http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lan Yao,Zhen Wang,Qingbiao Wang,Jianwei Xia,Hao Shen 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.7
In this paper, the exponential stabilization of delayed complex-valued neural networks (DCNNs) is addressed via sampled-data control. First, aperiodic sampled-data control aimed at further reducing the frequency of data transmission is adopted, which covers the periodic sampling as a special case. Then, a free-matrix-based timedependent Lyapunov functional is specially constructed for stability analysis of closed-loop DCNNs, in which two extra free matrices are introduced and the available information of system states at the sampling instants are fullyutilized. Accordingly, some less conservative stability conditions are established. By resorting to a matrix transformation, the design scheme for the feedback gains can be obtained. Meanwhile, the qualitative relationship between the decay rate and the upper bound of the variable sampling period is established and the maximum allowable value of the variable sampling period is determined. Finally, an illustrative example is provided to demonstrate the feasibility of the proposed stabilization criteria.
중국유학생들의 학습동기 및 사회적 지지가 대학생활적응에 미치는 영향 - 부산지역을 중심으로 -
( Yao Lan ),주동범 ( Ju Dong-beom ) 한국다문화 디아스포라학회 2018 다문화와 디아스포라연구 Vol.12 No.-
본 연구는 부산지역 소재 대학에 재학하고 있는 중국유학생들을 대상으로 학습동기 및 사회적지지가 대학생활적응에 미치는 영향을 분석하였다. 이를 위해 210명의 표본을 추출하여 중국유학생들의 일반적 특성, 학습동기, 사회적 지지, 대학생활적응을 측정하였으며, 최종 208명이 최종분석에 사용되었다. 주요 결과는 다음과 같다. 첫째, 대학생활적응의 경우 중국유학생들의 일반적 특성을 통제한 후 학습동기 요인에서 자기조절학습전략이 통계적으로 유의한 부적 영향을 미치는 것으로 나타났으며, 사회적지지 요인에서 중국인친구 지지가 통계적으로 유의한 정적 영향을 미치는 것으로 나타났다. 둘째, 학업적응의 경우 중국유학생들의 일반적 특성을 통제한 후 학습동기 요인에서 자기효능감이 통계적으로 유의한 정적 영향을 미치는 것으로 나타났다. 셋째, 사회적응의 경우 중국유학생들의 일반적 특성을 통제한 후 사회적지지 요인에서 중국인친구 지지가 사회적응에 통계적으로 유의한 정적 영향을 미치는 것으로 나타났다. 넷째, 개인정서적응의 경우 중국유학생들의 일반적 특성을 통제한 후 학습동기 요인에서 자기조절학습전략이 통계적으로 유의한 부적 영향을 미치는 것으로 나타났다. 다섯째, 대학환경적응의 경우 중국유학생들의 일반적 특성을 통제한 후 학습동기 요인에서 통제소재가 통계적으로 유의한 정적 영향을 미치는 것으로 나타났으며, 사회적지지 요인에서 중국인친구 지지가 통계적으로 유의한 정적 영향을 미치는 것으로 나타났다. 이러한 주요 결과에 대한 시사점 및 제언이 논의되었다. This study analyzed the impact of learning motivation and social support on college life adjustment using Chinese international students who were attending at university located in Busan. For this, the Chinese international students’ general characteristics, learning motivation, social support, and college life adjustment were measured for a sample of 210 students and 208 students were used for final analysis. Main results were as the followings. First, for college life adjustment, after controlling the Chinese international students’ general characteristics, self-regulation learning strategy in learning motivation factor had statistically significant negative influence and Chinese friend support in social support factor had statistically significant positive influence. Second, for academic adjustment, after controlling the Chinese international students’ general characteristics, self-efficacy in learning motivation factor had statistically significant positive influence. Third, for social adjustment, after controlling the Chinese international students’ general characteristics, Chinese friend support in social support factor had statistically significant positive influence. Fourth, for personal emotion adjustment, after controlling the Chinese international students’ general characteristics, self-regulation learning strategy in learning motivation factor had statistically significant negative influence. Fifth, for college environment adjustment, after controlling the Chinese international students’ general characteristics, locus of control in learning motivation factor had statistically significant positive influence and Chinese friend support in social support factor had statistically significant positive influence. Some implications and suggestions on these main results were discussed.
Smads as therapeutic targets for chronic kidney disease
( Hui Yao Lan ) 대한신장학회 2012 Kidney Research and Clinical Practice Vol.31 No.1
Renal fibrosis is a hallmark of chronic kidney disease (CKD). It is generally thought that transforming growth factor-b1 (TGF-b1) is a key mediator of fibrosis and mediates renal scarring positively by Smad2 and Smadbut negatively by Smad7. Our recent studies found that in CKD, TGF-b1 is not a sole molecule to activate Smads. Many mediators such as angiotensin II and advanced glycation end products can also activate Smads via both TGF-b-dependent and independent mechanisms. In addition, Smads can interact with other signaling pathways, such as the mitogen-activated protein kinase and nuclear factor-kappaB (NF-kB) pathways, to regulate renal inflammation and fibrosis. In CKD, Smad2 and Smad3 are highly activated, while Smad7 is reduced or lost. In the context of fibrosis, Smad3 is pathogenic and mediates renal fibrosis by upregulating miR-21 and miR-19 but down-regulating miR-29 and miR-200 families. By contrast, Smad2 and Smad7 are protective. Overexpression of Smad7 inhibits both Smad3-mediated renal fibrosis and NF-kB-driven renal inflammation. Interestingly, Smad4 has diverse roles in renal fibrosis and inflammation. The complexity and distinct roles of individual Smads in CKD suggest that treatment of CKD should aim to correct the imbalance of Smad signaling or target the Smad3-dependent genes related to fibrosis, rather than to block the general effect of TGF-b1. Thus, treatment of CKD by overexpression of Smad7 or targeting Smad3-dependent miRNAs such as downregulation of miR-21 or overexpression of miR-29 may represent novel therapeutic strategies for CKD.
Effects of Gastric Cancer Cells on the Differentiation of Treg Cells
Hu, Jing-Lan,Yang, Zhen,Tang, Jian-Rong,Fu, Xue-Qin,Yao, Lan-Jie Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
The aim of this study was evaluated the prevalence of Treg cells in peripheral blood in patients with gastric cancer, and investigate the effect of gastric cancer cells on their differentiation. ELISA was employed to assess the concentrations of TGF-${\beta}$ and IL-10 in gastric cancer patients' serum. Then, mouse gastric cancer cells were co-cultured with T lymphocytes or T lymphocytes + anti-TGF-${\beta}$. Flow cytometric analysis and RT-PCR were then performed to detect Treg cells and TGF-${\beta}$ and IL-10 expression in gastric cancer cells. Our data showed that the expression of TGF-${\beta}$ and IL-10 in the patients with gastric cancer was increased compared to the case with healthy donors. The population of Treg cells and the expression levels of TGF-${\beta}$ and IL-10 in the co-culture group were much higher than in the control group (18.6% vs 9.5%) (P<0.05). Moreover, the population of Treg cells and the expression levels of TGF-${\beta}$ and IL-10 in the co-culture systerm were clearly decreased after addition of anti-TGF-${\beta}$ (7.7% vs 19.6%) (P<0.01). In conclusion, gastric cancer cells may induce Treg cell differentiation through TGF-${\beta}$, and further promote immunosuppression.
( Ya-min Lai ),( Wei-yan Yao ),( Yao He ),( Xuan Jiang ),( Yu-bei Gu ),( Min-hu Chen ),( Yu-lan Liu ),( Yao-zong Yuan ),( Jia-ming Qian ) 대한소화기학회 2017 Gut and Liver Vol.11 No.2
Background/Aims: Patients with active ulcerative colitis (UC) have elevated levels of activated myeloid-derived leukocytes as a source of inflammatory cytokines. The selective deple-tion of these leukocytes by adsorptive granulocyte/monocyte apheresis (GMA) with an Adacolumn should alleviate inflammation, promote remission and enhance drug efficacy. However, studies have reported contrasting efficacy out-comes based on patients` baseline demographic variables. This study was undertaken to understand the demographic features of GMA responders and nonresponders. Methods: This was a multicenter study in China involving four institutions and 34 patients with active UC. Baseline conventional medications were continued without changing the dosage. The treatment efficacy was evaluated based on the endo-scopic activity index and the Mayo score. Results: Thirty of the 34 patients completed all 10 GMA treatment sessions. The overall efficacy rate was 70.59%. The receiver operating characteristic analysis showed that the area under the curve was approximately 0.766 for a Mayo score of ≤5.5 with 0.273 specificity and 0.857 sensitivity (Youden index, 0.584) for GMA responders. No GMA-related serious adverse events were observed. Conclusions: The overall efficacy of GMA in patients with active UC who were taking first-line medications or were corticosteroid refractory was encouraging. Addition-ally, GMA was well tolerated and had a good safety profile. (Gut Liver 2017;11:216-225)
Irinotecan as a Palliative Therapy for Metastatic Breast Cancer Patients after Previous Chemotherapy
Lan, Hai,Li, Yan,Lin, Cong-Yao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Background: This analysis was conducted to evaluate the efficacy and safety of irinotecan based chemotherapy for treatment of patients with metastatic breast cancer (MBC) who experienced disease progression after one to three chemotherapy regimens, including at least one anthracycline- or taxane-based. Methods: Clinical studies were identified using a predefined search strategy. Pooled response rates (RR) to treatment were calculated. Results: As irinotecan based regimens, 5 clinical studies which including 217 patients with refractory MBC were considered eligible for inclusion, with irinotecan, cisplatin, capecitabine, or TS-1. Systemic analysis suggested that, in all patients, pooled RR was 48.8% (106/217) with irinotecan based regimens. Thrombocytopenia and leukocytopenia were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment related deaths occurred. Conclusion: This systemic analysis suggests that irinotecan based regimens are beneficial and safe for treating patients with MBC after other chemotherapy.
DsLCYB Directionally Modulated β-Carotene of the Green Alga Dunaliella salina under Red Light Stress
Lan Yanhong,Song Yao,Guo Yihan,Qiao Dairong,Cao Yi,Xu Hui 한국미생물·생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.12
Carotenoids, which are natural pigments found abundantly in wide-ranging species, have diverse functions and high industrial potential. The carotenoid biosynthesis pathway is very complex and has multiple branches, while the accumulation of certain metabolites often affects other metabolites in this pathway. The DsLCYB gene that encodes lycopene cyclase was selected in this study to evaluate β-carotene production and the accumulation of β-carotene in the alga Dunaliella salina. Compared with the wild type, the transgenic algal species overexpressed the DsLCYB gene, resulting in a significant enhancement of the total carotenoid content, with the total amount reaching 8.46 mg/g for an increase of up to 1.26-fold. Interestingly, the production of α-carotene in the transformant was not significantly reduced. This result indicated that the regulation of DsLCYB on the metabolic flux distribution of carotenoid biosynthesis is directional. Moreover, the effects of different light-quality conditions on β-carotene production in D. salina strains were investigated. The results showed that the carotenoid components of β-carotene and β-cryptoxanthin were 1.8- fold and 1.23-fold higher than that in the wild type under red light stress, respectively. This suggests that the accumulation of β-carotene under red light conditions is potentially more profitable.