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Artificial Slanted Nanocilia Array as a Mechanotransducer for Controlling Cell Polarity
Kim, Hong Nam,Jang, Kyung-Jin,Shin, Jung-Youn,Kang, Daeshik,Kim, Sang Moon,Koh, Ilkyoo,Hong, Yoonmi,Jang, Segeun,Kim, Min Sung,Kim, Byung-Soo,Jeong, Hoon Eui,Jeon, Noo Li,Kim, Pilnam,Suh, Kahp-Yang American Chemical Society 2017 ACS NANO Vol.11 No.1
<P>We present a method to induce cell directional behavior using slanted nanocilia arrays. NIH-3T3 fibroblasts demonstrated bidirectional polarization in a rectangular arrangement on vertical nanocilia arrays and exhibited a transition from a bidirectional to a unidirectional polarization pattern when the angle of the nanocilia was decreased from 90 degrees to 30 degrees. The slanted nanocilia guided and facilitated spreading by allowing the cells to contact the sidewalls of the nanocilia, and the directional migration of the cells opposed the direction of the slant due to the anisotropic bending stiffness of the slanted nanocilia. Although the cells recognized the underlying anisotropic geometry when the nanocilia were coated with fibronectin, collagen type I, and Matrigel, the cells lost their directionality when the nanocilia were coated with poly-D-lysine and poly-L-lysine. Furthermore, although the cells recognized geometrical anisotropy on fibronectin coatings, pharmacological perturbation of PI3K-Rac signaling hindered the directional elongation of the cells on both the slanted and vertical nanocilia. Furthermore, myosin light chain II was required for the cells to obtain polarized morphologies. These results indicated that the slanted nanocilia array provided anisotropic contact guidance cues to the interacting cells. The polarization of cells was controlled through two steps: the recognition of underlying geometrical anisotropy and the subsequent directional spreading according to the guidance cues.</P>
( Noo Ri Lee ),( Bo Kyung Kim ),( Na Young Yoon ),( Sung Yul Lee ),( Seok Yong Ahn ),( Won Soo Lee ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.6
Background: Alopecia areata (AA) is a common dermatologic condition with a broad spectrum of clinical features and age of onset, classically characterized by nonscarring patches of hair loss. In the past, early-onset (before adolescence) AA has been associated with various autoimmune diseases, especially atopic diseases and lupus erythematosus and demonstrates a worse prognosis compared with late onset AA. Objective: To evaluate the differences in the comorbidity profile of AA with regard to age at onset. Methods: We completed a retrospective study of 871 Korean AA patients seen at our department within the last 10 years. After these patients were subdivided according to onset before or after age 13 years, the two groups were compared on the basis of their comorbid disorders, family history of AA, and hematologic test results. Results: Our results demonstrate that significantly more patients in the early-onset group had a personal history of atopic dermatitis or family history of AA. These findings are consistent with previous reports associating early-onset AA with autoimmune diseases and a family history of AA in different ethnic populations. Most of the serologic test values showed no significant differences between the groups and the results were considerably affected by age. Conclusion: This study is significant because it is a large group study in Korean AA patients, and Korean AA patients with an onset age before adolescence show similar clinical manifestations to other ethnic populations. (Ann Dermatol 26(6) 722∼726, 2014)
유아누리과정의 활동목표에 나타난 창의융합관련 요소 분석
전경원(Kyung Won, Jeon),조현서(Hyeon Seo, Jo),김누리(Noo Ree, Kim) 한국영재교육학회 2015 영재와 영재교육 Vol.14 No.1
본 연구는 3~5세의 누리과정 내에서 창의융합 교육활동이 전체 교육활동 중 어느 정도의 비율을 차지하는지 다각적으로 분석하여 유아교육 현장에서의 창의융합인재 양성을 위한 교육과정의 적용과 변화 가능성에 시사점을 제공하고자 한다. 이를 위해 3~5세 누리과정 교사용 지도서 32권을 면밀하게 분석결과 창의융합 교육활동은 전체 2116개의 활동중 총 231(10.92%)개였고, 생활주제별로 살펴보면 ‘봄‧여름‧가을‧겨울’이 39(17.89%)개로 가장 많았으며, ‘교통기관’이 10(5.56%)개로 가장 적게 나타났다. 이를 다시 연령별로 살펴본 결과, 연령이 증가할수록 창의융합 활동이 많은 것으로 확인되었다. 또한 활동유형별 창의융합 활동을 살펴보면 3세와 5세는 자유선택활동, 4세는 대소집단 활동의 수가 더 많은 것으로 나타났다. 누리과정 하위영역을 중심으로 창의융합 활동을 분석한 결과 예술경험과의 창의융합활동이 가장 많았으며, 반면에 신체‧운동 건강과 의사소통과의 창의융합 활동의 비율이 가장 낮았다. 이러한 결과를 중심으로 본 연구의 논의를 제시하였다. This research center has performed an analytic study of creative convergence related factors reflected in the activity goal of the teacher's manual for 3-5 year's “Nuri Curriculum” as announced for 2011. It was the intent of this study to use the results of this study to provide basic data related to how much creative convergence related factors can be applied and put into practice in the field of early childhood education. For this study, all activity objectives listed in book 32 of the Teacher's Manual for 3-5 year old “Nuri Curriculum” was selected for use as sampling. The analysis of the results involved creative convergence activities were full of activities, a total of 231 of 2116 (10.92%). And in the “Life Themes” ‘Spring Summer Autumn Winter' was the most activity with 39 (17.89%),’ ‘Transportation’ was the lowest in 10(5.56%) activities. And the more creative convergence activities were found to the elder years. In the activity types, free choice activities for 3 and 5 years the number of Large-small group activities were more. Creative convergence was the most activities associated with the arts. Exercise health and communication was the lowest. Finally, several suggestions to be considered for creative convergence activity in Nuri Curriculum were presented.
P011 : Clinical effect of an acidic moisturizer with physiologic lipid mixture for atopic dermatitis
( Dong Hye Kim ),( Noo Ri Lee ),( Na Young Yoon ),( Hye Rin Jeon ),( Jong Kyung Youm ),( Eung Ho Choi ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Since atopic dermatitis (AD) presents an impaired barrier and elevated skin pH of the lesion, barrier replacement therapy using physiologic lipid mixture (PLM) was proposed for AD. Also, maintenance of acidic stratum corneum (SC) prevented emergence of atopic lesion in AD mice. Objectives: To find out efficacy of an acidic moisturizer with PLM that is customized for AD. Methods: Total 34 AD patients were enrolled. An acidic moisturizer (pH 4.5) containing physiologic lipid mixture as active ingredients and a conventional moisturizer (pH 6.5) without PLM were applied on left and right sides of body separately for 4 weeks. Before and after their application, eczema area and severity index (EASI) and investigator`s global assessment (IGA) were measured on both upper and lower extremities. SC hydration, basal transepidermal water loss (TEWL) and skin surface pH were also measured on the non-lesion skin of forearm and calf. Results: EASI and IGA scores were significantly improved in the customized moisturizer site compared to the conventional moisturizer. No serious side effect was related with moisturizers. SC hydration were significantly increased by both moisturizers, and skin surface pH was decreased by both moisturizers, even though no significant differences between them. Conclusion: Collectively, an acidic moisturizer with physiologic lipid mixture customized for AD significantly improved their eczema lesions and SC hydration.
( Hae Jin Lee ),( Bo Kyung Kim ),( Min Young Jung ),( Dong Hye Kim ),( Noo Ri Lee ),( Na Young Yoon ),( Eung Ho Choi ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Maintenance of acidic pH in the stratum corneum (SC) is an important factor for normal skin barrier function. Long standing or repeated skin barrier damage followed by atopic dermatitis (AD) is the initial step of the atopic march that eventually progresses to respiratory allergies. Objectives: We determined whether an flaky tail mice(ft/ft, ma/ma) model and Nc/Nga mice can develop airway inflammation by topical application and nasal inhalation of a house dust mite, Dermatofagoides pteronyssinus (Dp) (defined as a novel ‘atopic march animal model’), and whether maintenance of an acidic SC environment by continuous application of acidic cream can interrupt these animal models of atopic march. Methods: During the course of Dp treatment to the atopic march murine models, an acidic cream with pH 2.8 and neutral cream(pH7.4) adjusted by citric acid and sodium hydroxide mixed with vehicle were applied twice daily. Repeated Dp applications on flaky tail mice induced AD skin lesions followed by respiratory allergies, defining it as an atopic march model. Results: Taken together, a novel atopic march animal model can be developed by repeated application of house dust mites on flaky tail mice, which supports the ‘outside-inside hypothesis’ Conclusion: The acidification of SC can be a novel intervention method to block the progress of the atopic march.
윤나영 ( Na Young Yoon ),김보경 ( Bo Kyung Kim ),이누리 ( Noo Ri Lee ),이해진 ( Hae Jin Lee ),최응호 ( Eung Ho Choi ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.3
Impetigo herpetiformis is a rare and acute pustular eruption that is often accompanied by fever and leukocytosis, which occurs during the 3rd trimester of pregnancy and usually resolves after delivery. In general, impetigo herpetiformis is regarded as a variant of psoriasis that has histopathologic features of pustular psoriasis. The lesions typically begin in the flexural areas, but rarely involve the mucous membranes. The face, palms, and soles are commonly spared. However, we report a 29-year-old woman with impetigo herpetiformis showing mucosal, face and palm involvement, atypical skin manifestation. (Korean J Dermatol 2013;51(3):206∼210)
( Myungsoo Jun ),( Na Young Yoon ),( Hye-young Wang ),( Minyoung Jung ),( Dong Hye Kim ),( Noo Ree Lee ),( Kyung-won Hong ),( Seong Jun Seo ),( Eunhee Choi ),( Hyeyoung Lee ),( Eung Ho Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Hereditary factor has been emphasized for a cause of atopic dermatitis (AD). AD-related gene variations are significantly different across ethnicities. Objectives: To develop a reverse blot hybridization assay (REBA) to detect genetic variations in Korean AD patients. Methods: REBA was performed to detect multiple variations of barrier- and immune- related genes simultaneously. Their frequencies were compared in mild AD, moderate to severe AD, and non-atopic control. Results: The mutant type (MT) of KLK7 was more frequent in AD significantly. The mixed type of FLG 3321delA and SPINK5 1156, and the MT of SPINK5 2475 were also more frequent in AD significantly. The MT and mixed type of DEFB1, mixed type of KDR, IL-5Ra, IL-9, IL12-RB1, 2, and MT of IL-13 were significantly more frequent in AD. It was predicted that the greater the number of gene variations, the higher odd ratio of AD occurrence. However, there was no significant correlation between the number of gene variations and the AD severity. Conclusion: A correlation between the KLK7 mutation and AD was identified firstly in Koreans. By the REBA, we found that more genetic variations could predict more AD occurrence. We also verified that the REBA can be applied to detect multiple AD-related gene variations easily, simply, and accurately.