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( Lilian Yan Liang ),( Hye Won Lee ),( Vincent Wai-sun Wong ),( Terry Cheuk-fung Yip ),( Yee-kit Tse ),( Vicki Wing-ki Hui ),( Grace Chung-yan Lui ),( Henry Lik-yuen Chan ),( Grace Lai-hung Wong ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.3
Background/Aims: Serum fibrosis scores comprised of common laboratory tests have high utility to assess severity of liver fibrosis. We aimed to derive and validate a hepatocellular carcinoma (HCC) risk score based on serum fibrosis scores to predict HCC in treatment-naive chronic hepatitis B (CHB) patients. Methods: Fifteen thousand one hundred eighty-seven treatment-naive adult CHB patients were identified to form the training cohort in this retrospective study. Individual fibrosis score was included to construct a new HCC prediction score. The score was externally validated in an independent treatment-naive Korean CHB cohort. Results: 180/15,187 patients (1.2%) in training cohort and 47/4,286 patients (1.1%) in validation cohort developed HCC during a mean follow-up of 52 and 50 months, respectively. The newly developed HCC risk score, Liang score, is composed of gender, age, hepatitis B virus DNA, fibrosis-4 (FIB-4) index, and ranges from 0 to 22. Area under the time-dependent receiver operating characteristic curve of Liang score was 0.79 (95% confidence interval, 0.70-0.89). A cutoff value of nine provided an extremely high negative predictive value of 99.9% and high sensitivity of 90.0% at 5 years in the validation cohort. Patients with Liang score ≤9 had HCC incidence <0.2% per year in both training and validation cohorts, in whom HCC surveillance might be exempted. Conclusion: A novel HCC risk score, Liang score, based on FIB-4 index, is applicable and accurate to identify treatment-naive CHB patients with very low risk of HCC to be exempted from HCC surveillance. (Clin Mol Hepatol 2021;27:499-509)
Liang Yan,Wu Jie,Ma Yuan 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.7
It is an important foundation for the in-depth application of the propositional logic to compute all reductions, and this is a hot subject at present. This paper defines the identity element concept and the zero element concept in concept lattice. It proves that the minimal transversal of waned values hypergraph of zero element concept is a reduction in inducible context, and it also proves that the minimal transversal set is a full reduction set. Furthermore, the paper presents a new method based on intent waned values and hypergraph minimal transversal of concept lattice. By this method, all reductions can be quickly computed all at once. It develops the reducing algorithm. Compared with the original algorithm, which compute a reduction every time in first and gradually aggregate all reductions, the operating number of the improved algorithm is remarkably reduced. The approach has the remarkable advantages and good results.
Nonlegumes Respond to Rhizobial Nod Factors by Suppressing the Innate Immune Response
Liang, Yan,Cao, Yangrong,Tanaka, Kiwamu,Thibivilliers, Sandra,Wan, Jinrong,Choi, Jeongmin,Kang, Chang ho,Qiu, Jing,Stacey, Gary American Association for the Advancement of Scienc 2013 Science Vol.341 No.6152
<P><B>Stealth Nod Factor Recognition</B></P><P>Legumes' symbiotic interaction with nitrogen fixing bacteria supplies the plant with nitrogen. Many important crop plants, however, cannot establish these symbioses and, thus, agriculture depends on externally applied fertilizers. Surprisingly, <B>Liang <I>et al.</I></B> (p. 1384, published online 5 September) found that several nonleguminous plants, including <I>Arabidopsis</I>, tomato, and corn, were able to respond to the same Nod factors that initiate the microbial symbiosis in soybean.</P>
Applicability Analysis of Microseismic Technology in Tunnel Water Inrush Monitoring
Yan-hao Chen,Shuai Cheng,Li-Ping Li,Jun-yan Yang,Hong-liang Liu,Wen-feng Tu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.7
Water inrush disaster is one of the most serious geological disasters in tunnel construction. There are still some problems in the existing researches, such as the activity information of surrounding rock is difficult to obtain, the mechanism of water inrush disaster is unclear, the correlation between water inrush disaster and microseismic (MS) information is missing, which have caused the water inrush disaster to be passively controlled. Combining with the practical experience of tunnel engineering, the application problems of MS technology in tunnel engineering is summarized, which provides ideas for monitoring of surrounding rock activity. The formation mechanism of water inrush disaster caused by rock mass fracturing and filling medium instability has been revealed. The MS characteristics of the water inrush channel in different water inrush disasters have also been revealed. The MS response characteristics of water inrush and rockburst disasters are compared, which provides guidance for the improvement of MS monitoring technology and the analysis of effective MS information. The compression failure test of limestone under saturated and natural conditions is carried out. The results show that the presence of water weakens the ability of rock to store energy. The acoustic emission (AE) phenomenon is weaker in the process of saturated limestone failure, which increases the difficulty of AE monitoring. The number of AE events of natural limestone and saturated limestone shows a slow increase to a sudden increase in the process stress loading, which can be regarded as an important precursor of rock failure.
Yan-Jun Liang,You-Jun Lu,De-Xin Gao,Zhong-Sheng Wang 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.2
The vibration control problem of offshore jacket platforms is studied. The model of offshore platforms with nonlinear interactions of the pile-soil affected by the wave load disturbances is established. The wave loads are determined by using the Morison equation and are considered as disturbances with known dynamic characteristics but unknown initial conditions. Based on the successive approximation approach (SAA), we propose an approximate optimal vibration control scheme for the nonlinear systems of the offshore jacket platforms. Numerical simulations illustrate the effectiveness of the proposed approach.
Liang Sun,Fei Shang,Chang-Qing Duan,Guo-liang Yan 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.7
Transferring the recombinant S. cerevisiae T73-63 from 30 oC to 4 oC resulted in 41.4% increment of β-carotene concentration (3.96mg/g dry cell weight) relative to that of 30 oC, which was accompanied with the accumulation of fatty acid and ergosterol. The comparisons of the transcriptional levels of mevalonate pathway genes indicated that the expressions of HMG1, ERG9, ERG19, ERG20 and IDI1 at 4 oC were all higher than those of 30 oC, respectively. This suggested that increased transcriptions of mevalonate pathway genes contribute to the improvement of β-carotene production at low temperature. We also found that supplementation of 30mg/L triclosan, an inhibitor of fatty acid synthesis, led to further 28.3% enhancement of β-carotene concentration (4.94mg/g DCW), which was 18.8% higher than that of 30 oC with the same concentration of triclosan. The higher expressional levels of HMG, ERG19 and ERG20 and the simultaneous increment of ergosterol content (17.8%) suggested that more carbon source was transferred from fatty acid synthesis to mevalonate pathway under the circumstance of appropriately blocking fatty acid synthesis at low temperature (4 oC), which resulted in a higher increment of β-carotene production compared to that of 30 oC. The results of this study collectively suggest that the combination of reducing temperature and adding fatty acid synthesis inhibitors is a potential approach to improve the production of desirable isoprenoid compounds such as carotenoids.