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Rapamycin-Induced Abundance Changes in the Proteome of Budding Yeast
신춘식,장연지,이훈구,허원기 한국유전체학회 2009 Genomics & informatics Vol.7 No.4
The target of rapamycin (TOR) signaling pathway conserved from yeast to human plays critical roles in regulation of eukaryotic cell growth. It has been shown that TOR pathway is involved in several cellular processes, including ribosome biogenesis, nutrient response, autophagy and aging. However, due to the functional diversity of TOR pathway, we do not know yet some key effectors of the pathway. To find unknown effectors of TOR signaling pathway, we took advantage of a green fluorescent protein (GFP)-tagged collection of budding yeast Saccharomyces cerevisiae . We analyzed protein abundance changes by measuring the GFP fluorescence intensity of 4156 GFP-tagged yeast strains under inhibition of TOR pathway. Our proteomic analysis argues that 83 proteins are decreased whereas 32 proteins are increased by treatment of rapamycin, a specific inhibitor of TOR complex 1 (TORC1). We found that, among the 115 proteins that show significant changes in protein abundance under rapamycin treatment, 37 proteins also show expression changes in the mRNA levels by more than 2-fold under the same condition. We suggest that the 115 proteins indentified in this study may be directly or indirectly involved in TOR signaling and can serve as candidates for further investigation of the effectors of TOR pathway.
이형기,김남호,변기식,노창주,신춘식 釜山工業大學校 1995 論文集 Vol.37 No.-
Linear pulse motor(LPM) has been used in a wide range of application due to many advantages for the precision position and speed control system for the bidirectional linear motion. In this study, the hybrid, single-side type LPM was designed and examined for characteristics of position detection. Precision position detection signals could be sensed by synchronous rectifier method from the LPM stator scale. Experimental results show that the position precisions are good enough to perform the LPM position control.
변기식,박한석,신춘식 釜山工業大學校 1994 論文集 Vol.36 No.-
As jumpers for overhead transmission lines increase in size, it is necessary to take into the characteristics of jumper swing and wind in oder to determine jumper reinforcements adequately. From the theory of a structure made of beams, formulas for the sideway swaying of overhead transmission lines due to wind are modeled. And also natural frequency of the vibrated jumper is estimated to check the system resonance. The theoretical results can be led good sugesstions to improve the economy and reliability of jumper wire.