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Zhao, Pu Su,Li, Rong Qing,Song, Jie,Guo, Meng Ping Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.3
The title compound of nicotinato lead(II) complex [Pb$(C_5H_4NCOO)_2$] has been optimized at B3LYP/LANL2DZ and HF/LANL2DZ levels of theory. The calculated results show that the lead(II) ion adopts 2- coordinate geometry, which is the same as its crystal structure and different from the 4-coordinate geometry of isonicotinato lead(II) complex. Atomic charge distributions indicate that during forming the title compound, each nicotinic acid ion transfers their negative charges to central lead(II) ion. The electronic spectra calculated by B3LYP/LANL2DZ level show that there exist two absorption bands, which have some red shifts compared with those of isonicotinato lead(II) complex and the electronic transitions are mainly derived from intraligand $\pi$ -$\pi$ transition and ligand-to-metal charge transfer (LMCT) transition. CIS-HF method is not suitable for the system studied here. The thermodynamic properties of the title compound at different temperatures have been calculated and corresponding relations between the properties and temperature have also been obtained. The second order optical nonlinearity was calculated, and the molecular hyperpolarizability was $1.147754{\times}10^{-30}$ esu.
Identification of a Novel Human Zinc Finger Gene, ZNF438, with Transcription Inhibition Activity
( Zhao Min Zhong ),( Bo Wan ),( Yun Qiu ),( Jun Ni ),( Wen Wen Tang ),( Xin Ya Chen ),( Yun Yang ),( Su Qin Shen ),( Ying Wang ),( Mei Rong Bai ),( Qing Yu Lang ),( Long Yu ) 생화학분자생물학회 2007 BMB Reports Vol.40 No.4
( Qing Zhao ),( Cheng Zhu Wu ),( Jae Kyoung Lee ),( Su Rong Zhao ),( Hong Mei Li ),( Qiang Huo ),( Tao Ma ),( Jin Zhang ),( Young Soo Hong ),( Hao Liu ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.7
Triple-negative breast cancer (TNBC) possesses a higher rate of distant recurrence and a poorer prognosis than other breast cancer subtypes. Interestingly, most of the heat shock protein 90 (Hsp90) client proteins are oncoproteins, and some are closely related to unfavorable factors of TNBC patients. 17-Demethoxy-reblastatin (17-DR), a novel nonbenzoquinone- type geldanamycin analog, exhibited potent Hsp90 ATPase inhibition activity. In this study, the anticancer effects of 17-DR on TNBC MDA-MB-231 cells were investigated. These results showed that 17-DR inhibited cell proliferation, induced apoptosis, and suppressed cell invasion and migration in the MDA-MB-231 cells. Down-regulation of the key Hsp90-dependent tumor-driving molecules, such as RIP1 and MMP-9, by 17-DR may be related to these effects. Taken together, our results suggest that 17-DR has potential as a therapeutic agent for the treatment of TNBC.
Quantum Chemical Studies on Nicotinato Lead(II) Complex [Pb(II)(C5H4NCOO)2]
Pu Su Zhao*,Rong Qing Li,Jie Song,Meng Ping Guo 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.3
The title compound of nicotinato lead(II) complex [Pb(C5H4NCOO)2] has been optimized at B3LYP/LANL2DZ and HF/LANL2DZ levels of theory. The calculated results show that the lead(II) ion adopts 2-coordinate geometry, which is the same as its crystal structure and different from the 4-coordinate geometry of isonicotinato lead(II) complex. Atomic charge distributions indicate that during forming the title compound, each nicotinic acid ion transfers their negative charges to central lead(II) ion. The electronic spectra calculated by B3LYP/LANL2DZ level show that there exist two absorption bands, which have some red shifts compared with those of isonicotinato lead(II) complex and the electronic transitions are mainly derived from intraligand π-π* transition and ligand-to-metal charge transfer (LMCT) transition. CIS-HF method is not suitable for the system studied here. The thermodynamic properties of the title compound at different temperatures have been calculated and corresponding relations between the properties and temperature have also been obtained. The second order optical nonlinearity was calculated, and the molecular hyperpolarizability was 1.147754 ´ 10^30 esu.
Acupuncture inhibits liver injury induced by morphine plus acetaminophen through antioxidant system
Lee, Young Joon,Zhao, Rong Jie,Kim, Young Woo,Kang, Su Jin,Lee, Eun Kyung,Kim, Nam Jun,Chang, Suchan,Kim, Jin Mook,Lee, Ji Eun,Ku, Sae Kwang,Lee, Bong Hyo Elsevier 2016 European journal of integrative medicine Vol.8 No.3
<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>Morphine (MP) and acetaminophen (APAP), widely used-pain relievers and antipyretics, are known to induce hepatotoxicity. Acupuncture, a traditional therapy in Asia, is used for various reasons including detoxification. This study aimed to examine whether acupuncture exerts protective effects against MP+APAP-induced hepatic damage.</P> <P><B>Methods</B></P> <P>Male Sprague-Dawley rats received chronic MP, withdrawal, and APAP. Thereafter, blood and liver were taken. Acupuncture was performed once daily. Asparte aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured, and percentages of abnormally decreased-hepatocyte regions, mean liver cell counts, and mean inflammatory cell numbers infiltrated on hepatic parenchyma were examined. In addition, antioxidant effects were evaluated based on liver lipid peroxidation malondialdehyde (MDA) and glutathione (GSH) contents, superoxide dismutase (SOD) and catalase (CAT) activities with the number of immunopositive hepatocytes against nitrotyrosine (NT) as a marker of inducible nitric oxide synthase (iNOS) related-oxidative stresses and 4-hydroxynonenal (4HNE) as a marker of lipid peroxidation.</P> <P><B>Results</B></P> <P>Significant elevations of AST and ALT were noted of MP or APAP. They also induced an increase in MDA contents as well as decreases in GSH levels and activities of SOD and CAT activity. A centrolobular decrease in hepatocytes along with degenerative changes of hepatocytes were also observed, and increases of NT and 4HNE immunoreactive hepatocytes were shown. These hepatocellular damages were more severe with the combination of MP+APAP. However, these MP+APAP-induced hepatic damages were significantly inhibited by acupuncture.</P> <P><B>Conclusion</B></P> <P>This study suggests that acupuncture may have a protective effect against the MP+APAP-induced hepatic damage through the amelioration of antioxidant defense systems.</P>
Zhang, Sheng-Chang,Huang, Peng,Zhao, Yong-Xiang,Liu, Shu-Yan,He, Shu-Jia,Xie, Xiao-Xun,Luo, Gou-Rong,Zhou, Su-Fang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Senescence marker protein 30 (SMP30), a hepatocellular carcinoma (HCC) associated antigen, was earlier shown by our research group to be highly expressed in HCC paracancerous tissues, but have low levels in HCC tissues. In order to detect anti-SMP30 antibody in serum of HCC patients, we established pET30a-SMP30 and pColdIII-SMP30 expression systems in Escherichia coli. However, the expression product was mainly in the form of inclusion bodies. In this research, we used several combinations of chaperones, four molecular chaperone plasmids with pET30a-SMP30 and five molecular chaperone plasmids with pColdIII-SMP30 to increase the amount of soluble protein. Results showed that co-expression of HIS-SMP30 with pTf16, combined with the addition of osmosis-regulator, and a two-step expression resulted in the highest enhancement of solubility. A total of 175 cases of HCC serum were studied by ELISA to detect anti-SMP30 antibody with recombinant SMP30 protein. Some 22 were positive and x2 two-sided tests all showed P>0.05, although it remained unclear whether there was a relationship between positive cases and clinical diagnostic data.
A new dimeric neolignan from Magnolia grandiflora L. seeds
Hong-Mei Li,홍영수,Cheng-Zhu Wu,Su-Rong Zhao,Qiang Huo,Tao Ma,Hao Liu,이재경 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Bioassay-guided fractionation of the MeOHextract of Magnolia grandiflora seeds resulted in the isolationof a new dimeric neolignan, named bishonokiol A(1), as well as two known neolignans magnolol (2) andhonokiol (3). The structures of the compounds weredetermined on the basis of data obtained using NMR andMS. Bishonokiol A (1) showed potent anti-proliferativeactivities in four human cancer cell lines, with IC50 valuesranging from 5.1 to 7.5 lM. Additionally, bishonokiol A(1) induced apoptosis, as well as down-regulated theexpression of the anti-apoptotic protein Bcl-2 and caspase-3 cleavage in HepG2 cell line.