http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Genetic association of swine leukocyte antigen class II haplotypes and body weight in Microminipigs
Tatsuya Matsubara,Masaki Takasu,Noriaki Imaeda,Naohito Nishii,Satoshi Takashima,Takashi Nishimura,Toshiaki Nishimura,Takashi Shiina,Asako Ando,Hitoshi Kitagawa 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.2
Objective: Microminipigs are a novel animal model with extensive applications in laboratory studies owing, in part, to their extremely small body sizes. In this study, the relationship between swine leukocyte antigen (SLA) class II haplotype and body weight was evaluated in the Microminipig population. Methods: A total of 1,900 haplotypes, covering SLA class II haplotypes Lr-0.7, Lr-0.23, Lr-0.17, Lr-0.37, Lr-0.16, Lr-0.11, Lr-0.13, and Lr-0.18, were analyzed in 950 piglets. Birth weights and weights on postnatal day 50 were examined in piglets with eight different SLA class II haplotypes. Results: The mean birth weight of piglets with the Lr-0.23 haplotype (0.415 kg, n = 702) was significantly lower than that of piglets with Lr-0.17 (0.445 kg, n = 328) and Lr-0.37 (0.438 kg, n = 383) haplotypes. At postnatal day 50, the mean body weight of piglets with the Lr-0.23 haplotype (3.14 kg) was significantly lower than that of piglets with the Lr-0.13 haplotype (3.46 kg, p<0.01). There were no significant differences in daily gains (DGs) among the eight haplotypes. However, piglets with the Lr-0.11 and -0.18 haplotype combination or any heterozygous haplotype combinations containing Lr-0.23 had significantly lower DGs than those of piglets with the Lr-0.18, 0.37 haplotype combination. Conclusion: Piglets with the Lr-0.23 haplotype had relatively low body weights at birth and on postnatal day 50 and slightly lower DGs than those of piglets with other haplotypes. Therefore, the Lr-0.23 SLA class II haplotype may be a suitable marker for the selective breeding of Microminipigs with small body sizes.
Nishimura, Mai,Miyatake, Takashi,Nakashima, Ayaka,Miyoshi, Ai,Mimura, Mayuko,Nagamatsu, Masaaki,Ogita, Kazuhide,Yokoi, Takeshi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Background: Atypical squamous cells of undetermined significance (ASCUS) feature a wide variety of cervical cells, including benign and malignant examples. The management of ASCUS is complicated. Guidelines for office gynecology in Japan recommend performing a high-risk human papillomavirus (HPV) test as a rule. The guidelines also recommend repeat cervical cytology after 6 and 12 months, or immediate colposcopy. The purpose of this study was to determine the clinical significance of ASCUS. Materials and Methods: Between January 2012 and December 2014, a total of 162 patients underwent cervical conization for cervical intraepithelial neoplasia grade 3 (CIN3), carcinoma in situ, squamous cell carcinoma, microinvasive squamous cell carcinoma, and adenocarcinoma in situ at our hospital. The results of cervical cytology prior to conization, the pathology after conization, and high-risk HPV testing were obtained from clinical records and analyzed retrospectively. Results: Based on cervical cytology, 31 (19.1%) of 162 patients were primarily diagnosed with ASCUS. Among these, 25 (80.6%) were positive for high-risk HPV, and the test results of the remaining 6 patients (19.4%) were uncertain. In the final pathological diagnosis after conization, 27 (87.1%) and 4 patients (12.9%) were diagnosed with CIN3 and carcinoma in situ, respectively. Conclusions: Although ASCUS is known as a low-risk abnormal cervical cytology, approximately 20% of patients who underwent cervical conization had ASCUS. The relationship between the cervical cytology of ASCUS and the final pathological results for CIN3 or invasive carcinoma should be investigated statistically. In cases of ASCUS, we recommend HPV tests or colposcopic examination rather than cytological follow-up, because of the risk of missing CIN3 or more advanced disease.
Hashimoto, Takashi,Nishimura, Takuma,Lim, Jong Min,Kim, Dongho,Maeda, Hiromitsu Wiley (John WileySons) 2010 Chemistry Vol.16 No.38
<P>Bidipyrrin-bridged macrocycles, prepared from Ni(II)-bridged dipyrrin-based nanorings by intramolecular oxidative biaryl coupling reactions, yielded [2+4]-type Zn(II)-assisted stable twisted-ring dimers comprising two double helices. These [2+4]-type metal complexes can be optically resolved by chiral HPLC and exhibit tunable electronic and optical properties as a result of spring-like motions. The double helices behave as glue to connect two macrocycles and as the screws of hinges to form thermally responsive synchronized spring systems.</P>
Saori Nishimura,Ryou Tanaka,Shigeshi Kamikawa,Isao Waki,Daiki Yamashita,Natsumi Tabita,Shunichi Higashiya,Hirosuke Yamaji,Takashi Murakami,Shozo Kusachi 한국운동재활학회 2024 JER Vol.20 No.2
The determination of precise exercise intensity is essential for effective exercise rehabilitation. The Borg rating of perceived exertion category ratio (CR) scale is utilized to prescribe an appropriate level of exertion intensity. A Borg CR of approximately 13 coincides with the ventilatory aerobic threshold (VAT). Patients with atrial fibrillation (AF) exhibit various symptoms. We hypothesized that the workload at Borg CR13 (Borg CR13-Watt) differs from the workload at the VAT level (VAT-Watt) in AF patients with restored sinus rhythm (SR) following ablation. Accordingly, the relationship between Borg CR13-Watt and VAT-Watt was studied in patients with restored SR. Cardiopulmonary exercise testing (CPET) was performed at 101± 88 days after ablation in 150 patients using a bicycle ergometer. No adverse events were observed during CPET. Borg CR13-Watt was significantly higher than VAT-Watt (67.2± 27.8 Watt vs. 54.7± 17.6 Watt, P< 0.0001). Borg CR13-Watt showed significant linear regression with VAT-Watt (regression coefficient, 0.49, P< 0.01; correlation coefficient, 0.80, P< 0.01). Higher Borg CR13-Watt was associated with greater differences between Borg CR13-Watt and VAT-Watt (ΔWatt). The Bland–Altman plot showed nonconcordance between the two. Male sex, use of antiarrhythmic drugs, and smoking had contributed to the increased ΔWatt. Duration from ablation to time of CPET did not correlate with ΔWatt. Therefore, Borg CR13-Watt did not coincide with VAT-Watt in patients with restored SR. Higher Borg CR13-Watt was associated with greater ΔWatt. Prescribing exertion intensity as determined solely by perceived exertion is inadequate. CPET is required to determine the precise exercise intensity in AF patients with restored SR after ablation.
Keisuke Nishimura,Takashi Ikeda,Yuji Harata 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.춘계 No.-
The behavior of dual centrifugal pendulum vibration absorbers (CPVAs) are investigated when they are attached to a rotor in order to suppress torsional vibrations of a horizontally rotating shaft. The frequency response curves are theoretically determined using van der Pol’s method in the two cases where CPVAs are attached at point-symmetrical positions and identical positions. In the former case, Hopf bifurcations occur and combination resonances appear at comparatively higher rotational seeds than a Hopf bifurcation point. In the latter case, two types of localization phenomena may occur depending on the stiffnesses of torsion springs installed at the supporting points of the CPVAs. These phenomena are confirmed by calculating time histories and their frequencies. It is concluded that the optimal positions of the two pendula may exist to suppress the torsional vibrations of the rotor.