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Expression Profile of Fas-Fas Ligand in Spiral Ganglion Cells During Apoptosis
구태우,배우용,박환태,이재훈,강민영,정성욱,신윤경 대한이비인후과학회 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.1
Objectives. To examine the expression profile of Fas-Fas ligand (FasL) during glutamate (Glu)-induced spiral ganglion cell (SGC) apoptosis. Methods. Cultured SGCs were treated with 10-mM, 25-mM, and 50-mM concentrations of Glu and incubated for 24 or 48 hours. The expression intensity of FasL, Fas, caspase 3, and morphology of single SGC were evaluated using immu- nofluorescence staining. Results. In semiquantitative analysis of the Glu-treated SGC, FasL, and caspase 3 expression intensity were increased with concentration- and time-dependent manner. Fas expression intensity did not change with different concentration at 48 hours. In morphologic analysis of the Glu-treated SGC, number of apoptotic cells were increased with concentra- tion- and time-dependent manner. Conclusion. FasL was expressed in apoptotic SGCs, suggesting that the Fas-FasL signaling pathway may be involved in the Glu-induced apoptosis of dissociated SGCs.
구태우,배우용,박정홍,이승철 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.9
end of a proximal nerve stump folowing partial or complete transection of a nerve. Traumatic neuromas of the head and neck are relatively rare, and pain is the main symptom. Several cases of the traumatic neuromas of the head and neck have been reported in the literature at such sites as oral cavity, maxillary division of the trigeminal nerve, the inferior alveolar of the mandible, the auriculotemporal nerve, the glossopharyngeal nerve, and the facial nerve. We experienced a 60-year-old woman s excised and the pathologic diagnosis was traumatic neuroma. We report this case here with a review of the literature. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :826-8)