Bone Homeostasis and Gut Microbial-Dependent Signaling Pathways

( Xiaohui Zhong ),( Feng Zhang ),( Xinyao Yin ),( Hong Cao ),( Xuesong Wang ),( Dongsong Liu ),( Jing Chen ),( Xue Chen ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.6

Although research on the osteal signaling pathway has progressed, understanding of gut microbialdependent signaling pathways for metabolic and immune bone homeostasis remains elusive. In recent years, the study of gut microbiota has shed light on our understanding of bone homeostasis. Here, we review microbiota-mediated gut-bone crosstalk via bone morphogenetic protein/SMADs, Wnt and OPG/receptor activator of nuclear factor-kappa B ligand signaling pathways in direct (translocation) and indirect (metabolite) manners. The mechanisms underlying gut microbiota involvement in these signaling pathways are relevant in immune responses, secretion of hormones, fate of osteoblasts and osteoclasts and absorption of calcium. Collectively, we propose a signaling network for maintaining a dynamic homeostasis between the skeletal system and the gut ecosystem. Additionally, the role of gut microbial improvement by dietary intervention in osteal signaling pathways has also been elucidated. This review provides unique resources from the gut microbial perspective for the discovery of new strategies for further improving treatment of bone diseases by increasing the abundance of targeted gut microbiota.

Current Review on the Research Status of Cemented Carbide Brazing: Filler Materials and Mechanical Properties

Xiaohui Yin,Qunshuang Ma,Bing Cui,Lei Zhang,Xingyan Xue,Sujuan Zhong,Dong Xu 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.4

Cemented carbides have been widely applied in cutting tools and wear-resistant components due to their ultrahigh hardnessand good wear resistance. However, the disadvantages of limited impact toughness and high cost have restricted their furtherapplication. Consequently, cemented carbides are usually joining with ductile steels to combine the advantages of both. Among various materials joining technologies, brazing have been an effective method to achieve high quality dissimilarcemented carbide joints. In this paper, the research status of cemented carbide brazing is reviewed. The materials utilized asbrazing filler metal in cemented carbide brazing joints are summarized in detail. Researchers have done lots of works utilizingCu based and Ag based brazing filler metals which are the most commonly used interlayers in brazed joints of cementedcarbide and ductile steel. The effects of different filler metal on wettability, microstructure, phase constitution and mechanicalproperties of brazed cemented carbides joints are analysed. Besides, a series of newly developed brazing filler materialsuch as nickel-based high temperature brazing filler metal, amorphous brazing filler metal and high entropy alloy brazingfiller materials are also involved. These newly developed brazing filler metals have shown great potential in fabricating highquality joints. Finally, the current issues of cemented carbide brazing are reviewed and the develop trend is predicted.

A Multi-objective Planning of Transmission Line Balance Degree Based on Power Flow Entropy Theory

Jiaqing Zhong,Fanfan Gao,Xiaohui Zhang 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.5

The equilibrium degree of transmission lines in the multi-objective planning of power grid is studied in this paper. The main purpose of the study is to ensure the economy and improve the balanced distribution of active power fl ow of transmission lines, furthermore increase the adaptability of transmission lines in the future power grid. The problem is mainly focus on the single-level of line load rate, in researching on the distribution balance of active power fl ow in transmission lines. Three indexed, which are line load rate power fl ow entropy, active loss rate power fl ow entropy and transmission effi ciency power fl ow entropy, are defi ned in this paper. The weighted sum of the three indexes is defi ned as the balance factor of active power fl ow distribution in transmission lines. This factor is used in transmission network planning to improve the overall balance of active power fl ow distribution in transmission lines. On this basis, a multi-objective programming model with minimum economic cost and maximum equilibrium factor of transmission network is established. The model is solved by using multiobjective bacterial colony chemotactic algorithm (BCC) and optimal compromise solution method. The results verify the superiority and rationality of the proposed method and model.

Secrecy Spectrum and Secrecy Energy Efficiency in Massive MIMO Enabled HetNets

( Zhihao Zhong ),( Jianhua Peng ),( Kaizhi Huang ),( Lu Xia ),( Xiaohui Qi ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.2

Security and resource-saving are both demands of the fifth generation (5G) wireless networks. In this paper, we study the secrecy spectrum efficiency (SSE) and secrecy energy efficiency (SEE) of a K-tier massive multiple-input multiple-output (MIMO) enabled heterogeneous cellular network (HetNet), in which artificial noise (AN) are employed for secrecy enhancement. Assuming (i) independent Poisson point process model for the locations of base stations (BSs) of each tier as well as that of eavesdroppers, (ii) zero-forcing precoding at the macrocell BSs (MBSs), and (iii) maximum average received power-based cell selection, the tractable lower bound expressions for SSE and SEE of massive MIMO enabled HetNets are derived. Then, the influences on secrecy oriented spectrum and energy efficiency performance caused by the power allocation for AN, transmit antenna number, number of users served by each MBS, and eavesdropper density are analyzed respectively. Moreover, the analysis accuracy is verified by Monte Carlo simulations.

Research on “Wind‑Net‑Vehicle Load” Optimization Scheduling Considering Load Margin Domain

Jiaqing Zhong,Yiming Wang,Xiaohui Zhang 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.3

Under the current situation of widespread application of electric vehicles (EV), how to optimize the two uncertain loads of electric vehicle charging and battery charging in the Battery Charge-Swap Station (BCSS) has become an urgent problem. In view of the above problem, this paper defnes the load margin domain index, detects the daily load change, and performs peak shaving and valley flling on the load with large fuctuation range to make it smooth and stable. On this basis, with the obtained load margin domain as a constraint, combined with time-of-use electricity prices and considering wind farm gridconnected access, an “wind-net-vehicle load” optimized dispatching model was established to maximize system economic benefts, and at the same time play an important role in reducing the rate of wind abandonment. Finally, this paper studies the fusion of credibility theory and fuzzy chance constraints programming, introduces the credibility measure index, and makes the explicit equivalent treatment of the fuzzy chance constraint condition. The particle swarm optimization algorithm with a constriction factor is used to optimize the scheduling model. The rationality of the model and its strategy is verifed by examples.

Complete mitochondrial genome of freshwater goby Rhinogobius cliffordpopei (Perciformes, Gobiidae): genome characterization and phylogenetic analysis

Liqiang Zhong,Minghua Wang,Daming Li,Shengkai Tang,Tongqing Zhang,Wenji Bian,Xiaohui Chen 한국유전학회 2018 Genes & Genomics Vol.40 No.11

Freshwater gobies Rhinogobius cliffordpopei and R. giurinus are invasive species with particular concern because they have become dominant and were fierce competitors in the invaded areas in Yunnan-Guizhou Plateau (southwest of China). Information about genetic characteristics of R. giurinus have been published, but there were still no relevant reports about R. cliffordpopei. In present study, the complete mitochondrial genome of R. cliffordpopei was determined, which was 16,511 bp in length with A + T content of 51.1%, consisting of 13 protein-coding genes, 22 tRNAs, 2 ribosomal RNAs, and a control region. The gene composition and the structural arrangement of the R. cliffordpopei complete mtDNA were identical to most of other teleosts. Phylogenetic analyses placed R. cliffordpopei in a well-supported monophyletic cluster with other Rhinogobius fish. But the phylogenetic relationship between genus Rhinogobius and Tridentiger remained to be resolved.

Study of Credibility Evaluation of Dynamic Models and their Parameters

Guo, Weimin,Ye, Xiaohui,Zhong, Wuzhi,Su, Yi,Tang, Yaohua,Song, Xinli,Liu, Tao The Korean Institute of Electrical Engineers 2014 The Journal of International Council on Electrical Vol.4 No.1

The time-domain simulation plays an important role in planning, designing and operation of the power system, but mismatches between its results and the actual system response show that the credibility evaluation of dynamic models is critical in all the above aspects of power systems. This paper discusses the technologies of credibility evaluation, including hybrid dynamic simulation with PMU measurements, error analysis and the calculated indices. Moreover, a phase shift method is presented to implement hybrid dynamic simulation in PSD-FDS. Then the paper proposes a credibility evaluation scheme to provide solution for the evaluation. At last, one sample is used to validate the implementation of hybrid dynamic simulation, while the other sample illustrates the effectiveness of the credibility evaluation approach.

Densifi cation of matrix graphite for spherical fuel elements used in molten salt reactor via addition of green pitch coke

Zhao He,Hongchao Zhao,Jinliang Song,Xiaohui Guo,Zhanjun Liu,Yajuan Zhong,T. James Marrow 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.4

Green pitch coke with an average particle size of 2 mm was adopted as densifier and added to the rawmaterials of conventional A3-3 matrix graphite (MG) to prepare modified A3-3 matrix graphite (MMG)by the quasi-isostatic molding method. The structure, mechanical and thermal properties were assessed. Compared with MG, MMG had a more compact structure, and exhibited improved properties of highermechanical strength, higher thermal conductivity and better molten salt barrier performance. Notably,under the same infiltration pressure of 5 atm, the fluoride salt occupation of MMG was only 0.26 wt%,whereas it was 15.82 wt% for MG. The densification effect of green pitch coke endowed MMG withimproved properties for potential use in the spherical fuel elements of molten salt reactor.

Temporal expression profiling of long noncoding RNA and mRNA in the peripheral blood during porcine development

Gu, Yiren,Zhou, Rui,Jin, Long,Tao, Xuan,Zhong, Zhijun,Yang, Xuemei,Liang, Yan,Yang, Yuekui,Wang, Yan,Chen, Xiaohui,Gong, Jianjun,He, Zhiping,Li, Mingzhou,Lv, Xuebin Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.5

Objective: We investigated the temporal expression profiles of long noncoding RNA (lncRNA) and mRNA in the peripheral blood of pigs during development and identified the lncRNAs that are related to the blood-based immune system. Methods: Peripheral blood samples were obtained from the pigs at 0, 7, 28, and 180 days and 2 years of age. RNA sequencing was performed to survey the lncRNA and mRNA transcriptomes in the samples. Short time-series expression miner (STEM) was used to show temporal expression patterns in the mRNAs and lncRNAs. Gene ontology and Kyoto encyclopedia of genes and genomes analyses were performed to assess the genes' biological relevance. To predict the functions of the identified lncRNAs, we extracted mRNAs that were nearby loci and highly correlated with the lncRNAs. Results: In total of 5,946 lncRNA and 12,354 mRNA transcripts were identified among the samples. STEM showed that most lncRNAs and mRNAs had similar temporal expression patterns during development, indicating the expressional correlation and functional relatedness between them. The five stages were divided into two classes: the suckling period and the late developmental stage. Most genes were expressed at low level during the suckling period, but at higher level during the late stages. Expression of several T-cell-related genes increased continuously during the suckling period, indicating that these genes are crucial for establishing the adaptive immune system in piglets at this stage. Notably, lncRNA TCONS-00086451 may promote blood-based immune system development by upregulating nuclear factor of activated T-cells cytoplasmic 2 expression. Conclusion: This study provides a catalog of porcine peripheral blood-related lncRNAs and mRNAs and reveals the characteristics and temporal expression profiles of these lncRNAs and mRNAs during peripheral blood development from the newborn to adult stages in pigs.