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리도카인을 이용한 경막외 마취시 Nitrous Oxide가 감각차단에 미친 영향
구영권(Young Gwon Goo),우수영(Soo Young Woo),조강 대한통증학회 1999 The Korean Journal of Pain Vol.12 No.1
N/A Backgroud: Systemic administration of opioid can prolong the duration of epidural anesthesia. The authors examined the effect of nitrous oxide (NO) on the level of sensory block induced by epidural lidocaine. Methods: Twenty minutes after epidural injection of 2% lidocaine (below 70 years: 20 ml, 70 years and above: 15 ml), the level of sensory block was assessed (2nd stage). Patients were randomly assigned to receive either medical air (control group, n-15) or 50% N2O in oxygen (N2O group, n 15) for 10 minutes, the level of block was reassessed (3rd stage). Pateints were given room air (control group) or 100% oxygen for 5 minutes and room air for 5 minutes (N2O group), and the level of block was reassessed (4th stage). Results: At the 3rd stage, N2O group showed 4.3 cm cephalad increase in the level of sensory block (p-0.005), but control group revealed 1.43 cm regression. After discontinuation of gas, the level of block regressed in both group (p 0.000). At the 4th stage, NO group revealed 3.5 cm cephalad increase (p 0.048) and control group 1.97 cm regression (p=0.001) as compared with the 2nd stage. Conclusions: The level of sensory block induced by epidural lidocaine was significantly increased cephalad by concommitant use of 50% NO for 10 minutes.
요관경하배석술을 위한 Propofol 단독 정맥마취의 평가
김운영,구영권,주경화,신혜원,서규석,어홍선,유탁근 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.34 No.3
Background: Propofol is an intravenous anesthetic characterized by rapid induction and prompt recovery. Recently, its is used widely in clinical practice, especially when early discharge is advisable. We conducted this study for the evaluation of the effects of propofol as a sole intravenous anesthetic on the operation with minimal pain such as TUL(transurethral lithotripsy). Methods : Patients were recruited for ASA class 1 and 2 from those who received TUL operation. Propofol was administered 2 mg/kg for induction and continuously infused at the rate of 1.2∼1.4 mg/kg/hr after the loss of consciousness. With the stabilization of the vital signs, we reduced the dose of propofol to 1.0∼1.2 mg/kg/hr. We checked the patients' movement, vital signs, recovery time and monitored the appearance of the symtoms such as nausea, vomiting postoperatively. Results : 1) The average time of operation was 15 12 minutes. 2) The average recovery time was 15 9 minutes(range 2∼30 min). 3) Blood pressure and peripheral oxygen uration(SpO2) were declined during anesthesia, but SpO2 was normalized in the recovery room. 4) No significant complications were observed. 5) Mild movement of the patient was noticed in the begining of operation, but it did not affect the surgical procedure. Conclusions : Propofol was effective as a sole intravenous anesthetic to minimize postoperative complications such as nauea, vomiting for TUL with minimal pain. (Korean J Anesthesiol 1998; 34: 531∼536)
김영재,조강희,박주열,신치만,구영권,김환덕 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.37 No.3
Background : The reduction in hematocrit (Hct) by hemodilution tends to cause an increase in cardiac output and a proportional decrease in arterial oxygen content. Additionally the reduction of systemic oxygen delivery (DO2) leads to significant differences in regional blood flow. It is therefore important to characterize the effects of hemodilution on regional oxygen metabolism in individual organs. This study was undertaken to evaluate and compare the effects of acute normovolemic anemia induced by hemodilution. Methods : Six dogs were anesthetized and mechanically ventilated. Catheters were inserted in the right femoral and pulmonary arteries for blood sampling, and a gastric tonometer catheter was inserted into the gastric lumen. Baseline measurements of systemic hemodynamics, arterial ketone body ratio (AKBR), gastric intramucosal pH (pHi) and arterial lactate were recorded. Hemodilution was then begun by 6% pentastarch and was made in four levels of hematocrit values of 20%, 15%, 10% and 6%. Results : Mean arterial pressures of Hct 10% and 6% was decresaed (P < 0.05) and Hct 15% and 10% increases in cardiac output and pulmonary capillary wedge pressure (PCWP) were observed. Central venous pressure and mean pulmonary arterial pressure were incresed (P < 0.05) at Hct 15%, 10% and 6%. DO2 progressively decreased (P < 0.05). AKBR and pHi began to decreased at Hct 15%. Arterial lactate decrease at Hct 15% and was above 7.4 mmol/L at Hct 6%. Conclusions : By the measurements of AKBR and pHi, the disturbance of splanchnic oxygenation can be detected early compared to those of O2 in terms of oxygen metabolism and the critical point of DO2 during acute normovolemic anemia induced by hemodilution. (Korean J Anesthesiol 1999; 37: 478∼488)