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Lee,Jongkook 한국유통과학회 2019 KODISA ICBE (International Conference on Business Vol.2019 No.-
Regarding restructuring value factor of Lotte Mart, key strategies could be proposed as follows; First of all, Lotte Mart would be recommended to launch the lowest price discount store, as new category to be created, with enhancing brand image of cheaper price to take a lead the market ahead of Bic C and Vin Mart. Another strategy is expanding business scale. Lotte Mart would be recommended to expand new openings focusing on the commercial area of Hanoi, the capital city of Vietnam, to overcome less numbers of stores. (Lotte Mart: 2 stores, Bic C: 13 stores in North part of Vietnam) At the last point, PB (Private Brand) developing needs to be expanded to enhance the competitiveness of product better than Bic C and Vin Mart for changing perception of local customer. Lotte Mart should establish the strategy following direction to zero base approach from the customer viewpoint, strengthen the product innovation having attraction to customers and accumulating internal capabilities.
Lee, Song Yi,Lee, Jeong-Jun,Park, Ju-Hwan,Lee, Jae-Young,Ko, Seung-Hak,Shim, Jae-Seong,Lee, Jongkook,Heo, Moon Young,Kim, Dae-Duk,Cho, Hyun-Jong Elsevier 2016 Colloids and Surfaces B Vol.145 No.-
<P><B>Abstract</B></P> <P>Nanocomposite (NC) based on hyaluronic acid-ceramide (HACE) and Soluplus (SP) was fabricated by electrospraying for the tumor-targeted delivery of resveratrol (RSV). Amphiphilic property of both HACE and SP has been used to entrap RSV in the internal cavity of NC. Electrospraying with established experimental conditions produced HACE/SP/RSV NC with 230nm mean diameter, narrow size distribution, negative zeta potential, and >80% drug entrapment efficiency. Sustained and pH-dependent drug release profiles were observed in drug release test. Cellular uptake efficiency of HACE/SP NC was higher than that of SP NC, mainly based on HA-CD44 receptor interaction, in MDA-MB-231 (CD44 receptor-positive human breast cancer) cells. Selective tumor targetability of HACE/SP NC, compared to SP NC, was also confirmed in MDA-MB-231 tumor-xenograted mouse model using a near-infrared fluorescence (NIRF) imaging. According to the results of pharmacokinetic study in rats, decreased <I>in vivo</I> clearance and increased half-life of RSV in NC group, compared to drug solution group, were shown. Given that these experimental results, developed HACE/SP NC can be a promising theranostic nanosystem for CD44 receptor-expressed cancers.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Electrosprayed nanocomposite (NC) was fabricated for the delivery of resveratrol. </LI> <LI> Resveratrol was incorporated into hyaluronic acid-ceramide (HACE) and Soluplus-based NC. </LI> <LI> Interaction between hyaluronic acid and CD44 receptor was used for tumor targeting. </LI> <LI> <I>In vivo</I> tumor targetability of developed NC was confirmed by optical imaging. </LI> <LI> <I>In vivo</I> clearance of drug from HACE/Soluplus NC was reduced compared to drug solution. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jongkook Jung,Seungtae Kim,Sooyeon Lee,Hunsung Kim,Myeong-Pyo Jung,Sejin Kim,Chang-Kyu Park,Eunhee Lee,Joon-Ho Lee 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.05
This study was conducted to explore if the ground beetle (Coleoptera: Carabidae) can be used as an indicator classifying habitat types. Thirteen land use types were selected as survey sites in Jeonju. Ground beetles were collected by 3 pitfall traps (15 cm diameter) for each site from June 20 to September 22, 2008. Pitfall traps were replaced at one month interval. Total 919 ground beetles of 31 species belonging to 17 genera were collected. Land use types were classified and ordinated by two-way indicator species analysis and detrended correspondence analysis. Land use types were classified and ordinated into two major groups, forest and non-forest, by Synuchus nitidus and Dolichus halensis. Two major groups were subdivided into 4 end groups; forest, riverside, upland and other sites. Other sites group including 4 sites; levee, public garden, outfield and manufacturing area were not coincided with land use types. Nevertheless, ground beetles appear to be used as indicators of habitat types.
A Small-Molecule Antagonist of the Hedgehog Signaling Pathway
Lee, Jongkook,Wu, Xu,Pasca di Magliano, Marina,Peters, Eric C.,Wang, Yan,Hong, Jiyong,Hebrok, Metthias,Ding, Sheng,Cho, Charles Y.,Schultz, Peter G. Wiley-VCH Verlag 2007 Chembiochem Vol. No.
<B>Graphic Abstract</B> <P>Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK184 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling. <img src='wiley_img/14394227-2007-8-16-CBIC200700403-content.gif' alt='wiley_img/14394227-2007-8-16-CBIC200700403-content'> </P>
Lee, Ji Hyun,Park, Han Na,Ganganna, Bogonda,Jeong, Ji Hye,Park, Sung-Kwan,Lee, Jongkook,Baek, Sun Young Informa UK (TaylorFrancis) 2016 Food additives & contaminants. Part A. Chemistry, Vol.33 No.6
<P>A newtadalafil analoguewas found, alongwith nortadalafil, using HPLC-DAD during the inspection of a health product sold without official approval. The analogue was separated using a semi-preparative HPLC system and its structure was determined by a combination of mass spectrometry and NMR spectroscopy. The compound was identified as a tadalafil analogue in which the N-methyl group of tadalafil was replaced with a tadalafil precursor moiety. Nuclear Overhauser effect spectroscopy experiments suggested a cis-relationship between the substituents on a piperidine ring in the tadalafilmoiety.</P>
Lee, Ji Hyun,Park, Han Na,Park, Hyoung Joon,Kim, Nam Sook,Park, Sung-Kwan,Lee, Jongkook,Baek, Sun Young Informa UK (TaylorFrancis) 2018 Food additives & contaminants. Part A. Chemistry, Vol.35 No.1
<P>A new minoxidil analogue was detected in an illegal dietary supplement advertised as a hair-growth treatment. The analogue was identified using ultra-performance liquid chromatography (UPLC), high-resolution mass spectrometry (LC-HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. The compound was structurally elucidated as a minoxidil analogue in which the piperidinyl group of minoxidil was replaced with a pyrrolidinyl group corresponding to a molecular formula of C8H13N5O. The new analogue has been named triaminodil. As this is the first report of the compound, there are no chemical, toxicology or pharmacological data available.</P>
FMS-like tyrosine kinase 3 inhibitors: a patent review
Lee, Jongkook,Paek, Seung-Mann,Han, Sun-Young Informa UK, Ltd. 2011 Expert opinion on therapeutic patents Vol.21 No.4
<P><B><I>Introduction:</I></B> Flt3 (FMS-like tyrosine kinase 3) has been presented as a target for novel anti-leukemic drugs because Flt3 mutations have been observed in acute myeloid leukemia (AML) cells. Due to both the poor efficacy and high toxicity of current standard AML therapies, there is an unmet need for new, improved therapies. Flt3 inhibitors have great potential to address this with mutated Flt3.</P><P><B><I>Areas covered:</I></B> This paper provides a comprehensive review of the Flt3 inhibitor patents currently available. Information from original research articles in peer-reviewed journals and current clinical developments from several resources is also described.</P><P><B><I>Expert opinion:</I></B> Our understanding of Flt3 inhibitors has been increased by findings from recent preclinical and clinical trials. Some Flt3 inhibitors show good efficacy in AML patients, but relapse and resistance to these inhibitors are still unavoidable. To address these problems, structurally diverse inhibitors, which exhibit inhibitory activities against both wild type and mutated Flt3, should be explored.</P>
Lee, Ji Hyun,Park, Han Na,Kang, Gihaeng,Kim, Nam Sook,Park, Seongsoo,Lee, Jongkook,Kang, Hoil The Korean Society of Analytical Science 2019 분석과학 Vol.32 No.2
Recently, a number of adulterated products, which are advertised as hair-growth enhancer have been emerged among those who suffer hair loss disease. For continuous control of illegal products, in this study, a rapid and sensitive method for simultaneous screening of 12 compounds that enhance hair-growth was established to protect public health by ultrahigh-performance liquid chromatography coupled to quadrupole-orbitrap mass spectrometry (UHPLC-Q-Orbitrap-MS). Fragmentation pathways of them were proposed based on $MS^2$ spectral data obtained using the established method. In this analysis, the LODs and LOQs ranged from 0.05 to 50 ng/mL and from 0.17 to 167 ng/mL, respectively. The square of the linear correlation coefficient ($R^2$) was determined as more than 0.995. The intra- and inter-assay accuracies were respective 88-112 % and 88-115 %. Their precision values were measured within 5 % (intra-day) and 10 % (inter-day). Mean recoveries of target compounds in adulterated products ranged from 84 to 115%. The relative standard deviation of stability was less than 12 % at $4^{\circ}C$ for 48 h. The method was employed to screen 14 dietary supplements advertised to be effective for the treatment of hair loss. Some of the products (~21 %) were proven to contain synthetic drugs that promote hair growth such as triaminodil, minoxidil, and finasteride.
Lee, Ji Hyun,Jung, Aeran,Park, Han Na,Lee, Changhee,Mandava, Suresh,Lim, Sung-jun,Lim, Byoung-bok,Park, Sung-Kwan,Lee, Jongkook,Kang, Hoil Elsevier 2018 Forensic Science International Vol.291 No.-
<P><B>Abstract</B></P> <P>Illicit psychoactive substances have threatened public health worldwide. An active metabolite of ADB-CHMINACA and MDMB-CHMINACA was identified for the first time in a powder-type product found in an airmail package. The structure of compound 1 was elucidated by a combination of gas chromatography-mass spectrometry (GC–MS), liquid chromatography-high resolution mass spectrometry (LC-HRMS), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. Compound 1 was proven to be an analogue of MDMB-CHMINACA, an indazole-based synthetic cannabinoid. The methyl ester group in MDMB-CHMINACA was replaced with a carboxylic acid group in compound 1. Compound 1 was determined as 2-[1-(cyclohexylmethyl)-1<I>H</I>-indazole-3-carboxamido]-3,3-dimethylbutanoic acid and named as DMBA-CHMINACA.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new indazole-3-carboxamide class synthetic cannabinoid was identified. </LI> <LI> Compound 1 was named as DMBA-CHMINACA according to the EMCDDA guideline. </LI> <LI> DMBA-CHMINACA is a hydrolysed form of MDMB-CHMINACA. </LI> <LI> DMBA-CHMINACA is a potential CB1 and CB2 agonist. </LI> <LI> DMBA-CHMINACA can work as a synthetic precursor of several synthetic cannabinoids. </LI> </UL> </P>