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Process development of a virally-safe dental xenograft material from porcine bones
김동명,강호창,차형준,배정은,김인섭,Kim, Dong-Myong,Kang, Ho-Chang,Cha, Hyung-Joon,Bae, Jung Eun,Kim, In Seop The Microbiological Society of Korea 2016 미생물학회지 Vol.52 No.2
동물유래성분을 원재료로 사용하는 의료기기는 원료물질 유래 바이러스가 오염될 가능성이 있기 때문에 생산과정 중 바이러스가 오염되지 않도록 하여야 한다. 또한 생산공정은 오염될 가능성이 있는 바이러스들을 불활화하거나 제거하는 공정을 포함하여야 한다. 본 연구를 통해 돼지유래 이종골을 원재료로 사용한 바이러스 안전성이 보증된 치과용 골이식재(THE Graft$^{(R)}$) 제조공정을 개발하였다. THE Graft$^{(R)}$ 제조공정은 30% 과산화수소수와 80% 에탄올을 각각 처리하여 지방을 제거하는 공정과 $1,300^{\circ}C$ 열처리 공정을 통해 콜라겐과 유기물을 제거하는 공정을 포함한다. 또한 최종적으로 생산된 hydroxyapatite 성분의 골이식재에 25 kGy의 감마선을 조사하여 감염성 위해인자를 불활화하는 공정을 포함한다. THE Graft$^{(R)}$의 형태학적 특성을 소유래 hydroxyapatite 성분의 골이식재인 Bio-Oss와 SEM과 TEM을 이용하여 비교한 결과 구조적 특성이 유사함을 확인하였다. $1,300^{\circ}C$ 열처리 공정과 25 kGy 감마선 조사 공정의 바이러스 불활화 효과를 평가하기 위해 transmissible gastroenteritis virus (TGEV), pseudorabies virus (PRV), porcine rotavirus (PRoV), porcine parvovirus (PPV)를 모델 바이러스로 선정하였다. $1,300^{\circ}C$ 열처리 공정에서 TGEV, PRV, PRoV, PPV 모두 검출한계 이하로 불활화되었으며, 바이러스 로그 감소 값은 각각 ${\geq}4.65$, ${\geq}5.81$, ${\geq}6.28$, ${\geq}5.21$이었다. 또한 감마선 조사 공정에서도 TGEV, PRV, PRoV, PPV 모두 검출한계 이하로 불활화되었으며, 바이러스 로그 감소 값은 각각 ${\geq}4.65$, ${\geq}5.87$, ${\geq}6.05$, ${\geq}4.89$이었다. 두 공정에서 TGEV, PRV, PRoV, PPV의 누적 바이러스 로그 감소 값은 각각 ${\geq}9.30$, ${\geq}11.68$, ${\geq}12.33$, ${\geq}10.10$이었다. 이상의 결과에 의하면, THE Graft$^{(R)}$ 제조공정은 바이러스 안전성 보증을 위한 충분한 바이러스 불활화 능력을 가지고 있는 것으로 판단된다. A process for manufacturing virally-safe porcine bone hydroxyapatite (HA) has been developed to serve as advanced xenograft material for dental applications. Porcine bone pieces were defatted with successive treatments of 30% hydrogen peroxide and 80% ethyl alcohol. The defatted porcine bone pieces were heat-treated in an oxygen atmosphere box furnace at $1,300^{\circ}C$ to remove collagen and organic compounds. The bone pieces were ground with a grinder and then the bone powder was sterilized by gamma irradiation. Morphological characteristics such as SEM (Scanning Electron Microscopy) and TEM (Transmission Electron Microscopy) images of the resulting porcine bone HA (THE Graft$^{(R)}$) were similar to those of a commercial bovine bone HA (Bio-Oss$^{(R)}$). In order to evaluate the efficacy of $1,300^{\circ}C$ heat treatment and gamma irradiation at a dose of 25 kGy for the inactivation of porcine viruses during the manufacture of porcine bone HA, a variety of experimental porcine viruses including transmissible gastroenteritis virus (TGEV), pseudorabies virus (PRV), porcine rotavirus (PRoV), and porcine parvovirus (PPV) were chosen. TGEV, PRV, PRoV, and PPV were completely inactivated to undetectable levels during the $1,300^{\circ}C$ heat treatment. The mean log reduction factors achieved were $${\geq_-}4.65$$ for TGEV, $${\geq_-}5.81$$ for PRV, $${\geq_-}6.28$$ for PRoV, and $${\geq_-}5.21$$ for PPV. Gamma irradiation was also very effective at inactivating the viruses. TGEV, PRV, PRoV, and PPV were completely inactivated to undetectable levels during the gamma irradiation. The mean log reduction factors achieved were $${\geq_-}4.65$$ for TGEV, $${\geq_-}5.87$$ for PRV, $${\geq_-}6.05$$ for PRoV, and $${\geq_-}4.89$$ for PPV. The cumulative log reduction factors achieved using the two different virus inactivation processes were $${\geq_-}9.30$$ for TGEV, $${\geq_-}11.68$$ for PRV, $${\geq_-}12.33$$ for PRoV, and $${\geq_-}10.10$$ for PPV. These results indicate that the manufacturing process for porcine bone HA from porcine-bone material has sufficient virus-reducing capacity to achieve a high margin of virus safety.
석곡 및 병풀 복합 추출물의 피부 색소 침착 방지 및 피부재생 효과
김동명,박혜령,이형곤,권용성,최연매,한인석,Kim, Dong-Myong,Park, Hye-Ryung,Lee, Hyung-Kon,Kwon, Yong-Seong,Choi, Yeon-Mea,Han, In-Suk 한국생약학회 2022 생약학회지 Vol.53 No.2
The objective of this study was to assess the effect of preventing pigmentation caused by external stimuli, promoting skin regeneration and whitening of the skin composition containing complex extract of Dendrobii Caulis and Centella asiatica (CE). We evaluated cell viability, tyrosinase and melanin inhibition activity, skin irritation test, and skin moisturizing and regenerative effects using CE. As a result of the tyrosinase inhibitory activity, 100 ㎍/mL CE (35.31%) showed higher value than kojic acid (21.32%). The results of melanin synthesis inhibition in B16F10 melanoma cells after treatment with α-melanocyte stimulating hormone showed a similar level of activity to that of arbutin, indicating an excellent whitening effect. In clinical test of the skin composition containing CE, we confirmed that CE is non-irritated in human skin primary irritation test as well as have a high skin moisturizing and regenerative effect. From these results, we suggested the CE not only prevents skin damage and pigmentation caused by external stimuli but has remarkable skin brightening activity and skin regeneration effect.
알로에 베라 부정근 추출물을 함유하는 피부 개선용 화장료 조성물에 관한 연구
김동명(Dong-Myong Kim),정주영(Ju-Yeong Jung),이형곤(Hyung-Kon Lee),권용성(Yong-Seong Kwon),백진홍(Jin-Hong Baek),한인석(In-Suk Han) 한국생물공학회 2020 KSBB Journal Vol.35 No.3
The objective of this study was to investigate whether extracts of aloe vera adventitious root produced by plant tissue culture technology has better effects on anti-wrinkle effect and skin-brightening than aloe vera extracts by performing in vitro assays. Aloe vera adventitious root and aloe vera were extracted by either water or 70% ethanol. Among water extract of aloe vera, water extract of aloe vera adventitious root, ethanol extract of aloe vera (AVE) and ethanol extract aloe vera adventitious root (AVRE), nitric oxide production inhibitory activity was the highest at AVRE, with a value of 62.28%. Inhibitory activities of matrix metalloproteinase (MMP)-1 and MMP-3 syntheses were highest at AVRE (65.11 and 37.21%, respectively). When analyzing synthetic activity of type I procollagen which has an antiwrinkle effect, AVRE showed higher value by 379.43% than UV-irradiated control group. The anti-melanogenic activity which correlates skin-brightening effect was also the highest at AVRE (83.77%), although, inhibitory activity of tyrosinase was not shown. Moreover, the value of DPPH radical scavenging activity of AVRE was higher than that of AVE by more than 10 times. From these results, it was confirmed that aloe vera adventitious root has better effect on wrinkle prevention and skin-brightening than aloe vera.
알팔파 ( Medicago sativa L. ) 의 원형질체로부터 다경 (多莖) 유도 (誘導) 식물체의 재분화
김동명(Dong Myong Kim),최관삼(Kwan Sam Choi),정원일(Won Il Chung) 한국식물학회 1989 Journal of Plant Biology Vol.32 No.4
A system was established for induction of multi-shoots and plant regeneration from mesophyll protoplasts of alfalfa, Medicago sativa L. cv. Vernal. Different hormonal effects were tested at each step of protoplast culture, i.e. cell division in modified Kao`s liquid medium (K566-7). calli formation on SH semi solid medium, and multi-shoot regeneration from calli on SHa and SHb solid media. Frequency of multi-shoots and plant regeneration was affected by various combinations of phytohormones in final step. The evaluation of multi-shoots induction systems via protoplast culture was discused.
심바이오디니움으로부터 추출된 유효성분을 함유하는 신규 SUN BLOCK 물질에 관한 연구
김동명(Dong-Myong Kim),정주영(Ju-Yeong Jung),이형곤(Hyung-Kon Lee),박상근(Sang-Keun Park),권용성(Yong-Sung Kwon),양승구(Seung-Koo Yang),한인석(In-Suk Han) 한국해양바이오학회 2020 한국해양바이오학회지 Vol.12 No.1
Symbiodinium is a dinoflagellate genus that coexists with coral reefs and is known to provide ultraviolet (UV) protection in nature through the synthesis of mycosporin-like amino acids (MAA). In order to develop a natural and ecofriendly sunblock for use in summer resorts, the possibility of using a Symbiodinium microbiome extract or an MAA was investigated. Two sunblocks, one containing 7% Symbiodinium extract and the other containing MAA were prepared to be tested on hairless mice and human skin. In this clinical study, the sun protection factor (SPF) and Protection factor of UV A (PFA) values of the sunblock containing either Symbiodinium extract or MAA were determined. The SPF values of the sunblock containing Symbiodinium extract and MAA were 10.43 and 10.83, respectively, and the PFA values were 3.42 and 3.39, respectively. Based on their PFA values of ≥2, the UV A protection can be graded as PA+ (low) for both the sunblocks. In addition, the UV-blocking extract of Symbiodinium has a low phototoxicity and cytotoxicity, reducing the possibility of a heavy feeling to the skin or a foreign-body sensation caused by residue build-up. The low toxicity feature of the major sunblock component will also prevent side effects, such as allergic reactions. Although Symbiodinium extract or MAA alone do not provide effective protection against UV irradiation, their protection capacity can be complemented by the addition of inorganic UV-protecting compounds.
식용 제비집으로부터 비극성 비드기술을 활용한 시알산의 분리정제방법에 관한 연구
김동명(Dong-Myong Kim),정주영(Ju-Yeong Jung),이형곤(Hyung-Kon Lee),권용성(Yong-Sung Kwon),백진홍(Jin-Hong Baek),한인석(In-Suk Han) 한국해양바이오학회 2020 한국해양바이오학회지 Vol.12 No.2
Sialic acid, which is contained in about 60-160 mg/kg in the edible bird’s nest(EBN), is known to facilitate in the proper formation of synapses and improve memory function. The objective of this study is to extract effectively the sialic acid from edible bird’s nest using affinity bead technology (ABT). After preparing the non-polar polymeric bead “KJM-278-28A” having a porous network structure, and then desorbed sialic acid was concentrated and dried. The analysis of the physicochemical properties of bead “KJM-278-28A” showed that the particle size was 400-700 μm, the moisture holding capacity was 67-70%, the surface area (BET) was 705-900 m²/g, and the average pore diameter 70-87 Å. The adsorption capacity of the bead “KJM-278-28A” for sialic acid was shown a strong physical force to bind sialic acid to the bead surface of 400 mg/L. In addition, as a result of analyzing the adsorption and desorption effects of sialic acid on water, ethanol, and 10% ethanol on the bead, it was confirmed that desorption effectively occurs from the beads when only ethanol is used. As a result of HPLC measurement of the separated sialic acid solution, a total of four sialic acid peaks of N-acetyl-neuraminic acid (Neu5Ac), α,β-anomer of Neu5Ac and N-glycoly-neuraminic acid were identified. Through these results, it was confirmed that it is possible to separate sialic acid from EBN extract with efficient and high yield when using ABT.
새로운 ERM-방법에 의한 미세구조 N-채널 MOSFET의 유효 캐리어 이동도와 소스 및 드레인 기생저항의 정확한 분리 추출
金炫昌(Hyun Chang Kim),曺洙東(Su Dong Cho),宋尙駿(Sang Jun Song),金大井(Dea Jeong Kim),金東明(Dong Myong Kim) 大韓電子工學會 2000 電子工學會論文誌-SD (Semiconductor and devices) Vol.37 No.12
미세구조 N-채널 MOSFET의 게이트-소스 전압에 의존하는 유효 채널 캐리어 이동도와 소스 및 드레인 기생저항의 정확한 분리 추출을 위해서 새로운 ERM 방법을 제안하였다. ERM-방법은 선형영역에서 동작하는 게이트 길이가 다른 두개의 소자(W<SUB>m</SUB>/L<SUB>m</SUB>=30㎛/0.6㎛, 30㎛/1㎛)에 적용되었고 유효 채널 캐리어 이동도를 모델링하고 추출하는 과정에서 게이트-소스 전압에 의존하는 소스 및 드레인 기생저항의 영향 을 고려하였다. ERM-방법으로 추출된 특성변수들을 사용한 해석적 모델식과 소자의 측정데이터를 비교해본 결과 오차가 거의 없이 일치하는 것을 확인하였다. 따라서 ERM-방법을 사용하면 대칭구조 및 비대칭구조 소자의 유효 채널 캐리어 이옹도, 소스 및 드레인 기생저항과 다른 특성변수들을 정확하고 효율적으로 추출 할 수 있을 것으로 기대된다. A new method, the external resistance method (ERM method), is proposed for accurate extraction of the gate bias-dependent effective channel carrier mobility (μ<SUB>eff</SUB>) and separated parasitic source/drain resistances (R<SUB>S</SUB> andR<SUB>D</SUB>) of n-channel MOSFET’s. The proposed ERM method is applied to n-channel LDD MOSFETs with two different gate lengths (W<SUB>m</SUB>/L<SUB>m</SUB>=30 ㎛/0.6 ㎛, 30 ㎛/1 ㎛) in the linear mode of current-voltage characteristics (I<SUB>D</SUB>-V<SUB>GS</SUB>, V<SUB>DS</SUB>). We also considered gate voltage dependence of separated R<SUB>S</SUB> and R<SUB>D</SUB> in the accurate modeling and extraction of effective channel carrier mobility. Good agreement of experimental data is observed in submicron n-channel LDD MOSFETs. Combining with capacitance-voltage characteristics, the ERM method is expected to be very useful for accurate and efficient extraction of μ<SUB>eff</SUB>, R<SUB>D</SUB>, R<SUB>S</SUB>, and other characteristic parameters in both symmetric and asymmetric structure MOSFET’s in which parasitic resistances are critical to the improvement of high speed performance and reliability.