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저비중 척추마취시 국소마취제의 용적이 마취 높이에 미치는 영향
김승준,한동우,남용택,배선준,오경미 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.2
The Effect of the Injected Volume on the Spread of Spinal Anesthesia with Hypobaric Tetracaine Dong Woo Han, M.D., Seung Jun Kim, M.D., Sun Joon Bai, M.D. Kyeong Mee Oh, M.D., and Yong Taek Nam, M.D. Department of Anesthesiology, Yonsei University College of Medicine, Seoul, Korea Background: The properties of hypobaric spinal anesthesia are excellent in sensory and motor block with low concentration solutions, increased venous return, and hemodynamic stability. Much volume is needed with hypobaric spinal anesthesia because low concentration solutions are used. The purpose of this study was to examine the effects of the injected volume on the level of anesthesia in hypobaric spinal anesthesia during a total hip replacement. Methods: Twenty-seven adult patients scheduled for a total hip replacement were assigned randomly to two groups, one with 0.1% (n = 14), and the other with 0.2% (n = 13) hypobaric tetracaine spinal anesthesia. 8 mg of tetracaine was used for male patients and 7 mg for female patients. Hence the injected volumes were 8 ml for male and 7 ml for female patients in 0.1% solution and 4 ml for male and 3.5 ml for female patients in 0.2% solution, respectively. Epinephrine was mixed to either solution in concentrations of 1 : 200,000. The speed of injection was fixed at the rate of 0.2 ml/sec. Results: The height of sensory block with the 0.1% was one dermatome higher (T5.7) than with the 0.2% tetracaine solution (T6.7). The time for sensory block (11.4 min vs 12.3 min) and the time for motor block (10.0 min vs 15.0 min) with 0.1% was shorter than that with the 0.2% tetracaine solution. The duration of sensory block and the duration of motor bllock were not significantly different in either groups. Complete motor block was achieved in all patients. Conclusions: Both 0.1% and 0.2% hypobaric tetracaine spinal anesthesia are suitable for a total hip replacement. However we got better results with 0.1% than with 0.2% retracaine such as rapid and high sensory block with rapid motor block. (Korean J Anesthesiol 2001; 41: 159~164)
Pain-Relieving Effects of mTOR Inhibitor in the Anterior Cingulate Cortex of Neuropathic Rats
Um, Sun Woo,Kim, Min Jee,Leem, Joong Woo,Bai, Sun Joon,Lee, Bae Hwan Springer US 2019 Molecular Neurobiology Vol.56 No.4
<P>The anterior cingulate cortex (ACC) is a well-known brain area that is associated with pain perception. Previous studies reported that the ACC has a specific role in the emotional processing of pain. Chronic pain is characterized by long-term potentiation that is induced in pain pathways and contributes to hyperalgesia caused by peripheral nerve injury. The mammalian target of rapamycin (mTOR) signaling, which is involved in synaptic protein synthesis, could be a key factor controlling long-term potentiation in neuropathic pain conditions. Until now, there have been no reports that studied the role of mTOR signaling in the ACC involved in neuropathic pain. Therefore, this study was conducted to determine the relationship of mTOR signaling in the ACC and neuropathic pain. Male Sprague-Dawley rats were subjected to cannula implantation and nerve injury under pentobarbital anesthesia. Microinjection with rapamycin into the ACC was conducted under isoflurane anesthesia on postoperative day (POD) 7. A behavioral test was performed to evaluate mechanical allodynia, and optical imaging was conducted to observe the neuronal responses of the ACC to peripheral stimulation. Inhibition of mTOR by rapamycin reduced mechanical allodynia, down-regulated mTOR signaling in the ACC, and diminished the expressions of synaptic proteins which are involved in excitatory signaling, thereby reducing neuropathic pain-induced synaptic plasticity. These results suggest that inhibiting mTOR activity by rapamycin in the ACC could serve as a new strategy for treating or managing neuropathic pain before it develops into chronic pain.</P>
Cho, Jin Sun,Kim, Hyoung-Il,Lee, Ki-Young,An, Ji Yeong,Bai, Sun Joon,Cho, Ju Yeon,Yoo, Young Chul Williams & Wilkins Co 2015 Medicine Vol.94 No.24
<P><B>Abstract</B></P><P>Sympathetic hyperactivation is one of the causes of postoperative ileus, which occurs frequently after abdominal surgery and adversely influences the patient's prognosis. We aimed to investigate whether dexmedetomidine (DEX) could attenuate postoperative ileus in patients undergoing laparoscopic gastrectomy.</P><P>Ninety-two patients were randomized to the control (n = 46) or DEX group (n = 46). DEX was administered at a loading dose of 0.5 μg/kg for 10 minutes, followed by an infusion rate of 0.4 μg/kg/h from insufflation of the pneumoperitoneum to the end of surgery. The primary goal was to compare postoperative bowel movements by evaluating the time to first flatus. The balance of the autonomic nervous system, duration of postoperative hospital stay, and pain scores were assessed.</P><P>The time to first flatus was shorter in the DEX group compared with the control group (67.2 ± 16.8 hours vs 79.9 ± 15.9 hours, <I>P</I> < 0.001). The low-frequency/high-frequency power ratio during pneumoperitoneum increased in the control group, compared with baseline values and the DEX group. The length of postoperative hospital stay was shorter in the DEX group compared with the control group (5.4 ± 0.7 days vs 5.8 ± 1.1 days, <I>P</I> = 0.04). Patients in the DEX group had lower pain scores and required fewer analgesics at 1 hour postoperatively.</P><P>DEX facilitated bowel movements and reduced the length of hospital stay in patients undergoing laparoscopic gastrectomy. This may be attributed to the sympatholytic and opioid-sparing effects of DEX.</P>
한국과학재단의 농수산분야 기초연구지원 추이분석을 통한 연구활동지원 활성화 제언
민태선 ( Tae Sun Min ),최형균 ( Hyung Kyoon Choi ),김성용 ( Seong Yong Kim ),배승철 ( Sung Chul C. Bai ),김유용 ( Yoo Yong Kim ),양문식 ( Moon Sik Yang ),정봉현 ( Bong Hyun Chung ),황준영 ( Joon Young Hwang ),한인규 ( In Kyu Ha 한국응용생명화학회(구 한국농화학회) 2005 Applied Biological Chemistry (Appl Biol Chem) Vol.48 No.1
Choi, Mi-Hwa,Sun, Hui-Yu,Park, Ra-Young,Kim, Choon-Mee,Bai, Young-Hoon,Kim, Young-Ran,Rhee, Joon-Haeng,Shin, Sung-Heui Published by Elsevier/North Holland on behalf of t 2006 FEMS microbiology letters Vol.257 No.2
<P>Cyclic AMP-cAMP receptor protein (CRP) complex plays an essential role in the global regulation of Vibrio vulnificus virulence. We found that growth retardation of V. vulnificus caused by mutation of the crp gene encoding CRP was exacerbated under iron-limited conditions. Accordingly, we investigated the effect of crp mutation on the expression of the vulnibactin-mediated iron-uptake system and the ability of V. vulnificus to utilize transferrin-bound iron, and thus to grow in cirrhotic ascites, a human ex vivo system. The production of vulnibactin was suppressed, and the transcription of the vis and vuuA genes, which encode an enzyme required for vulnibactin synthesis and vulnibactin receptor protein, was also suppressed in the crp mutant. Moreover, the crp mutant could not utilize transferrin-bound iron, and its growth was severely suppressed both on transferrin-bound iron and in cirrhotic ascites. All the defects in the crp mutant were recovered by the in trans complementation of the wild-type crp gene. Putative CRP-binding sequences were found in the regulatory regions of the fur, vis and vuuA genes. These results indicate that crp mutation attenuates the ability to grow on transferrin-bound iron and in a human body fluid by down-regulating the vulnibactin-mediated iron-uptake system.</P>
Inactivation of <i>Vibrio vulnificus</i> Hemolysin by Oligomerization but Not Proteolysis
Shin, Sung-Heui,Sun, Hui-Yu,Choi, Mi-Hwa,Park, Ra-Young,Bai, Young-Hoon,Kim, Choon-Mee,Kim, Soo-Young,Kim, Young-Ran,Lee, Shee-Eun,Rhee, Joon-Haeng Pharmaceutical Society of Japan 2005 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.28 No.7
<P><I>Vibrio vulnificus</I> extracellular protease (VvpE) is believed to destroy its hemolysin (VvhA) in the late growth phase, without obvious experimental evidence. So, we attempted to elucidate the mechanism. The hemolytic activity steeply increased with the expression of the VvhA in the early growth phase, and then abruptly declined with the expression of VvpE in the late growth phase. However, the VvhA activity also abruptly declined in a VvpE-deficient mutant. In Western blot, the degradation of VvhA was not observed; instead, the oligomerization of VvhA increased with the concomitant loss of hemolytic activity. These results evidently indicate that the inactivation of VvhA is due to the novel oligomerization of VvhA by unknown mechanism, but not to the destruction of VvhA by VvpE, so that the routine functional assay measuring hemolytic activity cannot reflect the actual production of VvhA.</P>
Cha, Myeoung Hoon,Bai, Sun Joon,Lee, Kyung Hee,Cho, Zang Hee,Kim, Young-Bo,Lee, Hye-Jung,Lee, Bae Hwan Butterworths [etc.] 2010 Neurological research Vol.32 No.suppl1
<P>OBJECTIVES: To examine the effects of electroacupuncture stimulation on behavioral changes and neuronal nitric oxide synthase expression in the rat spinal cord after nerve injury. METHODS: Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery by tightly ligating and cutting the left tibial and sural nerves. Behavioral responses to mechanical stimulation were tested for 2 weeks post-operatively. At the end of behavioral testing, electroacupuncture stimulation was applied to ST36 (Choksamni) and SP9 (Eumleungcheon) acupoints. Immunocytochemical staining was performed to investigate changes in the expression of neuronal nitric oxide synthase-immunoreactive neurons in the L4-5 spinal cord. RESULTS: Mechanical allodynia was observed by nerve injury. The mechanical allodynia was decreased after electroacupuncture stimulation. Neuronal nitric oxide synthase expression was also decreased in L4-5 spinal cord by electroacupuncture treatment. DISCUSSION: These results suggest that electroacupuncture relieves mechanical allodynia in the neuropathic rats possibly by the inhibition of neuronal nitric oxide synthase expression in the spinal cord.</P>