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- 저자 : ( Shih Chieh Chuang ) (검색결과 4 건)
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Ming-Chieh Cheng,Shih-Ping Liu,Yao-Chi Chuang,Karina Chin Po Hsu,Po-Ming Chow 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.1
Purpose: Male urinary incontinence (UI) is a global health issue associated with bothersome symptoms which affect daily life. This study aims to evaluate the prevalence of male UI in China, Taiwan, and South Korea and to determine if UI is an independent risk factor affecting the health-related quality of life (HRQoL), mental health, work limitations, and healthcare seeking behavior. Materials and Methods: A post-hoc analysis was conducted on the LUTS Asia database which was collated from a cross-sectional, population-based internet survey in China, Taiwan, and South Korea. Prevalence of male UI was assessed, and the effect on HRQoL, Hospital Anxiety and Depression Scale (HADS) depression and anxiety scores, work performance, and healthcare seeking behaviors was determined using univariate and multivariate analyses. Results: A total of 4,076 male participants were surveyed. Prevalence of male UI was 17.3%. UI adversely affected the HRQoL in both physical and mental domains. Both multivariate and univariate analyses showed that male UI could be correlated with a negative effect on the HADS anxiety and depression scores. Multivariate analysis suggested that work difficulties were correlated to the presence of UI. Up to 28% of participants who reported urge UI only did not adopt any management measures. Conclusions: UI is common in men over 40 years and adversely impacts HRQoL. It is an independent risk factor for anxiety and depression and may cause significant work limitations. Despite these negative effects, many men still do not seek any intervention.
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Wang Chung-Chieh,Tseng Li-Shan,Huang Chien-Chang,Chuang Pi-Yu,Su Nan-Chou,Chen Cheng-Ta,Lo Shih-How,Tsuboki Kazuhisa 한국기상학회 2024 Asia-Pacific Journal of Atmospheric Sciences Vol.60 No.3
Typhoons Morakot (2009) and Mindulle (2004) were two of the rainiest and most damaging typhoons to hit Taiwan on record, where both cases are associated with a strong low-level southwesterly monsoon flow. The moisture-rich southwesterly monsoon flow and the typhoon-induced northwesterly current usually converge on Taiwan’s Central Mountain Range to produce catastrophic rainfall. The two storms are simulated with a cloud-resolving model (CRM) using the pseudo-global-warming (PGW) methodology to assess the fraction of precipitation attributable to long-term climate change. For each storm, two scenarios are simulated and compared—the control run in present-day climate and the sensitivity test in a past environment four decades ago, where the climate-change signal (“deltas”) is computed using global reanalysis data as the difference between 1990–2009 and 1950–1969. Being realistically reproduced by the CRM at a 3-km grid size in the control run, both typhoons progress in the sensitivity test with highly similar evolution to their present-day counterpart, even though the background in the sensitivity run is slightly cooler and drier than the present. Under the current climate, Morakot and Mindulle produce more rainfall by about 5 mm per day within 300–400 km from the center during their lifespan (equal to an increase of ~4–8%) compared to their counterparts in past climates. Such results are in close agreement with previous studies, and the shift in mean daily rainfall is tested as statistically significant at a confidence level of 99.5%. The water budget analysis shows that the increased rainfall from past to present climate is accounted for mainly by the low-level convergence of moisture associated with a more vigorous secondary circulation and a higher precipitable water amount.
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Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.
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