ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense

Kim, Soo Yeon,Yang, Chul-Su,Lee, Hye-Mi,Kim, Jin Kyung,Kim, Yi-Sak,Kim, Ye-Ram,Kim, Jae-Sung,Kim, Tae Sung,Yuk, Jae-Min,Dufour, Catherine Rosa,Lee, Sang-Hee,Kim, Jin-Man,Choi, Hueng-Sik,Giguè,re Informa UK (TaylorFrancis) 2018 AUTOPHAGY Vol.14 No.1

Sensory-parietal cortical stimulation improves motor recovery in severe capsular infarct

Kim, Ra Gyung,Cho, Jongwook,Ree, Jinkyue,Kim, Hyung-Sun,Rosa-Neto, Pedro,Kim, Jin-Myung,Lee, Min-Cheol,Kim, Hyoung-Ihl SAGE Publications 2016 Journal of cerebral blood flow and metabolism Vol.36 No.12

<P> The prevalence of subcortical white matter strokes in elderly patients is on the rise, but these patients show mixed responses to conventional rehabilitative interventions. To examine whether cortical electrical stimulation can promote motor recovery after white matter stroke, we delivered stimulation to a small or wide region of sensory-parietal cortex for two weeks in a rodent model of circumscribed subcortical capsular infarct. The sham-operated group (SOG) showed persistent and severe motor impairments together with decreased activation in bilateral sensorimotor cortices and striatum. In contrast, sensory-parietal cortex stimulation significantly improved motor recovery: final recovery levels were 72.9% of prelesion levels in the wide stimulation group (WSG) and 37% of prelesion levels in the small stimulation group (SSG). The microPET imaging showed reversal of cortical diaschisis in both groups: in both hemispheres for the WSG, and in the hemisphere ipsilateral to stimulation in the SSG. In addition, we observed activation of the corpus callosum and subcortical corticostriatal structures after stimulation. The results from the c-Fos mapping study were grossly consistent with the microPET imaging. Sensory-parietal cortex stimulation may therefore be a useful strategy for overcoming the limits of rehabilitative training in patients with severe forms of subcortical capsular infarct. </P>

한국 성인의 수면시간과 체성분 인자와의 연관성

김은영(Eun Young Kim),최윤선(Youn Seon Choi),김선미(Seon Mee Kim),최선영(Sun Young Choi),김은혜(Eun Hye Kim),김정은(Jung Eun Kim),김이연(E Yeon Kim),정재훈(Jae Hoon Jeong),진로사(Rosa Jin),정상아(Sang Ah Jung) 대한임상노인의학회 2014 대한임상노인의학회지 Vol.15 No.1

연구배경: 수면부족은 당 대사조절 등 체내 생리적 시스템에 영향을 주면서 비만의 유병률을 높일 것으로 생각되는데, 국내외적으로 수면시간과 비만과의 연관성을 다룬 연구는 많이 있으나 체지방량의 분포 등 체성분과의 연관성을 다룬 연구는 거의 없는 실정 이다. 이에 본 논문에서는 우리나라 성인의 수면시간과 체성분과의 연관성을 확인하고자 했다. 방법: 제 4기(2008∼2009)와 제 5기(2010) 국민건강영양조사 자료를 분석하였으며 고령, 미측, 갑상샘 질환, 신부전, 임신을 제외한 총 9880명을 대상으로 하였다. 체성분인자로 BMI, 허리둘레, 총체지방률, 몸통체지방률, 제지방률, 몸통제지방률, 근량을 사용하였고, 수면시간에 따른 체성분 분석의 연관관계를 보기 위해 선형 회귀분석 및 로지스틱 회귀분석을 이용하였으며, 나이, 흡연, 운동, 음주 등의 교란변수를 보정하여 다중 로지스틱 회귀분석을 실시하였다. 결과: 남성과 여성 모두 BMI, 허리둘레, 몸통체지방률, 근량에서 수면시간과 유의한 음의 상관관계를 보였으며, 비만 관련 위험도를 알아보기 위하여 BMI≥25 kg/㎡, 허리둘레(남자≥90 cm, 여자≥85 cm), 체지방률과 제지방률, 근량의 상위 25%값의 비율에 대해 다중 로지스틱 회귀분석을 실시하였을 때는, 남성에서만 유의한 교차비를 보였다. 남성에서 수면시간이 1시간 증가할수록 BMI 25이상의 위험은 0.89배, 허리둘레 90 cm이상 위험은 0.90배, 몸통 체지방률과 근량도 각각 0.93배, 0.89배 감소하였다. 결론: 우리나라 성인의 수면시간은 체성분인자 중 BMI, 허리둘레, 몸통 체지방률, 몸통 제지방률, 근량과 유의한 연관성이 있었으며, 남성에서는 수면시간이 부족할수록 BMI 25 kg/㎡ 이상, 허리둘레 90 cm이상 될 위험이 증가하고, 몸통체지방률이 증가할 위험도 높은 것으로 나타났다. 이러한 결과는 수면부족이 몸통에 체지방량의 분포를 증가시켜 중심비만을 야기시키는 원인이 될 수 있음을 뒷받침하며, 적절한 수면관리를 통해 이를 예방할 수 있을 것으로 사료되므로 이를 지키기 위한 노력이 필요하겠다. Background: Despite the large number of epidemiological studies linking obesity and short sleep duration, there is paucity of data carefully examining the relationship between body composition and sleep duration. So, through national undertaking Korea National Health and Nutrition Examination Surveys (KNHANES), we examined the relationship between sleep duration and BMI, waist circumference, and percent body fat in Korean adults. Methods: From the data of KNHANES in the year of 2008∼2010, over 19 years old 4337 men and 5543 women, relationship between sleep duration and indices of body composition was examined. Anthropometric and dual-energy X-ray absorptiometry (DXA) measures of body composition were used. Sleep duration was measured using information obtained from self-reported questionnaires. Results: The study results revealed a negative association between sleep duration and most of body composition variables - body mass index, waist circumference, truncal fat percentage, muscle mass - and positive association with truncal lean mass percentage. In men, increasing sleep duration 1 hour, prevalence of obesity (BMI≥25 kg/㎡) is decreasing (OR=0.89, CI:0.837-0.939), risk of waist circumference over 90 cm is decreasing (OR=0.90, CI:0.851-0.966), truncal fat percentage (OR=0.93, CI:0.869-0.992) and muscle mass (OR=0.89, CI: 0.835-0.949) are also decreasing. Conclusion: Our results are consistent with previous findings that sleep duration is associated with obesity. However, the relationship between sleep duration and body composition may be stronger in men than in women. Short sleep duration was associated with increased truncal fat. And it supports that short sleep duration may increase prevalence of central obesity in Korean men.

김영란법 정책결정과정 분석

정기덕(Jung, Kideok),정주호(Jung, Juho),김민정(Kim, Minjung),조민효(Cho, Rosa Minhyo) 서울행정학회 2017 한국사회와 행정연구 Vol.28 No.2

본 연구는 김영란법의 정책결정과정을 분석하고 정책적 함의를 제시하기 위하여 다중흐름모형과 정책옹호연합모형의 융합모형을 활용하였다. 이를 통해 단일모형의 한계를 극복하고 정책결정 과정을 보다 더 정밀히 분석하고자 하였다. 분석결과 문제·정치·대안의 세 가지 흐름이 확인되었고, 흐름들이 독립적으로 흘러가는 가운데 추친옹호연합과 저지옹호연합 간 세 번의 갈등이 발생하였다. 세월호 침몰사고가 외부충격으로 작용하며 국회에서 계류 중이던 김영란법이 다시 주목받게 되었다. 또한 이완구 국무총리 후보자의 녹취록 공개사건이 내부충격으로 발생하며 정책의 창이 열렸다. 이때 김영란법은 국회 본회의를 통과하였으나 옹호연합들 간 갈등은 계속 이어졌고, 헌법재판소의 합헌 판결 끝에 갈등이 소강되고 김영란법은 계획대로 시행되었다. 이러한 분석결과는 실제 정책결정이 우연한 사건 등을 포함한 다양한 요인들의 상호작용을 통해 매우 복잡하게 이루어지기 때문에 체계적인 분석을 위해서는 하나의 모형에만 의존하기 보다는 다양한 모형들의 적절한 수정 또는 융합이 유용함을 보여준다. The purpose of this paper is to critically analyze the policymaking process of Improper Solicitation and Graft Act, often referred to as the Kim Young-ran Act, and suggest the policy implications. Authors use a combined model of the Advocacy Coalition Framework and the Multiple Streams Framework to overcome the limitations of the single model and examines policy change more precisely. Results show that three flows of problems, politics, and alternatives were confirmed, and conflicts between the advocacy coalition occurred three times while the flows flowed independently. The tragic sinking of ferry Sewol was an external shock and attracted the attention to Kim Young-ran Act, which had been pending in the National Assembly. In addition, revealing the tape-recording case of Prime Minister Lee Wan-koo was an internal shock which opened a window of policy. At this moment, Kim Young-ran Act passed the National Assembly plenary session, however, the conflict between the advocacy alliances continued. After the constitutional decision by Constitutional Court, the conflict was lulled and Kim Young-ran Act was implemented as planned. These findings suggest that proper modification or convergence of policy making model is useful for comprehensive and systematic analysis, rather than relying solely on single model, since the actual policy decisions are made very complex interaction of various factors including accidental events.

A case of epithelioid angiosarcoma in the vulva

( Rosa Kim ),( Ji Yeon Byun ),( You Won Choi ),( Hae Young Choi ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2

Analysis of nickel content in Korean food products and revised Korean nickel restricted diet

( Rosa Kim ),( Jin Ju Lee ),( Ji Yeon Byun ),( You Won Choi ),( Hae Young Choi ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.74 No.1

Assessment of efficacy and adherence of nickel restricted diet in nickel allergic patients

( Rosa Kim ),( Min Young Lee ),( Ji Yeon Byun ),( You Won Choi ),( Hae Young Choi ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Nickel is contained in everyday objects, and it is one of the leading causes of allergic contact dermatitis. Positive patch tests to nickel suggest possibility of dermatitis from nickel-plated item usage and nickelcontaining- food ingestion. Objectives: This was a retrospective study to assess efficacy of nickel restricted diets in nickel sensitized patients and to evaluate their adherence to nickel restricted diet. Methods: A review of the records of nickel sensitized patients from June 1st 2018 to April 30th 2020 with positive patch tests to nickel was conducted. Patients were phone interviewed in May 2020 to assess current status of their dermatitis, frequency of flare-up, and self-reported adherence to the diet. Results: Of 245 patients, only 100 patients were able to be contacted. Patients with localized skin lesion (n=44) and with generalized skin lesion (n=56) did not show difference in nickel sensitivity. The extent of involved skin lesion and nickel sensitivity did not predict compliance. 24 of 29 (82.7%) patients with good compliance reported improvement; only 32 of 71 (45.1%) patients with poor compliance reported improvement. The percentage of improved patients with good compliance and that of the group with poor compliance showed statistically significant difference (p<0.05). Conclusion: To improve patient compliance, a simplified and interventional guidelines for nickel restricted diet should be implemented along with dermatologists’ encouragement and reassurance.

Effects of cobalt and iron-doped zinc oxide nanoparticles on zebrafish embryos survival and hatching

Rosa Kim(김로사),June-Woo Park(박준우) 환경독성보건학회 2014 한국독성학회 심포지움 및 학술발표회 Vol.2014 No.11

A case of linear hypertrophic lichen planus in a pediatric patient

( Rosa Kim ),( Min Young Lee ),( Ji Yeon Byun ),( You Won Choi ),( Hae Young Choi ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2

Lichen planus (LP) is a chronic inflammatory disease of the skin, mucous membranes and hair follicles. Of the various types, hypertrophic type, characterized by verrucous hyperkeratotic plaques and nodules, tends to be more chronic. A 12-year-old girl presented with 2-year history of warty papules and plaques with intermittent pruritus arranged in a zosteriform configuration along her flank. She did not have any particular contact or travel history. Histopathological examination showed hyperkeratosis and papillomatosis with wedge-shaped hypergranulosis. Lichenoid dermal lymphocytic infiltrate with vacuolar alteration of the basal layer was observed, forming the Caspary-Joseph space. Such findings were consistent with hypertrophic lichen planus. She was prescribed with oral doxycycline and topical steroid and tacrolimus. After 7 weeks of treatment, her skin lesions were flattened and significantly faded. Lichen planus is less common but more severe in children than in adults. Hypertrophic LP usually occurs on the shins, and it is often refractory to topical therapy. To our knowledge, only three cases of linear hypertrophic LP have been reported in Korean dermatologic literature, and this case to be the first case of pediatric case. Herein, we report a rare case of hypertrophic LP occurring in a child.

Effect of Titanium Addition on High Temperature Workability of High Manganese Austenitic Steel

KIM, Rosa,BAE, Cheoljun,HA, Yu-Mi,KIM, Jongryoul Iron and Steel Institute of Japan 2018 ISIJ international Vol.58 No.3

<P>In the present study, the high temperature workability of high manganese austenitic steel has been examined to prevent the grain boundary embrittlement cracking problems in the continuous casting process. As-cast Fe-22Mn-0.4C steel exhibited poor hot ductility behaviors at 900 degrees C tensile test. Phosphorus segregation and BN precipitation at grain boundaries were mainly responsible for this deterioration. In order to enhance the hot ductility, titanium was added to this steel, and high temperature workability was compared in view of reduction of area in tensile test at 900 degrees C. BN precipitation at grain boundaries was effectively suppressed by the formation of interior Ti(C,N) precipitates. Furthermore, phosphorus atoms, a grain boundary embrittlement element, were observed to segregate at Ti(C,N) interfaces in Auger electron spectroscopy and atom probe tomography. These results show that titanium addition in Fe-22Mn-0.4C steel can effectively improve the high temperature workability by decreasing the segregation of phosphorus at grain boundary.</P>