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Capeding, Maria Rosario,Teshome, Samuel,Saluja, Tarun,Syed, Khalid Ali,Kim, Deok Ryun,Park, Ju Yeon,Yang, Jae Seung,Kim, Yang Hee,Park, Jiwook,Jo, Sue-Kyoung,Chon, Yun,Kothari, Sudeep,Yang, Seon-Young Elsevier Science 2018 Vaccine Vol.36 No.26
<▼1><P><B>Highlights</B></P><P>•<P>Vi-DT is safe and well tolerated in participants aged 2–45 years.</P>•<P>Significantly higher immune responses post Vi-DT compared to Vi polysaccharide vaccine.</P>•<P>No further increase in GMT post second dose as compared to post first dose of Vi-DT.</P></P></▼1><▼2><P><B>Background</B></P><P>Typhoid fever remains a major public health problem in low- and middle-income countries where children aged 2–14 years bear the greatest burden. Vi polysaccharide is poorly immunogenic in children <2 years of age, and protection in adults is modest. The limitations of Vi polysaccharide vaccines can be overcome by conjugation of the Vi to a carrier protein. A typhoid conjugate vaccine composed of Vi polysaccharide conjugated to diphtheria toxoid (Vi-DT) has been developed. The Phase I study results are presented here.</P><P><B>Methods</B></P><P>This was a randomized, observer-blinded Phase I study to assess the safety and immunogenicity of Vi-DT compared to Vi polysaccharide vaccine, conducted in Manila, Philippines. Participants enrolled in an age de-escalation manner (18–45, 6–17 and 2–5 years) were randomized between Test (Vi-DT, 25 µg) administered at 0 and 4 weeks and Comparator (Vi polysaccharide, Typhim Vi® and Vaxigrip®, Sanofi Pasteur) vaccines.</P><P><B>Results</B></P><P>A total of 144 participants were enrolled (48 by age strata, 24 in Test and Comparator groups each). No serious adverse event was reported in either group. Solicited and unsolicited adverse events were mild or moderate in both groups with the exception of a 4-year old girl in Test group with grade 3 fever which resolved without sequelae. All participants in Test group seroconverted after first and second doses of Vi-DT while the proportions in the Comparator group were 97.1% and 97.2%, after first dose of Typhim Vi® and second dose of Vaxigrip®, respectively. Vi-DT showed 4-fold higher Geometric Mean Titers (GMT) compared to Typhim Vi® (adjusted for age strata, p < 0.001). No further increase of GMT was detected after the second dose of Vi-DT. Anti-DT IgG seroresponse rates were 81.2% and 84.5% post first and second Vi-DT doses, respectively.</P><P><B>Conclusions</B></P><P>Vi-DT vaccine was safe, well-tolerated and immunogenic in participants aged 2–45 years.</P><P>ClinicalTrials.gov registration number: NCT02645032.</P></▼2>
( Ana Maria Teixeira ),( Raul Martins ),( Mafalda Martins ),( Maria Do Rosario Cunha ) 한국스포츠정책과학원(구 한국스포츠개발원) 2008 International Journal of Applied Sports Sciences Vol.20 No.2
This study analysed the influence of a 19 week exercise program in the functional fitness, salivary IgA and mood states of an elderly population. Thirty three subjects with ambulatory capacity and without any medical contraindications to exercise aged between 68 and 95 years old participated and were distributed into 2 groups: 15 subjects performed aerobic exercise that included low-impact rhythmic work sequences with music, three times a week, and 18 remained sedentary. The exercising group attained improvements in all components of functional fitness with significant differences registered for aerobic endurance, lower and upper body strength. The exercising group also showed improvements in the mood states, with statistically significant less depression, less tension, less fatigue, more vigour and less anger. On the other hand, the sedentary control group showed an increase in confusion and a loss of vigour. For the exercising group salivary IgA levels were higher after the 19 week exercise program with no changes for the control group. This study shows a positive effect of exercise on physical, psychological and mucosal immune parameters in elderly populations which may improve quality of life.
Comparison among different software for the evaluation of moment-curvature of R.C. columns
Rosario Montuori,Elide Nastri,Maria Ilenia Palese,Vincenzo Piluso 사단법인 한국계산역학회 2019 Computers and Concrete, An International Journal Vol.24 No.3
The work aims at the comparison among commonly used research programs concerning moment-curvature (M−χ) diagrams of confined R.C. members. The software considered in this work are Sap2000, SeismoStruct and Opensees. The curves provided by these software, given the same modelling, have been compared to those provided by a theoretical fiber model. A parametric analysis has been led on rectangular column sections with different level of axial load and different stirrups spacing. The accuracy of the modelling of the considered structural programs has been investigated by comparing their results with those obtained by applying the theoretical fiber model.
Maria Ruth B. Pineda-Cortel,Elner H. del Rosario,Oliver B. Villaflores The Korean Society of Veterinary Science 2024 Journal of Veterinary Science Vol.25 No.2
Agricultural production is a major driver of the Philippine economy. Mass production of animal products, such as livestock and poultry farming, is one of the most prominent players in the field. Filipino farmers use veterinary medicinal products (VMPs) when raising agricultural animals to improve animal growth and prevent diseases. Unfortunately, the extensive use of VMPs, particularly antibiotics, has been linked to drug resistance in animals, particularly antibiotics. Antimicrobial gene products produced in animals due to the prolonged use of VMPs can passed on to humans when they consume animal products. This paper reviews information on the use of VMPs in the Philippines, including the regulations, their impact, challenges, and potential recommendations. The Philippines has existing legislation regulating VMP use. Several agencies were tasked to regulate the use of VMPs, such as the Department of Agriculture, the Department of Health, and the Philippine National Action Plan. Unfortunately, there is a challenge to implementing these regulations, which affects consumers. The unregulated use of VMPs influences the transmission of antibiotic residues from animals to crops to humans. This challenge should be addressed, with more focus on stricter regulation.
( Maria Elisa Rodrigues ),( Ana Rita Costa ),( Pedro Fernandes ),( Mariana Henriques ),( Philip Cunnah ),( David W Melton ),( Joana Azeredo ),( Rosario Oliveira ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.9
The emergence of microcarrier technology has brought a renewed interest in anchoragedependent cell culture for high-yield processes. Well-known in vaccine production, microcarrier culture also has potential for application in other fields. In this work, two types of microcarriers were evaluated for small-scale monoclonal antibody (mAb) production by CHOK1 cells. Cultures (5 ml) of microporous Cytodex 3 and macroporous CultiSpher-S carriers were performed in vented conical tubes and subsequently scaled-up (20 ml) to shake-flasks, testing combinations of different culture conditions (cell concentration, microcarrier concentration, rocking methodology, rocking speed, and initial culture volume). Culture performance was evaluated by considering the mAb production and cell growth at the phases of initial adhesion and proliferation. The best culture performances were obtained with Cytodex 3, regarding cell proliferation (average 1.85 ± 0.11 × 106 cells/ml against 0.60 ± 0.08 × 106 cells/ ml for CultiSpher-S), mAb production (2.04 ± 0.41 μg/ml against 0.99 ± 0.35 μg/ml for CultiSpher-S), and culture longevity (30 days against 10-15 days for CultiSpher-S), probably due to the collagen-coated dextran matrix that potentiates adhesion and prevents detachment. The culture conditions of greater influence were rocking mechanism (Cytodex 3, pulse followed by continuous) and initial cell concentration (CultiSpher-S, 4 × 105 cells/ml). Microcarriers proved to be a viable and favorable alternative to standard adherent and suspended cultures for mAb production by CHO-K1 cells, with simple operation, easy scaleup, and significantly higher levels of mAb production. However, variations of microcarrier culture performance in different vessels reiterate the need for optimization at each step of the scale-up process.
Kreich, Eliane Maria,Chibinski, Ana Claudia,Coelho, Ulisses,Wambier, Leticia Stadler,Zedebski, Rosario de Arruda Moura,de Moraes, Mari Eli Leonelli,de Moraes, Luiz Cesar Korean Academy of Oral and Maxillofacial Radiology 2016 Imaging Science in Dentistry Vol.46 No.1
Purposes: This study employed a posteriori registration and subtraction of radiographic images to quantify the apical root resorption in maxillary permanent central incisors after orthodontic treatment, and assessed whether the external apical root resorption (EARR) was related to a range of parameters involved in the treatment. Materials and Methods: A sample of 79 patients (mean age, $13.5{\pm}2.2years$) with no history of trauma or endodontic treatment of the maxillary permanent central incisors was selected. Periapical radiographs taken before and after orthodontic treatment were digitized and imported to the Regeemy software. Based on an analysis of the post-treatment radiographs, the length of the incisors was measured using Image J software. The mean EARR was described in pixels and relative root resorption (%). The patient's age and gender, tooth extraction, use of elastics, and treatment duration were evaluated to identify possible correlations with EARR. Results: The mean EARR observed was $15.44{\pm}12.1pixels$ (5.1% resorption). No differences in the mean EARR were observed according to patient characteristics (gender, age) or treatment parameters (use of elastics, treatment duration). The only parameter that influenced the mean EARR of a patient was the need for tooth extraction. Conclusion: A posteriori registration and subtraction of periapical radiographs was a suitable method to quantify EARR after orthodontic treatment, and the need for tooth extraction increased the extent of root resorption after orthodontic treatment.