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UPS Applying Big Data Analytics to Logistics:
Sung-Hee “Sunny” Park,Do-Hong Kim 한국경영정보학회 2014 한국경영정보학회 학술대회논문집 Vol.2014 No.1
Managing big data has become increasingly important to businesses as big data analytics can transform big data into insightful information. But, not many companies utilize it efficiently and effectively. While many companies in the transportation industry are facing many challenges with big data, United Parcel Service (UPS) is successfully applying big data analytics to logistics. UPS’s proprietary routing software, called ORION (On-Road Integrated Optimization and Navigation), uses package-level detail and customized online map data to provide drivers with optimized routing information. In 2013, ORION resulted in reductions of more than 1.5 million gallons of fuel and 14,000 metric tons of CO2 emissions. This paper discusses UPS’s innovative path to optimization from data gathering to visualization.
Sunny-Kim Barden 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.2
This case study details the treatment of a 59-year-old male with Stage 3B chronic kidney disease (CKD) and chemotherapy-induced peripheral neuropathy of the left limbs using acupuncture and bulk herbs. After 6 weeks of combined acupuncture and herbal treatments, glomerular filtration rate increased significantly from 37 mL/min to 51 mL/min and serum creatinine level decreased from 1.85 mg/dL to 1.41 mg/dL. After a course of 15 acupuncture treatments over 4 months with some appointments in closer proximity, the patient additionally reported increased sensation of his left limbs. Since there are limited treatments for CKD, others with CKD may benefit from acupuncture and herbal treatments. This study offers an approach to managing CKD and chemotherapy-induced peripheral neuropathy more effectively using herbs and acupuncture supported by biomedical verification results.
Effects of Kimchi on human health : A protocol of systematic review of controlled clinical trials
Kim, Myung-Sunny,Yang, Hye Jeong,Kim, Soon-Hee,Lee, Hye Won,Lee, Myeong Soo Williams & Wilkins Co 2018 Medicine Vol.97 No.13
<P><B>Abstract</B></P><P><B>Background:</B></P><P>Kimchi, a traditional, fermented Korean food that is consumed daily, has been recognized as a health food due to its beneficial effects on human health. The aim of this overview is to critically evaluate all clinical trials of the use of Kimchi in the treatment of any condition or symptom.</P><P><B>Methods and analysis:</B></P><P>Eight databases will be searched from inception until March 2018. We will include all prospective trials, including randomized controlled trials (RCTs), non-RCTs, and uncontrolled trials. The methodological quality of the trials will be assessed using Cochrane risk of bias (ROB) assessment tool and ROB in nonrandomized studies-I for RCTs and non-RCTs, respectively.</P><P><B>Ethics and dissemination:</B></P><P>Ethical approval will not be required, given that this protocol is for a systematic review. The full systematic review will be published in a peer-reviewed journal. The review will also be disseminated electronically and in print. Updates of the review will be conducted to inform and guide health care practice and policy.</P><P><B>Trial registration number:</B></P><P>PROSPERO 2018 CRD42018087375</P>
Kim, Do-Sung,Kwon, Dae-Young,Kim, Myung-Sunny,Kim, Hye Kyung,Lee, Yong Chul,Park, Seong Ju,Yoo, Wan Hee,Chae, Soo-Wan,Chung, Myoung-Ja,Kim, Hyung-Ryong,Chae, Han-Jung Pharmaceutical Society of Great Britain 2010 Journal of pharmacy and pharmacology Vol.62 No.2
<P>Objectives We have investigated whether endoplasmic reticulum stress and Bcl-2 proteins were linked to the protective effect exerted by flavonoids on ischaemia/reperfusion-induced cardiac damage. Methods Cell viability and immunoblotting were performed. Key findings H9c2 cardiac muscle cells were exposed to flavonoids such as biochanin A, daidzein, genistein, luteolin, quercetin and rutin, followed by ischaemia 12 h/reperfusion 4 h. The flavonoids protected against cell death induced by ischaemia/reperfusion. Flavonoid treatment significantly increased the expression level of the anti-apoptotic protein, Bcl-2, but decreased that of the proapoptotic protein, Bax. The flavonoids down-regulated the expression levels of endoplasmic reticulum stress proteins, glucose-regulated protein-78, activating transcription factor 6alpha, X-box binding protein 1, inositol-requiring protein-1, phosphor-eukaryotic initiation factor 2alpha, and C/EBP-homologous protein. Conclusions This study suggested that the protective mechanisms of flavonoids included regulation of Bcl-2/Bax proteins as well as the endoplasmic reticulum stress proteins.</P>
Kim, Myung-Sunny,Kim, Soon-Hee,Park, Su-Jin,Sung, Mi Jung,Park, Jaeho,Hwang, Jin-Taek,Yang, Hye Jeong,Kim, Sunmi,Seo, Daebang,Shin, Song Seok,Hur, Haeng Jeon Elsevier 2017 Journal of Functional Foods Vol.35 No.-
<P><B>Abstract</B></P> <P>This study investigated the effect and the underlying mechanism of ginseng berry (GB) in a mouse model of type 2 diabetes, supplied with 0.05% or 0.1% dietary GB for 12weeks. GB significantly improved hyperglycemia and insulin resistance, as demonstrated by the blood glucose and insulin levels, HOMA-IR, and GTT. Moreover, the expression of gluconeogenic genes such as PEPCK and G6Pase and the hepatic metabolites involved in the pathway of gluconeogenesis, such as glucose-6-phosphate and dihydroxyacetone phosphate, were significantly reduced by GB. Hepatic steatosis was also significantly ameliorated; TG content and expression of lipogenic enzymes and transcriptional factors such as FAS, ACC, and SREBP1 were reduced by GB. Simultaneously, AMPK phosphorylation was increased both in fatty liver and in lipid-accumulated HepG2 cells by GB. In conclusion, GB improved hyperglycemia by downregulating hepatic glucose production and hepatic steatosis, and AMPK appeared to be an important regulator of these effects.</P> <P><B>Highlights</B></P> <P> <UL> <LI> GB significantly improves obesity-induced hyperglycemia and insulin resistance. </LI> <LI> Anti-diabetic effects of ginseng berry is mediated by downregulating hepatic glucose production and hepatic steatosis. </LI> <LI> AMPK may be an important contributing regulator in the GB-mediated suppression of hepatic glucose production. </LI> </UL> </P>
Ginseng for managing menopause symptoms: a systematic review of randomized clinical trials
Kim, Myung-Sunny,Lim, Hyun-Ja,Yang, Hye Jeong,Lee, Myeong Soo,Shin, Byung-Cheul,Ernst, Edzard The Korean Society of Ginseng 2013 Journal of Ginseng Research Vol.37 No.1
The aim of this review was to assess the effectiveness of ginseng as a treatment option for managing menopause symptoms. We searched the literature using ll databases from their inception to 26 September 2012 and included all randomised clinical trials (RCTs) that compared any type of ginseng to a placebo controls in postmenopausal women. The methodological quality of all studies was assessed using a Cochrane risk of bias tool. Four RCTs met our inclusion criteria. Most RCTs had high risk of bias. One RCT showed that Korean red ginseng (KRG) significantly improved sexual arousal and global health compared with placebo. Another RCT reported the superiority of KRG over placebo for treating menopause symptoms on Kupperman's index and menopausal rating score. The third RCT failed to show a significant effect of KRG on hot flash frequency compared to placebo. The fourth RCT found beneficial effects of ginseng compared to placebo on depression and well-being. In conclusion, the evidence on ginseng as an effective treatment for managing menopause symptoms is limited. Most of the RCTs are burdened with a high risk of bias. Thus firm conclusions cannot be drawn. Rigorous studies seem warranted.
Kim, Heewon,Kim, Youngshin,Choi, Hyung-Min,Ham, Sunny The Korean Nutrition Society 2018 Nutrition Research and Practice Vol.12 No.4
BACKGROUND/OBJECTIVES: Obesity is a serious concern worldwide, for which the restaurant industry holds partial responsibility. This study was conducted to estimate restaurant consumers' intention to select healthy menu items and to examine the relationships among behavioral beliefs, past behaviors, attitudes and behavioral intentions, which are known to be major determinants of consumer behaviors. SUBJECTS/METHODS: An online, self-administered survey was distributed for data collection. The study sample consisted of customers who reported having visited casual dining restaurants in the last three months at the time of the survey. Structural equation modeling was used to verify the fit of the proposed research model. RESULTS: Structural equation modeling revealed that the proposed model supports the sequential, mediated (indirect) relationships among behavioral beliefs, past behaviors, attitudes and behavioral intentions toward healthy menu selection. CONCLUSION: This study contributes to the available literature regarding obesity by adding past behaviors, one of the most influential variables involved in prediction of future behaviors of consumers, to the TPB model, enabling a better understanding of restaurant consumers' rational decision process regarding healthy menu choices. The results of this study provide practical implications for restaurant practitioners and government agencies regarding ways to promote healthy menus.
Protective effects of Korean herbal remedy against oxidative stress in cardiomyocytes
Kim, Myung-Sunny,Kwon, Dae Young,Cho, Hye-Jin,Lee, Myeong Soo John Wiley Sons, Ltd. 2006 Phytotherapy research Vol.20 No.3
<P>Ondamtanggagambang (ODG) has been used as a prescription for psychological anxiety and depression in Korean medicine. In this study, we found that ODG have protective effects against oxidative stress in cardiomyocytes. Pretreatment with ODG extract prevented H<SUB>2</SUB>O<SUB>2</SUB> and ZnCl<SUB>2</SUB>-induced cell damage in H9c2 cardiomyocytes, whereas simultaneous treatment of ODG extract did not. The protective effect of ODG extract on oxidative stress-induced damage was suppressed significantly by heme oxygenase (HO) inhibitors, zinc protoporphyrin-IX (ZnPP-IX, p < 0.01) and tin protoporphyrin-IX (SnPP-IX, p < 0.01) in H9c2 cells. ODG stimulation of cells strongly induced the expression of HO-1 protein. Taken together, it is suggested that ODG-induced expression of HO-1 may have a beneficial role in cardiomyocytes under oxidative stress. Copyright © 2006 John Wiley & Sons, Ltd.</P>
Kim, Sung Hee,Hur, Haeng Jeon,Yang, Hye Jeong,Kim, Hyun Jin,Kim, Min Jung,Park, Jae Ho,Sung, Mi Jeong,Kim, Myung Sunny,Kwon, Dae Young,Hwang, Jin-Taek Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>The antidiabetic effect of the <I>Citrus junos</I> Tanaka (also known as yuja or yuzu) was examined. Ethanol extract of yuja peel (YPEE) significantly stimulated 2-[<I>N</I>-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) uptake in C2C12 myotubes. However, ethanol extract of yuja pulp (YpEE) and water extract of yuja peel (YPWE) or pulp (YpWE) did not stimulate glucose uptake. In addition, peroxisome proliferator-activated receptor gamma (PPAR-<I>γ</I>) and AMP-activated protein kinase (AMPK) activities were increased by YPEE in a dose-dependent manner. Pretreatment of AMPK inhibitor decreased the glucose uptake stimulated by YPEE in C2C12 myotubes. We confirmed the anti-diabetic effect of YPEE in mice fed a high fat-diet (HFD). Compared with control mice on a normal diet (ND), these mice showed increased body weight, liver fat, insulin resistance, triacylglycerol (TG), and total cholesterol content. Addition of 5% YPEE significantly reduced the weight gain and rise in liver fat content, serum triacylglycerol (TG), total cholesterol, and insulin resistance found in mice fed a high-fat diet (HFD). Moreover, YPEE reduced the secretion of HFD-induced adipocytokines such as leptin and resistin. YPEE also resulted in increased phosphorylation of AMPK in muscle tissues. These results suggest that ethanol extract of yuja peel exerts anti-diabetic effects via AMPK and PPAR-<I>γ</I> in both cell culture and mouse models.</P>