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급성 신부전으로 발현되어 다발성 장기부전을 동반한 λ형 경쇄침착질환
고강지 ( Gang Jee Ko ),김정엽 ( Jeong Yup Kim ),김명규 ( Myung Kyu Kim ),최혜민 ( Hye Min Choi ),현영율 ( Young Youl Hyun ),부창수 ( Chang Su Boo ),성수아 ( Su Ah Sung ),원남희 ( Nam Hui Won ),조상경 ( Sang Kyung Jo ),조원용 ( Won 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.6
혈액투석을 시행하는 만성 신부전 환자에서 IL-10 유전자형 및 혈중농도와 심혈관계 합병증과의 관계에 대한 고찰
고강지 ( Gang Jee Ko ),김정엽 ( Jeong Yup Kim ),김명규 ( Myung Kyu Kim ),서순용 ( Soon Yong Suh ),최혜민 ( Hye Min Choi ),현영율 ( Young Youl Hyun ),부창수 ( Chang Su Boo ),이지은 ( Jee Eun Lee ),성수아 ( Su Ah Sung ),조상경 ( San 대한내과학회 2005 대한내과학회지 Vol.68 No.5
목적 : 혈액투석을 시행하는 만성 신부전 환자에서 만성 염증상태가 지속되는 것이 영양 결핍과 심혈관계 합병증 증가와 관련되어 있다는 연구가 이루어지고 있다. IL-10은 항염증 사이토카인 중 중추적 역할을 담당하는 것으로 유전자형에 따라 혈중 농도의 변화가 보고된 바 있다. 이에 본 연구에서는 만성 신부전 환자에서의 IL-10 혈중농도를 정상군과 비교하고 유전자형에 따른 농도변화와 심혈관계 질환 위험인자와의 상관성을 분석하였다. 방법 : 정상군 98명, Background : Chronic systemic inflammation in ESRD patients due to uremia and hemodialysis procedure itself comes into notice as a main factor for premature mortality secondary to rapid progressing atherosclerosis. Various pro-inflammatory cytokine, known
고강지 ( Gang Jee Ko ) 대한내과학회 2015 대한내과학회지 Vol.88 No.4
Radiocontrast-induced nephropathy (CIN) is the third most common cause of acute renal failure among inpatients. The number of patients undergoing examinations using radiocontrast is increasing, and the population at risk for CIN is growing; this population includes older individuals and those with underlying diabetes mellitus, chronic kidney disease, hypertensive nephropathy, and concomitant use of nephrotoxic drugs. However, little progress in CIN treatment has been made. CIN remains a substantial medical problem because of its association with prolonged hospitalization, the potential need for renal replacement therapy, and increased mortality. The exact pathogenesis of CIN has not been fully elucidated―and multiple factors including tubular renal vasoconstriction, direct renal tubular toxicity, increased oxidative stress, and cellular apoptosis―may contribute to the proximal tubular damage that occurs in patients with CIN. Despite the exploration of numerous prophylactic regimens and treatments, definite therapeutic and preventive strategies for CIN have not been established. This article reviews recent studies involving the risk factors for CIN as well as its pathophysiology and prevention.
당뇨병성 신증 : 아포지단백 E 제거 백서에서 장기적인 Deoxycorticosterone acetate 투여가 미치는 영향에 관한 연구
고강지 ( Gang Jee Ko ),강영선 ( Young Sun Kang ),송혜경 ( Hye Kyoung Song ),이미화 ( Mi Hwa Lee ),권오성 ( Oh Sung Kwon ),한금현 ( Kum Hyun Han ),한상엽 ( Sang Youb Han ),한지영 ( Jee Young Han ),김형규 ( Hyoung Kyu Kim ),차대룡 ( 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1
복막투석 환자에서 Listeria Monocytogenes에 의한 복막염
주문경 ( Moon Kyung Joo ),고강지 ( Gang Jee Ko ),조원용 ( Won Yong Cho ),김형규 ( Hyoung Kyu Kim ),권보성 ( Bo Sung Kwon ),장진수 ( Jin Su Jang ),박재연 ( Jae Youn Park ),김승영 ( Seung Young Kim ),김진남 ( Jin Nam Kim ),노경호 ( 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.5
Peritonitis in continuous ambulatory peritoneal dialysis is a major cause of technical failure in peritoneal dialysis. The major pathogen is gram positive bacteria, and other main pathogens include gram negative bacteria, mixed infection and fungal infection actively involved in the order named. Coagulate-negative Staphylococcus, Streptococcus, Staphylococcus aureus and Enterococcus cause most of the gram positive bacterial infections, and cases with other pathogens are very rare. We hereby report a case of peritonitis by Listeria Monocytogenes that was not responsive to the usual antibiotics for CAPD-associated peritonitis. A 58-year-old male who has been treated with CAPD for 17 years visited our hospital for abdominal pain, fever and turbid peritoneal fluid. He was diagnosed as diabetes mellitus 20 years ago. White blood cell and neutrophil count increased at the initial peritoneal fluid analysis, so we diagnosed him as CAPD-associated peritonitis. Antibiotic therapy was initiated with intraperitoneal injections of cefazolin/tobramycin, which were soon changed to vancomycin/ceftazidime. However, vancomycin/ceftazidime regimen was also proven ineffective. On the sixth hospital day, L. Monocytogenes was cultured in the peritoneal fluid sampled on the first visiting day. So we accordingly changed the antibiotics for ampicillin/sulbactam, which led to clinical and laboratory improvement. In the cases of CAPD associated peritonitis in immunosuppressive patients such as the elderly, caused either by diabetes or by taking immunosuppressive agent, if they do not respond to the usual antibiotics, we should consider the possible infection by unusual pathogens. Gram positive rod in peritoneal fluid is a supporting evidence of peritonitis by L. monocytogenes. (Korean J Nephrol 2006;25(5):857-861)