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( Dae Suk Kim ),( Dongyun Shin ),( Minseok Lee ),( Hyunjoong Jee ),( Tae Gyun Kim ),( Sung Hee Kim ),( Do Young Kim ),( Soo Min Kim ),( Min Geol Lee1 ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Circulating inflammatory cytokines and markers are increased in patients with psoriasis. Recent studies have shown that a higher red blood cell distribution width (RDW) is associated with disease activity in various disorders. Objectives: Our objective was to investigate whether RDW is increased in psoriasis patients, and to evaluate its association with disease severity. Methods: We conducted a retrospective study of psoriasis patients seen in single hospital in Korea. Demographic data, hematologic parameters and disease severity were collected. Results: A total of 261 psoriasis patients and 102 healthy controls were included in our study. The RDW value was significantly increased in psoriasis patients compared to healthy control (p=0.037). Compared to mild psoriasispatients (PASI<7), moderate to severe patients (PASI≥7) showed significantly higher RDW values (p=0.044). RDW did not show significant correlation with PASI (p=0.358). When patients were divided into two groups according to their RDW value (<14.6% and ≥14.6%), the mean value of PASI was not significantly different (p=0.219). Conclusion: Patients with psoriasis showed increased RDW values compared to healthy controls. It was also higher in moderate and severe disease group than mild group. RDW values were increased in psoriasis patients and it is possible that RDW value reflects the inflammatory status of psoriasis, but this needs to be evaluated in near future.
편마비 환자에서 정량적 감각기능 검사로 측정한 온도감각역치
배하석,심은결,윤태식,이정민,김성민 이화여자대학교 의과대학 2009 EMJ (Ewha medical journal) Vol.32 No.1
Objectives:Hemiplegic patients with unilateral cerebral lesions suffer from sensory deficit as well as motor deficit. But clinical assessment of thermal sensation is one of the least reliable components of neurological examination and is difficult to quantify. Methods:We measured thermal sensory thresholds of cold sense, warm sense, cold pain and hot pain in hemiplegic patients with thermal sensory analyzer(TSA). To investigate and quantify the thermal sensory deficit of hemiplegic patients, we compared the measurements with normal con-trols, between body regions, and between hemiplegic and sound side. Results:Hemiplegic patients showed impaired thermal sensory thresholds in all modalities compared to their sound side and normal controls. Conclusion:Quantitative sensory test using thermal sensory analyzer can be useful to quantify the thermal sensory deficit and follow up the progress.
Lee, Minseok,Kim, Sung Hee,Kim, Tae-Gyun,Park, Jeyun,Lee, Jae Won,Lee, Min-Geol Elsevier 2018 Journal of dermatological science Vol.91 No.1
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Langerhans cells (LCs) are dendritic cells that reside in the epidermis and local inflammation results in an increased differentiation of monocyte-derived LCs. Only few studies have investigated on the role of LCs in psoriasis-like dermatitis model, but the results are variable and the exact role of LCs in psoriasis model remains to be elucidated.</P> <P><B>Objective</B></P> <P>To explore the functional role of resident (rLCs) and monocyte-derived LCs (mLCs) in imiquimod (IMQ)-induced psoriasis-like inflammation using human Langerin-diphtheria toxin subunit A (huLang-DTA) mice.</P> <P><B>Methods</B></P> <P>5% IMQ cream was topically applied on the skins. Clinical and histopathological features were evaluated. Psoriasis-related gene expression was analyzed by quantitative polymerase chain reaction. The production of psoriasis-related cytokines including IL-17A and IL-22 by T cells were assessed by flow cytometry from the lesional skins.</P> <P><B>Results</B></P> <P>huLang-DTA mice showed a common depletion of both rLCs and mLCs in the IMQ-treated skins. huLang-DTA mice had a reduced IMQ-induced psoriasis-like inflammation featuring erythema, scale, and thickness compared with wild-type mice. Psoriatic lesions from huLang-DTA mice had a decreased level of <I>Il23a</I> and accordingly demonstrated an attenuated cytokine production of IL-17A and IL-22 from γδ<SUP>low</SUP> T cells. mLCs revealed a significantly greater level of IL-23 expression compared to rLCs in response to topical IMQ treatment.</P> <P><B>Conclusion</B></P> <P>Although both rLCs and mLCs are involved in the development of IMQ-induced psoriasis-like dermatitis, inflammation-induced mLCs present a superior capacity for producing IL-23 in this murine experimental model of psoriasis.</P>
( Tae-gyun Kim ),( Keum Ji Jung ),( Jae Won Lee ),( Minseok Lee ),( Jongwook Oh ),( Sun Ha Jee ),( Min-geol Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Psoriasis is a chronic inflammatory skin disorder which has been reported to be associated with cardiometabolic comorbidities in Caucasians. However, the association between psoriasis and risk of atherosclerotic cardiovascular disease (ASCVD) among Asians is largely unclear yet. Objectives: To examine the risk of ASCVD in Korean patients with psoriasis. Methods: 1,733,620 Koreans who received health insurance from the National Health Insurance System and had a medical evaluation every two years between 1997-2000 were prospectively followed. Results: The point prevalence of psoriasis was 0.42% and 0.35% among Korean men and women, respectively and there was an age-dependent increase in psoriasis prevalence among men. In Cox proportional hazard analyses, the individuals with psoriasis had a higher hazard ratio (HR) for incidence of ASCVD (HR = 1.18, 95% CI = 1.09-1-27) compared to controls during the observational period. The increased risk for ischemic heart disease was only observed among male psoriatic patients (HR = 1.33, 95% CI = 1.18-1.50), while that for thrombotic stroke was in case among female patients (HR = 1.37, 95% CI = 1.08-1.74), indicating that there are gender-dependent atherosclerotic comorbidities affecting Korean patients with psoriasis. Conclusion: Psoriasis is associated with the long-term risk of ASCVD in Korean.