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Anti-aging Effect of Ganoderol A in UVA-irradiated Normal Human Epidermal Keratinocytes
Joong Hyun Shim 한국피부과학연구원 2021 아시안뷰티화장품학술지 Vol.19 No.1
목적: 본 연구는 Ganoderol A가 자외선에 의해 광노화가 유발된 인간각질형성세포의 항노화 효능을 확인하기 위해 수행되었다. 방법: 자외선으로 노화를 유도한 인각각질형성세포에서 Ganoderol A의 보습효과를 확인하기 위해 세포생존율, 보습에 관련된 유 전자 발현양상, 히알루론산 단백질의 생합성 정도를 확인하였다. 결과: Ganoderol A의 항노화 효능을 확인하기 위하여 AQP3, HAS2, FLG, LOR, KRT1, KRT10의 유전자 발현양상을 확인한 결과, 자외선 처리에 의해 감소된 AQP3와 HAS2 유전자의 발현이 Ganoderol A에 의해 증가하였다. 인각각질형성세포의 과각질화를 유도하는 KRT1과 KRT10의 발현이 Ganoderol A에 의해 감소하 였다. 또한 히알루론산 단백질의 생성이 Ganoderol A 처리에 의해 증가함을 확인하였다. 결론: 본 연구를 통해 Ganoderol A의 항노 화 효능을 확인하였고, 향후 Ganoderol A가 화장품 및 건강식품과 의약품의 개발에 활용될 수 있는 소재로서의 가능성을 확인하기 위해 추가연구가 필요할 것으로 사료된다. Purpose: This research was carried out to investigate the moisturizing effects of Ganoderol A on normal human epidermal keratinocytes (NHEKs). Methods: The moisturizing effects of Ganoderol A on NHEKs were measured by quantitative realtime RT-PCR to verify the gene expressions related to skin hydration, hyaluronic acid (HA)-enzyme-linked immunosorbent assay (ELISA) to detect HA production, and cell viability assays. Results: Ganoderol A increased the mRNA levels of the aquaporin 3 (AQP3 ) and hyaluronan synthase 2 (HAS2 ) genes and the production of HA in NHEKs. On the other hand, Ganoderol A decreased the mRNA levels of the keratin 1 (KRT1 ) and keratin 10 (KRT10 ) genes, which are known as differentiated keratinocyte markers, in NHEKs. Conclusion: This research showed the moisturizing effects of Ganoderol A. The results indicate that Ganoderol A can be a potent functional ingredient for skin hydration and anti-aging products. Further study is warranted regarding the use of Ganoderol A to develop not only cosmetics but also food and medicine.
( Joong Hyun Shim ) 한국조직공학·재생의학회 2015 조직공학과 재생의학 Vol.12 No.2s
Tissue specific stem cells were identified in adult stromal tissues. Ultraviolet (UV) radiation induces photo-aging on human skin. Because of UVA irradiation, it is thought that aging phenomenon such as skin elasticity reduction, wrinkle formation, and retardation of wound healing were occurred. In the present study we found that reduction of human dermal stem/progenitor cells (hDSPCs) functionality by UVA irradiation. We enriched hDSPCs from normal human dermal fibroblasts. To develop the screening system for potential anti-aging agent using hDSPCs, we treated UVA in the hDSPCs. To evaluate whether the stemness of hDSPCs is down-regulated in UVA treated hDSPCs, we measured the expression levels of SOX2, NANOG, and S100B, which are well-known representative dermal stem/progenitor cell markers. We observed that UVA-irradiated hDSPCs had lower expression levels of those markers compared with non-treated hDSPCs. Furthermore UVA irradiation reduces the multipotency of hDSPCs to differentiate into adipocytes, chondrocytes, and osteoblasts. In this study, we suggest that chronic aging model by UVA treated hDSPCs can be used for new screening system for anti-aging agents. Tissue Eng Regen Med 2015;12(Suppl 2):155-161
Anti-aging Effect of Sulfuretin in UVA-irradiated Normal Human Epidermal Keratinocytes
Joong Hyun Shim 한국피부과학연구원 2020 아시안뷰티화장품학술지 Vol.18 No.3
목적: 본 연구는 sulfuretin이 자외선에 의해 광노화가 유도된 인간각질형성세포의 항노화 효능을 확인하기 위하여 수행되었다. 방 법: 자외선으로 노화를 유도한 인각각질형성세포에서 sulfuretin의 보습효과를 확인하기 위하여 세포생존율, 보습에 관련된 유전자 발현양상, 히알루론산 단백질의 발현 정도를 확인하였다. 결과: Sufuretin의 항노화 효능을 확인하기 위하여 AQP3, HAS2, FLG, KRT1, KRT10의 유전자 발현을 확인한 결과, 자외선 조사에 의해 감소한 AQP3와 HAS2 유전자의 발현이 sulfuretin에 의해 증가 하였다. 인각각질형성세포의 과각질화를 유도하는 KRT1과 KRT10과 과분화의 표지인자인 FLG의 발현이 sufuretin에 의해 감소 하였다. 또한 히알루론산 단백질의 생성이 sulfuretin에 의해 증가함을 확인하였다. 결론: 본 연구를 통해 sulfuretin의 항노화 효능 을 확인하였고, 향후 sulfuretin이 화장품 및 의약품과 건강식품의 개발에 활용할 수 있는 소재로서의 가능성을 확인하기 위해 심도 있는 추가연구가 필요할 것으로 사료된다. Purpose: This study was carried out to investigate the epidermal moisturizing effects of sulfuretin on normal human epidermal keratinocytes (NHEKs). Methods: Epidermal moisturizing effects of sulfuretin on NHEKs were assessed by quantitative real-time RT-PCR to monitor the expression of genes related to skin hydration, hyaluronic acid (HA)-ELISA assays to detect HA production, and cell viability assays. Results: Sulfuretin increased the mRNA levels of the AQP3 /HAS2 /KRT1 /KRT10 genes and HA production in NHEKs. Conclusion: This study led to the identification of the epidermal moisturizing effects of sulfuretin. The results indicate that sulfuretin can be a potent cosmetic ingredient for skin moisturizing and antiaging products. However, further research is warranted regarding the use of sulfuretin to develop not only cosmetics but also medicines and food.
Shim, Ju Hyun,Park, Joong-Won,Kim, Ji Hoon,An, Min,Kong, Sun-Young,Nam, Byung-Ho,Choi, Joon-Il,Kim, Hyun Beom,Lee, Woo Jin,Kim, Chang-Min Japanese Cancer Association 2008 CANCER SCIENCE Vol.99 No.10
<P>We prospectively investigated the association between a change of serum vascular endothelial growth factor (VEGF) level after transcatheter arterial chemoembolization (TACE) and hepatocellular carcinoma (HCC) patient prognosis. The study involved 147 patients with unresectable HCC treated at the National Cancer Center, Korea, between July and December 2005. Serum samples were collected from each patient before TACE, and 1-2 days and 1 month after TACE. Serum VEGF concentrations were measured using an enzyme-linked immunosorbent assay (ELISA). The log(e)(VEGF/platelets) increased transiently 1-2 days after TACE and declined thereafter. Frequency of previous TACE did not correlate with log(e)(VEGF/platelets). This study found that log(e)(VEGF/platelets) 1-2 days after TACE, but not log(e)(VEGF/platelets) at baseline, was strongly correlated with vascular or nodal invasion and AJCC (American Joint Committee on Cancer)/UICC (International Union Against Cancer) stage, and was significantly greater in men. Relative changes in serum VEGF/platelet levels 1-2 days after TACE (DeltaVEGF) > 0.5 were directly correlated with tumor size, vascular invasion and modified UICC and AJCC/UICC stage (P < 0.05 for each). Additionally, DeltaVEGF > 0.5 was significantly correlated with newly developed extrahepatic metastases one and six months after TACE (P = 0.005 and 0.003, respectively). Progression free survival of patients with DeltaVEGF > 0.5 was significantly worse (P < 0.001) and DeltaVEGF > 0.5 was an independent prognostic factor for PFS (hazard ratio, 3.111; P < 0.001). This study showed that a high increment in serum VEGF level 1-2 days after TACE in HCC patients was associated with distant metastasis and unfavorable outcomes.</P>