for the construction, which would have been secured as contributions from the townspeople. In this manner, the people of some To‘s and Pu's ended up partially carrying the burden of building construction costs. In the end, new construction for To and Pu government buildings came to realization only after their need reached urgent status, which shows how little the Choson Government-General was active in the construction of To and Pu office facilities. However, records show that the construction of new To offices of Pyongbuk (平北), Kyongnam (慶南), and Choongnam (忠南) were executed at the same time that the operation of these buildings were transferred to key points along the railroad connecting Pusan (釜山) and Manchuria. Also, the construction of Hambuk (咸北) To's office building occurred at the time of its relocation to the military city of Nanam (羅南). Both of these cases demonstrates that the Choson Government-General implemented the construction of To office buildings not in response to local needs, but for the overall interest of imperialist Japan.