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( Su Bin Park ),( Kyo Hwa Kang ),( Hyo Jin Park ),( Jong Soon Park ),( Su Hak Heo ),( Hong Kim ),( Young Bin Choy ),( Chan Yeong Heo ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.4
Bioabsorbable plates and screws for bone fixation system have been used owing to many advantages over conventional metallic devices. This study investigated the effects and safety of recently developed modifiable bioabsorbable plate and screw made of 100% poly (L-lactic acid) in the healing process of mandible fracture in arabbit model. In vitro extract test for cytotoxicity and bacterial reverse mutation test for genotoxicity were carried out. Any cytotoxicity caused by extract from experiment sample was not observed. In genotoxicity test, increase in the number of revertants was not observed. As an in vivo test, plates and screws were used for rigid fixation of exper-imental mandible fracture in twenty rabbits. Tissue specimens with plate were taken from the rabbits after 4, 6, 8,10 weeks and histological analysis was studied. After 4 weeks, the plate was covered by connective tissue and severe chronic active inflammation in soft tissue was observed. After 6 weeks, absorbed part in plate and new bone forma-tion around periostium and decrease in inflammation were detected. After 10 weeks, new bone formation was observed in all samples and the thickness of bone increased. The remodeling was not complete yet. This study dem-onstrates that recently developed biodegradable plate and screw system made of poly(L-lactic acid) was effective in mandible fracture regions known as high load-bearing areas. This indicates that bioabsorbable poly (L-lactic acid) plates and screws are available for most of bone fractures, although the adjustment process and long-term follow-up study are necessary for clinical application.
허수범 ( Su Beom Heo ),노은숙 ( Eun Suk Roh ),김대성 ( Dae Sung Kim ),김의형 ( Eui Hiung Kim ),강지호 ( Ji Ho Kang ),이상학 ( Sang Haak Lee ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Park ),박찬범 ( Chan 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.2
47세 여자가 흉부 엑스선상 종격동 종괴가 우연히 발견되어 입원하였다. 16개월전 흉부 엑스선은 정상이었고 흉부 전산화단층촬영에서 좌측 흉곽 하부에 미세한 선음영을 포함한 지방 음영 종괴가 관찰되었고 횡격막의 결손이 의심되었다. 흉강경을 시행하여 그물막 이탈을 확인하였고 개흉술을 통해 횡격막 복원술을 시행하였다. 저자들은 지방음영의 종격동 종괴가 관찰되었을 때는 감별진단에 반드시 그물막의 횡격막 이탈을 생각하여야 할 것으로 생각한다. A 47-year-old female was admitted for an evaluation of a left mediastinal mass. The chest X-ray performed 16 months ago was normal, but the chest X-ray upon admission showed a large mass adjacent to the anterior aspect of the left hemidiaphragm. The CT sc
Park, Gyeong-Su,Lee, Eun Kyung,Lee, Jun Ho,Park, Juyeon,Kim, Seong Keun,Li, Xiang Shu,Park, Ju Cheol,Chung, Jae Gwan,Jeon, Woo Sung,Heo, Sung,Lee, Jae Hak,Choi, Byoung Lyong,Kim, Jong Min American Chemical Society 2009 NANO LETTERS Vol.9 No.5
<P>Methods of producing Si nanodots embedded in films of silicon oxide and silicon nitride abound, but fabrication of Si nanodots in a nanowire of these materials is very rare despite the fact that nanowire architecture enhances the charge collection and transport efficiencies for solar cells and field-effect transistors. We report a novel fabrication method for a high-density array of size-controlled sillicon nanodots from a silicon oxide nanowire using electron-beam irradiation. Our results demonstrate that a highly dense phase of Si nanodots with a narrow size distribution can be made from a silicon oxide nanowire with a core-shell structure of crystalline silicon-rich oxide (c-SRO)/amorphous silicon oxide (a-SiO(2)). This new nanomaterial shows the carrier transport characteristics of a semiconductor. The initially produced amorphous Si nanodots can be readily turned into crystalline Si (c-Si) nanodots by thermal annealing. Key characteristics of c-Si nanodots such as their size, number density, and rate of nucleation and growth are easily controlled by varying the electron radiation dose and annealing temperature. Nanodot formation is mechanistically initiated by electron trapping at the c-SRO core as well as at the core-shell interface, which leads to out-diffusion of the negatively charged oxygen through Coulomb repulsion, fostering the aggregation of Si atoms.</P>
Fabrication of Surface Plasmon-Coupled Si Nanodots in Au-Embedded Silicon Oxide Nanowires
Park, Gyeong-Su,Kwon, Hyuksang,Lee, Eun Kyung,Kim, Seong Keun,Lee, Jun Ho,Li, Xiang Shu,Chung, Jae Gwan,Heo, Sung,Song, In Yong,Lee, Jae Hak,Choi, Byoung Lyong,Kim, Jong Min WILEY-VCH Verlag 2010 Advanced Materials Vol.22 No.22
<B>Graphic Abstract</B> <P>High-density amorphous silicon nanodots are easily produced by irradiating gold-nanoparticle-embedded silicon oxide nanowires with a low-intensity electron beam. The optical characteristics of Si nanodots in the vicinity of gold nanoparticles exhibit evidence of strong coupling to the surface plasmon resonance of the Au nanoparticles, as manifested by their markedly enhanced electron-induced excitation in our monochromated scanning transmission electron microscopy–electron energy-loss spectroscopy measurements. <img src='wiley_img_2010/09359648-2010-22-22-ADMA201000328-content.gif' alt='wiley_img_2010/09359648-2010-22-22-ADMA201000328-content'> </P>
Park, Gyeong-Su,Kwon, Hyuksang,Kwak, Dong Wook,Park, Seong Yong,Kim, Minseok,Lee, Jun-Ho,Han, Hyouksoo,Heo, Sung,Li, Xiang Shu,Lee, Jae Hak,Kim, Young Hwan,Lee, Jeong-Gun,Yang, Woochul,Cho, Hoon Young American ChemicalSociety 2012 Nano letters Vol.12 No.3
<P>We report on rapid thermal chemical vapor depositiongrowth of silicon nanowires (Si NWs) that contain a high density ofgold nanoclusters (Au NCs) with a uniform coverage over the entirelength of the nanowire sidewalls. The Au NC-coated Si NWs with anantibody-coated surface obtain the unique capability to capture breastcancer cells at twice the highest efficiency currently achievable(∼88% at 40 min cell incubation time) from a nanostructuredsubstrate. We also found that irradiation of breast cancer cells capturedon Au NC-coated Si NWs with a near-infrared light resulted in a highmortality rate of these cancer cells, raising a fine prospect forsimultaneous capture and plasmonic photothermal therapy for circulatingtumor cells.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2012/nalefd.2012.12.issue-3/nl2045759/production/images/medium/nl-2011-045759_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl2045759'>ACS Electronic Supporting Info</A></P>