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Kenichi Harano,Akihiro Hirakawa,Takayuki Kato,Keisuke Suzuki,Sachiko Watanabe,Noriyuki Katsumata 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.2
Objective: To assess the use of colony-stimulating factors (CSFs) in patients with ovarian cancer who receive adjuvant paclitaxel and carboplatin chemotherapy in clinical practice and to assess whether the frequency of CSF use differs among hospitals in Japan. Methods: CSF use in patients with ovarian cancer who received first-line paclitaxel and carboplatin was analyzed retrospectively using data from the Japanese hospitalization payment system. Results: A total of 1,050 patients at 104 hospitals were identified. The median age was 60 years (range, 22 to 88 years). Of these, 163 patients (15.5%) were diagnosed with neutropenia and 134 patients (12.8%) received CSFs. Among the patients who received CSFs, 125 (93%) received them for the treatment of neutropenia without fever and 1 received them for febrile neutropenia. In total, CSFs were administered for 272 cycles of chemotherapy. Among them, CSFs were used as treatment for neutropenia without fever in 259 cycles (95%), as prophylaxis (primary or secondary) in 12 cycles (4%), and as treatment for febrile neutropenia in 1 cycle. Among hospitals, a median of 4.0% of patients received CSFs with an interquartile range of 25% (Q1, 0%; Q3, 25%). A logistic random effects model showed that the variation in the proportion of patients receiving CSFs among the 104 hospitals was 2.0 (p<0.001), suggesting that the use of CSFs varied across hospitals. Conclusion: Most patients received CSFs for neutropenia without fever. Standardized and evidence-based use of CSFs is critically required among hospitals in Japan.
Drop Metastasis of Adrenocorticotropic Hormone-Producing Pituitary Carcinoma to the Cauda Equina
Kenichi Takeuchi,Yoko Hagiwara,Koichi Kanaya,Keiji Wada,Masahiro Shiba,Yoshiharu Kato 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.5
The diagnosis of pituitary carcinoma cannot be made easily histologically, and most cases of pituitary carcinoma are diagnosed only after the clinical detection of metastasis. Distant metastasis of pituitary tumor occurs in 0.1% to 0.2% of cases and has been reported in the liver, bone and central nervous system, with only one case of metastasis to the cauda equine reported. This study describes a rare case of the drop metastasis of adrenocorticotropic hormone-producing pituitary adenocarcinoma to the cauda equina, causing cauda equina syndrome.
DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers
Masafumi Kato,Masashi Takano,Morikazu Miyamoto,Naoki Sasaki,Tomoko Goto,Hitoshi Tsuda,Kenichi Furuya 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.1
Objective: Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not determined. Correlations between MMR-related protein expression and clinicopathological factors of endometrial cancers are analyzed in the present study. Methods: A total of 191 endometrial cancer tissues treated between 1990 and 2007 in our hospital were enrolled. Immunoreactions for MSH2, MLH1, MSH6, and PMS2 on tissue microarray specimens and clinicopathological features were analyzed retrospectively. Results: Seventy-six cases (40%) had at least one immunohistochemical alteration in MMR proteins (MMR-deficient group). There were statistically significant differences of histology, International Federation of Gynecology and Obstetrics (FIGO) stage, and histological grade between MMR-deficient group and the other cases (MMR-retained group). Response rate of first-line chemotherapy in evaluable cases was slightly higher in MMR-deficient cases (67% vs. 44%, p=0.34). MMR-deficient cases had significantly better progression-free and overall survival (OS) compared with MMR-retained cases. Multivariate analysis revealed MMR status was an independent prognostic factor for OS in endometrial cancers. Conclusion: MMR-related proteins expression was identified as an independent prognostic factor for OS, suggesting that MMR was a key biomarker for further investigations of endometrial cancers.
학생의 사회 인식 발달의 변용에 관한 조사적 연구 -중학교 역사 학습의 경우-
가토토시아키 ( Kato Toshiaki ),우메즈마사미 ( Umezu Masami ),마에다켄이치 ( Maeda Kenichi ),니미나오 ( Niimi Naoko ) 역사교육학회 2014 역사교육논집 Vol.52 No.-
The purpose of this study is to conduct a developmental research on junior high school students` social thinking abilities and judgmental abilities. Specifically, this study focused on the following two. First, we clarified the developmental changes in students` social cognition: social thinking abilities and judgmental abilities. Second, the relationships among the five predicted components of the social thinking skills and judgmental skills as a part of social science skill were examined. The five predicted components were factual judgment ability, inductive reasoning ability, deductive reasoning ability, social judgment ability, and critical thinking ability. The results showed that the students` inductive reasoning ability, deductive reasoning ability, social judgment ability, and critical thinking ability were positively related with their grade levels, and this tendency was especially prominent in their transition from the second to the third grades. Also, the sequential order in degree of difficulties (e.g. from inductive and deductive reasoning abilities to social judgment ability, followed by critical thinking ability) and the interrelationship among these five abilities were revealed.
Fukui, Norihito,Lee, Seung-Kyu,Kato, Kenichi,Shimizu, Daiki,Tanaka, Takayuki,Lee, Sangsu,Yorimitsu, Hideki,Kim, Dongho,Osuka, Atsuhiro Royal Society of Chemistry 2016 Chemical science Vol.7 No.7
<▼1><P>Oxidation of 10,15,20-triaryl Ni(<SMALL>II</SMALL>)-porphyrins bearing an electron-withdrawing substituent at the 5-position with DDQ and FeCl<SUB>3</SUB> gave 10,12- and 18,20-doubly phenylene-fused Ni(<SMALL>II</SMALL>)-porphyrins regioselectively.</P></▼1><▼2><P>Oxidation of 10,15,20-triaryl Ni(<SMALL>II</SMALL>)-porphyrins bearing an electron-withdrawing substituent at the 5-position with DDQ and FeCl<SUB>3</SUB> gave 10,12- and 18,20-doubly phenylene-fused Ni(<SMALL>II</SMALL>)-porphyrins regioselectively. A doubly phenylene-fused <I>meso</I>-chloro porphyrin thus prepared was reductively coupled to give a <I>meso</I>–<I>meso</I> linked dimer, which was further converted to a quadruply phenylene-fused <I>meso</I>–<I>meso</I>, β–β, β–β triply linked Zn(<SMALL>II</SMALL>)–diporphyrin <I>via</I> inner-metal exchange followed by oxidation with DDQ and Sc(OTf)<SUB>3</SUB>. As compared to the usual <I>meso</I>–<I>meso</I>, β–β, β–β triply linked Zn(<SMALL>II</SMALL>)-diporphyrin, this π-extended porphyrin dyad exhibits a smaller HOMO–LUMO gap and a larger two-photon absorption cross-section.</P></▼2>
Morikazu Miyamoto,Masashi Takano,Tomoko Goto,Masafumi Kato,Naoki Sasaki,Hitoshi Tsuda,Kenichi Furuya 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.1
Objective: Compared with serous adenocarcinoma (SAC), clear cell carcinoma (CCC) often shows chemo-resistance, which would potentially lead to a poor prognosis. On the other hand, there have been arguments over prognoses of CCC and SAC disease. In the present study, multivariate analysis to compare prognosis of CCC patients with that of SAC was aimed for the patients selected from central pathologic review. Methods: Between 1984 and 2009, a total of 500 ovarian cancer patients were treated at our university hospital. Among them,111 patients with CCC and 199 patients with SAC were identified through central pathological review. Overall survival and progression-free survival were compared using Kaplan-Meier method, and prognostic factors were investigated by multiple regression analyses. Results: Median age was 52 years for CCC and 55 years for SAC (p=0.03). The ratio of stage I patients were significantly higher in CCC compared with SAC (55% vs. 13%, p<0.01). Among evaluable cases, response rate was significantly lower in CCC than that in SAC (32% vs. 78%, p<0.01). No significant differences of progression-free survival and overall survival were observed in stage I patients; however, prognoses of CCC were significantly poorer than those of SAC in advanced-stage disease. In stage II-IV patients, not only residual tumors and clinical stages, but also clear cell histology were identified as predictors for poor prognosis. Conclusion: Clear cell histology was identified as a prognostic factor for advanced-stage ovarian cancers. Histologic subtypes should be considered in further clinical studies, especially for advanced epithelial ovarian cancers.