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        Invited Papers : Is IFRS Related to Lower IPO Valuation Error?

        ( Hsuan Chu Lin ),( She Chih Chiu ),( Shih Han Chuang ) 한국회계학회 2015 會計學硏究 Vol.40 No.2

        This study compares the accuracies in IPO valuation under International Financial Reporting Standards (IFRS) and under U.S. Generally Accepted Accounting Principle (US GAAP). This study conducts comparable-firms approach with a sample of recent IPOs in the US capital market during 2005-2013. The IPOs are grouped into three sub-samples: (1) IFRS adopters, (1) US GAAP adopters, (2) US GAAP adopters, and (3) Local GAAP adopters. The findings show that IFRS adopters exhibit prediction errors smaller than other adopters in the IPO valuation. In addition, IFRS adopters among the adopters provide financial reporting users with higher predict value than other accounting standards after the IPO. The findings remain robust after additional checks. Overall, the findings are supportive to the viewpoint that IFRS is conducive to the quality of accounting information and financial statement users`` investment decisions. However, several limitations in this study are also mentioned.

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        Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

        Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

        In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.

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