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Interface Shear Strength at Joints of Ultra‑High Performance Concrete Structures
Young?Jin Kim,Won?Jong Chin,Se?Jin Jeon 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.6
When ultra-high performance concrete (UHPC) is fabricated as precast members such as in a UHPC segmental bridge, the joint design between the precast members can significantly affect the overall integrity and safety of the structure. Therefore, the structural behavior of the UHPC joint was experimentally investigated in this study with test variables including joint type, number and height of shear keys, type of filler, curing temperature, and lateral compressive stress. The UHPC considered in this study is the K-UHPC developed in Korea with a specified compressive strength as high as 180 MPa and high flowability. The joint shear strengths affected by the test variables were investigated in detail. The test results were also compared with two representative predictive equations for interface shear strength to determine an appropriate equation for the joint design of UHPC. These equations did not match well with the test data because they were originally proposed for normal strength concrete. However, the JSCE equation could be improved by modifying a coefficient to show good agreement with the test especially in the case of the dry joint with epoxy application.
Won, Hee‐,Young,Lee, Jeong‐,Yeon,Shin, Dong‐,Hui,Park, Ji‐,Hye,Nam, Jeong‐,Seok,Kim, Hyoung‐,Chin,Kong, Gu Federation of American Society for Experimental Bi 2012 The FASEB Journal Vol.26 No.12
<P>Mel-18 has been proposed as a negative regulator of Bmi-1, a cancer stem cell (CSC) marker, but it is still unclear whether Mel-18 is involved in CSC regulation. Here, we examined the effect of Mel-18 on the stemness of human breast CSCs. In Mel-18 small hairpin RNA (shRNA)-transduced MCF-7 cells, side population (SP) cells and breast CSC surface marker (CD44(+)/CD24(-)/ESA(+))-expressing cells, which imply a CSC population, were enriched. Moreover, the self-renewal of CSCs was enhanced by Mel-18 knockdown, as measured by the ability for tumorsphere formation in vitro and tumor-initiating capacity in vivo. Similarly, Mel-18 overexpression inhibited the number and self-renewal activity of breast CSCs in SK-BR-3 cells. Furthermore, our data showed that Mel-18 blockade up-regulated the expression of the Wnt/TCF target Jagged-1, a Notch ligand, and consequently activated the Notch pathway. Pharmacologic inhibition of the Notch and Wnt pathways abrogated Mel-18 knockdown-mediated tumorsphere formation ability. Taken together, our findings suggest that Mel-18 is a novel negative regulator of breast CSCs that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt-mediated Notch signaling.</P>
REVIEW : The Korean Cough Guideline: Recommendation and Summary Statement
( Chin Kook Rhee ),( Ji Ye Jung ),( Sei Won Lee ),( Joo Hee Kim ),( So Young Park ),( Kwang Ha Yoo ),( Dong Ah Park ),( Hyeon Kyoung Koo ),( Yee Hyung Kim ),( Ina Jeong ),( Je Hyeong Kim ),( Deog Kyeo 대한결핵 및 호흡기학회 2016 Tuberculosis and Respiratory Diseases Vol.79 No.1
Cough is one of the most common symptom of many respiratory diseases. The Korean Academy of Tuberculosis and Respiratory Diseases organized cough guideline committee and cough guideline was developed by this committee. The purpose of this guideline is to help clinicians to diagnose correctly and treat efficiently patients with cough. In this article, we have stated recommendation and summary of Korean cough guideline. We also provided algorithm for acute, subacute, and chronic cough. For chronic cough, upper airway cough syndrome (UACS), cough variant asthma (CVA), and gastroesophageal reflux disease (GERD) should be considered. If UACS is suspicious, first generation anti-histamine and nasal decongestant can be used empirically. In CVA, inhaled corticosteroid is recommended in order to improve cough. In GERD, proton pump inhibitor is recommended in order to improve cough. Chronic bronchitis, bronchiectasis, bronchiolitis, lung cancer, aspiration, angiotensin converting enzyme inhibitor, habit, psychogenic cough, interstitial lung disease, environmental and occupational factor, tuberculosis, obstructive sleep apnea, peritoneal dialysis, and idiopathic cough can be also considered as cause of chronic cough. Level of evidence for treatment is mostly low. Thus, in this guideline, many recommendations are based on expert opinion. Further study regarding treatment for cough is mandatory.
Young-Suk Won,Hyo-Jung Kwon,Yang-Kyu Choi,Won-Kee Yoon,Sang-Woon Kim,Hae Jin Lee,Bon-Chul Koo,Sae-Bhom Lee,Ki-Hoan Nam,Oc-Sung Moon,Hyoung-Chin Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
Dermatophytes are the most important dermatological zoonosis pathogen. Although it is well known as a transmittable disease from animal to human, control of dermatophyte is still difficult in conventionally housed animals. Laboratory New Zealand White rabbits and Hartley guinea pigs bred in conventional facility were sent to the Korea Research Institute of Biotechnology and Biology for health monitoring. Two of five rabbits and six of ten guinea-pigs had discrete, irregularly shaped and encrusted alopecia around eye, legs, mouth and thigh area. Histopathologically, epidermis showed hyperkeratosis, parakeratosis and acantosis. Dermis and hair follicle were infiltrated with numerous neutrophils, macrophages and lymphocytes. The PAS staining demonstrated large numbers of arthrospores and branched hyphae within stratum corneum and hair follicle. Fungal culture of the skin lesions revealed characteristic fungi colony and conidia of Trichophyton mentagrophyte. For rapid identification of this fungus using molecular method, we performed ITS gene specific PCR and sequenced the products. Results of ITS gene sequencing, our isolates have very similar sequence with previous reported Arthroderma vanbreuseghemii. These results suggest that our isolated fungi could be cause of these rabbits and guinea pigs dermal disease.
Two Step Carcinogen Screening Model Using Neonatal FVB/NJ Mouse
Young-Suk Won,Hyo-Jung Kwon,Yang-Kyu Choi,Hyun-Ji Park,Eui-Suk Jeong,Bon-Chul Koo,Oc-Sung Moon,Ki-Hoan Nam,Hyoung-Chin Kim 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.3
A long-term carcinogenicity study is required to assess the safety of new drug candidates. This classical toxicological method has been using rats and mice as animal systems. The International Conference on Harmonization (ICH) of technical requirements of pharmaceuticals for human use have recommended one long-term rodent carcinogenicity test using rat and one other supplementary mouse study such as an initiation-promotion model, a transgenic model or a neonatal model. This study was carried out to develop an initiation-promotion liver carcinogenicity model using a mouse. Twelve-day old FVB/NJ mice were intraperitoneally injected with diethyl nitrosamine (DEN) as an initiator and orally administered with 2-acetlyaminofluorene (2-AAF) as a promoter. And o-galactosamine (DGA) was injected as a stimulator for tumorigenic progress. Basophilic foci in the liver were observed 16 weeks after initiation. The incidence of hepatocellular adenoma was increased in animals 2-AAF-treated at 20 and 26 weeks after initiation. The tumor incidence in 2-AAF-treated animals were significantly higher than with the untreatment and initiator treatment control groups. Hepatocellular carcinoma (HCC) was found in some cases. These results suggest that two-step neonatal FVB/NJ mouse model could be useful for carcinogenic assay of new drug candidates.