http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
고옥현(Ok Hyung Ko),강형룡(Hyung Ryong Kang),유진철(Jin Cheol Yoo),김경수(Gyung Soo Kim),홍석순(Suk Soon Hong),김영수(Young Soo Kim),황화영(Hwa Young Hwang) 대한약학회 1992 약학회지 Vol.36 No.2
7beta-(5-Aryl-2H-tetrazol-2-yl)acetamidocephalosporanic acid (23~26) and 7beta-(5-Aryl-4-phenyl-4H-1,2,4-triazol-3-yl)thioacetamidocephalosporanic acid were synthesized by condensation of 5-Aryl-2H-tetrazol-2-acetyl choloride(17~20) and 5-Aryl-4-phenyl-4H-1,2,4-triazol-3-thioacetyl chloride(22~24) with 7-Aminocephalosporanic acid (7-ACA), respectively. These seven compounds were tested in vitro antimicrobial activity. These exhibited good antimicrobial activity against Gram-positive bacteria whereas most compounds showed decreased antimicrobial activity against Gram-negative bacteria.
7 beta-Diphenyl Triazolyl Thioacetamidocephalosporin의 합성과 항균작용
김영수(Young Soo Kim),고옥현(Ok Hyun Ko),강형룡(Hyung Ryong Kang) 대한약학회 1990 약학회지 Vol.34 No.2
7beta-[4-Phenyl-5-(3.4.5-trimethoxyphenyl)-4H-1.2.4-triazol-3-yl]thioacetoamidocepharosporanic acid was synthesized by condensation of 7-Aminocephalosporanic acid (7-ACA) with [4-Phenyl-5-(3.4.5-trimethoxyphenyl)-4H-1.2.4-triazol-3-yl] thioacetylchloride. This compound was tested for antimicrobial activity in vitro against nine species of microorganisms. It showed remarkable antibacterial activity against Bacillus subtilis, Micrococcus luteus, and Staphylococcus aureus.
유지석(Ji Seak Yoo),하재천(Jai Chun Ha),고옥현(Ok Hyun Ko),유진철(Jin Cheol Yoo),강형룡(Hyung Ryong Kang) 대한약학회 1999 약학회지 Vol.43 No.3
To develop new cephalosporin antibiotics with improved antibacterial activities, a series of 7beta-[2-(2-aminothiazol-4-yl)-(Z)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-[5-(heterocycle)thiomethylpyrrolidin-3-ylthio]methyl-3-cephem-4-carboxylic acid (14-18) having aminothiazol carboxymethylethoxyimino group on the C-7 position and (heterocycle) thiomethyl pyrrolidinthiomethyl group on the C-3 position of the cephem ring were synthesized. These compounds were tested for antimicrobial activity in vitro against Gram(+) and Gram(-) bacteria. Compounds 15 and 16 showed remarkable antibacterial activity against Salmonella typhimurium TV119 and Alcalienes faecalis KCTC1004, but most of compounds showed lower activity than cefotaxime.
3-(치환) 테트라조일메칠세파로스포린의 합성과 생리활성
고옥현(Ok Hyun Ko),김영수(Young Soo Kim),고봉석(Bong Suk Ko),이재영(Jae Young Lee),하재천(Jai Chun Ha),방희재(Hee Jae Bang),유진철(Jin Cheol Yoo),강형룡(Hyung Ryong Kang) 대한약학회 1998 약학회지 Vol.42 No.1
For the development of new cephalosporin antibiotics with aminothiazolcarboxymethylethoxyimino moiety on the C-7 position and tetrazolymethyl moiety on the C-3 position of cephem ring, 70-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-[5-(substituted)tetrazol-2-yl]methyl-3-cephem-4-carboxylic acids(28-35) were synthesized. These compounds were tested for antimicrobial activity in vitro against Gram(+) and Gram(-) bacteria. They showed remarkable antibacterial activity against Escherichia coli AB 1157, Escherichia coli AB 0111, Escherichia coli BE 1186, Micrococcus luteus ATCC 9341, Salmonella typhimurium TV 119, Salmonella typhimurium SL 1102, Staphylococcus aureus IFO 12732, Staphylococcus aureus R-209, but these compounds were not active against Pseudomonas aeruginosa N-10.
고옥현,강형룡,유진철,김경수,홍석순,김영수,황화영,하재천 조선대학교 약학연구소 1992 藥學硏究誌 Vol.14 No.1
7β[5-(Substituted) phenyl-2H-tetrazol-2-yl]acetamidocephalospranic acid, 7β-(5-Diphnenyl-methyl-2H-tetrazol-2-yl) acetamidocephalosporanic acid and 7β-[5-(Substituted)-4-phenyl-1.2.4-triazol2-yl]thioacetamidocephalosporanic acid were synthesized and tested in vitro antimicrobial activity. These compounds exhibited good antimicrobial activity against Gram-positive bacteria whereas most compounds showed decreased antimicrobial activity against Gram-negative bacteria
Aminothiazole Cephalosporin 계 항생물질의 합성
고옥현,강형룡 조선대학교 약학연구소 1998 藥學硏究誌 Vol.19 No.1
In order to develop new cephalosporin antibiotics with improved antimicrobial activities, 7-[(Z)-2-(aminothiazo1-4-y1)-2-(methoxyimino) acetamido]-3-[5-(4-methylthiophenyl) tetsazol-2-yl] thiocarbonylthiomethyl-3-cephem-4-carboxvlic acid and 7-[(Z)-2-(aminothiazo1-4-y1)-2-(methoxyimino) acetamido]-3-[5-(diphenyl methyl) tetrazol-2-yl] thiocarbonylthiomethy1-3-cephem-4-carboxylic acid were synthesized from 5-(4-methylthiophenyl) tetrazolyl-2- dithiocarbamate potassium salt or 5-(diphenylmethyl)tetrazolyl- 2-dithiocarbamate potassium salt and p-methoxybenzyl 7-[(Z)-2-(2- trity-laminothiazo1-4-yl)-2-(methoxyimino)acetamidol-3-chloromethyl-3-cephem-4-carboxylate, respectively.
C-3 및 C-7(치환) 세파로스포린계 항생제의 합성과 항균활성에 관한 연구(2)
河在天,高玉鉉,姜馨龍 조선대학교 약학연구소 1995 藥學硏究誌 Vol.17 No.1
In order to development new cephalosporin antibiotics 7β[(z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[5-(1,5-dimethyl-2-pyrroletetrazol-2-yl]methyl-3-cephem-4-carboxylic acid(9) and 7β-[(z)-2-(2-aminothiazol-4-yl)-2-(methoxyimi no) acetamido]-3-[5-naphthyltetrazol-2-yl]methyl-3-cephem-4-carboxylic acid(10) were synthesized. These compounds were tested for antimicrobial activities in vitro against Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341, Mycobacterium phlei IFO 3158, Alcaligenes faecalis KCTC 1004, Escherichia coli 8S, Salmonella typimurium KCTC 1925, Pseudomonas aeruginosa IFO 13130, Klebsiella pneumoniae KCTC 1560 and Candida albicans ATCC 10231, respectively. Compound(10) showed good antimicrobial activities against Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341 and Mycobacterium phlei IFO 3158 but compound(9) showed lower antimicrobial activities as compare with cefotaxime and cefazolin.
3-Nicotinonium thiosemicatbazide cephalosporins류의 합성과 항균활성에 관한 연구
이재영,고옥현,강형룡 朝鮮大學校 1996 藥學硏究誌 Vol.18 No.1
For the development of new cephalosporin antibiotics with improved antimicrobial activities , a series of 7β-〔(Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido〕-3-〔4-alkyl(or aryl)-3-thisemicarbazid-1-nicotinonium〕methyl-3-cephem-4-carboxylate and 7β-〔(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido〕-3-〔(4-alkyl(or aryl)-3-thisemicarbazid-1-nicotinonium〕methyl-3-cephem-4-carboxylate were synthesized. Antimicrobial activities of these new compounds were examined against Gram(+) and Gram(-) bacteria. It was found that the synthesized cephalosporin derivatives were good antibacterial activities against Escherichia coil. Almost these compounds were antibacterial activities than cefazoline. These new compounds showed lower activity than cefotaxime against Pseudomonas aeruginosa.
C_3 및 C_7위치에 치환된 새로운 세파로스포린 化合物의 合成과 抗菌活性(Ⅰ)
황화영,하재천,김영수,고옥현,강형룡 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1
The synthesis and antimicrobial activity of cephalosporin having (Z)-2-(2-aminothiazol-4-yl)-2-trityloxyiminoacetamido group and 5-(2-chlorophenyl)-4-phenyl-4H-1, 2, 4-triazol-3-thiomethyl group on the C_3 and C_7 position of the cephem ring, respectively are descrived. This compound was tested for antimicrobial activity in vitro against Candida albicans ATCC 10231, Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 6538P, Mycobacterium phlei IIP-IPH, Escherichia coli KCTC 1039, Escherichia coli ESS, Klebisiella pneumoniae KCTC 1560, Salmonella typhymurium TV-119, Pseudomonas aeruginosa IFO 13130. The antimicrobial activity of synthetic compound was better as compare with cefotaxime and cefazoline against Micrococcus luteus ATCC 9341 & Escherichia coli KCTC ESS.