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Isolation of a New Carotenoid Pigment from an Undescribed Gorgonian of the Genus Muricella
Rho, Jung-Rae,Seo, Youngwan,Cho, Ki Woong,Song, Jun-Im,Shin, Jongheon 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-
Muricellaxanthin, a novel carotenoid pigment has been isolated by activity-guided separation from an undescribed gorgonian of the genus Muricella collected from Jaeju Island. Structure of this compound has been determined by a combination of spectral methods. Stereochemistry has been defined by interpretation of nOe data and comparison of CD data with related compounds. Muricellaxanthin exhibited potent lethality against brine-shrimp larvae.
Inhibition of VLA-4/VCAM-1-mediated Cell Adhesion by Triterpenoid Saponins from Bupleurum falcatum L
Lee, Seung-Woong,Kim, Min-Seok,Lim, Ju-Hwan,Chang, Jong-Sun,Ling, Jin,Bae, Ki-Hwan,Lee, Woo-Song,Rho, Mun-Chual Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.7
Discovery and isolation of compounds capable of blocking the interactions between VCAM-1 and VLA-4, a major pair of adhesion molecules contributing to the different steps of leukocyte migration across the endothelium in inflammatory responses, has been a major goal of this lab. Through bioactivity-guided fractionation, five saikosaponins were subsequently isolated from the methanol extracts of the roots of Bupleurum falcatum L. Their structures were elucidated by spectroscopic analysis ($^1H-$, $^{13}C$-NMR and 2D-NMR), as follows, saikosaponins: A (1); D (2); C (3); B3 (4); B4 (5). Compounds 1 and 2 inhibited interaction of sVCAM-1 and VLA-4 of THP-1 cells with respective $IC_{50}$ values of 7.8 and 1.7 ${\mu}M$. The aglycone structure of 2 also showed cell adhesion inhibitory activity with an $IC_{50}$ value of 21.1 ${\mu}M$. With these results, we suspect these two saikosaponins from the Bupleurum falcatum L. roots to be prime candidates for therapeutic strategies towards inflammation.
NEW FARNESYLHYDROQUINONE GLYCOSIDES FROM THE GORGONIAN EUPLEXAURA ANASTOMOSANS
SEO, YOUNGWAN,RHO, JUNG-RAE,CHO, KI WOONG,SHIN, JONGHEON 韓國海洋大學校 附設 海洋科學技術硏究所 2001 硏究論文集 Vol.10 No.2
Euplexides F(3) and G(4), novel farnesylhydroquinone glycosides, have been isolated as minor constituents of the gorgonian Euplexaura anastomosans. The structures of these compounds have been determined by combined spectroscopic methods. These compounds exhibited moderate cytotoxicity and inhibitory activity against PLA_2.
Sarcotragins A and B, new sesterterpenoid alkaloids from the sponge Sarcotragus sp.
Shin, Jongheon,Rho, Jung-Rae,Seo, Youngwan,Lee, Hyi-Seung,Cho, Ki Woong,Sim, Chung J. 한국해양대학교 해양과학기술연구소 2001 硏究論文集 Vol.10 No.1
Sarcotragins A (1) and B (2), two terpenoid alkaloids of an unusual structural class, have been isolated from the sponge Sarcotragus sp. collected from Jaeju Island, Korea. The structures of these compounds have been determined as linear trisnorsesterterpenes containing a phenethylamine lactam or the corresponding glycine lactam moiety by combined chemical and spectral methods. ⓒ 2001 Elsevier Science Ltd. All rights reserved.
노영우 ( Young Woo Rho ),김태원 ( Tae Won Kim ),이웅재 ( Woong Jae Lee ),서기범 ( Ki Beom Shur ),이증훈 ( Jeung Hoon Lee ),박장규 ( Jang Kyu Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1
Background: Vitiligo is an acquired depigmentary disorder characterized by loss of melanocytes from the epidermis. Autografting using the suction blistered epidermis technique is one of the surgical modalities of vitiligo treatment, and has been successfully used by several authots. Objective : The purpose of this study was to evaluate the effect of the autografting using the suction blistered epidermis technique for the treatment of vitiligo. Methods : 142 sites from 39 patients with vitiligo were treated with autografting using the suction blistered epidermis technique. The recipient sites were prepared by freezing with liquid nitrogen of the sites 48 hours prior to grafting. Results: Better results were seen in cases with the following Factors : a) cases where the disease had been present for more than 3 years b) the post-operative period had been Longer than a year c) the Lesional sites of the vitiligo were on the trunk and neck rather than the neck and extremities d) the vitiligo had affected the grabous rather than the hairy areas on the face. However, there were no differences between the clinical types(such as generalized, localized, and segmental) in the success rate of treatment. Preopera'tive PUVA or post operative PUVA also did not affect the statistical results. Conclusion: On autografting using the suction blistered epidermis, it is better to select the patients who have had the disease for more than 3 years, and graft the epidermis which has increased melanocytes by preoperative PUVA for good treatment results and even pigmentation. (Korean J Dermatol 1998;36(1): l03-106)