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해외유입 말라리아의 진단에서 말라리아 신속항원검사의 유용성
권용환 ( Yong Hwan Kwon ),김석원 ( Seok Won Kim ),박수연 ( Soo Yeon Park ),장동원 ( Dong Won Jang ),정연오 ( Yeon Oh Jeong ),김가연 ( Ga Yeon Kim ),진범식 ( Bum Sik Chin ),신형식 ( Hyoung Shik Shin ) 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.2
Objectives: Peripheral blood smear is the gold standard for the diagnosis of malaria. However, it is labor-intensive, time consuming, and more importantly, requires skill and experienced microscopists. This study was carried out to evaluate diagnostic performance of rapid diagnostic test (RDT) for detection of imported malaria. Methods: Peripheral blood smears, and RDT on the medical records were analyzed retrospectively for patients with a history of a foreign travel who visited National Medical Center between August 2009 and December 2013. Compared with the peripheral blood smear, the sensitivity and specificity of RDT were evaluated. Results: Among the total of 368 blood samples, the peripheral blood smear diagnosed 42 P. falciparum and 6 non-falciparum infections. The overall sensitivity of RDT was 91.7% (44/48) and the overall specificity of RDT was 94.1% (301/320). The sensitivity for P. falciparum of the RDT was 97.6% (41/42) and it was increased up to 100% (39/39) with the parasite densities of > 50 parasites/μL. Conclusion: Considering rapidity, high sensitivity and specificity, RDT was useful as an adjunctive tool for diagnosis of imported malaria.
권용환 ( Yong Hwan Kwon ) 대한내과학회 2021 대한내과학회지 Vol.96 No.1
Helicobacter pylori (H. pylori) is the main cause of most gastroduodenal diseases. Triple therapy including two antibiotics, amoxicillin and clarithromycin, and a proton pump inhibitor given for a week has been recommended as the treatment of choice since the revision of the Korean H. pylori Clinical Practice Guidelines in 2013. However, antimicrobial resistance significantly decreased the cure rate of H. pylori eradication to 63.9%. Thus, the new H. pylori treatment regimen would be needed to increase the eradication rate in Korea. Recently, the update of clinical practice guideline for treatment of H. pylori was developed by conducting a meta-analysis. In this review, the recommended H. pylori eradication regimen in current 2020 guideline will be discussed. (Korean J Med 2021;96:13-21)
권용환 ( Yong Hwan Kwon ),김현진 ( Hyun Jin Kim ) 대한소화기학회 2016 대한소화기학회지 Vol.68 No.3
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. The pathophysiology of IBS is not completely understood. Genetic, immune, environmental, inflammatory, neurological and psychological factors contribute to the risk of this condition. Traditional research explored gastrointestinal motor abnormalities, central neural dysregulation, abnormal psychological features, and visceral hypersensitivity. More recent investigations consider bacterial overgrowth, abnormal serotonin pathways, altered gut flora, immune activation and mucosal inflammation. The purpose of this article is to review recent translational research concerning the pathophysiology, biomarker and genetic factors of IBS and to encourage IBS research in Korea. (Korean J Gastroenterol 2016;68:138-142)
권용환(Yong Hwan Kwon),이정동(Jeong Dong Lee),정도철(Do Chul Jung),윤세진(Se Jin Yoon),황영현(Young Hyun Hwang) 한국자원식물학회 2005 한국자원식물학회지 Vol.18 No.3
천마 재배에서 차광방법 개발과 접종목 재활용의 가능성을 검정하여 저 비용, 고 생산의 재배법을 확립하기 위한 실험을 수행하였다. 비가림을 하지 않은 노지재배에서는 종마의 수량이 성마의 수량 보다 높았다. 차광 방법에 따른 천마의 수량은 95% 차광망 1겹, 2겹 및 무차광순 이었으며, 접종목 혼용에 따른 천마의 수량은 생목만 사용하였을 경우에 가장 높았고, 다음으로는 생목과 재활용목을 2:1로 및 1:1 혼용처리 처리 순이었다. 접종목 혼용에 따른 수익성 비교에서 95% 차광막 1겹 처리시 생목과 재생목을 2:1로 혼용한 경우는 생목만 사용한 경우 수익의 81%이었다. 재배법 개선을 통해 수량성을 높일 수 있다면 생목과 재생목을 적당한 비율로 섞어 재배할 경우 비용 절감과 환경보호 차원에서 유용한 방법으로 사료된다. To establish the economical cultivation method of Gastrodia elata Blume by controlling the shading rate and the mixing ratio of recycling spawn bed logs, a serial experiment was carried out. When G. elata was grown in the field with no shading, the yield of spawn tuber was higher than that of tuber of G. elata. The yield of G. elata was high in the rainproof green house covered with one layer of 95% shading net, in the rainproof green house covered with two layers of 95% shading net, and in the field with no shading, in that order. In the case of mixing ratio of recycling spawn bed logs, the yield was high in the fresh logs, in the mixing ratio of 2:1, and the ratio of 1:1, in that order. The income of the rainproof green house covered with one layer of 95% shading net which brought the best yield was 81% in the mixing ratio of 2:1 over the fresh logs.