PER3, a novel target of miR-103, plays a suppressive role in colorectal cancer in vitro

( Zhang Hong ),( Zhang Feng ),( Zhang Sai ),( Su Tao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.9

Colorectal cancer has become the third most common cancerand leads to high mortality worldwide. Although colorectalcancer has been studied widely, the underlying molecularmechanism remains unclear. PER3 is related to tumordifferentiation and the progression of colorectal cancer. Highexpression of miR-103 is associated with poor prognosis inpatients with colorectal cancer. However, the relationshipbetween miR-103 and PER3 in CRC cells remains unclear. Inthis study, we found that PER3 was downregulated in CRC tissues and CRC cell lines, whereas miR-103 was upregulatedin CRC cell lines. We also found that PER3 promoted CRCcells apoptosis. These results indicate that PER3 plays asuppressive role in CRC cells. Moreover, we found that PER3was targeted, at least partially, by miR-103. Taken together, weprovide evidence to characterize the role of PER3 in CRC, which may be a new therapeutic target for CRC.

The influence of soil aggregation induced by water content variation on the engineering behaviors of cement-treated silt subgrade

Sai Zhang,Jian-Wen Ding,Zhenyuan Lai,Qinying Guo,Xing Wan 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.10

Water content is an important indicator of highway subgrade compaction, which has an impact on the engineering behaviors of pavement structures significantly. To study the influence of soil aggregation induced by water content variation on the engineering behaviors of silt subgrade, a series of laboratory experiments, including sieving analysis, unconfined compression tests and hydraulic conductivity tests, were conducted on the cement-treated silt subgrade. The influence of water content on the soil aggregation, unconfined compressive strength (UCS) and hydraulic conductivity were examined, respectively. The distribution range of UCS index (IUCS) and hydraulic conductivity index (Ik) were expressed accordingly. Test results demonstrate that when the water content lower than the optimum water content (wopt), the specimens are more homogeneous, the UCS increases regularly with the increase of curing time and water content, the hydraulic conductivity decreases regularly with curing time and water content increased. When the water content is higher than the wopt, the silt aggregation leads to the structural inhomogeneity of specimens, the strength decreases irregularly with the increase of curing time and water content, the hydraulic conductivity increases irregularly with the increase of curing time and water content accordingly. The soil aggregation induced by water content variation is proved to be a major reason for the ununiformly distribution of the UCS and hydraulic conductivity, the influence of which is more significant than that of binders when the water content higher than the wopt. Hence, controlling water content within 2% lower the wopt is strongly suggested to forming a more homogeneous structure of the subgrade.

Korea and Japan trade friction and its impact on China’s semiconductor industry

ZHANG SAI(장세) 한국산업경제학회 2019 한국산업경제학회 정기학술발표대회 논문집 Vol.2019 No.12

Synthesis of Trilaminar Core–Shell Au/α-Fe2O3@SnO2 Nanocomposites and their Application for Nonenzymatic Dopamine Electrochemical Sensing

Sai Zhang,Shijun Yue,Jiajia Li,Jian-Bin Zheng,Guojie Gao 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.11

Au nanoparticles anchored on core–shell α-Fe2O3@SnO2 nanospindles were successfully constructed through hydrothermal synthesis process and used for fabricating a novel nonenzymatic dopamine (DA) sensor. The structure and morphology of the Au/α-Fe2O3@SnO2 trilaminar nanohybrid film were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The electrochemical properties of the sensor were investigated by cyclic voltammetry and amperometry. The experimental results suggest that the composites have excellent catalytic property toward DA with a wide linear range from 0.5 μM to 0.47 mM, a low detection limit of 0.17 μM (S/N = 3) and high sensitivity of 397.1 μA mM -1 cm -2. In addition, the sensor exhibits long-term stability, good reproducibility and anti-interference.

전자 폐기물 회수 로봇 개발을 위한 사용자 중심 서비스 디자인 방향성 제안

장새난(Sai Nan Zhang),송지성(Ji Sung Song) 한국디자인리서치학회 2023 한국디자인리서치 Vol.8 No.4

전자 폐기물 처리는 환경 지속 가능성 발전의 도전 중 하나이다. 이 연구는 H 대학 캠퍼스 내에서 이러한 문제가 된 개선의 필요성을 발견하였으며, 문헌 및 사례 조사와 이해당사자 요구분석을 통해 현재 주요 문제점을 파악하였다. 학생, 교직원, 캠퍼스 환경미화원을 대상으로 설문조사와 심층 인터뷰를 진행하였다. “심리스 집적” “적응 학습“” 지식 보급“ ”참여 독려”의 디자인 콘텐츠를 식별하였다. ICT 기반의 캠퍼스 전자 폐기물 회수 시스템을 도입하여 캠퍼스에서 전자 폐기물 처리 서비스 효율성을 향상하는 것을 목표로 한다. 사용자 중심으로 각 이해당사자들의 경험을 서비스 디자인 방향을 제안하였다. 딥 러닝 모델을 기반으로 ICT 전자 폐기물 회수 로봇은 H 대학 캠퍼스 전자 폐기물 회수 서비스 과정에서 효과적인 실행 가능성이 있다는 것을 연구 결과를 도출하였다. 캠퍼스 내에서 발생하는 전자 폐기물의 효과적인 회수를 위한 혁신적인 해결책을 제공이 되기를 기대한다. The management of electronic waste represents a challenge in the advancement of environmental sustainability. At H University's campus, the necessity for improvement in this area has been identified, with major issues being pinpointed through literature and case studies, as well as stakeholder needs analysis. Surveys and in-depth interviews were conducted with students, faculty, and campus janitorial staff. The research identified design contents The goal is to enhance the efficiency of electronic waste disposal services on campus through the introduction of an ICT-based e-waste collection system. A service designt, based on deep learning models, in effectively implementing e-waste collection services at H University. This research provides innovative solutions for the effective collection of e-waste generated on campus.

아프리카 전자상거래 법률 및 규정이 중국과 아프리카의 디지털 무역에 미치는 영향 분석

장새(Sai Zhang),조국봉(Guofeng Zhao) 한국정치사회연구소 2023 한국과 국제사회 Vol.7 No.4

노년층의 전자 개인 건강 기록(ePHR) 시스템 UI/UX 요소 선호에 관한 실증 연구-원격 문진표 인터페이스 개발을 중심으로-

장새난(Zhang, Sai Nan),송지성(Song, Jisung) 한국디자인문화학회 2023 한국디자인문화학회지 Vol.29 No.4

With the advent of digital technology, the significance of Electronic Personal Health Records (ePHR) in the medical sector is increasingly becoming salient. ePHRs comprehensively document medical information, medication prescriptions, and health indices prior to treatment. Such systems are evaluated to provide end users with expanded control over health data and convenience. However, a preponderance of system interface designs is youth-centric, thereby lacking consideration for the elderly demographic. This results in varied challenges experienced by older individuals in utilizing these systems. Given the unique technological utilization characteristics of the elderly, understanding their preferences regarding ePHR system design is of paramount importance. This study investigated the needs and preferences of elderly individuals concerning online medical questionnaire interface design through Conjoint Analysis. Adhering to UX design principles, five primary factors were measured: “platform, color combination, icon design style, page layout, and navigation menu”, utilizing Orthogonal Design through SPSS to form a variety of attribute and factor level combinations, thereby generating eight representative design combinations. High-fidelity models were developed using Figma, followed by a survey conducted among 164 elderly individuals to gauge the preferences concerning design models. The outcomes of this study, obtained through this process, are as follows. Firstly, among the attributes of online medical questionnaire interface design, elderly individuals considered color combinations as the most prioritized attribute, followed by icon design style, and subsequently, the navigation menu. These findings are anticipated to elucidate the ideal combination of ePHR UI UX elements for the elderly and provide insightful information concerning online medical questionnaire interface design. Additionally, it enables the provision of more tailored services to the elderly demographic. Identifying the ideal composition of UI UX elements for online medical questionnaires aimed at the elderly provides invaluable insights into the interface design of ePHR systems. Moreover, it aids in the extensive promotion of mobile health medical services within elderly communities, and is expected to further enhance the user interface usage experience of elderly individuals in managing their health.

Enrichment of valuable elements from vanadium slag using superconducting HGMS technology

Sai He,hang-qiaoYang,Su-qin Li,Chang-quan Zhang 한국초전도저온학회 (구 한국초전도저온공학회) 2017 한국초전도저온공학회논문지 Vol.19 No.1

Enrichment of valuable elements from vanadium slag using superconducting HGMS technology

He, Sai,Yang, Chang-qiao,Li, Su-qin,Zhang, Chang-quan The Korea Institute of Applied Superconductivity a 2017 한국초전도저온공학회논문지 Vol.19 No.1

Vanadium slags is a kind of vanadiferous solid waste from steelmaking process. It not only occupies land, pollutes environment, but also leads to waste of resources. Based on the difference of magnetic susceptibility of different particles caused by their chemical and physical properties from vanadium slag, a new technology, superconducting high gradient magnetic separation was investigated for separation and extraction of valuable substances from vanadium slag. The magnetic concentrate was obtained under optimal parameters, i.e., a particle size -200 mesh, a magnetic flux density of 0.8 T, a slurry concentration of 5 g/L, an amount of steel wools of 25 g and a slurry flow velocity of 2 L/min. The content of $Fe_2O_3$ in concentrate could be increased from 39.6% to 55.0% and $V_2O_5$ from 2.5% to 4.0%, respectively. The recovery rate is up to 42.9%, and the vanadium slag has been effectively reused.

Chattering-free Fast Fixed-time Sliding Mode Control for Uncertain Robotic Manipulators

Huayang Sai,Zhenbang Xu,Enyang Zhang,Chunyang Han,Yang Yu 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.2

In this paper, we introduce a dynamic controller that dedicates fixed-time trajectory tracking for uncertain robotic manipulators. First, a new nonlinear function is designed and applied to the fixed-time sliding mode (FSM) surface. The derivative of the proposed nonlinear function is continuous, which can ensure the continuity and smoothness of the control torque, and it makes the sliding surface facilitate fast convergence rates of the system tracking error. Then, a FSM control scheme is designed using the proposed sliding mode surface. Combined the Lyapunov stability theory, we show that the proposed controller has fixed-time convergence independent of the initial state of the system. Moreover, the proposed control scheme is advantageous in that the control torque is continuous without transient change. This eliminates the chattering of uncertain robotic manipulators and makes the control torque smoother. Simulation results show that a faster error convergence rate can be obtained with a smaller control torque range. Finally, the above-mentioned effectiveness and superiority of the proposed control scheme are validated using simulations and experimental results.