Overexpression of Neuron-Specific Enolase as a Prognostic Factor in Patients with Gastric Cancer

Park, Taejin,Lee, Young-Joon,Jeong, Sang-Ho,Choi, Sang-Kyung,Jung, Eun-Jung,Ju, Young-tae,Jeong, Chi-Young,Park, Miyeong,Hah, Young-Sool,Yoo, Jiyun,Ha, Woo-Song,Hong, Soon-Chan,Ko, Gyung Hyuck The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.3

Purpose: Enolase is a cytoplasmic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway. The aim of this study was to investigate whether the overexpression of neuron-specific enolase (NSE) can serve as a prognostic factor in patients with gastric cancer (GC). Materials and Methods: To assess its prognostic value in GC, NSE expression was measured by immunohistochemistry in a clinically annotated tissue microarray comprising of 327 human GC specimens. Cytoplasmic NSE expression was scored from 0 to 4, reflecting the percentage of NSE-positive cells. Results: In terms of histology as per the World Health Organization criteria (P=0.34), there were no differences between the NSE overexpression (NSE-OE) and NSE underexpression (NSE-UE) groups. The NSE-OE group showed a significantly lower rate of advanced GC (P<0.01), lymph node metastasis (P=0.01), advanced stage group (P<0.01), cancer-related death (P<0.01), and cancer recurrence (P<0.01). Additionally, a Kaplan-Meier survival analysis revealed that the NSE-OE group had longer cumulative survival times than the NSE-UE group (log-rank test, P<0.01). However, there were no significant differences in the serum levels of NSE expression in patients with GC and healthy volunteers (P=0.28). Conclusions: Patients with NSE overexpressing GC tissues showed better prognostic results, implying that NSE could be a candidate biomarker of GC.

A Case of Advanced Gastric Cancer with Para-Aortic Lymph Node Metastasis from Co-Occurring Prostate Cancer

Park, Miyeong,Jeong, Sang-Ho,Lee, Young-Joon,Park, Ji-Ho,Choi, Sang-Kyung,Hong, Soon-Chan,Jung, Eun-Jung,Ju, Young-tae,Jeong, Chi-Young,Lee, Jeong-Hee,Ha, Woo-Song The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.1

An 84-year-old man was diagnosed with two synchronous adenocarcinomas, a Borrmann type IV advanced gastric adenocarcinoma in his antrum and a well-differentiated Borrmann type I carcinoma on the anterior wall of the higher body of his stomach. Pre-operatively, computed tomography of the abdomen revealed the presence of advanced gastric cancer with peri-gastric and para-aortic lymph node (LN) metastasis. He planned for palliative total gastrectomy owing to the risk of obstruction by the antral lesion. We performed a frozen biopsy of a para-aortic LN during surgery and found that the origin of the para-aortic LN metastasis was from undiagnosed prostate cancer. Thus, we performed radical total gastrectomy and D2 LN dissection. Post-operatively, his total prostate-specific antigen levels were high (227 ng/mL) and he was discharged 8 days after surgery without any complications.

유치원 교사의 교권 및 교권침해에 대한 인식

박미영(Park, MiYeong),박한숙(Park, HanSook) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.8

본 연구는 유치원 교사의 교권 및 교권침해에 대한 인식과 그 차이를 분석하여 교권의 보호와 교권침해 예방을 위해 필요한 정책 제안의 기초 자료를 제시하는데 그목적이 있다. 본 목적 달성을 위해 B광역시에 근무하는 유치원 교사들 295명을 대상 으로 2017년 1월 3주부터 2017년 2월 2주까지 약 4주에 걸쳐 설문 조사를 실시하였 다. 연구 결과에서 첫째, 유치원 교사의 교권 인식 수준은 보통 정도이며 교권 가운데 교육의 권리를 가장 중요하게 인식하는 것으로 나타났다. 반면 신분, 재산, 교원 단체 활동권의 보장에 대해 잘 알지 못하며 각 권리의 보장에 대한 이해나 인식 정도는 미흡한 것으로 나타났다. 그러나 고연령의 교사는 교원단체 역할의 필요성을 인식하는 정도가 높았다. 둘째, 고연령의 교사일수록 교권침해가 사회적 문제와 관련이 있다는 인식이 나타났다. 교권침해의 가장 큰 주체는 학부모이며 다른 교육 관련 당사자 간에도 교육활동을 방해하는 형태로 침해가 발생한다는 인식이 나타났다. 그러나 유치원 교사는 교권침해 발생에도 소극적 대응을 하는 것으로 나타났다. 따라서 교권의 보호와 교권침해 예방을 위해서는 교사의 전문성 향상을 위한 노력이 필요하며 유치원 교사의 교권을 존중하는 사회적 분위기의 선행과 함께 이를 뒷받침 해주는 제도적 보완과 보호 정책이 필요한 것으로 나타났다. The purpose of this study is to present the basic data to the policy proposals necessary for the protection of pedestrian rights and the prevention of infringement of pedestrian rights by analyzing the perception and differences of pedagogical rights and infringement of pedestrian rights of kindergarten teachers. For the purpose of this study, we surveyed 295 kindergarten teachers who work in B city for 3 weeks from January 3, 2017 to February 2, 2017 for about 4 weeks. First, Kindergarten teachers showed that the level of perception of jurisdiction was normal and that the right of education was the most important among the jurisdictions. On the other hand, it is not well understood about the guarantee of the status, property, and the right of activity of teachers group and it is not recognized that understanding of guarantee of each right is insufficient. Especially, teachers with higher age were more aware of the necessity of the role of teachers organizations. Second, the higher the age of the teacher, the more perceptions that the infringement of the authority is related to social problems. The perception that violation occurred in the form of interfering with educational activities among parents and other education related parties appeared to be the main subject of infringement of authority. However, Kindergarten teachers responded positively to the occurrence of infringement of the authority. Therefore, in order to protect the right of the church and prevent the infringement of the right of the church, efforts are needed to improve the professionalism of the teachers, and the social atmosphere that respects the right of the teachers of the kindergarten teachers is necessary and institutional supplement and protection policy are needed.

간호사 맞춤 핸드크림 사용이 손 피부 보습에 미치는 효과

박미영 ( Park Miyeong ),이미라 ( Lee Mira ),정진희 ( Jung Jinhee ),황혜영 ( Hwang Hyeyoung ),박동순 ( Park Dongsoon ) 서울대학교 간호과학연구소 2020 간호학의 지평 Vol.17 No.2

Purpose: This study sought to verify the effectiveness of the Nurse Hand Cream developed to protect the skin of the hands of nurses damaged by frequent hand hygiene. Methods: A randomized controlled trial was conducted that compared the hand skin moisture content of subjects using the Nurse Hand Cream that had been developed for nurses with that of the other hand cream. Results: After applying the hand cream, the subjects’ skin moisture content were measured using a skin moisture measuring device; the moisture content of the experimental group significantly increased compared with the control group (p<.001). In particular, as a result of the second experiment that involved the four-time performance of hand hygiene every 30 minutes for two hours, the skin moisture content of the experimental group significantly increased compared with the control group, and 84.4% of the experimental group maintained a normal or higher skin moisture content. Conclusion: The hand cream for nurses was statistically confirmed to strengthen the moisturizing power and prevention of skin moisture loss compared with the other hand cream.

Nasal packing with bupivacaine during nasotracheal intubation can reduce intubation-related epistaxis

( Ho Kyung Yu ),( Jiyoung Park ),( Young-hoon Kang ),( Hee Bin Park ),( Sung Il Bae ),( Soo Hee Lee ),( Seong-ho Ok ),( Sang-ho Jeong ),( Miyeong Park ) 조선대학교 치의학연구원 2021 Oral Biology Research (Oral Biol Res) Vol.45 No.3

Epistaxis often is caused by nasal mucosal damage and vascular injury after nasotracheal (NT) intubation. Bupivacaine constricts blood vessels at low concentrations and dilates them at high concentrations. In this study, in which we evaluated the effects of intranasal packing with bupivacaine to prevent epistaxis and pain induced by NT intubation, we classified 180 patients into three groups: an untreated group (n=60), a group pretreated with epinephrine (n=60), and a group pretreated with bupivacaine (n=60). In all groups, we used nasal Ring-Adair-Elwyn tubes with the thermosoftening method for NT intubation. We classified the degree of epistaxis as Grade 0 (none), Grade 1 (mild), Grade 2 (moderate), or Grade 3 (severe). We assessed postoperative visual analog scale (VAS) scores for nose pain in the recovery room. We found that the incidence of epistaxis in the group pretreated with bupivacaine was significantly less than was that of the untreated group (55% vs. 35%, p<0.05). Univariate logistic regression analysis revealed a reduction in epistaxis with bupivacaine nasal packing (odds ratio=0.689, 95% confidence interval=0.478, 0.992). Postoperative VAS scores after 30 minutes in the nasal area were lower in the group pretreated with bupivacaine than were those in the untreated group or the group pretreated with epinephrine (p<0.05). Therefore, we conclude that nasal packing with bupivacaine can help reduce epistaxis and nasal pain more effectively as compared to cases without pretreatment with this anesthetic.

Microwave-assisted Weak Acid Hydrolysis of Proteins

Miyeong Seo,JinHeeKim,Sehwan Park,Ji-Hye Lee,Taehee Kim,Jihyeon Lee,김정권 사단법인 한국질량분석학회 2012 Mass spectrometry letters Vol.3 No.2

Myoglobin was hydrolyzed by microwave-assisted weak acid hydrolysis with 2% formic acid at 37 oC, 50 oC, and100 oC for 1 h. The most effective hydrolysis was observed at 100 oC. Hydrolysis products were investigated using matrixassistedlaser desorption/ionization time-of-flight mass spectrometry. Most cleavages predominantly occurred at the C-termini ofaspartyl residues. For comparison, weak acid hydrolysis was also performed in boiling water for 20, 40, 60, and 120 min. A 60-min weak acid hydrolysis in boiling water yielded similar results as a 60-min microwave-assisted weak acid hydrolysis at100 oC. These results strongly suggest that microwave irradiation has no notable enhancement effect on acid hydrolysis of proteinsand that temperature is the major factor that determines the effectiveness of weak acid hydrolysis.

음성 데이타베이스에서의 패턴 데이타 클러스터링

신미영(Miyeong Shin),김영인(Youngin Kim),박영배(Youngbae Park) 한국정보과학회 1991 한국정보과학회 학술발표논문집 Vol.18 No.2

대량의 음소 패턴 데이타를 중에서, 유사성이 가장 높은 음소를 판별하여 음소를 인식 하는일은 음소 패턴 데이타가 가변길이면서, 음소 패턴 전체를 처음부터 끝까지 순차적으로 탐색해야 하므로 많은 시간을 필요로 한다. 본 논문에서는 탐색 시간을 줄이기 위해서 전체 음소 패턴을 처음부터 끝까지 탐색하지 않고 클러스터링된 패턴만을 탐색할 수 있도록 음소 패턴 데이타들 중에서 특성이 유사한 음소들을 추출하는 클러스터링 알고리즘을 두가지 제시한다. 첫째는 신경 회로망의 Back Propagation알고리즘을 이용하여 음소 패턴 데이타를 학습한후 그 결과를 클러스터링에 이용하는 방법이고, 둘째는 DP-매칭을 이용한 알고리즘으로 유사성이 높은 음소 패턴 데이타들의 거리값이 가장 짧은 음소 패턴 데이타들을 클러스터링하는 방법이다.

Weak Acid Hydrolysis of Proteins

Seo, Miyeong,Kim, Jinhee,Park, Sehwan,Lee, Ji-Hye,Kim, Taehee,Lee, Jihyeon,Kim, Jeongkwon Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1

텍스타일 이미지 검색 및 클러스터링

강미영 ( Miyeong Kang ),이은옥 ( Eunok Lee ),박우창 ( Uchang Park ) 한국정보처리학회 2010 한국정보처리학회 학술대회논문집 Vol.17 No.2

본 연구에서는 내용 기반의 텍스타일 이미지 검색 시스템을 구축하였다. 텍스타일 이미지에 대한 색상, 질감, 모양 특성 추출 조합을 각각 혹은 가중치를 이용한 방법으로 검색한다. 검색은 사용자 인터페이스에서 오라클 데이터베이스 시스템에서 제공되는 이미지의 색상, 질감 특성 값에 대한 검색과 결과 피드백을 보면서 진행된다. 또 검색 대상 이미지들을 유사도에 따라 다차원 비례법에 의하여 2차원 화면에 클러스터링하여 전체 이미지의 군집화 특성을 쉽게 파악할 수 있는 기능을 구현하였다.

Surgical outcomes and survival of patients over 80 years old who underwent curative resection for gastric cancer

Seunghui Lee*,Miyeong Lee*,Sangdon Kwan,Soohyung Kim,Ki Bum Park,Oh Kyoung Kwon,Ji Yeon Park 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.6

Purpose: Among patients with gastric cancer who underwent radical gastrectomy, the proportion of patients aged ≥80 years has increased. This study aimed to evaluate surgical outcomes and survival of patients aged ≥80 years who underwent curative resection for gastric cancer and identify independent factors that affect postoperative survival. Methods: This retrospective study enrolled 1,066 patients aged ≥65 years with gastric cancer who underwent curative resection between January 2014 and December 2018 at a single institution. They were divided into those aged ≥80 years (old-elderly group) and 65–79 years (young-elderly group). Their clinicopathological characteristics and surgical outcomes were compared. Results: Of the 1,066 patients, 136 (12.8%) were 80 years or older. Higher American Society of Anesthesiologists (ASA) physical status classification and more advanced cancers were observed in the old-elderly group than in the young-elderly group. No significant difference in postoperative complications was found between the groups. At a median follow-up of 49.1 months, the 5-year overall survival rate after surgery for the old-elderly group was lower than that for the young-elderly group (75.6% vs. 87.0%, P < 0.001). However, the 5-year disease-specific survival rate was comparable between the groups (90.1% vs. 92.2%, P = 0.324). ASA physical status classification, pathologic stage, and surgical approach were independent predictors of overall survival. Conclusion: Old-elderly patients aged ≥80 years had comparable postoperative outcomes and disease-specific survival to the young-elderly group, suggesting that curative gastrectomy can be considered a viable option for octogenarian patients with gastric cancer.