http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice
Hwang, Jung Hwan,Kim, Dong Wook,Jo, Eun Jin,Kim, Yong Kyung,Jo, Young Suk,Park, Ji Hoon,Yoo, Sang Ku,Park, Myung Kyu,Kwak, Tae Hwan,Kho, Young Lim,Han, Jin,Choi, Hueng-Sik,Lee, Sang-Hee,Kim, Jin Man,L American Diabetes Association 2009 Diabetes Vol.58 No.4
<P><B>OBJECTIVE</B></P><P>Nicotinamide adenine dinucleotides (NAD<SUP>+</SUP> and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD<SUP>+</SUP>-to-NADH ratio is implicated in metabolic syndrome. However, it is still unknown whether a modulating intracellular NAD<SUP>+</SUP>-to-NADH ratio is beneficial in treating metabolic syndrome. We tried to determine whether pharmacological stimulation of NADH oxidation provides therapeutic effects in rodent models of metabolic syndrome.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We used β-lapachone (βL), a natural substrate of NADH:quinone oxidoreductase 1 (NQO1), to stimulate NADH oxidation. The βL-induced pharmacological effect on cellular energy metabolism was evaluated in cells derived from NQO1-deficient mice. In vivo therapeutic effects of βL on metabolic syndrome were examined in diet-induced obesity (DIO) and <I>ob/ob</I> mice.</P><P><B>RESULTS</B></P><P>NQO1-dependent NADH oxidation by βL strongly provoked mitochondrial fatty acid oxidation in vitro and in vivo. These effects were accompanied by activation of AMP-activated protein kinase and carnitine palmitoyltransferase and suppression of acetyl-coenzyme A (CoA) carboxylase activity. Consistently, systemic βL administration in rodent models of metabolic syndrome dramatically ameliorated their key symptoms such as increased adiposity, glucose intolerance, dyslipidemia, and fatty liver. The treated mice also showed higher expressions of the genes related to mitochondrial energy metabolism (PPARγ coactivator-1α, nuclear respiratory factor-1) and caloric restriction (Sirt1) consistent with the increased mitochondrial biogenesis and energy expenditure.</P><P><B>CONCLUSIONS</B></P><P>Pharmacological activation of NADH oxidation by NQO1 resolves obesity and related phenotypes in mice, opening the possibility that it may provide the basis for a new therapy for the treatment of metabolic syndrome.</P>
Effects of Anode Buffer Layers on the Performance of P3HT/C70-PCBM Photovoltaic Devices
Hwang, Yong Mook,Moon, Sang-Jin,So, Won-Wook,Yoon, Sung Cheol,Lee, Chang Jin,Shin, Won Suk TaylorFrancis 2008 Molecular Crystals and Liquid Crystals Vol.491 No.1
<P> In this paper, we fabricated and compared the photovoltaic properties of two different kinds of PEDOT:PSS buffer layer systems. The first was with the PEDOT:PSS buffer layers of different PEDOT to PSS ratios, 1 to 2.5 for Baytron P and 1 to 6 for Baytron PVP AI4083, respectively. The second system included the buffer layers with the same PEDOT to PSS ratio, but with the changed conductivities by doping with 2, 4, 6, 8, and 10 wt% of glycerol. The power conversion efficiency was governed by the series resistance of the device and the resistivity of the applied PEDOT:PSS films, while the parallel resistance and the diode rectification characteristics are affected by the ratio of PEDOT to PSS on buffer layer.</P>
Synthesis and Characterization of Nanostructured Titania Films for Dye-Sensitized Solar Cells
Hwang, Kyung-Jun,Yoo, Seung-Joon,Jung, Sung-Hoon,Park, Dong-Won,Kim, Sun-Il,Lee, Jae-Wook Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.1
The nature and morphology of titanium dioxide films play a significant role in determining the overall efficiency of dye-sensitized solar cell (DSSCs). In this work, the preparation of nanostructured titania particles by sol-gel method (SG-$TiO_2$) and its characterization were investigated for the application of DSSCs. The samples were characterized by XRD, XPS, FE-SEM, BET and FT-IR analysis. The energy conversion efficiency of SG-$TiO_2$ was approximately 8.3 % under illumination with AM 1.5 (100 mW/$cm^2$) simulated sunlight. DSSCs made of SG-$TiO_2$ nanocrystalline films as photoanodes achieved better energy conversion efficiency compared to those prepared using commercially available Degussa P25.
Clinicopathological Characteristics of Colon Cancer Diagnosed at Primary Health Care Institutions
( Sang Hyun Park ),( Chi Wook Song ),( Yun Bae Kim ),( Young Sun Kim ),( Hwang Rae Chun ),( Jung Hyun Lee ),( Won Jong Seol ),( Hyung Sun Yoon ),( Myung Kwon Lee ),( Jong Hyup Lee ),( Choon Sang Bhang 대한장연구학회 2014 Intestinal Research Vol.12 No.2
Background/Aims: The purpose of this study was to evaluate the clinicopathologic characteristics of colon cancers detectedat the SOK Sokpeynhan Internal Medical Network, a nationwide system of primary health care institutions. Methods: Weanalyzed 579 colon cancer patients diagnosed using colonoscopy at the SOK network from January 2011 through December2012. Cancers from the rectum to the splenic flexure were classified as left colon cancer. Patients over 65 were classified assenior. Results: The mean age (±SD) of subjects was 60.9±10.5 years and 61.1% were men. More than one quarter (28.2%) ofpatients were asymptomatic. The prevalence of left colon cancer was higher (77.9%) than that for right colon cancer. The mostfrequent macroscopic and histologic types were depressed (58.9%) and moderately differentiated adenocarcinoma (52.2%),respectively. Asymptomatic subjects displayed protruding or well differentiated adenocarcinoma, while symptomatic patientswere more likely to display depressed or moderately differentiated adenocarcinoma (P <0.05). The mean age of the right coloncancer group was higher than that for the left colon cancer group (P <0.05). Among symptomatic patients, the most frequentsymptoms were bloody stool for patients with left colon cancer and abdominal discomfort for patients with right colon cancer(P <0.05). The prevalence of depressed cancer was higher in older subjects as compared to younger subjects (P <0.05). Theprevalence of right colon cancer tended to increase with age, although this difference did not achieve statistical significance(P >0.05). Conclusions: Study results indicated an increase of colon cancer amongst younger demographics in recent years.The effectiveness of colonoscopy screening was also evident, as asymptomatic patients demonstrated frequent findings of welldifferentiated adenocarcinomas. Study results also suggested a need for closer examination of older patients, as right coloncancer tended to increase with age. (Intest Res 2014;12:131-138)
Hwang, Ko-Eun,Choi, Yun-Sang,Choi, Ji-Hun,Kim, Hack-Youn,Kim, Hyun-Wook,Lee, Mi-Ai,Chung, Hae-Kyung,Kim, Cheon-Jei Korean Society for Food Science of Animal Resource 2011 한국축산식품학회지 Vol.31 No.2
The efficiency of three concentrations (0.05, 0.1, and 0.2%) of Ganghwayakssuk (Artemisia princeps Pamp.) extract on the susceptibility of raw chicken nugget batter to lipid oxidation was investigated after 0, 3, 7, and 10 d of refrigerated storage at $4^{\circ}C$. The pH and yellowness values of all treatments were higher than those of the control (p<0.05). Additionally, the lightness and redness values of all treatments were lower than those of the control and as the amount of Ganghwayakssuk ethanolic extracts increased. At the end of the storage period (10 d), the peroxide values (POV), conjugated dienes (CD), and thiobarbituric acid reactive substances (TBARS) values were lower than those of the control. The results show that Ganghwayakssuk prevents lipid oxidation in raw chicken nugget batter.
Combined Effects of Mugwort Herb and Vitamin C on Shelf-Life of Vacuum-Packed Seasoned Pork
Hwang, Ko-Eun,Choi, Yun-Sang,Kim, Hyun-Wook,Choi, Min-Sung,Song, Dong-Heon,Kim, Yong-Jae,Ham, Youn-Kyung,Kim, Cheon-Jei Korean Society for Food Science of Animal Resource 2015 한국축산식품학회지 Vol.35 No.4
This study was performed to investigate the possibility of the addition of mugwort herb extract (MH) and vitamin C (VC) alone (0.05%) and in combination (0.05% each) on shelf-life of seasoned pork. The combination of VC+MH demonstrated a significant reduction in thiobarbituric acid reactive substances, and volatile basic nitrogen in seasoned pork. Also, the pH values, total lactic acid concentration, lactic acid bacteria count, and the sensory properties (discoloration, flavor, and overall acceptability) of seasoned pork were not significantly affected by adding MH and/or VC. All seasoned pork were rejected by sensory panel when LAB count reached levels of 5-6 Log CFU/g, TLA concentration has been above a level of 3.6-3.9 mg lactic acid/g, and pH values ranged from 5.31-5.51 (15 d). Therefore, the findings showed that spoilage of seasoned pork does not appear to be the result of lipid oxidation, but is caused by lactic acid producing bacteria which result in sour odor.
Hwang, Ko-Eun,Kim, Hyun-Wook,Song, Dong-Heon,Kim, Yong-Jae,Ham, Youn-Kyung,Choi, Yun-Sang,Lee, Mi-Ai,Kim, Cheon-Jei Korean Society for Food Science of Animal Resource 2014 한국축산식품학회지 Vol.34 No.5
The effect of mugwort extract (ME) and vitamin C (VC), added individually or in combination, on color, lipid oxidation, and sensory characteristics of chicken nuggets stored for 12 d was investigated. Eight treatments of chicken nuggets contained the following: Control (no antioxidant added), VC (0.05% VC), ME 0.05 (0.05% ME), ME 0.1 (0.1% ME), ME 0.2 (0.2% ME), VC+ME 0.05 (0.05% VC + 0.05% ME) and VC+ME 0.1 (0.05% VC + 0.1% ME), VC+ME 0.2 (0.05% VC + 0.2% ME). Results showed that the mixture of 0.05% VC and 0.2% ME was most effective for delaying lipid oxidation (thiobarbituric acid reactive substances, conjugated dienies, and peroxide formation) when compared to the control or ME alone added. The color values of all treatments were significantly affected by adding ME. Additionally, the total color difference (${\Delta}E$), chroma ($C^*$), and hue angle ($H^{\circ}$) values of all treatments, except for VC, were lower than those of the control as the amount of ME increased. The sensory characteristics (flavor, odor, and overall acceptability) did not differ significantly in any of the chicken nugget samples, whereas storage time had a significant effect. The results suggest that the possibility of utilizing chicken nuggets with a mixture of mugwort extract and vitamin C for the increase of shelf-life and quality.