Evaluation of hematologic parameters in adnexal torsion

( Subeen Lee ),( Jisun Lee ),( Mi Joo Kim ),( Hyung Jeong Lee ),( Yoon Hee Lee ),( Gun Oh Chong ),( Dae Gy Hong ),( Taek Hoo Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: Adnexal torsion is a condition which requires urgent surgical intervention to preserve ovarian function. Preoperative diagnosis of adnexal torsion is difficult because the diagnosis depends on findings from imaging studies along with various clinical symptoms. This study aims to compare preoperative hematologic parameters in patients with adnexal torsion and ovarian cyst. Methods: This is a retrospective study of 70 patients who visited emergency medical center for abdominal pain and received emergency operation under impression of adnexal torsion. Patients were categorized according to operative findings as adnexal torsion (Group1) and ovarian cyst (Group 2). Clinical characteristics and preoperative hematological parameters including age, body mass index (BMI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), mean platelet volute (MPV) were compared the two groups. All statistical analyses were performed by using the IBM SPSS statistics ver. 20.0 (IBM Co., Armonk, NY, USA). Results: Out of 70 patients, a total of 29 patients were found to have adnexal torsion and a total of 41 patients had ovarian cyst without torsion. The median BMI for Group 1 was 23.37 (18-29.73) and 20.9 (16-30.9) for Group 2 (p = 0.005). Group 1 group showed Group 1 had a median NLR of 4.94 (0.64-27.4), PLR of 195.53 (18.37-821), and Group 2 had a median of NLR 3.53 (1.05-21.56), PLR of 143 (35-345). The median MPV was 7.8 (6.3-10.30) for Group 1 and 7.9 (6.7-11.8) for Group 2. Group 1 had a median PT of 11.2 (10.1-13.5), aPTT of 25.5 (1.24-37.5), and Group 2 had a median PT of 11.6 (10.4-13), aPTT of 27.8 (21.2-37.2). There were no statistical differences between the two groups in terms of hematological parameters. Conclusion: Hematological parameters were not significantly different between ovarian torsion and ovarian cyst group. Further study with higher number of patients is needed to evaluate the preoperative role of hematological parameters in diagnosis of ovarian torsion.

Comparison of Long-Term Outcomes of Single-Port Total Hysterectomy and Multiport Total Hysterectomy with Cumulative Sum Analysis and Exponentially Weighted Moving Average Chart

( Subeen Lee ),( Hyun Jung Lee ),( Yoon Hee Lee ),( Gun Oh Chong ),( Dae Gy Hong ),( Yoon Soon Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aimed to define the initial and post-learning curves of single-port total laparoscopic hysterectomy (TLH) and multiport TLH by evaluating the data of the initial surgical outcome of a single surgeon. Methods: Comparison between consecutive 325 cases of single-port TLH undertaken between July 2010 and May 2019 and 441 cases of multiport TLH completed between Jan 2005 and Sep 2017 by the same surgeon at Kyungpook National University Hospital and Kyungpook National University Chilgok Hospital. The results of surgical outcomes were analyzed for changes over the case sequence in each group by using the cumulative sum (CUSUM) analysis and exponentially weighted moving average (EWMA) charts. Results: According to CUSUM analysis, the initial learning curve of single-port TLH (phase 1) was the 127th case and multiport TLH was the 64th case. Additionally, the initial learning curve of a single port takes more than twice as long as the multiport TLH. Phase two (post-learning curve period) of both groups were between the 128th and 208th (n = 80) cases and the 65th and 245th (n = 153) cases, with multiport TLH being 1.9 times longer. The peak CUSUM time of single-port TLH (1180.3 min) was 71.4 min less than that of multiport TLH (1251.7 min). After post-learning curve periods, the multiport TLH group had a period of secondary learning curves with no plateau curve. In phase two (post-learning curve period), the EWMA chart showed a descending slope in both TLH groups. However, the multiport TLH group showed multiple ascending slopes exceeding the EWMA during phase three (plateau period). The operating times, hospital stays, and blood loss were significantly reduced from phase one to phase three of the both TLH groups, but not the operating times in phase three of the multiport TLH group. Conclusion: Our long-term present study had demonstrated initial learning curve (efficiency) of 127 cases for single-port TLH and 64 cases for multiport TLH. After overcoming the initial learning curve, it was found that single-port TLH was performed easier than multiport TLH.

Clinical significance of tumor size and post treatment neutrophil to lymphocyte ratio in patients with Locally Advanced Cervical cancer Treated With Concurrent Chemoradiotherapy

( Subeen Lee ),( Juyeon Kang ),( Hyun Jung Lee ),( Yoon Hee Lee ),( Gun Oh Chong ),( Dae Gy Hong ),( Yoon Soon Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: We evaluated the clinical significance of clinical factors and hematological parameters as prognostic factors in patients with locally advanced cervical cancer (LACC) who received definitive concurrent chemoradiotherapy (CCRT). Methods: We retrospectively analyzed 125 patients with LACC (FIGO stage IIB to IIIB) who received definitive CCRT. Clinical factors and hematological parameters, including neutrophil-to-lymphocyte ratio (NLR) were assessed pre- and post-CCRT. Neutrophil-to-lymphocyte ratio (NLR) was calculated by dividing absolute neutrophil counts by absolute lymphocyte counts. Tumor size was determined by measuring the largest tumor diameter in MRI or CT images. Univariate and multivariate analysis for disease-free survival (DFS) and overall survival (OS) were performed using clinical factors and hematological parameters. Results: Disease recurred in 46 (36.8%) patients, and 24 patients (19.2%) died. On multivariate analysis, tumor size, paraaortic lymph node metastasis, post-treatment NLR, NLR (pre-treatment NLR/post-treatment NLR) and PLR (platelet-to-lymphocyte ratio) (pretreatment PLR /posttreatment PLR) were significant prognostic factors for DFS. Among them, only post-treatment NLR and tumor size were a significant prognostic factor for OS (p<0.001). Combination of tumor size and post-treatment NLR were significant prognostic factor for DFS and OS. Patients with large tumor size and elevated post-treatment elevated NLR were shown poor prognosis. Conclusion: Combination of tumor size and post-treatment NLR may serve as a prognostic indicator in patients with LACC who received definitive CCRT.

Posterior reversible encephalopathy syndrome related to anemia correction in a patient with uterine myoma: a case report

( Subeen Lee ),( Hyun Jung Lee ),( Jisun Lee ) 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

Uterine lipoleiomyoma presenting as an ovarian dermoid cyst

( Juyeon Kang ),( Subeen Lee ),( Heejeong Kim ),( Hyejin Lee ),( Dayong Lee ),( Taek Hoo Lee ),( Jisun Lee ) 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

Analysis of volatile compounds in Lycium chinense Miller with various extraction and drying methods

Subeen Do,Junyoung Park,Minju Lee,Kwang-Geun Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

In this study, the concentration of the volatile compounds of Lycium chinense Miller with various extraction and drying methods was analyzed. The extraction process was conducted by three solvents (water, 50% ethanol, and 70% ethanol) using a water bath at 80 ℃ for 2 hours. The drying process was performed using two drying methods (spray, freeze-drying). The manufacturing process was divided into three; extraction, concentration, and drying. Volatile compounds were extracted with solid phase micro extraction (SPME) fiber and analyzed using a gas chromatography-mass spectrometer (GC-MS). Total 52 volatile compounds were analyzed qualitatively and quantitatively. The main volatile compounds were acetic acid, 2-Acetylfuran, Safranal, 2-Furanmethanol. The total amount of volatile compounds was higher in water extraction than in ethanol extraction. However, the major volatile compounds were higher in ethanol extraction than the water extraction. The content of volatile compounds significantly increased in the order of freeze and spray drying.

Synthesis and biological evaluation of 2‐benzylaminoquinazolin‐4(3H)‐one derivatives as a potential treatment for SARS‐CoV‐2

Lee Jun Young,Shin Young Sup,Jeon Sangeun,Lee Se In,Cho Jung‐Eun,Myung Subeen,Jang Min Seong,Kim Seungtaek,Song Jong Hwan,Kim Hyoung Rae,Park Chul Min 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.3

Despite the continuing global crisis caused by coronavirus disease 2019 (COVID-19), there is still no effective treatment. Therefore, we designed and synthesized a novel series of 2-benzylaminoquinazolin-4(3H)-one derivatives and demonstrated that they are effective against SARS-CoV-2. Among the synthesized derivatives, 7-chloro-2-(((4-chlorophenyl)(phenyl)methyl)amino)quinazolin- 4(3H)-one (Compound 39) showed highest anti-SARS-CoV-2 activity, with a half-maximal inhibitory concentration value greater than that of remdesivir (IC50 = 4.2 μM vs. 7.6 μM, respectively), which gained urgent approval from the U.S. Food and Drug Administration. In addition, Compound 39 showed good results in various assays measuring metabolic stability, human ether a-go-go, Cytochromes P450 (CYPs) inhibition, and plasma protein binding (PPB), and showed better solubility and pharmacokinetics than our previous work.

2016년 국회의원선거 출구조사 오차 분석

이수빈 ( Subeen Lee ),정진우 ( Jinwoo Chung ),김영원 ( Youngwon Kim ) 한국조사연구학회 2017 조사연구 Vol.18 No.4

본 연구에서는 2016년 실시된 20대 국회의원선거 출구조사 자료를 토대로 하여 출구조사에서 발생한 오차의 발생원인을 분석하였다. 분석 결과, 새누리당과 더민주당에 대해서는 후보자 지지율을 실제보다 크게 예측하고 국민의당에 대해서는 작게 예측하는 경향이 있었다. 예측오차를 투표소추출오차와 투표소추출 외의 오차로 구분하여 보면, 새누리당의 경우에는 투표소추출에 의한 오차가 더 큰 반면에 더민주당과 국민의당의 경우에는 투표소추출 이외의 추가오차가 더 크게 발생했다. 예측오차를 당일투표자 예측오차와 사전투표자 예측오차로 구분하여 살펴본 결과 세 개의 정당 모두 당일투표자 예측오차가 더 컸다. In this study, we analyze the data of the exit poll for the 20th National Assembly election in Korea. The empirical studies show that systematical positive bias of candidates affiliated to Saenuri and Theminjoo Party occurs, whereas systematic negative bias of candidates affiliated to People21 Party occurs. The total survey error in exit poll is divided by sampling error of polling sites and the additional error which comes from non-response, early voting and second stage sampling error of voters in each sampled polling site. Our analysis show that the additional error is lower than the sampling error of Saenuri Party. In case of Theminjoo and People21 Party, the additional error is higher than the sampling error. In addition, we separate the final prediction error into the prediction error of voters on the election day and the prediction error of early voters. We notice that the prediction error of voters on election day is higher than the prediction error of early voters.

Implementation of LoRa-based Water-saving Irrigation System

Jeongjun Lee,Subeen Jeong,Myungwoo Yang,Connor Polanka,Anthony H Smith,Minsun Lee 한국통신학회 2020 한국통신학회 학술대회논문집 Vol.2020 No.8

Item Parameter Drift 분석을 통한 진로성숙도 척도의 종단적 측정불변성 검증

이수빈(Subeen Lee),박찬호(Chanho Park) 한국교육평가학회 2023 교육평가연구 Vol.36 No.1

본 연구는 시간의 흐름에 따른 문항 특성의 변화를 의미하는 Item Parameter Drift(IPD) 분석을 통해 중학생 진로성숙도의 종단적 측정불변성을 검증하는 데 그 목적이 있다. 분석에는 대구교육종단연구(DELS) 중학교 1학년 패널의 3개년 반복 측정 자료를 사용하였다. 다분문항으로 측정된 진로성숙도 척도는 등급반응모형을 기반으로 하는 우도비 검정방법을 이용하여, 1-2차년도와 2-3차년도로 나누어 분석을 실시하였다. 분석 결과, 1-2차년도에서 3개(1번, 2번, 10번), 2-3차년도에서 4개(1번, 2번, 6번, 8번)의 문항이 IPD가 나타나는 것으로 파악되었다. 이 중 특히 꾸준한 IPD가 나타난 1번, 2번 문항은 자기이해 문항으로, 중학생의 학년이 올라갈수록 자기이해 평균점수는 점점 감소하지만 범주 난이도 모수도 함께 낮아지는 것으로 나타났다. 진로성숙도 평균점수 변화를 확인한 결과, IPD 문항이 진로성숙도 평균점수의 감소폭을 크게 만드는 원인으로 작용한 것으로 나타났다. 이는 측정불변성을 사전에 검증하지 않고 IPD가 나타나는 문항을 사용하였을 경우 측정하고자 하는 구인의 변화 추정에 큰 차이가 발생할 수 있음을 시사한다. The purpose of this study is to examine longitudinal measurement invariance of a career maturity scale for middle school students through an item parameter drift (IPD) analysis. Data obtained from the middle school panel participating in the Daegu Education Longitudinal Study (DELS) for 3 years were analyzed. Career maturity was measured with polytomous items, and IPD items were detected for the first and the second grade and for the second and the third grade using the likelihood ratio test based on the graded response model. As a result of the IPD analysis, it was found that IPD was detected for 3 items (items 1, 2, and 10) between the first and the second grade and for 4 items (items 1, 2, 6, and 8) between the second and the third grade. Among them, items 1 and 2, which were consecutively flagged as IPD, are self-understanding questions, and the average score of self-understanding items gradually decreased although the step parameters of those items became smaller. As a result, it was found that the IPD items caused a large decrease in the average item scores of career maturity. This suggests that if the IPD items are used without testing longitudinal measurement invariance, the difference may look larger than what it actually is.