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간세포암종의 간절제술 후 장기 예후인자 - 단변량 및 다변량 분석
박철근(Cheol Keun Park),장우영(Woo Young Jang),이종임(Jong Im Lee),최문석(Moon Seok Choi),조재원(Jae Won Cho),김선우(Seon Woo Kim),송상용(Sang Yong Song) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.1
Background/Aims: We assessed prognostic factors affecting cumulative survival rate and recurrence-free survival rate after hepatic resection of hepatocellular carcinoma (HCC). Methods: Univariate and multivariate analyses were performed in 108 consecutive patients with HCC who underwent curative hepatic resection between November 1994 and March 1998. Results: The cumulative survival rates were 89.8%, 75.5%, and 56.6% at 1, 3, 5 years, respectively. The cumulative recurrence-free survival rates were 78.9%, 62.1%, and 53.0% at 1, 3, 5 years, respectively. The patients who had preoperative serum α-FP ≤ 20ng/mL showed high cumulative recurrence-free survival rates in univariate (p=0.020) and multivariate (p=0.061) analysis. Single tumor was associated with increased cumulative survival rates (p=0.034) and cumulative recurrence-free survival rates (p=0.029) in multivariate analysis. The presence of tumor capsule was associated with increased cumulative recurrence-free survival rates in univariate (p=0.031) and multivariate (p=0.030) analysis. Conclusions: By these results, resection alone is unlikely to cure HCC patients with multiple tumors or no tumor capsule. Preoperative serum α-FP level may be of prognostic significance in patients with HCC. (Korean J Gastroenterol 2002;39:33-39)
김경미 ( Kyoung Mee Kim ),박철근 ( Cheol Keun Park ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.4
It is widely accepted that endoscopic submucosal dissection (ESD) is an important treatment option for cases of early gastric carcinoma where the probability of lymph node metastasis is very low. The resected ESD specimens are carefully examined by serial sections at 2 mm intervals, and if pathology reveals submucosal invasion more than 500μm and/or lymphovascular invasion, or if the resection margin is involved by the tumor, surgery is recommended. In this point of view, thorough pathologic examination and reporting the accurate pathologic diagnosis of ESD specimen is very important. The diagnostic approach and pitfalls in the diagnosis of ESD specimen are reviewed. (Korean J Gastroenterol 2010;56:214-219)
간세포암종의 간절제술 후 p53 과발현의 예후에 미치는 영향
성창옥 ( Chang Okh Sung ),유병철 ( Byung Chul Yoo ),고광철 ( Kwang Cheol Koh ),조재원 ( Jae Won Cho ),박철근 ( Cheol Keun Park ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.6
Background/Aims: p53 mutation is the most common genetic abnormality in human cancers. However, although it has been reported that p53 overexpression in hepatocellular carcinoma (HCC) is associated with the aggressive behavior of tumor, the prognostic sig