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      • KCI등재

        Effects of habitat fragmentation on the functional diversity of insects in Thousand Island Lake, China

        Tian‐Hao Tu,Ji-Rui WANG,Jian-Qiang GU,Tian-Qi LI,Kun LV,Guo-Xin ZHOU,Zhi-Hong XU 한국곤충학회 2019 Entomological Research Vol.49 No.2

        Due to habitat fragmentation, the loss of species diversity has been extensively studied. On the contrary, the effects of habitat fragmentation on functional diversity is still poorly understood. In the Thousand Island Lake, we conducted studies of insect functional diversity on a set of 29 isolated islands. We used 10 functional diversity indices from three aspects (functional richness, functional evenness and functional divergence) to respectively describe functional diversity of insects on sample islands. We found the following results: (i) The functional indices selected could reflect the functional diversity of sample islands and it is further proved that in general, three components of functional diversity were independent of each other; (ii) Sample islands could be divided into two categories, island JSD and the remaining islands; (iii) Functional richness increased with island area and shape index, but had no significant correlation with isolation. Likewise, both functional evenness and functional divergence had no significant correlation with island attributes. The conclusion to emphasize from our research is that: (i) habitat fragmentation reduced the biological functional diversity to some extent, further demonstrating the importance of habitat continuity in biodiversity protection; and (ii) for functional diversity protection of insects in a fragmented landscape, an island which has high approximate shape index values of at least hundred hectare magnitude order has a critical promoting effect.

      • KCI등재

        Role of folP1 and folP2 Genes in the Action of Sulfamethoxazole and Trimethoprim Against Mycobacteria

        ( Tian Zhou Liu ),( Bang Xing Wang ),( Jin Tao Guo ),( Yang Zhou ),( Mugweru Julius ),( Moses Njire ),( Yuan Yuan Cao ),( Tian Wu ),( Zhi Yong Liu ),( Chang Wei Wang ),( Yong Xu ),( Tian Yu Zhang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.9

        The combination of trimethoprim (TMP) and sulfamethoxazole (SMX) has been shown to be active against Mycobacterium tuberculosis (Mtb) in clinical tuberculosis (TB) treatment. However, the mechanism of action of TMP-SMX against Mtb is still unknown. To unravel this, we have studied the effect of TMP and SMX by deleting the folP2 gene in Mycobacterium smegmatis (Msm), and overexpressing the Mtb and Msm folP1/2 genes in Msm. Knocking out of the folP2 gene in Msm reduced the minimum inhibitory concentration of SMX 8-fold compared with wild type. Overexpression of the folP1 genes from Mtb and Msm increased the MICs by 4- and 2-fold in Msm for SMX and TMP, respectively. We show a strong correlation between the expression of folP1 and folP2 genes and TMP-SMX resistance in mycobacteria. This suggests that a combination of FolP2 inhibitor and SMX could be used for TB treatment with a better outcome.

      • KCI등재

        R을 활용한 서비스마케팅 연구동향 분석

        주전전(Tian-Tian Zhou),김병대(Byung-Dae Kim) 한국콘텐츠학회 2023 한국콘텐츠학회논문지 Vol.23 No.3

        본 연구는 최근 5년간 서비스마케팅에 관한 연구 주제어를 분석하고, 주요 이슈들과 향후 연구 과제를 도출하기 위해 연구동향을 파악하여 정량분석을 시행하였다. 본 연구의 분석은 각 논문별 키워드에서 R을 활용한 워드클라우드 분석방법을 적용하여 서비스마케팅 연구 동향을 파악하고자 한다. 이를 위해 2017년~2021년간 최근 5년간의 KCI 등재 및 등재후보 연구를 분석하였다. 최근 5년 동안 코로나19를 기준으로 2017년~2019년과 2020년~2021년으로 나눠 분석하였다. 분석결과는 2017년~2019년과 2020년~2021년 연구 주제어의 이슈 차이가 나타났다. 2017년~2019년에서 3년간 SNS가 가장 높은 빈도를 보이며, 마케팅믹스, 내부마케팅, 체험마케팅, 고객만족, 마케팅, SNS마케팅 등의 순으로 나타났다. 2020년~2021년 2년간 내부마케팅은 가장 높은 빈도를 보였으며, 고객만족, 마케팅, 서비스마케팅, 관계마케팅, 서비스품질, 코로나19, SNS 등의 순으로 나타났다. 5년간 서비스마케팅에 대한 연구들은 SNS, 내부마케팅, 고객만족, 마케팅, 마케팅믹스, 서비스마케팅, 서비스품질 등의 이슈가 높은 것으로 나타났다. 국내 서비스마케팅연구 주제들은 몇몇 주제에 고착화되어 있지 않고 빠르고 다양하게 변화하고 있다. 이에 따라 SNS나 내부마케팅과 같은 연구의 주제가 지속적으로 등장하고 있는 것으로 확인된다. 본 연구는 서비스마케팅의 최근 5년간의 연구동향을 파악하고 향후연구를 위한 현안들을 제공한다는 점에서 그 의의를 찾을 수 있다. In this study, research keywords related to service marketing for the last 5 years were analyzed, research trends were identified and quantitative analysis was performed to derive major issues and future research tasks. This study analyses the trend of service marketing research by applying the word cloud analysis method using R to the keywords of each paper. To this end, The data were analyzed by dividing the three-year period from 2017 to 2019, the two-year period from 2020 to 2021, and the five-year research trend. As for the analysis results, there was a significant difference between the keywords of the studies from 2017 to 2019 and 2020 to 2021, but the research issues differed. SNS showed the highest frequency for 3 years, followed by the marketing mix, internal marketing, experiential marketing, customer satisfaction, marketing, and SNS marketing. Internal marketing showed the highest frequency for two years, followed by customer satisfaction, marketing, service marketing, relationship marketing, service quality, COVID-19, and SNS. Over the past 5 years, researchers on service marketing showed a lot of interest in issues such as SNS, internal marketing, customer satisfaction, marketing, marketing mix, service marketing, and service quality. Domestic service marketing research topics are not fixed to a few topics but are changing rapidly and diversely. Accordingly, it is confirmed that research topics such as SNS and internal marketing are continuously appearing. The significance of this study can be found in that it identifies research trends in service marketing for the last 5 years and provides current issues for future research.

      • KCI등재

        Supplementation of Clostridium butyricum Alleviates Vascular Inflammation in Diabetic Mice

        Tian Zhou,Shuo Qiu,Liang Zhang,Yangni Li,Jing Zhang,Donghua Shen,Ping Zhao,Lijun Yuan,Lianbi Zhao,Yunyou Duan,Changyang Xing 대한당뇨병학회 2024 Diabetes and Metabolism Journal Vol.48 No.3

        Background: Gut microbiota is closely related to the occurrence and development of diabetes and affects the prognosis of diabetic complications, and the underlying mechanisms are only partially understood. We aimed to explore the possible link between the gut microbiota and vascular inflammation of diabetic mice.Methods: The <i>db/db</i> diabetic and wild-type (WT) mice were used in this study. We profiled gut microbiota and examined the and vascular function in both <i>db/db</i> group and WT group. Gut microbiota was analyzed by 16s rRNA sequencing. Vascular function was examined by ultrasonographic hemodynamics and histological staining. Clostridium butyricum (CB) was orally administered to diabetic mice by intragastric gavage every 2 days for 2 consecutive months. Reactive oxygen species (ROS) and expression of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were detected by fluorescence microscopy. The mRNA expression of inflammatory cytokines was tested by quantitative polymerase chain reaction.Results: Compared with WT mice, CB abundance was significantly decreased in the gut of <i>db/db</i> mice, together with compromised vascular function and activated inflammation in the arterial tissue. Meanwhile, ROS in the vascular tissue of <i>db/db</i> mice was also significantly increased. Oral administration of CB restored the protective microbiota, and protected the vascular function in the <i>db/db</i> mice via activating the Nrf2/HO-1 pathway.Conclusion: This study identified the potential link between decreased CB abundance in gut microbiota and vascular inflammation in diabetes. Therapeutic delivery of CB by gut transplantation alleviates the vascular lesions of diabetes mellitus by activating the Nrf2/HO-1 pathway.

      • Relationship Between the Prohibitin 3' Untranslated Region C > T Gene Polymorphism and Cancer Susceptibility - Results of a Meta-analysis

        Zhou, Tian-Biao,Yin, Sheng-Sheng,Huang, Jian-Jian,Ou, Chao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

        Objective: The results from the published studies on the association between prohibitin 3' untranslated region C > T gene polymorphism and cancer risk are conflicting. This meta-analysis was performed to evaluate the relationship with cancer susceptibility overall, and to explore whether the T allele or TT genotype could become a predictive marker for cancer risk. Methods: Association studies were identified from the databases of PubMed, Embase, and Cochrane Library as of March 1, 2012, and eligible investigations were synthesized using the meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Results: Six investigations were identified for the analysis of association between the prohibitin 3' untranslated region C > T gene polymorphism and cancer risk, covering of 1,461 patients with cancer and 1,197 controls. There was a positive association between the T allele and cancer susceptibility (OR=1.20, 95% CI: 1.03-1.39, P=0.02), and CC homozygous might play a protective role (OR=0.80, 95% CI: 0.68-6.11, P=0.95). In the sub-group analysis, prohibitin 3' untranslated region C > T gene polymorphism and cancer risk appeared associated with the risk of breast cancer, but not ovarian cancer. Conclusions: Our results indicate that T allele is a significant genetic molecular marker to predict cancer susceptibility and CC genotype is protective, especially for breast cancer. However, more investigations are required to further clarify the association of the prohibitin 3' untranslated region C > T gene polymorphism with cancer susceptibility.

      • KCI등재

        ON THE POWER SEQUENCE OF A FUZZY MATRIX CONVERGENT POWER SEQUENCE

        Tian, Zhou,Liu, De-Fu 한국전산응용수학회 1997 Journal of applied mathematics & informatics Vol.4 No.1

        The convergence of the power sequence of an $n{\times}n$ fuzzy matrix has been studied. Some theoretical necessary and sufficient con-ditions have been established for the power sequence to be convergent generally. Furthermore as one of our main concerns the convergence index was studied in detail especially for some special types of Boolean matrices. Also it has been established that the convergence index is bounded by $(n-1)^2+1$ from above for an arbitrary $n{\times}n$ fuzzy matrix if its power sequence converges. Our method is concentrated on the limit behavior of the power se-quence. It helped us to make our proofs be simpler and more direct that those in pure algebraic methods.

      • SCIESCOPUSKCI등재

        The effect of Glomus intraradices on the physiological properties of Panax ginseng and on rhizospheric microbial diversity

        Tian, Lei,Shi, Shaohua,Ma, Lina,Zhou, Xue,Luo, Shasha,Zhang, Jianfeng,Lu, Baohui,Tian, Chunjie The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.1

        Background: Glomus intraradices is a species of arbuscular mycorrhizal fungi that, as an obligate endomycorrhiza, can form mutually beneficial associations with plants. Panax ginseng is a popular traditional Chinese medicine; however, problems associated with ginseng planting, such as pesticide residues, reduce the ginseng quality. Methods: In this experiment, we studied the effect of inoculating G. intraradices on several physiological properties and microbial communities of ginseng. UV-Visible Spectrum method was used to detect physical properties. Denaturing gradient gel electrophoresis method was used to analyze microbial communities. Results: The results indicated that inoculation with G. intraradices can improve the colonization rate of lateral ginseng roots, increase the levels of monomeric and total ginsenosides, and improve root activity as well as polyphenol oxidase and catalase activities. We also studied the bacterial and fungal communities in ginseng rhizospheric soil. In our study, G. intraradices inoculation improved the abundance and Shannon diversity of bacteria, whereas fungi showed a reciprocal effect. Furthermore, we found that G. intraradices inoculation might increase some beneficial bacterial species and decreased pathogenic fungi in rhizospheric soil of ginseng. Conclusion: Our results showed that G. intraradices can benefit ginseng planting which may have some instructive and practical significance for planting ginseng in farmland.

      • SCISCIESCOPUS
      • KCI등재후보

        The Effects of Fu Zi on Changes in the Body Heat of Dogs

        Tian-Tian Chen,Chunhua Qi,Huijun Guo,Ziqiang Cheng,Dong Zhou,Haitao Liu,Jianzhu Liu 사단법인약침학회 2009 Journal of Acupuncture & Meridian Studies Vol.2 No.1

        The aim of the present study was to investigate the effects of Fu Zi on changes in the body heat of dogs. Twelve clinically healthy dogs were divided into two groups: the control group (six dogs) and the experimental group (six dogs). The control group was made to ingest normal saline mixed with canned meat, while the experimental group was made to ingest the Fu Zi solution mixed with canned meat. The infrared thermographic system was used to determine the level of body heat generated by these dogs. These areas include the dorsocranial (DCr), dorsocaudal (DCd), ventrocranial (VCr), and ventrocaudal (VCd) regions at pretreatment and were determined at 10, 20, 30, 50, 90, 120, 240, and 360 minutes after treatment for each of these areas. The results showed a tendency toward increased body heat until 30 minutes after ingestion of the Fu Zi powder mixed with canned meat. The significant differences in the changes of body heat were detected at 360 minutes in the DCd regions, 20 minutes in the VCr regions, and 30 minutes in the VCd regions between the experimental and control groups (p < 0.05). Based from our results, we find that Fu Zi can increase and maintain the dogs’ body heat for at least 6 hours. The aim of the present study was to investigate the effects of Fu Zi on changes in the body heat of dogs. Twelve clinically healthy dogs were divided into two groups: the control group (six dogs) and the experimental group (six dogs). The control group was made to ingest normal saline mixed with canned meat, while the experimental group was made to ingest the Fu Zi solution mixed with canned meat. The infrared thermographic system was used to determine the level of body heat generated by these dogs. These areas include the dorsocranial (DCr), dorsocaudal (DCd), ventrocranial (VCr), and ventrocaudal (VCd) regions at pretreatment and were determined at 10, 20, 30, 50, 90, 120, 240, and 360 minutes after treatment for each of these areas. The results showed a tendency toward increased body heat until 30 minutes after ingestion of the Fu Zi powder mixed with canned meat. The significant differences in the changes of body heat were detected at 360 minutes in the DCd regions, 20 minutes in the VCr regions, and 30 minutes in the VCd regions between the experimental and control groups (p < 0.05). Based from our results, we find that Fu Zi can increase and maintain the dogs’ body heat for at least 6 hours.

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