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최인후,장영석,김길하,김정화 한국응용곤충학회 2004 한국응용곤충학회지 Vol.43 No.2
몇가지 살충제에 대한 파굴파리 충태별 약제 방제효과를 조사한 결과, 알 상태에서 엽면 살포시 spinosad, dimethoate, emamectin benzoate, cartap 등의 방제가가 83% 이상으로 효과적이었다. 유충에 대해서는 dimethoate와 cartap이 87% 이상의 살충활성을 나타내었다. Dimethoate와 cartap을 엽면살포 후 잔효력을 조사한 결과 dimethoate는 약제처리 후 3일까지 93.3%의 높은 활성을 유지하였다. 번데기에 대해서는 terbufos GR, cartap GR이 88.2% 이상의 살충활성을 보였으며, 성충에 대해서는 dimethoate와 cartap이 95%이상 살충활성을 나타내었다. 이상의 결과에서 알, 유충, 성충방제에는 dimethoate EC와 cartap SP, 번데기 방제에는 terbufos GR, cartap GR가 효과적이었다. Control effects of some insecticides were evaluated against the stone leek leafminer, Liriomyra chinensis Kato (Diptera: Agromyzidae) with the some different treatment methods. Insecticidal activities effects were estimated on the different development stages of the insects on welsh onion. The insecticides that controlled L. chinensis eggs with over 83% efficacy were spinosad, dimethoate, emamectin, and cartap. The insecticides that showed over 87% of larvicidal activity were dimethoate and cartap. Dimethoate showed 93.3% insecticide residual activity for 3 days a(ter treatment as a foliar spray. For control of pupae, the insecticides that showed over 88% of contact insecticidal activity were terbufos GR and cartap GR. Both dimethoate and cartap had high adulticidal activity with over 95% control efficacy.
살충제 Monocrotophos 가 흰쥐에 대한 독성 및 혈액중 Cholinesterase 활성도에 미치는 영향
최인후,김광포,양재설 한국환경농학회 1988 한국환경농학회지 Vol.7 No.1
殺蟲劑 Monocrotophos의 毒性評價를 위하여 흰쥐에 1∼4주동안 투여후 急性 및 亞急性 毒性檢定 그리고 血液性狀 및 血漿中 Cholinesterase(ChE)를 測定하여 그 變化를 究明 하므로서 農藥中毒에 對한 基礎資料를 얻고자 本 試驗을 實施한 結果는 다음과 같다. 1. Monocrotophos의 急性經口 半數致死 藥量(LD_(50))은 흰쥐에서 암, 수 各各 5.1, 8.7㎎/㎏이었고 腹腔內 投與時에는 암컷이 4.9㎎/㎏ 수컷이 6.0㎎/㎏ 이었다. 2. Monocrotophos는 經口에 6.4㎎/㎏, 腹腔內 4.0㎎/㎏ 投與時에 4時間이 지난후 암, 수 모두의 血漿 ChE 活性度를 最大로 抑制 시켰고 投與 24時間 以後부터는 점차 回復 되었다. 3. Monocrotophos를 흰쥐에 4週間 經口投與 할 때 3.5㎎/㎏/day 投與群에서는 對照群에 比해 암, 수 모두 體重增體量과 수컷에서 사료섭취량이 현저하게 減少 되었다. 4. 약제 投與時에는 血漿 ChE 活性度를 크게 抑制시켰으나 投與 中斷후에는 2週가 지나면서 거의 回復되었다. 5. 藥劑投與된 쥐의 赤血球, 白血球, Ht値, Hb量에 對한 血液狀 變化는 거의 없었다. The acute oral, intraperitoneal and subacute toxicity of monocrotophos, an insecticide, was studied in albino rats. The acute oral LD_(50) values for female and male rats were 5.0㎎/㎏ and 8.7㎎/㎏, respectively. Conversely the intraperitoneal LD_(50) values for female and male rats were 4.9㎎/㎏ and 6.0㎎/㎏, respectively. Plasma cholinesterase (ChE) activity in rats treated with a single dose was the most depressed 4 hours after administration, but returned to normal within 72 hours of administration. Significant depression of body weight gain and food consumption was observed in rats receiving the 3.5㎎/㎏/day dose level for 28 days as compared with the controls. Additionally plasma ChE activity depression was also observed.
최인후,한세광,박원찬 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
We design a facile method to deliver drugs to the skin through microneedles (MNs) to stimulate the immune system in two ways. As one of the tumor vaccines, cancer cell membrane proteins can act as tumor-specific antigens that are presented to antigen presenting cells (APCs) to activate the immune system. In addition, a toll-like receptor 7 (TLR7) agonist of imiquimod (R837) can suppress cancer cell growth by inhibiting angiogenesis. Using poloxamer 407 (F127) as a nanocarrier, F127 nanoparticles (F127 NPs) are loaded with R837 and then coated with cancer cell membranes (M). These F127-R837@M NPs are loaded in rapidly dissolving MNs and delivered through the skin. MNs loaded with F127-R837@M NPs show significant inhibition of cancer cell growth in both prophylactic vaccination and antitumor immunotherapy in vivo.
흰쥐에 對한 Phosphamidon 및 Endosulfan의 亞急性毒性에 關한 硏究
申鎭燮,崔承允,李昌業,崔仁厚 서울大學校 農科大學 1984 서울대농학연구지 Vol.9 No.2
Subacute toxicity tests of phosphamidon and endosulfan were carried out to examine the adverse effects resulting from repeated daily oral administration of low dose levels (1, 2 and 5 mg/kg/day) to rats for 28 days. The results were summarized as follows: 1. Rats showed clinical signs of salivation hyperactivity, ataxia at 2mg/kg/day dosage of phosphamidon and, in addition, lachrymation, tremor, exophthalmus and diarrhea at the highest level. On the other hand, endosulfan caused only hyperactivity in rats treated with the highest dosage. There was no mortality at any dosage of either pesticide. 2. Rats gained significantly lower body weight, when treated at the 5mg/kg/day dose levels of phosphamidon and endosulfan, in comparison to normal, nontreated rats. 3. Plasma cholinesterase activity was significantly depressed at all levels of phosphamidon during the administration period, but returned to normal within 2 weeks after the last administration. Endosulfan did not change plasma cholinesterase activity at any levels. 4. Leukopenia was detected only in rats treated with phosphamidon at 5mg/kg/day level. No other adverse changes in hematology were observed in rats treated either with phosphamidon at lower levels or with endosulfan at any levels. 5. Cloudy swelling of liver was the only histological change in rats treated with phosphamidon or endosulfan at the highest level. No other histopathological change in rats treated with phosphamidon or endosulfan at the highest level. No other histopathological symptoms were found in spleen, heart, kidney, and bone marrow of rats treated. 6. It may be concluded from the results above that the "no effect level" is 1 mg/kg/day and 2 mg/kg/day for phosphamidon and endosulfan, respectively.