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Radioprotective and Antioxidant Activity of Fractionated Extracts of Berries of Hippophae rhamnoides
Rakesh Kumar Sharma,Raman Chawla,Rajesh Arora,Shikha Singh,Ravinder Kumar Sagar,Raj Kumar,Ashok Sharma,Manju L. Gupta,Surender Singh,Jagdish Prasad,Haider A. Khan,Anand Swaroop,A.K. Sinha,A.K. Gupta,R 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
Plants are an abundant source of medicinal compounds, some of which are useful in combating free radical-1002 (flavonoid-poor fraction) of Hippophae rhamnoideswere screened on the basis of their reducing power in the aqueousphase. REC-1001 was selected for further study, since it exhibited 27.38 times higher antioxidant activity than REC-1002.REC-1001 also showed significant (P. .05) membrane protection potential at 50 .g/mL, which was attributed to its abilityto scavenge peroxyl radicals (64.82. 1.25% scavenging within 1,440 min). A significant (P. .05) difference of 67.02% infree radical scavenging activity at 1,000 ng/mL between REC-1001 and vitamin E demonstrated the extract fraction’s worthc-tion. Further, REC-1001 was found to be nontoxic up to 200 mg/kg of body weight. This research suggests that the REC-1001 fraction of H. rhamnoidesextract is a safe and effective antioxidant nutraceutical product.
INTEGRABILITY OF DISTRIBUTIONS IN GCR-LIGHTLIKE SUBMANIFOLDS OF INDEFINITE KAEHLER MANIFOLDS
Kumar, Rakesh,Kumar, Sangeet,Nagaich, Rakesh Kumar Korean Mathematical Society 2012 대한수학회논문집 Vol.27 No.3
In present paper we establish conditions for the integrability of various distributions of GCR-lightlike submanifolds and obtain conditions for the distributions to define totally geodesic foliations in GCR-lightlike submanifolds.
GCR-LIGHTLIKE SUBMANIFOLDS OF A SEMI-RIEMANNIAN PRODUCT MANIFOLD
Kumar, Sangeet,Kumar, Rakesh,Nagaich, Rakesh Kumar Korean Mathematical Society 2014 대한수학회보 Vol.51 No.3
We introduce GCR-lightlike submanifold of a semi-Riemannian product manifold and give an example. We study geodesic GCR-lightlike submanifolds of a semi-Riemannian product manifold and obtain some necessary and sufficient conditions for a GCR-lightlike submanifold to be a GCR-lightlike product. Finally, we discuss minimal GCR-lightlike submanifolds of a semi-Riemannian product manifold.
Oxidative Stress and Antioxidants in Disease and Cancer: A Review
Gupta, Rakesh Kumar,Patel, Amit Kumar,Shah, Niranjan,Choudhary, Arun Kumar,Jha, Uday Kant,Yadav, Uday Chandra,Gupta, Pavan Kumar,Pakuwal, Uttam Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Reactive oxygen species (ROS), highly reactive molecules, are produced by living organisms as a result of normal cellular metabolism and environmental factors, and can damage nucleic acids and proteins, thereby altering their functions. The human body has several mechanisms to counteract oxidative stress by producing antioxidants. A shift in the balance between oxidants and antioxidants in favor of oxidants is termed as "oxidative stress". Paradoxically, there is a large body of research demonstrating the general effect of oxidative stress on signaling pathways, less is known about the initial and direct regulation of signaling molecules by ROS, or what we term the "oxidative interface." This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (MAP kinases and PI3 kinase), ROS homeostasis, and antioxidant gene regulation (Ref-1 and Nrf-2). This review also deals with classification as well as mechanisms of formation of free radicals, examining their beneficial and deleterious effects on cellular activities and focusing on the potential role of antioxidants in preventing and repairing damage caused by oxidative stress. A discussion of the role of phytochemical antioxidants in oxidative stress, disease and the epigenome is included.
GCR-LIGHTLIKE SUBMANIFOLDS OF A SEMI-RIEMANNIAN PRODUCT MANIFOLD
Sangeet Kumar,Rakesh Kumar,Rakesh Kumar Nagaich 대한수학회 2014 대한수학회보 Vol.51 No.3
We introduce GCR-lightlike submanifold of a semi-Riemann- ian product manifold and give an example. We study geodesic GCR- lightlike submanifolds of a semi-Riemannian product manifold and obtain some necessary and sufficient conditions for a GCR-lightlike submanifold to be a GCR-lightlike product. Finally, we discuss minimal GCR-lightlike submanifolds of a semi-Riemannian product manifold.
Pawan Kumar,Rakesh Kumar Dwivedi,Pawan Kumar,Ravikant Prasad,Praveen Kumar Siwach,Hari Krishna Singh 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.1
Thin films of La_(0.80)Sr_(0.20)Mn_(1−x)Cu_xO_3 with x = 0.00, 0.04, 0.08, 0.10, 0.15, and 0.20 were deposited on single-crystal LaAlO_3 (100) (LAO) substrates at 250 ± 10 ℃ by using a nebulized spray pyrolysis technique. Structural, surface, and transport characterizations were done by X-ray diffraction (XRD), atomic force microscopy (AFM) and the standard four probe technique, respectively. XRD patterns revealed the formation of single-phase polycrystalline films with a rhombohedral crystal structure. Cu substitution resulted in a uniform decrease in the metal insulator transition (T_(IM)) temperature up to x = 0.10, followed by a drastic decrease in T_(IM) for x = 0.15. Finally, the metal-insulator transition vanished for higher Cu concentrations (x = 0.20) in the observed temperature range. The variation in T_(IM) with the amount of added Cu is explained on the basis of the double exchange mechanism. Cu substitution has been found to perturb the Mn^(3+)-O-Mn^(4+) network and has a strong influence on T_(IM). The variation in resistivity maxima with temperature for different Cu concentrations showed a systematic trend up to x ∼ 0.10. We also explored the electrical conduction at T > T_(IM) in the framework of small polaron hopping in the adiabatic limit. The activation energy showed a strong dependence on the Cu concentration. The maximum magneto-resistance (MR) up to 10%, was observed for x = 0.15 at low temperatures.
Rakesh Sharma,Arpan Choudhary,Ranjit Kumar Das,Supriya Basu,Ranjan Kumar Dey,Rupesh Gupta,Partha Pratim Deb 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.2
Purpose: Extracorporeal shock wave lithotripsy (ESWL) is an established modality for renal calculi. Its role for large stones is being questioned. A novel model of temporary double J (DJ) stenting followed by ESWL was devised and outcomes were assessed. Materials and Methods: The study included 95 patients with renal calculi sized 1 to 2 cm. Patients were randomized into 3 groups. Group 1 received ESWL only, whereas group 2 underwent stenting followed by ESWL. In group 3, a distinct model was applied in which the stent was kept for 1 week and then removed, followed by ESWL. Procedural details, analgesic requirements, and outcome were analyzed. Results: Eighty-eight patients (male, 47; female, 41) were available for analysis. The patients' mean age was 37.9±10.9 years. Stone profile was similar among groups. Group 3 received fewer shocks (mean, 3,155) than did group 1 (mean, 3,859; p=0.05) or group 2 (mean, 3,872; p=0.04). The fragmentation rate was similar in group 3 (96.7%) and groups 1 (81.5%, p=0.12) and 2 (87.1%, p=0.16). Overall clearance in group 3 was significantly improved (83.3%) compared with that in groups 1 (63.0%, p=0.02) and 2 (64.5%, p=0.02) and was maintained even in lower pole stones. The percentage successful outcome in groups 1, 2, and 3 was 66.7%, 64.5%, and 83.3%, respectively (p=0.21). The analgesic requirement in group 2 was higher than in the other groups (p=0.00). Group 2 patients also had more grade IIIa (2/3) and IIIB (1/2) complications. Conclusions: Stenting adversely affects stone clearance and also makes the later course uncomfortable. Our model of brief stenting followed by ESWL provided better clearance, comfort, and a modest improvement in outcome with fewer sittings and steinstrasse in selected patients with large renal calculi.
Effect of temperature gradient on track-bridge interaction
Kumar, Rakesh,Upadhyay, Akhil Techno-Press 2012 Interaction and multiscale mechanics Vol.5 No.1
Considerable longitudinal rail forces and displacements may develop in continuous welded rail (CWR) track on long-span bridges due to temperature variations. The track stability may be disturbed due to excessive relative displacements between the sleepers and ballast bed and the accompanied reduction in frictional resistance. For high-speed tracks, however, solving these problems by installing rail expansion devices in the track is not an attractive solution as these devices may cause a local disturbance of the vertical track stiffness and track geometry which will require intensive maintenance. With reference to temperature, two actions are considered by the bridge loading standards, the uniform variation in the rail and deck temperature and the temperature gradient in deck. Generally, the effect of temperature gradient has been disregarded in the interaction analysis. This paper mainly deals with the effect of temperature gradient on the track-bridge interaction with respect to the support reaction, rail stresses and stability. The study presented in this paper was not mentioned in the related codes so far.
Development of a Cajanus cajanifolius-based CMS Hybrid Technology in Pigeonpea
Rakesh Kumar Srivastava,Kul Bhushan Saxena,Ravikoti Vijaya Kumar 한국작물학회 2018 Journal of crop science and biotechnology Vol.21 No.5
Pigeonpea is an important food legume of the semi-arid tropics grown mainly under subsistence agriculture. As a first step to address the five decades-long yield stagnation, a proof-of-concept for a commercially viable CMS-based hybrid technology with high standard heterosis and fertility restoration has been demonstrated. Six generations of backcrossing and selection for male sterility, and agronomic superiority using a Cajanus cajanifolius- (A4 cytoplasm) based CMS donor (ICPA 2039) and a medium-maturity group recurrent parent ICPL 20176 (ICPB 2043) which resulted in a stable male sterile line (ICPA 2043) with near-perfect male sterility and superior agronomic traits. Following backcrossing and selections, the A-line (ICPA 2043) appeared to be morphologically similar in terms of various qualitative and quantitative traits compared to the B-line (ICPB 2043). However, differences between ICPA 2043 and ICPB 2043 were observed for days to maturity, 100-seed weight, pods plant-1, and seed weight plant-1. These differences may not be genetic but physiological. The best heterotic restorer line selected in a cross (ICPH 2671) combination restored a mean of 96.49% male fertility in 36 environments (12 locations, 3 years). Present investigation did not reveal significant G×E interaction for fertility restoration, indicating the possibility of obtaining high and stable grain yields in the pigeonpea growing areas of South and Central India.