4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer

Seidel, C.,Schnekenburger, M.,Mazumder, A.,Teiten, M.H.,Kirsch, G.,Dicato, M.,Diederich, M. Pergamon Press 2016 Biochemical pharmacology Vol.99 No.-

<P>Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including a-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing HDAC6 inhibitors. Here, we identified two new structurally related 4-hydroxybenzoic acids as selective HDAC6 inhibitors reducing proliferation, colony and spheroid formation as well as viability of prostate cancer cells. Both compounds strongly enhanced alpha-tubulin acetylation leading to remodeling of microtubular organization. Furthermore, 4-hydroxybenzoic acids decreased HSP90 alpha regulation of the human androgen receptor in prostate cancer cells by increasing HSP90 alpha acetylation levels. Collectively, our data support the potential of 4-hydroxybenzoic acid derivatives as HDAC6-specific inhibitors with anti-cancer properties. (C) 2015 Elsevier Inc. All rights reserved.</P>

A green and efficient solid acid catalyst from coal fly ash for Fischer esterification reaction

Nurul A. Mazumder,Ruma Rano,Gitarthi Sarmah 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.32 No.-

A green and efficient solid acid catalyst (SAC) has been synthesized upon modification of F-type fly ashusing ortho-phosphoric acid (35 wt. %). Catalyst characterization has been accomplished using differentanalytical techniques, such as FT-IR, XRD, SEM–EDS, and BET surface area analysis. SAC possessedexcellent catalytic activity for Fischer esterification reaction between 4-aminobenzoic acid andmethanol at 95 8C to produce methyl 4-aminobenzoate (MAB), an important precursor for the synthesisof pharmaceutical drugs, ( ) martinelline, and ( ) martinellic acid. This investigation suggests theutilization of fly ash to develop novel solid acid catalyst system for catalyzing industrially importantesterification reaction.

A Comparative Study Between Cytomegalovirus Immunoglobulin M-Positive and CMV Immunoglobulin M-Negative Biliary Atresia in Infants Attending a Tertiary Care Hospital in Bangladesh

Sharmin Akter,A S M Bazlul Karim,Md Wahiduzzaman Mazumder,Md Rukunuzzaman,Khan Lamia Nahid,Bishnu Pada Dey,Maimuna Sayeed,A Z M Raihanur Rahman,Kaniz Fathema,Mukesh Khadga 대한소아소화기영양학회 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.5

Purpose: Perinatal cytomegalovirus (CMV) infection can lead to biliary atresia (BA) in different entities. This study aimed to compare the clinical, hematological, biochemical, and histological features of infants with BA based on their CMV immunoglobulin M (IgM) status at presentation. Methods: This cross-sectional descriptive study was carried out between January 2019 and June 2020 at the Department of Pediatric Gastroenterology and Nutrition at the Bangabandhu Sheikh Mujib Medical University (BSMMU) in Dhaka. Forty-three patients with BA were selected purposively and categorized into either the CMV IgM-positive or CMV IgM-negative BA group. Categorical variables were compared using Fisher’s exact test and chi-square tests, while the Student’s t-test and Mann–Whitney U-test were used to compare continuous variables. For all statistical tests, a p-value <0.05 was considered statistically significant. Results: Thirty-three (76.7%) of the cases were between 2 and 3 months of age on admission. The clinical, hematological, and biochemical parameters did not differ significantly between the CMV IgM-positive and CMV IgM-negative BA groups. Most (50.0%) of the CMV IgM-positive cases had fibrosis stage F2, while 43.5% of the CMV IgM-negative cases had fibrosis stage F3, with no significant difference between the groups (p=0.391). Conclusion: Our data shows no significant distinction between CMV IgM-positive and CMV IgM-negative BA, suggesting that CMV does not contribute to BA pathogenesis.

Prediction of gene expression and codon usage in human parasitic helminths

Supriyo Chakraborty,Gulshana A. Mazumder,Arif Uddin 한국유전학회 2017 Genes & Genomics Vol.39 No.1

Codon usage bias refers to the differences in the occurrence frequency of synonymous codons. To understand the patterns of codon usage in mitochondrial genes we used bioinformatic approaches to analyze the protein coding sequences of W. bancrofti and S. haematobium as no work was reported earlier. It was found that the ENC value ranged from 43 to 60 with a mean of 46.91 in W. bancrofti but varied from 49 to 60 with a mean of 45.17 in S. haematobium, respectively. In W. bancrofti a significant positive correlation was found between ENC and GC3% (r = 0.826**, p\0.01), but in S. haematobium significant correlation was found between ENC and GC3% (r = 0.983**, p\0.01). Principal component analysis suggests that the pattern of codon usage significantly differed between W. bancrofti and S. haematobium. Neutrality plot reveals that natural selection played a major role while mutation pressure played a minor role in codon usage pattern in the mitochondrial protein coding genes of W. bancrofti and S. haematobium. Various factors namely nucleotide composition, natural selection and mutation pressure affected the codon usage pattern.

Juvenile Polyps in Bangladeshi Children and Their Association with Fecal Calprotectin as a Biomarker

Subarna Rani Das,A S M Bazlul Karim,Md RukonUzzaman,Md Wahiduzzaman Mazumder,Rubaiyat Alam,Md Benzamin,Parisa Marjan,Mst. Naznin Sarker,Hazera Akther,Mohuya Mondal 대한소아소화기영양학회 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.1

Purpose: Colonoscopy is considered the most reliable method for the diagnosis of juvenile polyps. However, colonoscopic screening is an invasive and expensive procedure. Fecal calprotectin (FCP), a marker of intestinal inflammation, has been shown to be elevated in patients with polyps. Therefore, this study aimed to evaluate FCP as a screening biomarker for the diagnosis of juvenile polyps. Methods: This cross-sectional, observational study was conducted at the Pediatric Gastroenterology and Nutrition Department, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. For children with polyps, colonoscopic polypectomy and histopathology were performed. FCP levels were analyzed before and 4 weeks after polypectomy in all patients. Information was recorded in a datasheet and analyzed using the computer-based program SPSS. Results: The age of the children was between 2.5 and 12 years. Approximately 93% of the polyps were found in the rectosigmoid region. Children with juvenile polyps had elevated levels of FCP before polypectomy that subsequently normalized after polypectomy. The mean FCP levels before and after polypectomy were 277±247 μg/g (range, 80–1,000 μg/g) and 48.57±38.23 μg/g (range, 29–140 μg/g) (p<0.001), respectively. The FCP levels were significantly higher in patients with multiple polyps than in those with single polyps. Moreover, mean FCP levels in patients with single and multiple polyps were 207.6±172.4 μg/ g and 515.4±320.5 μg/g (p<0.001), respectively. Conclusion: Colonic juvenile polyps were found to be associated with elevated levels of FCP that normalized after polypectomy. Therefore, FCP may be recommended as a noninvasive screening biomarker for diagnosis of colonic juvenile polyps.

Investigation of the optical potentials for the 40Ca(α,t)41Sc reaction at 40 MeV

Mazumder U. K.,Somadder A.,Hoque E.,Das S. K. 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.80 No.7

The 40Ca(α,t)41Sc reaction has been studied at a 40 MeV incident energy. The angular distributions of the eight states of the reaction are analyzed using the full finite-range (FFR) distorted-wave Born approximation (DWBA) for both the bound and the unbound states of the 41Sc nucleus using the normal optical, Michel and molecular potentials. The spectroscopic factors that have been extracted for the three optical potentials are compared with the previous local zero-range (LZR) and local finite-range (LFR) calculations of the 40Ca(α,t)41Sc reaction for the normal optical potential. The χ2 values of all the potentials for different l transfers are calculated to estimate the quality of fits. The present analysis shows that the Michel and the molecular potentials fit the data more satisfactorily than the normal optical potential.

Effect of Levels of Concentrate Supplement on Live Weight Gain and Carcass Characteristics in Sheep on Restricted Grazing

Mazumder, M.A.R.,Hossain, M.M.,Akhter, S. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.1

Sixteen local sheep (8 male + 8 female) of about six months old with average live weight 10.78 $({\pm}1.11)$ kg were allocated into four treatments. The treatments (T) are : $T_0$ = Restricted grazing without concentrate; $T_1$, $T_2$ and $T_3$ = Grazing + 100, 200 and 300 g concentrate per sheep daily. Live weight of grazing (7.30 hrs daily) sheep was recorded in each week. The uncastrated male sheep were slaughtered for carcass and non-carcass parameters. Statistically significant (p < 0.05) differences were observed in live weight gain (g/day) among the treatments ($T_0=15.71$; $T_1=22.66$; $T_2 =32.66$ and $T_3=40.47$). The dressing % were : ($T_0=32.75$, $T_1=38.50$, $T_2=36.90 $ and $T_3=37.75$). The warm carcass weight represented 37.21% of live weight. Significant (p < 0.01) correlation were observed for live weight with carcass weight (r = 0.99) and dressing % (r = 0.88). Concentrate supplement increase live weight gain in sheep on grazing. Live weight is a good indicator to assess carcass characteristics.

Effect of Mg doping on the electrical properties of SnO2 nanoparticles

N. Mazumder,A. Bharati,S. Saha,D. Sen,K.K. Chattopadhyay 한국물리학회 2012 Current Applied Physics Vol.12 No.3

Sol-gel derived Mg doped tin oxide (Sn1-xMgxO2) nanocrystals were synthesized with x ranging between 0.5 and 7 at. %. Characteristic single phase tetragonal structure of pure and doped samples was obtained and doping saturation was inferred by X-ray diffraction analysis. Structural, morphological and phase informations were obtained by high resolution transmission electron microscope, field emission scanning electron microscope and X-ray photoelectron spectroscopy respectively whereas bonding information was obtained from Fourier transformed infrared spectroscopy. Measurement of different electrical parameters with frequency (200 Hze105 Hz) has been carried out at room temperature. Ultrahigh dielectric constant and metallic AC conductivity were observed for undoped tin oxide and the profiles reflected highly sensitive changes in the atomic and interfacial polarizability generated by doping concentrations. Relaxation spectra of tangent loss of any sample did not show any loss peak within the frequency range. Both the grain and grain boundary contributions are observed to increase as the doping concentration increased. Results of first principle calculation based on density functional theory indicated effective Fermi level (EF) suppression due to Mg doping which is responsible for the experimentally observed conductivity variation. AC conductivity was found to depend strongly on the doping concentration and the defect chemistry of the compound. Mg doped SnO2 may find applications as a low loss dielectric and high density energy storage material. Sol-gel derived Mg doped tin oxide (Sn1-xMgxO2) nanocrystals were synthesized with x ranging between 0.5 and 7 at. %. Characteristic single phase tetragonal structure of pure and doped samples was obtained and doping saturation was inferred by X-ray diffraction analysis. Structural, morphological and phase informations were obtained by high resolution transmission electron microscope, field emission scanning electron microscope and X-ray photoelectron spectroscopy respectively whereas bonding information was obtained from Fourier transformed infrared spectroscopy. Measurement of different electrical parameters with frequency (200 Hze105 Hz) has been carried out at room temperature. Ultrahigh dielectric constant and metallic AC conductivity were observed for undoped tin oxide and the profiles reflected highly sensitive changes in the atomic and interfacial polarizability generated by doping concentrations. Relaxation spectra of tangent loss of any sample did not show any loss peak within the frequency range. Both the grain and grain boundary contributions are observed to increase as the doping concentration increased. Results of first principle calculation based on density functional theory indicated effective Fermi level (EF) suppression due to Mg doping which is responsible for the experimentally observed conductivity variation. AC conductivity was found to depend strongly on the doping concentration and the defect chemistry of the compound. Mg doped SnO2 may find applications as a low loss dielectric and high density energy storage material.

An efficient solid base catalyst from coal combustion fly ash for green synthesis of dibenzylideneacetone

Nurul A. Mazumder,Ruma Rano 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.29 No.-

The objective of the investigation was to evaluate the catalytic efficiency of a solid base catalyst (SBC)derived from coal combustion fly ash to synthesize dibenzylideneacetone (DBA, 94% yield). The catalystwas produced using potassium hydroxide (30 wt.%) on thermally activated F-type fly ash. The physico-chemical, mineralogical and morphological characterization of the fly ash and catalyst were performedusing XRF, FT-IR, BET surface area analyser, XRD and SEM-EDS. The results of such analysis revealed thatthe catalyst obtained was associated with strong basic hydroxyl (–OH) sites that were highly suited toproduce DBA by crossed aldol condensation reaction.

The origin of the ligand-controlled regioselectivity in Rh-catalyzed [(2 + 2) + 2] carbocyclizations: steric vs. stereoelectronic effects

Crandell, D.,Mazumder, S.,Evans, P. A.,Baik, M. H. THE ROYAL SOCIETY OF CHEMISTRY 2015 Chemical Science Vol.6 No.12