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( Kwanghun Choi ),( Miae Kim ),( Sujin Moon ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Lymphangioleiomyomatosis (LAM) is a rare progressive cystic lung disease that mainly affects women of child-bearing age. Vascular endothelial growth factor-D (VEGF-D) was recently considered as a novel diagnostic marker for LAM. We evaluated diagnostic value of serum VEGF-D in Korean patients with LAM. Methods: Serum samples were prospectively obtained from patients with LAM (n = 8) and controls (IPF = 3, NSIP = 3, other cystic lung disease = 4, healthy volunteer = 3). VEGF-D was measured using enzyme-linked immunosorbent assay according to product instruction (R&D SYSTEMS). Results: Of total LAM patients, mean age was 37 years, and all were women. The serum level of VEGF-D was significantly increased in LAM patients compared with control group (mean values: LAM: 3,847.7 pg/mL, IPF: 234.5 pg/mL, NSIP: 227.1 pg/mL, other cystic lung disease: 364.1 pg/mL, healthy controls: 289.4 pg/ mL). In a receiver operating characteristics curve analysis, the optimal cut-off level for LAM diagnosis was 382.3 pg/mL (AUC 0.989, sensitivity 100%, specificity 92.3%, p-value < 0.001). In patients with LAM, 87.5% of patients had serum VEGF-D level over 690 pg/mL. Conclusions: Our findings suggest that serum VEGF-D may be useful in diagnosis of Korean patients with LAM.
The effect of 12-hydroxyeicosatetraenoic acid in idiopathic pulmonary fibrosis
( Kwanghun Choi ),( Miae Kim ),( Sujin Moon ),( Hyun Ju Yoo ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0
Background: Dysregulation of lipid metabolism has been implicated to be important in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the role of 12-hydroxyeicosatetraenoic acid (12S-HETE), a derivative of the arachidonic acid, is not well defined in the pathogenesis of IPF. Methods: The level of 12S-HETE was measured in human plasma (IPF = 76, control = 40) via liquid chromatography-mass spectrometry (LC-MS/MS). Western blot was performed to evaluate the protein expression of collagen type I (collagen I), alpha-smooth muscle actin (α-SMA) and arachidonate 12-lipoxygenase (ALOX12), lipoxygenase- type enzyme that produces 12S-HETE, in human lung tissues and 12S-HETE-treated human lung fibroblast (MRC-5) cells. The function of ALOX12 was confirmed by ALOX12 inhibitor (ML355) and siRNA in MRC-5 cells. Real-time quantitative polymerase chain reaction (RT-qPCR) was performed to evaluate the mRNA expression of epithelial-mesenchymal transition (EMT) markers such as CDH1, E-cadherin coding gene, SNAIL, SLUG and VIM, vimentin coding gene, in 12S-HETE-treated human lung bronchial alveolar epithelial (BEAS-2B) cells. Results: The level of 12S-HETE was increased in plasma of IPF patients compared with controls. The protein levels of collagen I, α-SMA, and ALOX12 were increased in human lung tissues of IPF patients compared with controls. The level of ALOX12 was increased in TGF-β1-treated MRC-5 cells. Moreover, 12S-HETE increased the protein expression of collagen I and α-SMA in MRC- 5 cells, and ML355 and ALOX12 siRNA decreased the protein levels of collagen I, and α-SMA in MRC-5 cells. 12S-HETE increased the mRNA expression levels of SNAIL, SLUG and VIM but, decreased the that of E-cadherin in BEAS-2B cells. Conclusions: Our findings suggest that 12S-HETE may have pro-fibrotic effects by activation of fibroblasts and be implicated as a potential therapeutic target in IPF.
The Effect of Rubicon on autophagy in idiopathic pulmonary fibrosis
( Kwanghun Choi ),( Hak-su Kim ),( Miae Kim ),( Jung Jin Hwang ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Rationale: Autophagy is catabolic process used to degrade and recycle proteins and organelles for cell survival. Dysregulated autophagy impacts the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, the mechanism is not well defined. We investigated the effect of RUN domain-containing Beclin1-interacting protein (Rubicon) which is a negative regulator of autophagosome maturation and endocytic pathway in IPF. Methods: Western blot was performed to assess protein expression in human lung tissue (IPF, control), MRC-5 and Beas-2B cells treated with or without TGF-β1 (10 ng/ml). We performed immunoprecipitation with Rubicon antibody to evaluate the interaction of UV radiation resistance-associated gene protein (UVRAG) and RAS-related GTP-binding protein 7 (Rab7). mRNA expression levels was measured via RT-qPCR. Rubicon was down-regulated using siRNA to assess its effect in MRC-5 and Beas-2B cells. Results: The levels of Rubicon was significantly increased in lung tissues of IPF patients compared with those of control lung. Treatment with TGF-β1 increased the level of Rubicon and recruited UVRAG and Rab7 into Rubicon in MRC-5 and Beas-2B cells. TGF-β1-induced mRNA expression level of Rubicon was significantly increased in MRC-5 and Beas-2B cells. The Rubicon siRNA reduced expression levels of collagen I and α-SMA in Beas-2B and MRC-5 cells treated with TGF-β1. Conclusions: We found that Rubicon was increased in human lung tissues and in vitro models of IPF and it suggests that Rubicon may contribute to suppression of autophagy in IPF.
소형 실내 와이브로 기지국을 위한 무선 파라미터 최적화
한광훈(Kwanghun Han),나민수(Minsoo Na),최영규(Youngkyu Choi),김동명(Dongmyoung Kim),최성현(Sunghyun Choi),한기영(Kiyoung Han),윤순영(Soonyoung Yoon) 한국통신학회 2008 韓國通信學會論文誌 Vol.33 No.7A
본 논문에서는 소형 와이브로 기지국을 실내에서 운용하고자 할 때 중앙 관리 서버를 통해 기지국의 무선 파라미터를 최적화하는 방법에 대해 논의한다. 운용요원에 의해 수동으로 기지국의 무선 파라미터가 설정되던 기존의 방식과는 달리, 원격 컨트롤러를 통해 자동으로 무선 파라미터들이 설정된다는 점에서 소형 와이브로 기지국은 자가 설정 기지국 (Self-Configurable Radio Access Station: SC-RAS)으로도 명명된다. 이러한 실내 SC-RAS 망을 도입하는 주된 목적이 전송 전력의 세기를 높여 건물 안에서 발생하는 음영지역 문제를 해결하기 위함이지만, 동시에 한 가지 고려해야 하는 점은 SC-RAS가 기존 와이브로 망에 미치는 신호 간섭을 최소화해야 한다는 것이다. 결과적으로 SC-RAS의 전송 전력과 주파수 (Frequency Assignment :FA)를 올바르게 선택하는 것이 매우 중요하다. 본 논문에서는 이 SC-RAS의 무선 파라미터 최적화 문제를 혼합 정수 계획법 (Mixed Integer Programming: MIP)을 이용하여 풀고, SC-RAS 설치 전과 후의 성능을 비교 및 분석한다. Compared with the existing cellular base station whose radio parameters are configured manually, the small base station named as self-configurable base station configures its radio parameters automatically by the central controller. When installing the self-configurable base station, it should be considered primarily that the seamless coverage for the target area is secured while the signal interference to the existing cellular service area must to be minimized. In order to achieve this, it is very important to select the correct radio parameters, e.g., transmission power and working frequency. In this work, we formulate and solve the optimization problem by using mixed integer programming to optimize the air parameter for the self-configurable base stations.