http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
수 종의 생약제제가 MC3T3-E1 세포의 염기성 인산분해효소 합성에 미치는 영향
김대겸,김탁,피성희,김현아,최광수,유형근,신형식,Kim, Dae-Kyum,Kim, Tak,Pi, Sung-Hee,Kim, Hyun-A,Choi, Kwang-Soo,You, Hyung-Keun,Shin, Hyung-Shik 대한치주과학회 1999 Journal of Periodontal & Implant Science Vol.29 No.4
Several growth factors and polypeptidesare not commonly yet used for regenerators of bone tissue or alveolar bone because of the insufficiency of studies on their side effects, genetic engineering for mass production and stability for clinical application. Recently, many natural medicines, which have advantage of less side effects and possibility of long-term use, have been studied for their capacity and effects of anti-bacterial, anti-inflammatory and regenerative potential of periodontal tissues. Olibanum, Myrrha, Phlomis Radix, and Cimicifugae Rhizoma have been traditionally used as a drug for treatment of bone disease in oriental medicine. The objective of this study was to examine the ability of alkaline phosphatase(ALP) synthesis of rat calvarial osteoblast(MC3T3-E1) when several natural medicines were supplemented. MC3T3-E1 cells were cultured with ${\alpha}$-MEM(negative control), dexamethasone(positive control), and each natural medicines for 3 and 5 days. And then ALP synthesis was measured by spectrophotometer for enzyme activity and by naphthol AS-BI staining for morphometry. All of the natural medicines induced higher activity of ALP synthesis than the negative controls. Especially Olibanumind uced the higher activity than the positive controls (p<0.05). In the aspects of culturing time, except Cimicifugae Rhizoma, the natural medicines induced higher activity of ALP synthesis at 5 days than at 3 days (p<0.05). In morphometry, all of the natural medicines showed statistical significance compared to the negative control (p<0.05). Myrrha a n d Phlomis Radix showed larger positively stained area at 5days than at 3 days, whereas the others did not showed the difference between at 5 and at 3 days(p<0.05). These results indicate that several natural medicines have an inducing ability of ALP synthesis in MC3T3-E1 cells.
김대겸 ( Dae-kyum Kim ) 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.1
Background and Objectives: Thyroid nodules are common and the incidence of thyroid cancer is rapidly increasing. Unlike other countries, incidence rate is highest in middle-aged people in Korea. The objective of this study was to determine the prevalence of thyroid nodules and thyroid cancers in a community clinic. Materials and Methods: Patients who visited Hyochon-prun clinic in Daejeon between July 2008 and Sep. 2008 were examined with high resolution ultrasonography and fine needle aspiration cytology (FNAC) after clinical evaluation. Results: Thyroid nodules were detected in 323 patients (28.7%) out of 1,125 subjects and the most prevalent age group was a group of more than 60 years. With palpation, the nodules were detected in 62 patients (5.5%) out of 1125 subjects. Five (7.2%) out of 70 nodules were malignant on FNAC, 8 (11.4%) suspicious, 1 (1.4%) indeterminate, 49 (70.0%) benign, and 7 (10.0%) inadequate for diagnosis. Thyroid cancer was diagnosed in 11 patients postoperatively and age-standardized prevalence of thyroid cancer was expected 8.5 per 1,000 persons. The most prevalent age group of thyroid cancer was a group of more than 60 years. Five patients (83.3%) out of 6 thyroid cancer patients who were more than 60 years were high-risk in AMES prognostic category. Conclusion: Prevalence of thyroid nodules and thyroid cancers is high and increased with age.
수종의 생약추출물이 MC3T3-E1 세포의 염기성 인산분해 효소 활성에 미치는 영향
박상기,김대겸,유승한,김현아,김명동,유형근,신형식,Park, Sang-Kee,Kim, Dae-Kyum,You, Seung-Han,Kim, Hyun-A,Kim, Myoung-Dong,You, Hyung-Keun,Shin, Hyung-Shik 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.1
Several growth factors and polypeptides were studied for the regeneration of periodontal supporting tissues which had been lost due to periodontal disease. But these are not commonly used for regenerators of bone tissue or alveolar bone, because of the insufficiency of studies on their side effects, genetic engineering for mass production and stability for clinical application. Recently, many natural products, which have advantage of less side effects and possibility of long-term use, have been studied for their capacity and effects of anti-bacterial, anti-inflammatory and regenerative potential or periodontal tissues. Cnidii Rhizoma, Rhinocerotis Cornu and Drynariae Rhizoma have been traditionally used as a drug for treatment of bone disease in oriental medicine. The purpose of this study was to examine the ability of alkaline phosphatase synthesis of MC3T3-E1 cells when above medicines were supplimented. MC3T3-E1 cells were cultured with ${\alpha}-MEM(negative control)$, dexamethasone(positive control), and each natural products for 3 and 5 days. And then ALP synthesis was measured by spectrophotometer for enzyme activity and by naphthol AS-BI staining for morphometry. Except Cnidii Rhizoma, all of the natural products of this study induced higher activity of ALP synthesis than controls. Among them Drynariae Rhizoma induced the highest activity. In the aspects of culturing time, all medicines did not showed the difference between 3 and 5 days, but $10^{-7}g/ml$ group of Rhinocerotis Corun showed significant increase at 3 days than at 5 days. These results indicate that several natural products have a inducing ability of ALP synthesis on osteoblasts.