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- 저자 : ( Ki Ho Seol ) (검색결과 125 건)
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Seol, Ki Ho,Lee, Jeong Eun The Korean Society for Radiation Oncology 2016 Radiation Oncology Journal Vol.34 No.1
Purpose: To evaluate the patterns of nodal failure after radiotherapy (RT) with the reduced volume approach for elective neck nodal irradiation (ENI) in nasopharyngeal carcinoma (NPC). Materials and Methods: Fifty-six NPC patients who underwent definitive chemoradiotherapy with the reduced volume approach for ENI were reviewed. The ENI included retropharyngeal and level II lymph nodes, and only encompassed the echelon inferior to the involved level to eliminate the entire neck irradiation. Patients received either moderate hypofractionated intensity-modulated RT for a total of 72.6 Gy (49.5 Gy to elective nodal areas) or a conventional fractionated three-dimensional conformal RT for a total of 68.4-72 Gy (39.6-45 Gy to elective nodal areas). Patterns of failure, locoregional control, and survival were analyzed. Results: The median follow-up was 38 months (range, 3 to 80 months). The out-of-field nodal failure when omitting ENI was none. Three patients developed neck recurrences (one in-field recurrence in the 72.6 Gy irradiated nodal area and two in the elective irradiated region of 39.6 Gy). Overall disease failure at any site developed in 11 patients (19.6%). Among these, there were six local failures (10.7%), three regional failures (5.4%), and five distant metastases (8.9%). The 3-year locoregional control rate was 87.1%, and the distant failure-free rate was 90.4%; disease-free survival and overall survival at 3 years was 80% and 86.8%, respectively. Conclusion: No patient developed nodal failure in the omitted ENI site. Our investigation has demonstrated that the reduced volume approach for ENI appears to be a safe treatment approach in NPC.
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Factors Associated with the Quality of Life of Patients with Cancer Undergoing Radiotherapy
Ki Ho Seol,Su Hyun Bong,Dae Hun Kang,Jun Won Kim 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.1
Objective Approximately half of patients with cancer have comorbidities, such as adjustment disorder, major depressive disorder, and delirium. Radiotherapy can cause psychological problems, e.g., the fear of treatment and its side effects, anxiety, depression, and social isolation. Health-related quality of life (QoL) must be determined to evaluate the effectiveness of cancer treatment. We analyzed the clinical, psychological, and sociodemographic factors influencing the QoL of patients with cancer who were undergoing radiotherapy. Methods Twenty-six patients undergoing radiotherapy (10 male, 16 female) were included. Sociodemographic and clinical data were collected prior to radiotherapy. Psychosocial factors were assessed by self-reported questionnaires before, immediately after, and 3 months after radiotherapy. A multivariate regression analysis identified factors affecting QoL at each time point. Results Patients’ diagnoses were breast, cervical, prostate, endometrial, rectal, hypopharyngeal, laryngeal, liver, gallbladder, esophageal, ovarian, lung, and skin cancers. Before radiotherapy, better resilience was significantly associated with a higher QoL score (R2=0.199, p=0.033). Immediately after radiotherapy, financial difficulty was significantly associated with a lower QoL score (R2=0.274, p=0.010). Three months after radiotherapy, the presence of chronic disease (R2=0.398, p=0.002) and the severity of nausea and vomiting were significantly associated with a lower QoL score (R2=0.278, p=0.014). Conclusion Resilience, financial difficulty, the presence of chronic diseases, and the severity of nausea and vomiting significantly influenced the QoL of patients with cancer who were undergoing radiotherapy. Factors affecting QoL varied at each time point. Thus, patients with cancer should undergo regular mental health assessments, including assessments of QoL. Multidimensional (physical, psychological, and social) approaches and individualized time-based interventions are needed to improve the QoL of cancer patients undergoing radiotherapy.
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PET/CT planning during chemoradiotherapy for esophageal cancer
Ki Ho Seol,Jeong Eun Lee 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.1
Purpose: To evaluate the usefulness of positron emission tomography/computed tomography (PET/CT) for field modification during radiotherapy in esophageal cancer. Materials and Methods: We conducted a retrospective study on 33 patients that underwent chemoradiotherapy (CRT). Pathologic findings were squamous cell carcinoma in 32 patients and adenocarcinoma in 1 patient. All patients underwent PET/CT scans before and during CRT (after receiving 40 Gy and before a 20 Gy boost dose). Response evaluation was determined by PET/CT using metabolic tumor volume (MTV), total glycolytic activity (TGA), MTV ratio (rMTV) and TGA ratio (rTGA), or determined by CT. rMTV and rTGA were reduction ratio of MTV and TGA between before and during CRT, respectively. Results: Significant decreases in MTV (MTV2.5: mean 70.09%, p < 0.001) and TGA (TGA2.5: mean 79.08%, p < 0.001) were found between before and during CRT. Median rMTV2.5 was 0.299 (range, 0 to 0.98) and median rTGA2.5 was 0.209 (range, 0 to 0.92). During CRT, PET/CT detected newly developed distant metastasis in 1 patient, and this resulted in a treatment strategy change. At a median 4 months (range, 0 to 12 months) after completion of CRT, 8 patients (24.2%) achieved clinically complete response, 11 (33.3%) partial response, 5 (15.2%) stable disease, and 9 (27.3%) disease progression. SUVmax (p = 0.029), rMTV50% (p = 0.016), rMTV75% (p = 0.023) on intra-treatment PET were found to correlate with complete clinical response. Conclusion: PET/CT during CRT can provide additional information useful for radiotherapy planning and offer the potential for tumor response evaluation during CRT. rMTV50% during CRT was found to be a useful predictor of clinical response.
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PET/CT planning during chemoradiotherapy for esophageal cancer
Seol, Ki Ho,Lee, Jeong Eun The Korean Society for Radiation Oncology 2014 Radiation Oncology Journal Vol.32 No.1
Purpose: To evaluate the usefulness of positron emission tomography/computed tomography (PET/CT) for field modification during radiotherapy in esophageal cancer. Materials and Methods: We conducted a retrospective study on 33 patients that underwent chemoradiotherapy (CRT). Pathologic findings were squamous cell carcinoma in 32 patients and adenocarcinoma in 1 patient. All patients underwent PET/CT scans before and during CRT (after receiving 40 Gy and before a 20 Gy boost dose). Response evaluation was determined by PET/CT using metabolic tumor volume (MTV), total glycolytic activity (TGA), MTV ratio (rMTV) and TGA ratio (rTGA), or determined by CT. rMTV and rTGA were reduction ratio of MTV and TGA between before and during CRT, respectively. Results: Significant decreases in MTV ($MTV_{2.5}$: mean 70.09%, p < 0.001) and TGA ($TGAV_{2.5}$: mean 79.08%, p < 0.001) were found between before and during CRT. Median $rMTV_{2.5}$ was 0.299 (range, 0 to 0.98) and median $rTGAV_{2.5}$ was 0.209 (range, 0 to 0.92). During CRT, PET/CT detected newly developed distant metastasis in 1 patient, and this resulted in a treatment strategy change. At a median 4 months (range, 0 to 12 months) after completion of CRT, 8 patients (24.2%) achieved clinically complete response, 11 (33.3%) partial response, 5 (15.2%) stable disease, and 9 (27.3%) disease progression. $SUV_{max}$ (p = 0.029), $rMTV_{50%}$ (p = 0.016), $rMTV_{75%}$ (p = 0.023) on intra-treatment PET were found to correlate with complete clinical response. Conclusion: PET/CT during CRT can provide additional information useful for radiotherapy planning and offer the potential for tumor response evaluation during CRT. $rMTV_{50%}$ during CRT was found to be a useful predictor of clinical response.
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Computational analysis of hemodynamics using a two-dimensional model in moyamoya disease
Seol, Ho Jun,Shin, Duk Chul,Kim, Yoo Seok,Shim, Eun Bo,Kim, Seung-Ki,Cho, Byung-Kyu,Wang, Kyu-Chang Journal of Neurosurgery Publishing Group 2010 Journal of Neurosurgery: Pediatrics Vol.5 No.3
<B>Object</B><P>Bilateral intimal thickening of the distal internal carotid arteries (ICAs) and the development of many collateral vessels in the base of the brain characterize moyamoya disease (MMD). Although the etiology of and the reason why MMD is limited to the major intracranial vessels remain unclear, flow dynamics, such as shear stress, may be related to its smooth-muscle cell migration. Therefore, this study was performed to determine the local hemodynamic factor, which concerns the predominance of specific anatomical sites, such as the distal ICA in the early stage and the proximal posterior cerebral artery (PCA) in the advanced stage of MMD.</P><B>Methods</B><P>The authors simulated the hemodynamics in the circle of Willis using computational models of 2D geometries of the distal ICA and PCA. A finite-element commercial package, automatic dynamics incremental nonlinear analysis (ADINA), was used to simulate blood flow in these arteries.</P><B>Results</B><P>Numerical results demonstrated that shear stress was relatively low at the ICA region. The distribution of shear stress was related to the predisposing area of MMD.</P><B>Conclusions</B><P>Diminished shear stress may promote stenosis of the distal ICA, which is a major pathological region in MMD.</P>
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Cardiac free wall rupture caused Streptococcus pneumoniae pericarditis
( Ho Chan Sim ),( Sang Hoon Seol ),( Seung Hyun Park ),( Joo Won Lee ),( Bo Min Park ),( Dong Kie Kim ),( Ki Hoon Kim ),( Doo Il Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
A 59-year-old man with history of diabetes mellitus presented to the emergency department with chest discomfort and pain. On admission, electrocardiogram revealed low voltage and ST-segment elevation (II, II aVF). Chest x-ray showed marked cardiomegaly. Laboratory test revealed leukocytosis (23.12 x10^9/L), elevated serum C-reactive protein (CRP): 16.84 mg/dL). The cardiac markers (CK-MB, TnI) were normal range but pro-BNP was elevated (9263.8 pg/mL). Echocardiogram showed rupture of the left ventricular apex with larged pericaridial effusion (Fig.1). Chest computed tomography revealed large left ventricular aneurysm with rupture in the anteroinferior wall and associated hemopericardium (Fig.2). The patient underwent emergency cardiac surgery. There was large amount of prulent pericardial effusion and detection of Streptococcus pneumoniae in culture of pericardial effusion. It was successfully repaired surgically and the patient received antibiotics management. Patient``s symptom was improved and the patient made a good recovery. We report uncommon case of left ventricular free wall rupture caused by Streptococcus pneumonia pericarditis.
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New Separators Based on Non-Polyolefin Polymers for Secondary Lithium Batteries
Seol, Wan-Ho,Lee, Yong-Min,Lee, Jun-Young,Han, Young-Dal,Ryu, Myung-Hyun,Park, Jung-Ki The Korean Electrochemical Society 2007 한국전기화학회지 Vol.10 No.2
New porous separators based on non-polyolefin materials including the blend of poly (vinyl chloride) (PVC)/poly (vinylidene fluoride-co-hexafluoropropylene) (P(VdF-co-HFP)/poly(methyl methacrylate) (PMMA), and the porous separator based on poly (vinylidene fluoride) (PVdF) were prepared by phase inversion method. The porosity and morphology were controlled with phase inversion rate, which is governed by the relative content of non-solvent and solvent in coagulation bath. To enhance tensile strength, the solvent pre-evaporation and uni-axial stretching processes were applied. The ionic conductivity was increased with increasing stretching ratio, and tensile strength was increased with increasing solvent pre-evaporation time and stretching ratio. The 200% stretched PVdF separator showed 56 MPa of tensile strength, and the ionic conductivity of the stretched PVdF separator was $8.6{\times}10^{-4}\;S\;cm^{-1}\;at\;25^{\circ}C$.
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Vasomotor Symptoms: More Than Temporary Menopausal Symptoms
( Ki-jin Ryu ),( Hyuntae Park ),( Jin Seol Park ),( Yeon Woo Lee ),( Soo Young Kim ),( Hayun Kim ),( Youngmi Jeong ),( Yong Jin Kim ),( Kyong Wook Yi ),( Jung Ho Shin ),( Jun Young Hur ),( Tak Kim ) 대한폐경학회 2020 대한폐경학회지 Vol.26 No.3
Vasomotor symptoms (VMS), such as hot flashes and night sweating, are classic menopausal symptoms experienced by a majority of perimenopausal and postmenopausal women. VMS have received a great deal of attention due to their relationship with cardiometabolic risk. Further, accumulating evidence indicates that VMS are associated with an increased risk of several chronic diseases, including metabolic syndrome, type 2 diabetes mellitus, nonalcoholic fatty liver diseases, and osteoporosis in perimenopausal and postmenopausal women. These findings suggest VMS as biomarkers of impaired cardiometabolic conditions rather than just temporary symptoms in menopausal women, warranting further studies to confirm the casual relationship of VMS with these diseases and the exact underlying mechanism in this context.
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