Enhanced electrocatalytic performance of an ultrafine AuPt nanoalloy framework embedded in graphene towards epinephrine sensing

Thanh, Tran Duy,Balamurugan, Jayaraman,Tuan, Nguyen Thanh,Jeong, Hun,Lee, Seung Hee,Kim, Nam Hoon,Lee, Joong Hee Elsevier 2017 Biosensors & bioelectronics Vol.89 No.2

<P><B>Abstract</B></P> <P>A novel hierarchical nanoporous thin film of AuPt alloy embedded in graphene (AuPt@GR) was successfully synthesized through the self-assembly of ultrafine AuPt nanoparticles (~3nm) within GR sheets by means of a facile chemical vapor deposition (CVD) procedure without the use of any external organic capping agent and reducing agent. A binder-free sensor based on the AuPt@GR hybrid material was fabricated and its electrocatalytic activity was evaluated by using it to determine epinephrine (EP) in PBS solution (pH=7.4) and in human serum spiked PBS solution. Amperometric measurements of the sensor response showed an extremely low limit of detection (0.9nM at a signal-to-noise ratio of 3), high sensitivity (1628µAmM<SUP>−1</SUP> cm<SUP>−2</SUP>), wide linear detection range (1.5×10<SUP>−9</SUP>–9.6×10<SUP>−6</SUP> M), and negligible response to interferents. At the same time, the sensor also exhibited very long-term amperometric stability (4000s), cyclic voltammetric stability (500 cycles), good reproducibility, and highly accurate detection of EP in real samples. The excellent electrochemical performance was attributed to synergistic effects of Au, Pt, and GR as well as to the formation of a unique nanoporous structure that provided enhanced electrocatalytic activity, a highly electroactive surface, and fast mass transport. These results suggest strong potential of the AuPt@GR hybrids for use in biosensors and bioelectronic devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A novel hierarchical nanoporous AuPt alloy embedded in graphene was successfully synthesized without capping and reducing agents. </LI> <LI> The AuPt@GR based sensor detected epinephrine with low LOD (0.9nM), high sensitivity (1628µAmM<SUP>−1</SUP> cm<SUP>−2</SUP>), and wide linear detection range (1.5×10<SUP>−9</SUP>–9.6×10<SUP>−6</SUP> M). </LI> <LI> The sensor exhibited very long-term amperometric stability (4000s), CV stability (500 cycles), and good reproducibility. </LI> </UL> </P>

A novel sensitive sensor for serotonin based on high-quality of AuAg nanoalloy encapsulated graphene electrocatalyst

Thanh, Tran Duy,Balamurugan, Jayaraman,Hien, Hoa Van,Kim, Nam Hoon,Lee, Joong Hee Elsevier Applied Science 2017 Biosensors & bioelectronics Vol. No.

<P><B>Abstract</B></P> <P>A high quality graphene-encapsulated AuAg alloy (AuAg-GR) nanohybrid with homogeneous structure and good reproducibility over a desired area was successfully fabricated. Taking benefits of the unique architecture, such nanohybrid was employed as an efficient electrocatalyst for sensing application. The AuAg-GR based sensor could sensitively detected neurotransmitter serotonin (5-HT) with wide linear detection range (2.7nM to 4.82μM), very low detection limit (1.6nM), negligible interference, and excellent reproducibility. In addition, AuAg-GR based sensor accurately determined 5-HT in human serum samples. This is due to the enhanced catalytic activity of GR nanosheets-encapsulated AuAg nanostructures, which possessed well monodispersion of AuAg alloy, greater electrochemical active sites, and good charge transfer possibility. The obtained results imply that such nanohybrid is a potential candidate for synthesizing electrochemical sensors in requirement of high sensitivity, long-term stability, and good reproducibility.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High quality of AuAg NPs-GR hybrid was successfully synthesized using electroless deposition. </LI> <LI> It demonstrated excellent catalytic activity towards serotonin with wide linear detection range. </LI> <LI> The AuAg-GR based sensor displayed good reproducibility and stability. </LI> </UL> </P>

Recent advances in two-dimensional transition metal dichalcogenides-graphene heterostructured materials for electrochemical applications

Thanh, Tran Duy,Chuong, Nguyen Dinh,Hien, Hoa Van,Kshetri, Tolendra,Tuan, Le Huu,Kim, Nam Hoon,Lee, Joong Hee Elsevier 2018 Progress in materials science Vol.96 No.-

<P><B>Abstract</B></P> <P>Recently, the research effort on two-dimensional transition metal dichalcogenides/graphene (2D-TMDs/Gr) hybrids has grown. These hybrids are emerging as a promising strategy for the preparation of advanced multifunctional materials with effectively upgraded properties, as well as performances. Due to their outstanding electrical, physical, and chemical properties, these materials have been extensively considered for various applications, both in academia, and industry. This review systematically assesses the important progress to date in the development of 2D-TMDs/Gr hybrids. The synthesis methods of 2D-TMDs/Gr hybrids for fabricating diverse types of nanostructured architectures are highlighted. In addition, the relationships between morphological and structural characteristics, and the physicochemical properties of 2D-TMDs/Gr hybrids, are recognized in detail. This review also discusses recent prospective applications of the 2D-TMDs/Gr hybrids in the areas of energy storage, energy conversion, energy harvesting technologies, and sensors. In summary, although there are still challenges for optimizing the synthesis process and performance of the 2D-TMDs/Gr hybrids, they offer unique candidates for a wide range of promising applications in the future.</P>

CuAg@Ag Core–Shell Nanostructure Encapsulated by N-Doped Graphene as a High-Performance Catalyst for Oxygen Reduction Reaction

Thanh, Tran Duy,Chuong, Nguyen Dinh,Hien, Hoa Van,Kim, Nam Hoon,Lee, Joong Hee American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.5

<P>Development of a robust, cost-effective, and efficient catalyst is extremely necessary for oxygen reduction reaction (ORR) in fuel cell applications. Herein, we reported a well-defined nanostructured catalyst of highly dispersed CuAg@Ag coreshell nanoparticle (NP)-encapsulated nitrogen-doped graphene nanosheets (CuAg@Ag/N-GNS) exhibiting a superior catalytic activity toward ORR in alkaline medium. The synergistic effects produced from the unique properties of CuAg@Ag core-shell NPs and N-GNS made such a novel nanohybrid display a catalytic behavior comparable to that of the commercial Pt/C product. In particular, it demonstrated a much better stability and methanol tolerance than Pt/C under the same conditions. Because of its outstanding electrochemical performance and ease of synthesis, CuAg@Ag/N-GNS material was expected to be a promising low-cost catalyst for ORR in alkaline fuel cell applications.</P>

Cu-Au nanocrystals functionalized carbon nanotube arrays vertically grown on carbon spheres for highly sensitive detecting cancer biomarker

Tran, Duy Thanh,Hoa, Van Hien,Tuan, Le Huu,Kim, Nam Hoon,Lee, Joong Hee Elsevier 2018 Biosensors & bioelectronics Vol.119 No.-

<P><B>Abstract</B></P> <P>A three-dimensional hierarchical nanohybrid based on Cu-Au bimetallic nanocrystals integrated carbon nanotube arrays vertically grown on carbon spheres was successfully developed as an active platform for sensing application. Such nanohybrid can provide abundant active sites and act as an exceptional platform for immobilizing highly dense and well-dispersed carcinoembryonic antibody (anti-CEA) to sensitively detect CEA, an emerging biomarker of various cancer diseases. Due to the unique nanoarchitecture with altered electronic structure of Cu-Au bimetallic catalyst and enhanced interactions between components, such nanohybrid based biosensor demonstrated excellent electrochemical performance towards CEA detection with great sensitivity, wide linear detection range (0.025–25 ng/mL), very low limit of detection (0.5 pg/mL), and good selectivity. The results imply that this sensor has great potential to offer essential information for cancer diagnosis and management with great clinical importance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A 3D hierarchical Cu-Au nanocrystal integrated CNTs was grown on carbon sphere. </LI> <LI> The hybrid showed a wide linear detection range (0.025–25 ng/mL) and low detection limit (0.5 pg/mL). </LI> <LI> The hybrid showed good reproducibility and accurate detection of CEA in human serum. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

정적 무선 네트워크에서 EGC 기법을 이용한 최소 에너지 협력 라우팅 기법에 관한 연구

장 충 두이(Tran Trung Duy),하 웬 부(Ha Nguyen Vu),트란 탄 트럭(Tran Thanh Truc),공형윤(Hyung-Yun Kong) 한국통신학회 2011 한국통신학회 학술대회논문집 Vol.2011 No.2

Influence of Credit on the Income of Households Borrowing from Banks: Evidence from Vietnam Bank for Agriculture and Rural Development, Kien Giang Province

Quang Vang DANG(Quang Vang DANG ),Viet Thanh Truc TRAN(Viet Thanh Truc TRAN ),Hieu PHAM(Hieu PHAM ),Van Nam MAI(Van Nam MAI ),Quoc Duy VUONG(Quoc Duy VUONG ) 한국유통과학회 2023 The Journal of Asian Finance, Economics and Busine Vol.10 No.2

This paper investigates the determinants of credit accessibility and the effect of credit on the income of farm households borrowing from Vietnam Bank for Agriculture and Rural Development, Giong Rieng District Branch, Kien Giang Province. Based on the primary data of 200 farming households who are the customer of the bank, the study applied the Probit regression model to examine determinant factors of credit accessibility of farm households and employed the Propensity score matching method to investigate the impact of credit on households’ income. The findings of the Probit regression shown that three independent variables that significantly influence the access to credit of households are household size, income source, and farm size. Besides that, the Propensity score matching method results showed a difference of 23.799 million VND/year between the income of borrowing households and that of non-borrowing households at the significance level of 1%. The difference in the imcome from the interval and central matching methods are VND 24.700 million VND/year and VND 24.633 million VND/year, respectively. Given empirical findings suggetsted that several recommendations to increase the credit accessibility of farm households, thereby creating favorable conditions for improving their income.

Toll-like receptor-targeted particles: A paradigm to manipulate the tumor microenvironment for cancer immunotherapy

Tran, Tuan Hiep,Tran, Thi Thu Phuong,Truong, Duy Hieu,Nguyen, Hanh Thuy,Pham, Tung Thanh,Yong, Chul Soon,Kim, Jong Oh Elsevier Science B.V. Amsterdam 2019 ACTA BIOMATERIALIA Vol. No.

<P><B>Abstract</B></P> <P>The expression of Toll-like receptors (TLRs) on antigen presenting cells, especially dendritic cells, offers several sensitive mediators to trigger an adaptive immune response, which potentially can be exploited to detect and eliminate pathogenic objects. Consequently, numerous agonists that target TLRs are being used clinically either alone or in combination with other therapies to strengthen the immune system in the battle against cancer. This review summarizes the roles of TLRs in tumor biology, and focuses on relevant TLR-dependent antitumor pathways and the conjugation of TLR agonists as adjuvants to nano- and micro-particles for boosting responses leading to cancer suppression and eradication.</P> <P><B>Statement of Significance</B></P> <P>Toll-like receptors (TLRs), which express on antigen presenting cells, such as dendritic cells and macrophages, play an important role in sensing pathogenic agents and inducing adaptive immunity. As a result, several TLR agonists have been investigating as therapeutic agents individually or in combination with other treatment modalities for cancer treatment through boosting the immune system. This review aims to focus on the roles of TLRs in cancer and TLR-dependent antitumor pathways as well as the use of different nano- or micro-particles bearing TLR agonists for tumor inhibition and elimination.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Discovering Community Interests Approach to Topic Model with Time Factor and Clustering Methods

( Thanh Ho ),( Tran Duy Thanh ) 한국정보처리학회 2021 Journal of information processing systems Vol.17 No.1

Many methods of discovering social networking communities or clustering of features are based on the network structure or the content network. This paper proposes a community discovery method based on topic models using a time factor and an unsupervised clustering method. Online community discovery enables organizations and businesses to thoroughly understand the trend in users’ interests in their products and services. In addition, an insight into customer experience on social networks is a tremendous competitive advantage in this era of ecommerce and Internet development. The objective of this work is to find clusters (communities) such that each cluster’s nodes contain topics and individuals having similarities in the attribute space. In terms of social media analytics, the method seeks communities whose members have similar features. The method is experimented with and evaluated using a Vietnamese corpus of comments and messages collected on social networks and ecommerce sites in various sectors from 2016 to 2019. The experimental results demonstrate the effectiveness of the proposed method over other methods.

Pancreaticoduodenectomy with superior mesenteric artery first-approach combined total meso-pancreas excision for periampullary malignancies: A high-volume single-center experience with short-term outcomes

Thanh Khiem Nguyen,Ham Hoi Nguyen,Tuan Hiep Luong,Kim Khue Dang,Van Duy Le,Duc Dung Tran,Van Minh Do,Hong Quang Pham,Hoan My Pham,Thi Lan Tran,Cuong Thinh Nguyen,Hong Son Trinh,Yosuke Inoue 한국간담췌외과학회 2024 Annals of hepato-biliary-pancreatic surgery Vol.28 No.1

Backgrounds/Aims: Pancreaticoduodenectomy (PD) is the only radical treatment for periampullary malignancies. Superior mesenteric artery (SMA) first approach combined with total meso-pancreas (MP) excision was conducted to improve the oncological results. There has not been any previous research of a technique that combines the SMA first approach and total MP excision with a detailed description of the MP macroscopical shape. Methods: We prospectively assessed 77 patients with periampullary malignancies between October 2020 and March 2022 (18 months). All patients had undergone PD with SMA first approach combined total MP excision. The perioperative indications, clinical data, intra-operative index, R0 resection rate of postoperative pathological specimens (especially mesopancreatic margin), postoperative complications, and follow-up results were evaluated. Results: The median operative time was 289.6 min (178−540 min), the median intraoperative blood loss was 209 mL (30−1,600 mL). Microscopically, there were 19 (24.7%) cases with metastatic MP, and five cases (6.5%) with R1-resection of the MP. The number of lymph nodes (LNs) harvested and metastatic LNs were 27.2 (maximum was 74) and 1.8 (maximum was 16), respectively. Some (46.8%) patients had pancreatic fistula, but mostly in grade A, with 7 patients (9.1%) who required re-operations. Some 18.2% of cases developed postoperative refractory diarrhea. The rate of in-hospital mortality was 1.3%. Conclusions: The PD with SMA first approach combined TMpE for periampullary malignancies was effective in achieving superior oncological statistics (rate of MP R0-resection and number of total resected LNs) with non-inferior short-term outcomes. It is necessary to evaluate survival outcomes with long-term follow-up.