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천연식품성분에 의한 발암성 니트로사민생성인자 분해작용 l. 야채유출물의 아질산염 분해작용
김동수,안방원,염동민,이동호,김선봉,박영호,KIM Dong-Soo,AHN Bang-Weon,YEUM Dong-Min,LEE Dong-Ho,KIM Seon-Bong,PARK Yeung-Ho 한국수산과학회 1987 한국수산과학회지 Vol.20 No.5
The present paper was investigated to elucidate the nitrite-scavenging ability of vegetable extracts. Vegetable extracts possessed the scavenging ability of nitrite. By fractionatioh of vegetable extracts,nitrite-scavenging ability of garlic (Allitum sativum for. Pekinense), chinese pepper (Zanthexylum schinifolium), onion (Allium cepa), welsh onion (Allium fistulosum) and ginger (Zingiber officinale) extracts were effective in the water-soluble fraction, but carrot (Daucus carota uar. sativa) in the methanol-soluble fraction. Nitrite-scavenging ability of vegetable extracts was also pH-dependent, highest at pH 1.2 and lowest at pH 6.0. Particularly, nitrite-scavenging abilities of water-soluble fractions obtained from garlic and chinese pepper were similar to that of L-ascorbic acid at pH 1.2. After vegetable extracts were treated with sodium borohydride, nitrite-scavenging ability was remarkably decreased at pH 1.2. It is assumed that reducing powers of vegetable extracts participated in their nitritescavenging abilities. 일상 식생활에서 널리 섭취하고 있는 야채류를 사용하여 니트로사민의 직접적인 생성인자인 아질산염 분해작용에 관하여 검토하였는데, 그 결과를 요약하면 다음과 같다. 1. 마늘, 산초, 생강, 양파 및 파 둥은 수용성획분에서 당근은 methanol 가용성획분에서 각각 아질산염 분핵능이 높게 나타났다. 2. 반응용액의 pH변화에 따른 아질산염 분해능은 pH 1.2에서 가장 컸으며, pH가 증가할수록 분해능은 감소하였다. 3. 각 시료를 10mg씩 취하여 얻은 아질산염 분해능을 동량의 L-ascorbic acid와 비교한 경우, 마늘과 산초가 수용성획분에서 L-ascorbic acid와 거의 비슷한 분해능을 나타내었다. 4. 각 시료를 $NaBH_4$로 처리하여 환원능을 소실시킨 후에 측정한 아질산염 분해능은 pH 1.2에서 시료 모두 모두 그 값이 현저하게 감소하였다
마우스에서 Collagen Induced Arthritis 발생에 미치는 Diterpenoid의 영양
김동수 ( Dong Soo Kim ),박용범 ( Yong Beom Park ),이봉기 ( Bong Ki Lee ),한덕룡 ( Dug Ryong Hahn ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.4
Objective: No medication currently available for the treatment of rheumatoid arthritis is universally effective, and all can produce adverse effects. It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. It is also reported that diterpenoid which is a partially purified product extracted from Acanthopanax koreanum has an anti-inflammatory effect. We conducted this study whether diterpenoid extracted from Acanthopanax koreanum has a regressive effect of collagen induced arthritis in DBA/1 mice. Methods: Four groups of DBA/1 mice were immunized by intradermal injection of 1mg/kg chicken type II collagen with complete Freund`s adjuvant. Group II received 5mg/kg of diterpenoid extracted from Acanthopanax koreanum orally daily and Group III receive 5mg/kg of phenylpropranoids extracted from Acanthopanax koreanum orally daily. Group IV received 1mg/kg dexamethasone intraperitoneally twice weekly. Group I received no treatment. The prevalence of arthritis were assessed twice weekly. Serum anti-collagen antibody was measured by ELISA. Stimulation index of caltured splenocytes was measured. Tumor necrosis factor-α and interleukin-10 levels in the supernatant of cultured splenocytes stimulated with Con. A were also measured by ELISA. Result: Collagen induced arthritis(CIA) started to develop 5 weeks after collagen injections. In diterpenoid treated group, CIA seemed to be regressed, but in phenylpropranoid group, regressive effect of arthritis was not observed. In dexamethasone treated group, both of suppression of CIA could be observed. Levels of anti-collagen antibodies were reduced in dexamethasone treated group, but not in both diterpenoid and phenylpropranoid group. No significant differences of splenic mononuclear cell SI among the groups was observed. There was an increased secretion of interleukin-10 in the supernatant of cultured splenocytes stimulated by Con A of the diterpenoid treated group. Conclusions: These findings showed that the diterpenoid extracted from Acanthopanax koreanum have an effect on supression of CIA.
바다송사리, Oryzias dancena와 자바송사리, O. javanicus 간 잡종에 대한 비스페놀 A의 효과
김봉석 ( Bong Seok Kim ),송하연 ( Ha Yeun Song ),남윤권 ( Yoon Kwon Nam ),김동수 ( Dong Soo Kim ) 한국어병학회 2011 한국어병학회지 Vol.24 No.2
본 연구에서는 비스페놀 A를 사용하여 바다 송사리 Oryzias dancena와 자바 송사리 O. javanicus의 잡종군(ODJ)의 성전환을 유도하였다. 부화 직후의 ODJ에 비스페놀 A를 2.5 mg/L, 5.0 mg/L와 10.0 mg/L의 농도로 56일간 처리한 결과 대조군의 경우 평균 전장이 18.0 ± 1.2 mm로 나타났고, 비스페놀 A 처리군에서는 2.5 mg/L로 처리한 경우 15.0 ± 2.0 mm, 5.0 mg/L 처리군은 13.7 ± 2.5 mm, 10.0 mg/L 처리군에서는 12.8 ± 2.5 mm로 나타나 대조군과 비스페놀 A 처리군에서 성장 차이가 관찰되었다. 또한, 처리군 간에서도 비스페놀 A의 농도가 높을수록 성장이 느린 것으로 나타났다. 기형률을 조사한 결과 대조군은 13.6%였고, 비스페놀 A 처리군의 경우 2.5 mg/L는 65.4%로 대조군에 비해 매우 높게 나타났으며, 이보다 농도가 높은 5.0 mg/L와 10.0 mg/L에서는 각각 81.3%와 98.1%로 처리 농도가 높아질수록 기형률이 높게 나타났다. 성전환율을 분석하기 위하여 조직학적 분석을 한 결과 대조군에서 사용된 ODJ 50마리 중 정상 수컷이 47마리였으나, 3마리가 간성(intersex)을 나타내었으며, 비스페놀 A 농도가 2.5 mg/L인 그룹에서 76.9%인 40마리가 간성으로 나타났으며, 23.1%인 12마리가 수컷으로 나타났다. 비스페놀 A 농도 5.0 mg/L와 10.0 mg/L인 그룹에서는 52마리 중 수컷은 한 마리도 나타나지 않았으며, 모든 개체에서 간성이 나타났다. Bisphenol A (BPA) is mainly used in the production of epoxy resins and polycarbonate plastics, which is a known endocrine disruptor and acutely toxic to aquatic organisms. In this study, estrogenic effect of BPA was investigated on hybrid between Oryzias dancena and O. javanicus (ODJ). ODJ were exposed to BPA of various concentrations (eg. 2.5 mg/L, 5.0 mg/L and 10.0 mg/L) for 56 days. The growth rate, abnormality and the ratio of female and male were observed in test group and control group. As a result, the growth was 14.7 ± 2.0 mm in total length (TL) in 2.5 mg/L, 13.7 ± 2.5 mm in 5.0 mg/L, 12.8 ± 2.5 mm in 10.0 mg/L in test group while it was 18.0 ± 1.2 mm in TL in control group which was not treated with bisphenol A. The result showed that the growth decreased as the concentration of BPA increased. The abnormality rate was 13.6% in control group, 65.4% in 2.5 mg/L, 81.3% in 5.0 mg/L and 98.1% in 10.0 mg/L which showed increase in abnormality as an increase of BPA concentration. As a result of analyzing ratio of sex in the test group and control group, 6.0% was examined to be interspecific in controls, 76.9% in 2.5 mg/L and 100.0% in 5.0 mg/L and 10.0 mg/L. In conclusion, these results suggest that BPA has estrogenic effect on ODJ.
신규호,김동수,한수봉,한대용,Shin, Kyoo-Ho,Kim, Dong-Soo,Hahn, Soo-Bong,Han, Dae-Yong 대한근골격종양학회 1995 대한골관절종양학회지 Vol.1 No.1
Metastatic cancer is the most common tumor of the skeleton. The prevalence of pathologic fracture may increase as patient survival is prolonged by improved cancer therapy. With recent advances in orthopaedic procedure and medical management of terminal cancer patients, it is generally agreed that aggressive treatment should be undertaken for patient with pathologic fracture secondary to metastatic disease, and a team approach should be utilized. The authors have reviewed twenty cases of pathologic fracture of the long bone due to metastatic tumor treated in the Department of Orthopedic Surgery, Yonsei University College of Medicine, from April 1989 to April 1994 and the following results were obtained. 1. The mean age at surgery was 58.4 years (ranged from 24years to 86years) and among 20 cases, 10 cases were male and the others were female. 2. The most frequent site of pathologic fracture in long bone is femur(15 cases, 75%), and followed by humerus(4 cases, 20%), tibia(1 case). 3. The frequently encountered primary tumors that metastases to long bone are those of the lung(7 cases, 35%), breast(4 cases, 20%), and prostate(2 cases, 10%). 4. The operative procedure was performed by resection of the tumor mass extensively, and we used polymethylmetacrylate for filling the dead space after resection, in all cases. 5. The mean survival period after operation is 9.2 months(ranged from 1 month to 4 years and 9 month). 6. The results of postoperative pain relief status were graded as fair to excellent in 17 cases(85%).