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Clonidine ( Catapres ) 의 정맥주사에 의한 강압 효과 및 혈장 내 Renin 활성도
고영박 ( Young Bark Koh ) 대한내과학회 1972 대한내과학회지 Vol.15 No.12
In order to assess the acute hypotensive effect of clonidine for emergency patients intravenous injection was used in 31 hypertensive patients, of whom 9 patients were selected out for evaluation of the changes of plasma renin activity. The results obtaine
관동맥 질환 환자에서 Lipoprotein ( a ) 농도와 당내인성과 관련성
두영철(Young Cheoul Doo),최조영(Jo Young Choi),장명국(Myung Kuk Jang),홍성훈(Sung Hun Hong),장명준(Myeong Jun Chang),고순희(Soon Hee Koh),한규록(Kyoo Rok Han),오동진(Dong Jin Oh),유규형(Kyu Hyung Ryu),고영박(Young Bahk Koh),이영(You 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: A raised Lp (a) lipoprotein concentration is associated with coronary artery disease and impaired glucose intolerance has also been shown to be predictive of coronary artery clisease in some studies. It has been suggested that there is a significant association between impaired glucose tolerance and increased circulating Lp (a) lipoprotein concentration. The object of this study is to determine whether glucose intolerance and raised Lp (a) concentration are associated in subjects with coronary artery disease. Methods: The study group comprised 60 patients with coronary artery disease (M:20, mean age 56+/-13 year) and 70 control subjects without coronary artery disease (M:15, mean age 58+/-10 year). We compared the clinical variables, lipid profile including Lp (a), fasting glucose, and fasting insulin in subjects with coronary artery disease with impaired glucose tolerance and normal glucose tolerance, and in controls. Results: 1) Nine of 60 patients (15%) with coronary artery disease had glucose intolerance. There were no significant difference in the incidence of cardiovascular risk factors, body mass index, left ventricular mass index, the levels of lipid including Lp (a), and the levels of fasting glucose, insulin, and C-peptide except in the incidence of smoking (48% in patients with coronary artery disease vs 24% in normal control, p<0.05) between patients with coronary artery disease and normal controls. 2) Between coronary artery disease patients group with and without glucose intolerance, and normal controls, there were no difference in the level of Lp (a) concentration. Conclusion: The level of fasting glucose and concentration of Lp (a) were no difference in between patients with coronary artery disease and normal controls. There was no difference in concentration of Lp (a) in patients of coronary artery disease with and without glucose intolerance, and so suggest that raised Lp (a) lipoprotein concentration are not responsible for the association between impaired glucose tolerance and coronary artery disease.
관동맥 연축환자의 약물투여기간 및 질병의 활성도에 대한 장기 추적 관찰
김철홍(Cheol Hong Kim),유규형(Kyu Hyung Ryu),한성우(Seong Woo Han),박규용(Kyu Yong Park),한윤창(Yun Chang Han),홍경순(Kyung Soon Hong),두영철(Young Cheoul Doo),한규록(Kyu Rok Han),오동진(Dong Jin Oh),임종윤(Chong Yun Rim),고영박(Youn 대한내과학회 1998 대한내과학회지 Vol.54 No.1
N/A Objectives: Clinical course of vasospastic angina is variable : spontaneous remission, persistent angina and progression of disease or death. Several studies from western institutes have been performed on the clinical characteristics and long-term prognosis of patient with coronary vasospasm. In these reports, 53-82% of patients had spontaneous remission. These results may be assumed differ from that of Korean patients with vasospastic angina, but no detailed studies have been reported in Korea. Currently, in patients with vasospastic angina, treatment with calcium antagonists and/or nitrates are effective in reducing the frequency of anginal attacks. And, clinical course and outcome of vasospastic angina may be different from previous western reports thereafter. The purpose of this study is to describe the disease activities and the factors influencing the clinical course of vasospastic angina in relation to medication-period; age, sex, risk factors, extents of coronary vasospasm, initial ischemic events and significance of fixed lesion. Also we tried to determine if clinical or angiographic variables might be useful in predicting the possibility of spontaneous remission for an each patient. Methods: Eighty-seven patients with vasospastic angina(M/F;58/29, mean age;53±9 years) were included and all documented coronary vasospasm on the coronary angiogram, spontaneous spasm in 35, positive ergonovine or acetylchoine provocation in 52. Coronary artery spasm was defined as more than 75% reduction in coronary luminal diameter and ST segment changes on electrocardiogram, or typical anginal symptoms together and then narrowed coronary arteries were recovered after intracoronary nitroglycerin. The patients were treated with calcium antagonists(nifedipine, diltiazem, amlodipine and felodipine) and nitrates single or both and were divided into 3 groups according to angina activity: group I, which anginal attacks less than one time monthly, group II, which anginal symptoms occurred in 24- 48 hours after withdrawal of medication, group III, which symptoms recurred frequently with the incidence of over one time weekly, After discharge, each patient returned to a medical out-patient department at every 1-2 months. Results: Age, gender, other coronary risk factors, disease activity of vasospastic angina, initial clinical presentation at admission, coronary angiographic findings, fixed lesion and alcohol-induced anginal attacks were not statistically different among the 3 groups. But admission frequency of group II and III, which had a high anginal activities, were more than that of group I significantly. Conclusion: In the present study, it is concluded that medical treatment in patients with vasospastic angina in Korea may be taken long duration during follow-up period if the patient of group II and III considered to persistent angina group. To assess the prevalence of spontaneous remission, we consider that systematic attempts to taper medication may be done for patient of group I(angina free-on treatment) after absence of anginal attacks for at least one year medication-period.
관상동맥질환 환자 , 운동선수 및 정상 대조군에서 혈청지질 및 Apolipoproteins 에 대한 연구
박정의(Jeong Euy Park),김우주(Woo Joo Kim),최인석(In Suok Choi),김대원(Dae Won Kim),이갑노(Kap No Lee),김성수(Sung Soo Kim),유원상(Won Sang Yoo),최석구(Suck Koo Choi),이건주(Kun Joo Rhee),서순규(Soon Kyu Suh),이영(Young Lee),고영박(You 대한내과학회 1991 대한내과학회지 Vol.40 No.5
N/A To investigate the usefulness of serum lipids and apolipoproteins as indices of risk factors for coronary artery disease (CAD) and to know the effects of regular exercise on the serum lipids and apolipoproteins, we measured the serum lipids and apolipoproteins in the patients with coronary artery disease, athletes and normal control persons. The study subjects included 67 patients with CAD (57. 8±11.2yr), 22 athletes (21.5±2.1yr) and 62 normal control persons (34.3±11.4yr). 1) In the patients with CAD the serum total cholesterol (TC) was 177. 2±38.5 mg/dl and the HDL-cholesterol (HDL-C) was 39.0±11.2mg/dl. In the normal control persons TC was 162.5±33.5 mg/dl and HDL-C was 42.4±12.6mg/dl, which were not significantly different from the values of CAD patients. 2) The serum apolipopratein A (Apo-A) was significantly lower (201.9±39.6mg/dl, p<0.05), and the apolipoprotein B (Apo-B) was significantly higher (132.3±29.7 mg/dl, p<0.05) in the patients with CAD, compared with normal control persons (age over 40 years; Apo-A: 246.3±39.9 mg/dl, Apo-B: 117.9±26.4 mg/dl). 3) The TC/HDL-C ratio and Apo B/A ratio were significantly higher (4.9±1.6, 0.67±0.17, p<0.005 for TC/HDL-C ratio and p<0.05 for Apo B/A ratio) in the CAD patients compared with normal control persons (age over 40 years; 3.6±1.1, 0.49±0.10). 4) The TC/HDL-C ratio ≥4.0 and Apo B/A ratio ≥0.55 were the good discriminating criteria separating the CAD patients from the normal control persons. 5) In the athletes, the serum triglyceride (TG) was significantly lower (65.7±20.7mg/dl, p<0.001), and the HDL-C was significantly higher (57.8±11.2 mg/dl, p<0.001) compared with normal control persons (age under 30 years; TG; 119.8±94.3 mg/dl, HDL-C: 44.6±11.0mg/dl). The Apo-A, Apo-B, TC/HDL-C ratio and Apo B/A ratio were all significantly lower (p<0.01) compared with those in the normal control persons. 6) Among the athletes, the HDL-C was highest and the TG was lowest in the swimmers compared with fencing players and wrestlers. The Apo B/A ratio and TC/HD1-C ratio were better discriminating indices of risk factors for CAD compared with individual lipids or apolipoprotein values. The Apo-A and Apo-B were considered to be good indices of risks for CAD. The athletes had lowest risks for CAD.