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<i>SERPINE2</i> Polymorphisms and Chronic Obstructive Pulmonary Disease
Cha, Seung Ick,Kang, Hyo-Gyoung,Choi, Jin Eun,Kim, Min Jung,Park, Jaeho,Lee, Won Kee,Kim, Chang Ho,Jung, Tae Hoon,Park, Jae Yong The Korean Academy of Medical Sciences 2009 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.24 No.6
<P>A number of genome-wide linkage analyses have identified the 2q33.3-2q37.2 region as most likely to contain the genes that contribute to the susceptibility to chronic obstructive pulmonary disease (COPD). It was hypothesized that the <I>SERPINE2</I> gene, which is one of the genes located at the 2q33.3-2q37.2 region, may act as a low-penetrance susceptibility gene for COPD. To test this hypothesis, the association of four <I>SERPINE2</I> single nucleotide polymorphisms (SNPs; rs16865421A>G, rs7583463A>C, rs729631C>G, and rs6734100C>G) with the risk of COPD was investigated in a case-control study of 311 COPD patients and 386 controls. The SNP rs16865421 was associated with a significantly decreased risk of COPD in a dominant model for the polymorphic allele (adjusted odds ratio [OR]=0.66, 95% confidence interval [CI]=0.45-0.97, <I>P</I>=0.03). In haplotype analysis, the GACC haplotype carrying the polymorphic allele at the rs16865421 was associated with a significantly decreased risk of COPD when compared to the AACC haplotype (adjusted OR=0.58, 95% CI=0.38-0.89, <I>P</I>=0.01), and this effect was evident in younger individuals (adjusted OR=0.30, 95% CI=0.14-0.64, <I>P</I>=0.002). This study suggests that the <I>SERPINE2</I> gene contributes to the susceptibility to COPD.</P>
Cha, Seung-Ick,Lee, Shin-Yeop,Kim, Chang-Ho,Park, Jae-Yong,Jung, Tae-Hoon,Yi, Jae-Hyuck,Lee, Jongmin,Huh, Seung,Lee, Hyun-Joo,Kim, Shin-Yoon The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.1
<P>In patients undergoing major orthopedic surgery, data of deep venous thrombosis (DVT) and pulmonary embolism (PE) are lacking as studied by computed tomographic (CT) pulmonary angiography and indirect CT venography (CTPA-CTV). A prospective observational study was performed for 363 Korean patients undergoing major orthopedic surgery to determine the incidence of venous thromboembolism (VTE), especially proximal DVT and PE. The incidence of VTE was 16.3% (n=59). Of them, 8 patients (2.2%) were symptomatic. The rate of VTE was the highest in patients who underwent total knee replacement (40.4%), followed by hip fracture surgery (16.4%), and total hip replacement (8.7%; <I>P</I><0.001). The incidence of PE was 6.6% (n=24). Of them, 4 patients (1.1%) were symptomatic. Forty-one patients (11.3%) were in the proximal DVT or PE group. Based on multivariate analysis, total knee replacement and age ≥65 yr were significant risk factors for proximal DVT or PE in patients undergoing major orthopedic surgery (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.1-5.1; <I>P</I>=0.025; and OR, 2.1; 95% CI, 1.0-4.4; <I>P</I>=0.046, respectively). Taken together, the overall incidence of PE was 6.6% and rate of symptomatic PE rate was 1.1%. Knee joint replacement and age ≥65 yr were significant risk factors for proximal DVT or PE.</P>
Clinical characteristics of in situ pulmonary artery thrombosis in Korea
( Seung Ick Cha ),( Keum Ju Choi ),( Seung Soo Yoo ),( Jaehee Lee ),( Shin Yup Lee ),( Chang Ho Kim ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.0
Objectives: Little is known regarding the clinical features and course of in situ pulmonary artery thrombosis (PAT). The aim of the present study was to investigate the clinical characteristics of PAT. Methods: Patients with PAT were retrospectively identified from a tertiary referral center in South Korea. A control group consisted of patients with pulmonary embolism (PE) in whom the right or left pulmonary artery was the largest PE-involved site. We compared various clinical parameters between the two groups. Results: Of 23 PAT patients, the most common underlying condition was tuberculosis (TB)-destroyed lung (11 [47.8%]), followed by pulmonary artery stump after lobectomy or pneumonectomy (7 [30.4%]). In all patients except one, PAT was located in the right or left pulmonary artery. Computed tomography scans demonstrated that clots were completely or partially resolved less frequently in the PAT group than in the control group (4 [25%] versus 62 [90%], p<0.001). In the PAT group, three of seven patients (43%) who had undergone anticoagulation therapy exhibited improvement, and one of nine (11%) who had not received anticoagulation therapy experienced improvement; however, the difference was not significant. Conclusions: TB-destroyed lung was the most common underlying condition in Korean PAT patients, followed by pulmonary artery stump after lung resection. The clots in patients with PAT were mostly located in the right or left pulmonary artery, and clot resolution was less frequent in the PAT group compared to the PE group.
Clinical characteristics of pulmonary embolism with concomitant pneumonia
Cha, Seung-Ick,Choi, Keum-Ju,Shin, Kyung-Min,Lim, Jae-Kwang,Yoo, Seung-Soo,Lee, Jaehee,Lee, Shin-Yup,Kim, Chang-Ho,Park, Jae-Yong YEAR Wolters Kluwer Health, Inc. All rights reserv 2016 Blood coagulation & fibrinolysis Vol.27 No.3
<P>Although pneumonia is associated with an increased risk of venous thromboembolism, patients with pulmonary embolism and concomitant pneumonia are uncommon. The aim of the present study was to investigate the clinical features of pulmonary embolism with coexisting pneumonia. We retrospectively compared clinical, radiologic and laboratory parameters between patients with pulmonary embolism and concomitant pneumonia (pneumonia group) and those with unprovoked pulmonary embolism (unprovoked group), and then between the pneumonia group and those with pulmonary infarction (infarction group). Of 794 patients with pulmonary embolism, 36 (5%) had coexisting pneumonia and six (1%) had no provoking factor other than pneumonia. Stroke was significantly more common in the pneumonia group, than either the unprovoked group or the infarction group. In the pneumonia group, fever was significantly more common and serum C-reactive protein levels were significantly higher. By contrast, central pulmonary embolism and right ventricular dilation on computed tomography were significantly less frequent in the pneumonia group. In addition, an adverse outcome due to pulmonary embolism was less common in the pneumonia group than in either of the other two groups. The coexistence of pulmonary embolism and pneumonia is rarely encountered in clinical practice, especially without the presence of other factors that could provoke venous thromboembolism and is commonly associated with stroke. It is characterized by lower incidences of central pulmonary embolism and right ventricular dilation and by a lower rate of adverse outcomes due to pulmonary embolism itself.</P>
면역적격환자에서 발생한 위막성 아스페르길루스 기관기관지염
차승익 ( Seung Ick Cha ),신경민 ( Kyung Min Shin ),유승수 ( Seung Soo Yoo ),정지윤 ( Ji Yun Jeong ),윤길숙 ( Ghil Suk Yoon ),이신엽 ( Shin Yeop Lee ),김창호 ( Chang Ho Kim ),박재용 ( Jae Yong Park ),정태훈 ( Tae Hoon Jung ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.5
Aspergillus tracheobronchitis (ATB), a variant of invasive pulmonary aspergillosis, is characterized by extensive tracheobronchitis and pseudomembrane formation. ATB usually occurs in immunocompromised patients with a high fatality rate. We report a case of ATB in a previously healthy patient who responded well to antifungal therapy.
한국인에서 SERPINA1 유전자 다형성과 만성폐쇄성폐질환의 위험도
차승익 ( Seung Ick Cha ),최진은 ( Jin Eun Choi ),이종명 ( Jong Myung Lee ),유승수 ( Seung Soo Yoo ),김창호 ( Chang Ho Kim ),이원기 ( Won Kee Lee ),정태훈 ( Tae Hoon Jung ),김능수 ( Nung Soo Kim ),박재용 ( Jae Yong Park ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.4
연구배경: 만성폐쇄성폐질환의 대부분은 흡연과 연관되어 발생하지만 흡연자의 약 10∼20%에서만 만성폐쇄성폐질환이 발생하는 현상은 질환의 발생에 개체의 유전적인 소인이 관여함을 시사한다. 저자들은 α1-antitrypsin 단백질을 암호화하는 SERPINA1 유전자의 다형성에 따른 만성폐쇄성폐질환의 위험도를 조사하였다. 방법: 경북대학교병원 호흡기내과에서 만성폐쇄성폐질환으로 진단 받은 93명의 환자와 112명의 정상인을 대상으로 하였다. SERPINA1 유전자의 M1Val, M1Ala, M2, S와 Z 대립유전자(allele)는 중합효소연쇄반응과 restriction fragment length polymorphism을 이용하여 조사하였다. 결과: 환자군과 대조군 모두에서 S 및 Z allele은 없었으며, M1Val allele의 빈도는 환자군에서 유의하게 낮았다(73.6% vs. 82.7%, p=0.03). M1Val/M1Val 유전자형인 경우에 비해 M2 혹은 M1Ala allele을 갖는 유전자형인 경우 만성폐쇄성폐질환의 대응비는 1.86 (95% CI: 1.02∼3.41, p=0.04)으로 유의하게 높았다. M2 allele 갖는 유전자형인 경우 대응비는 1.77 (95% CI: 0.96∼3.27, p=0.07)이었으며, 연령에 따라 구분한 경우 64세 미만에서는 M2 allele을 갖는 경우 대응비가 3.09 (95% CI: 1.16∼8.21, p=0.02)로 유의하게 높았다. 결론: SERPINA1 유전자의 유전자형은 만성폐쇄성폐질환의 위험도를 결정하는 인자로 생각되나, 보다 많은 예를 대상으로 한 연구가 필요할 것으로 생각된다. (Tuberc Respir Dis 2008;65:285-291) Background: We conducted a case-control study to evaluate the potential association between SERPINA1 genotypes (M1Val, M1Ala, S, and Z) and the risk COPD. Methods: The study population consisted of 93 patients with COPD and 112 healthy controls. The polymerase chain reaction and restriction fragment length polymorphism for detecting the SERPINA1 variants. Results: The M2 allele of the SERPINA1 gene was significantly associated with the risk of COPD in Koreans. The effect of the M2 allele on the risk of COPD was more pronounced in the subgroup<64 years. Conclusion: These results suggest that SERPINA1 polymorphisms may contribute to a genetic predisposition for COPD. However, additional studies with larger sample sizes are required to confirm our findings.
이용훈 ( Seung-ick Cha ),( Jae-kwang Lim ),( Seung-soo Yoo ),( Shin-yup Lee ),( Jaehee Lee ),( Chang-ho Kim ),( Jae-yong Park ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Background: Data regarding the radiological and clinical features of pulmonary tuberculosis (PTB) in patients with idiopathic pulmonary fibrosis (IPF) are limited. Objectives: To investigate the clinico-radiological features of PTB patients with IPF. Methods: Clinico-radiological variables were retrospectively compared between PTB patients with IPF (TB-IPF) and without IPF (TB-control), and computed tomography (CT) findings between the TB-IPF group and patients with nontuberculous mycobacterial lung disease and IPF (NTM-IPF). Results: Of 609 IPF patients, 28 (4.6%) were diagnosed with PTB. In the TB-IPF group, incidental radiological finding was the most common presenting manifestation, and the rate of treatment success was significantly lower than in the TB-control group. On CT scan, the typical locations of reactivated PTB were significantly less often involved in the TB-IPF group than in the TB-control group. The TB-IPF group exhibited a significantly lower frequency of centrilobular nodules and a higher rate of consolidation-predominant pattern than the TB-control group. CT findings in the TB-IPF group were similar to those in the NTM-IPF group. Conclusions: Incidental radiological finding was the most common presenting manifestation in patients with TB-IPF, who were more likely to present with atypical PTB manifestations on CT scan and experience a poorer treatment outcome.