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Hong, Sa-Ik,Kwon, Seung-Hwan,Hwang, Ji-Young,Ma, Shi-Xun,Seo, Jee-Yeon,Ko, Yong-Hyun,Kim, Hyoung-Chun,Lee, Seok-Yong,Jang, Choon-Gon The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2
Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain obscure. In this study, we investigated the relationship between melatonin (MT) and dopamine D2-like receptor signaling in pentobarbital-induced sleep and the intracellular mechanisms of sleep maintenance in the cerebral cortex. In mice, pentobarbital-induced sleep was augmented by intraperitoneal administration of 30 mg/kg MT. To investigate the relationship between MT and D2-like receptors, we administered quinpirole, a D2-like receptor agonist, to MT- and pentobarbital-treated mice. Quinpirole (1 mg/kg, i.p.) increased the duration of MT-augmented sleep in mice. In addition, locomotor activity analysis showed that neither MT nor quinpirole produced sedative effects when administered alone. In order to understand the mechanisms underlying quinpirole-augmented sleep, we measured protein levels of mitogen-activated protein kinases (MAPKs) and cortical protein kinases related to MT signaling. Treatment with quinpirole or MT activated extracellular-signal-regulated kinase 1 and 2 (ERK1/2), p38 MAPK, and protein kinase C (PKC) in the cerebral cortex, while protein kinase A (PKA) activation was not altered significantly. Taken together, our results show that quinpirole increases the duration of MT-augmented sleep through ERK1/2, p38 MAPK, and PKC signaling. These findings suggest that modulation of D2-like receptors might enhance the effect of MT on sleep.
( Sa Ik Hong ),( Seung Hwan Kwon ),( Ji Young Hwang ),( Shi Xun Ma ),( Jee Yeon Seo ),( Yong Hyun Ko ),( Hyoung Chun Kim ),( Seok Yong Lee ),( Choon Gon Jang ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2
Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain obscure. In this study, we investigated the relationship between melatonin (MT) and dopamine D2-like receptor signaling in pentobarbital-induced sleep and the intracellular mechanisms of sleep maintenance in the cerebral cortex. In mice, pentobarbital-induced sleep was augmented by intraperitoneal administration of 30 mg/kg MT. To investigate the relationship between MT and D2-like receptors, we administered quinpirole, a D2-like receptor agonist, to MT- and pentobarbital-treated mice. Quinpirole (1 mg/kg, i.p.) increased the duration of MT-augmented sleep in mice. In addition, locomotor activity analysis showed that neither MT nor quinpirole produced sedative effects when administered alone. In order to understand the mechanisms underlying quinpirole-augmented sleep, we measured protein levels of mitogen-activated protein kinases (MAPKs) and cortical protein kinases related to MT signaling. Treatment with quinpirole or MT activated extracellular-signal-regulated kinase 1 and 2 (ERK1/2), p38 MAPK, and protein kinase C (PKC) in the cerebral cortex, while protein kinase A (PKA) activation was not altered significantly. Taken together, our results show that quinpirole increases the duration of MT-augmented sleep through ERK1/2, p38 MAPK, and PKC signaling. These findings suggest that modulation of D2-like receptors might enhance the effect of MT on sleep.
( Sa Ik Hong ),( Seung Hwan Kwon ),( Min Jung Kim ),( Shi Xun Ma ),( Je Won Kwon ),( Seung Min Choi ),( Soo Im Choi ),( Sun Yeou Kim ),( Seok Yong Lee ),( Choon Gon Jang ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.4
Chrysanthemum indicum Linne is an ancient herbal medicine used to treat bone and muscle deterioration, ocular infl ammation, headache, and anxiety in Korea, China, and Japan. Furthermore, tea derived from Chrysanthemum indicum Linne has been used to treat anxiety by facilitating relaxation and curing insomnia. However, no reports exist on the anxiolytic-like effects of Chrysanthemum indicum Linne water extract (CWE) in mice. In the present study, we investigated the anxiolytic-like effects of CWE using the elevated plus-maze (EPM) test in mice. CWE, at a dose of 500 mg/kg (p.o.), signifi cantly increased the time spent in the open arms of the EPM compared to a vehicle-injected control group. Moreover, the effect of CWE (500 mg/kg) was blocked by bicuculline (a selective GABAA receptor antagonist) and WAY 100635 (a selective 5-HT1A receptor antagonist). Taken together, these fi ndings suggest that the anxiolytic-like effects of CWE might be mediated by the GABAA receptor and the 5-HT1A receptor.
방사익,진홍률,조용석 충북대학교 의과대학 충북대학교 의학연구소 1999 忠北醫大學術誌 Vol.9 No.2
연구목적: 하악골 골절의 치료법은 매우 다양한 방법들이 시도되고 발전되어져 왔는데 최근에는 관혈적 정복술과 소형금속판과 나사못을 이용한 내고정 수술법이 주류를 이루고 있다. 본 연구는 이러한 방법으로 충북대학교병원에서 하악골 골절 치료를 시행한 환자들의 치료 결과와 합병증등을 분석하여 이 방법의 유용성을 검정하고자 하였다. 재료 및 방법: 1991년 3월부터 1998년 12월까지 충북대학교병원에서 하악골 골절하에 치료를 받은 환자 중 소형금속판을 사용하여 치료한 총 177명이 이 연구에 포함되었다. 연구 방법은 환자들의 의무기록지와 방사선사진을 토대로 성별, 연령, 손상원인, 동반된 손상, 골절부위 수술결과 및 술후 합병증 등을 후향적으로 조사하였다. 결과: 하악골 골절은 젊은 남자에서 호발하였다. 골절부위는 하악골 우각부에서 가장 빈번하였는데 흔히 하악결합방 골절을 동반하였다. 술후 합병증은 10.7%에서 나타났는데 부정교합이 가장 흔하였다. 결론: 하악골 골절의 처치로, 관혈적 정복술과 소형금속판과 나사못을 이용한 내고정을 시행하는 것은 매우 신뢰할만한 효과적인 방법이었다. Purpose: Various methods have been tried and developed for the treatment of mandibular fracture, and recently open reduction and internal fixation using miniplates and screws is the most common modality of treatment. To determine clinical usefulness of this method, we evaluated results and complications of the patients who were treated for the mandibular fracture with this method in Chungbuk National University Hospital. Materials and Methods: We performed a retrospective study of 177 consecutive patients of Chungbuk National University Hospital, from May 1991 to Sept 1997, to analyze and evaluate the mandibular fractures. All of them were treated using miniplates. Outcome was measured by analyzing age, sex, etiology, associated injuries, associated other facial bone fracture, fracture site, and postoperative complications. Results: The occurrence of mandibular fracture was frequent in young male and mandibular angle fracture was the most common and frequently associated with parasymphysis fracture. Postoperative complication occurred in 10.7% of cases and malocclusion was the most common. Conclusion: Open reduction and internal fixation with miniplate was a reliable and effective technique for the treatment of mandibular fractures.
Strain Differences in the Chronic Mild Stress Animal Model of Depression and Anxiety in Mice
( Yang Hee Jung ),( Sa Ik Hong ),( Shi Xun Ma ),( Ji Young Hwang ),( Jun Sup Kim ),( Ju Hyun Lee ),( Jee Yeon Seo ),( Seok Yong Lee ),( Choon Gon Jang ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.5
Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that resembles some of the symptoms of human depression. In the present study, we used a chronic mild stress animal model of depression and anxiety to examine the responses of two strains of mice that have different behavioral responsiveness. An outbred ICR and an inbred C57BL/6 strain of mice were selected because they are widely used strains in behavioral tests. The results showed that the inbred C57BL/6 and outbred ICR mice were similarly responsive to CMS treatment in sucrose intake test (SIT) and open field test (OFT). However, the two strains showed quite different responses in forced swimming test (FST) and novelty-suppressed feeding (NSF) test after 3 weeks of CMS treatment. Only C57BL/6 mice displayed the depression- and anxiety-like behavioral effects in response to CMS treatment in FST and NSF test. Our results suggest that there are differences in responsiveness to CMS according to the different types of strain of mice and behavioral tests. Therefore, these results provide useful information for the selection of appropriate behavioral methods to test depression- and anxiety-like behaviors using CMS in ICR and C57BL/6 mice.
가청주파수를 이용한 모바일 청력측정 U-HealthCare 어플 개발
고정환 ( Jung-hwan Ko ),강사무엘 ( Sa-mu-el Kang ),홍성수 ( Sung-su Hong ),한익주 ( Ik-ju Han ),노영주 ( Young J. Rho ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.2
최근 스마트폰 사용자의 폭발적인 증가로 인하여 모바일을 이용한 U-Healthcare 어플리케이션이 주목 받고 있다. 하지만 적응하기 힘든 사용환경과 복잡한 인터페이스로 인해 실제 정기적인 검진이 필요한 장애인들이나 고 연령층의 사용자들에게는 낮은 접근성을 보여주고 있다. 또한 측정결과만을 보여주고 피드백이 전혀 없는 것은 의미가 약하다. 본 논문에서는 가청주파수를 이용해 측정하여 그 결과를 사용자에게 알려주고 피드백이 가능하도록 사용자가 등록한 번호로 검사결과를 보낼 수 있게 하였고 결과를 저장할 수 있도록 하여 정기적 관리가 유용하도록 하였다.
Oh, Ji-Hwan,Hwang, Ji-Young,Hong, Sa-Ik,Ma, Shi-Xun,Seo, Jee-Yeon,Lee, Seok-Yong,Kim, Hyoung-Chun,Jang, Choon-Gon Wiley (Blackwell Publishing) 2018 Addiction biology Vol.23 No.1
<P>Substituted cathinones are synthetic analogs of the active components of natural products and are widely abused worldwide. However, the rewarding properties of these agents have not yet been evaluated. In this study, we investigated the abuse potential of buphedrone [2-(methylamino)-1-phenylbutan-1-one, alpha-methylamino-butyrophenone] and its effects on the mesolimbic dopaminergic system in mice using conditioned place preference (CPP) analysis, a self-administration test, a locomotor activity test, a behavioral sensitization test and Western blot analysis. Treatment with buphedrone supported CPP and self-administration, enhanced locomotor activity and produced behavioral sensitization when mice were challenged with methamphetamine. SCH23390, a D1 dopamine antagonist, prevented buphedrone-induced CPP, whereas raclopride, a D2 dopamine antagonist, had no effect. SCH23390 also blocked locomotor activity increase by buphedrone, while raclopride partially attenuated locomotor activation. Western blot analysis revealed that repeated buphedrone treatment increased D1 dopamine receptor expression in the dorsal striatum and nucleus accumbens in mice. Collectively, these findings suggest the abuse potential of buphedrone and demonstrate the involvement of the dopaminergic system in the establishment of its rewarding properties.</P>