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Jayalakshmi Ayyavoo,김인철,권영남 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.65 No.-
For the efficient particle removal in an aged semiconductor photoresist solution, a nylon membrane having micro-sized pores was modified into membranes having nano-sized pores. Polyethylene(co-vinyl alcohol) and aramid were used as pore fillers to modify the membrane. The removable capability of soft and hard nano-colloids was systematically investigated. Porosity minimization, improved rejection efficiency, solvent resistance, and enhanced wettability were observed at the modified nylon composite membranes. The aramid pore-filled membrane showed higher rejection (>95%) than the virgin or the EVOH modified membrane, showing good feasibility for use as a separator for particle removal in a semiconductor process.
Jayalakshmi Krishnan,Jiayan Chen,Kum-Joo Shin,황종익,한상욱,이광,최상돈 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.5
Exposure to light can induce photoreceptor cell death and exacerbate retinal degeneration. In this study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin (Sag-/-), transducin (Gnat1-/-), c-Fos (c-Fos-/-) and arrestin/transducin (Sag-/-/Gnat1-/-), were examined. We measured the expression levels of thousands of genes in order to investigate their roles in phototransduction signaling in light-induced retinal degeneration using DNA microarray technology and then further explored the gene network using pathway analysis tools. Several cascades of gene components were induced or inhibited as a result of corresponding gene knockout under specific light conditions. Transducin deletion blocked the apoptotic signaling induced by exposure to low light conditions, and it did not require c-Fos/AP-1. Deletion of c-Fos blocked the apoptotic signaling induced by exposure to high intensity light. In the present study, we identified many gene transcripts that are essential for the initiation of light-induced rod degeneration and proposed several important networks that are involved in pro- and anti-apoptotic signaling. We also demonstrated the different cascades of gene components that participate in apoptotic signaling under specific light conditions.
Toll-like receptor signal transduction
Jayalakshmi Krishnan,최상돈,이광,Masa Tsuchiya,Kumar Selvarajoo 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.4
Toll-like receptors (TLRs) are the archetypal pattern recognition receptors in sensing exogenous pathogens. Activation of TLRs is a first line of defense of the immune system, leading to the activation and recruitment of neutrophils and macrophages to sites of infection and enhances antimicrobial activity. The TLR signaling through different intracellular molecules, such as MAP kinases and IκB kinases which are conserved signaling elements for many receptors, leads to a distinct set of proinflammatory gene expressions. However, how these pathways differentially and precisely control the transcription of identical genes remains largely unknown. Our review focuses on the details of up-todate signaling molecules including negative regulators and their role in controlling innate immune response. We also stress the importance of developing systemic approaches for the global understanding of TLR signaling so that appropriate drug therapeutic targets can be identified for regulating inflammatory diseases.
Jayalakshmi Krishnan,최상돈 한국유전체학회 2012 Genomics & informatics Vol.10 No.3
A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of pathogens and lead to primary innate immune activation against invaders, and G-protein coupled receptors (GPCRs), whose interaction with their cognate ligands activates heterotrimeric G proteins and regulates specific downstream effectors, including immuno-stimulating molecules. Once TLRs are activated, they lead to the expression of hundreds of genes together and bridge the arm of innate and adaptive immune responses. We characterized the gene expression profile of Toll-like receptor 4 (TLR4) in RAW 264.7 cells when it bound with its ligand, 2-keto-3-deoxyoctonate (KDO), the active part of lipopolysaccharide. In addition, to determine the network communications among the TLR, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), and GPCR, we tested RAW 264.7 cells with KDO, interferon-β, or cAMP analog 8-Br. The ligands were also administered as a pair of double and triple combinations.
ON CLASSES OF RATIONAL RESOLVING SETS OF POWER OF A PATH
JAYALAKSHMI, M.,PADMA, M.M. The Korean Society for Computational and Applied M 2021 Journal of applied mathematics & informatics Vol.39 No.5
The purpose of this paper is to optimize the number of source places required for the unique representation of the destination using the tools of graph theory. A subset S of vertices of a graph G is called a rational resolving set of G if for each pair u, v ∈ V - S, there is a vertex s ∈ S such that d(u/s) ≠ d(v/s), where d(x/s) denotes the mean of the distances from the vertex s to all those y ∈ N[x]. A rational resolving set is called minimal rational resolving set if no proper subset of it is a rational resolving set. In this paper we study varieties of minimal rational resolving sets defined on the basis of its complements and compute the minimum and maximum cardinality of such sets, respectively called as lower and upper rational metric dimensions for power of a path P<sub>n</sub> analysing various possibilities.
Thermal Stability and Mechanical Properties of Hydrogenated Zr-Ni-Nb-Co Amorphous Alloy
Jayalakshmi, S.,Fleury, Eric,Kim, Yu Chan,Kim, Ki Bae Trans Tech Publications, Ltd. 2005 Materials science forum Vol.486 No.-
<P>Zr50Ni27Nb18Co5 amorphous ribbons were hydrogenated using an electrochemical method. Under a current density of 30 mA/cm2, the thermal stability of the amorphous phase was found to increase with the charging time. Hardness and fracture strength were found to be independent of charging time, indicating that the Zr-Ni-Nb-Co amorphous alloys preserved its mechanical integrity.</P>