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Aryun Kim(Aryun Kim),Jeonghwan Lee(Jeonghwan Lee),Hansol Moon(Hansol Moon),Chulhan Kim(Chulhan Kim),Min Young Yoo(Min Young Yoo),Woo Yoon Park(Woo Yoon Park),Won Dong Kim(Won Dong Kim),Young-Seok Seo( 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Purpose: We aimed to determine whether low-dose radiotherapy (LDRT) is effective in patients with Alzheimer disease (AD). Materials and Methods: We included patients according to the following criteria: probable Alzheimer's dementia according to the New Diagnostic Criteria for Alzheimer’s Disease; confirmation of amyloid plaque deposits on baseline amyloid positron emission tomography (PET); a Korean Mini-Mental State Examination 2nd edition (K-MMSE-2) score of 13–26; and a Global Clinical Dementia Rating (CDR) score of 0.5–2 points. LDRT was performed six times at 0.5 Gy each. Post-treatment cognitive function tests and PET-CT examinations were performed to evaluate efficacy. The medication for AD treatment was maintained throughout the study period. Results: At 6 months after LDRT, neurological improvement was seen in 20% of patients. Patient #2 showed improvement in all domains of the Seoul Neuropsychological Screening Battery II (SNSB-II). Moreover, the K-MMSE-2 and Geriatric Depression Score-Short Form scores improved from 20 to 23 and from 8 to 2, respectively. For patient #3, the CDR score (sum of box score) improved from 1 (4.0) to 1 (3.5) at 3 months follow-up. Moreover, the Z scores for language and related functions, memory, and frontal executive function improved to -2.56, -1.86, and -1.32, respectively at the 6-month follow-up. Two patients complained of mild nausea and mild hair loss during LDRT, which improved after treatment. Conclusion: One of the five patients with AD treated with LDRT experienced a temporary improvement in SNSB-II. LDRT is tolerable in patients with AD. We are currently under follow-up and will conduct cognitive function tests after 12 months after LDRT. A large-scale randomized controlled trial with a longer follow-up period is warranted to determine the effect of LDRT on patients with AD.
( Jeonghwan Lee ),( Yong Chul Kim ),( Soie Kwon ),( Lilin Li ),( Sohee Oh ),( Do Hyoung Kim ),( Jung Nam An ),( Jang-hee Cho ),( Dong Ki Kim ),( Yong-lim Kim ),( Yun Kyu Oh ),( Chun Soo Lim ),( Yon Su 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.4
Background: The effect of each health-related quality of life (HRQOL) component on hemodialysis prognosis has not been well studied. We aimed to investigate the clinical factors associated with HRQOL and the effect of HRQOL after dialysis initiation on long-term survival in an Asian population. Methods: A total of 568 hemodialysis patients were included from a nationwide prospective cohort study. HRQOL was evaluated using the Kidney Disease Quality of Life (KDQOL) Short FormTM 1.3 at 3 months after dialysis initiation. The effect of each KDQOL item score on mortality was analyzed. Multivariable Cox analysis was performed after adjusting for age, sex, modified Charlson comorbidity index, and causes of primary kidney disease. Results: Old age, diabetes mellitus, high comorbidities, and low serum albumin levels were associated with poor physical health status. Decreased urine output was associated with both poor physical and mental health status. The scores of 3 indices in the kidney disease domain (effect of kidney disease, social support, and dialysis staff encouragement) showed significant associations with mortality, as did the 3 indices (physical function, physical role limitation, and body pain) in the physical health domain. Neither the 4 indices in the mental health domain nor the mental composite score showed a significant association with mortality. However, a high physical composite score was associated with decreased overall patient mortality (P = 0.003). The effect of physical composite score on survival was prominent among young or middle-aged groups. Conclusion: Poor physical health status 3 months after hemodialysis start correlates significantly with overall mortality.
Kim, Jeonghwan,Ramasamy, Thiruganesh,Choi, Ju Yeon,Kim, Ssang Tae,Youn, Yu Seok,Choi, Han-Gon,Yong, Chul Soon,Kim, Jong Oh Elsevier 2017 Colloids and Surfaces B Vol.150 No.-
<P><B>Abstract</B></P> <P>In this study, a core-shell type polypeptide-based lipid nanocapsule was developed to enhance anticancer efficacy of erlotinib in non-small cell lung cancers. Mean particle size of PEGylated polypeptide-lipid nanocapsules (PLN) for erlotinib (ERL) delivery was ∼200nm with an effective surface charge of −20mV. Protective PEGylated polypeptide layer acted as a molecular fence and effectively controlled the diffusion of erlotinib from the lipid nanocapsule core, whereas pH-responsiveness of poly(L-aspartic acid) accelerated the release of erlotinib in acidic conditions. Blank lipid nanocapsules showed excellent biocompatibility. ERL-loaded PLN (ERL-PLN) showed dose-dependent cytotoxicity in NCI-H358 and HCC-827 lung cancer cells. ERL-PLN treatment resulted in a superior tumor regression profile in a xenograft tumor model, compared to free ERL and control, suggesting high therapeutic efficacy. ERL-PLN-treated mice showed 5- and 2-fold smaller tumor volume compared to control and free ERL groups, respectively. Based on these results, PLN provide a promising drug delivery approach for lung cancer therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Erlotinib-loaded lipid nanocapsule consists of inner lipid core and outer polymeric shell. </LI> <LI> Protective PEGylated polypeptide layer effectively controlled the release of anticancer drug. </LI> <LI> It showed marked effect on NCI-H358 and HCC-827 lung cancer cells. </LI> <LI> Core-shell type polypeptide-based lipid nanocapsules enhanced the antitumor efficacy of erlotinib. </LI> <LI> PEGylated polypeptide-based nanocapsules offers a promising approach in lung cancer therapy. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Backki Kim,Dong-Gwan Kim,Gileung Lee,Jeonghwan Seo,Ik-Young Choi,Beom-Soon Choi,Tae-Jin Yang,Kwang soo Kim,Joohyun Lee,Joong Hyoun Chin,Hee-Jong Koh 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Tongil (IR667-98-1-2) rice, developed in 1972, is a high-yielding rice variety derived from a three-way cross between indica and japonica. Tongil contributed to staple food self-sufficiency of Korea, an achievement that was termed the ‘Korean Green Revolution’. In this study, we analyzed the nucleotide-level genome structure of Tongil rice and compared it to those of the parental varieties. A total of 17.3 billion Illumina Hiseq reads, 47× genome coverage, were generated from Tongil rice. Three parental accessions, two indica and one japonica types, of Tongil rice were also sequenced for approximately 30x genome coverage. A total of 2,149,991 SNPs were detected between Tongil and Nipponbare; the average SNP frequency of Tongil was 5.77 per kb. Genome composition based on the SNP data by comparing with the three parental genome sequences on sliding window of Nipponbare genome sequence revealed that 91.8% of the Tongil genome originated from the indica parents and 7.9% from the japonica parent, different from the theoretical expectation in a three-way cross, i.e., 75% indica and 25% japonica parental origins on average. Copy number of SSR motifs, ORF gene distribution throughout the whole genome, gene ontology (GO) annotation, yield-related QTLs or gene locations, and polymorphic transposon insertions were also comparatively analyzed between Tongil and parents using sequence-based tools. The results indicated that each genetic factor was transferred from parents into Tongil in proportion to the whole-genome composition. The Tongil rice is the first successful superior cultivar derived from indica × japonica hybridization in Korea. Defining of genome structure demonstrates that the Tongil genome is composed mostly of the indica genome with a small proportion of japonica genome introgression. This work was supported by a grant from the Next-Generation BioGreen 21 Program (Plant Molecular Breeding Center No. PJ008125), Rural Development Administration, Republic of Korea.
유사휘발유가 가솔린 엔진(흡기밸브)의 퇴적물에 미치는 영향에 대한 연구
김정환(Jeonghwan Kim),김성우(Sungwoo Kim),박종배(Jongbae Park),김재권(Jaigeoun Kim),정충섭(Choongsub Jung) 한국자동차공학회 2009 한국자동차공학회 학술대회 및 전시회 Vol.2009 No.11
자동차 배출가스 발생의 주요 원인은 자동차 엔진 자체의 결함 요인과 자동차에 공급되고 있는 연료의 품질 문제 요인으로 나눌 수 있다. 그러나 현재 비약적인 엔진 기술의 발전으로 인하여 자동차 엔진 자체의 결함으로 인한 배출가스 발생 요인은 많이 줄어든 실정이고, 오히려 연료의 품질 문제로 인한 요인의 중요성이 증대되고 있다. 본 연구에서는 지속적으로 치솟고 있는 원유가격 상승에 따라 급격히 확산, 증가되고 있는 유사휘발유의 제조ㆍ유통은 석유유통질서 파괴, 경제적 손실 등의 사회적인 문제를 일으키고 있는 것뿐만 아니라, 유해 오염물질의 과다 배출로 인한 환경오염문제가 발생되어 국민 건강에 악영향을 끼치고 있다. 따라서, 유사석유제품의 단시간 사용에 따른 폐해(배출가스 악화 등) 뿐만 아니라 장시간 사용에 따른 폐해(차량 손상 등)가 심각할 것으로 판단됨에 따라 냉시동의 운전성, 배출가스 악화, 출력 손실 및 연비 손실 등을 일으키는 유사휘발유가 흡기밸브 및 연소실 내 퇴적물 생성에 미치는 영향에 대하여 규명하였다.
점소성 전해질에서의 전하 선택적 표면 위에서 발생하는 전기수력학적 점성 핑거링
김정환(Jeonghwan Kim),김준현(Junhyun Kim),김민영(Minyoung Kim),곽노균(Rhokyun Kwak) 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.12
Viscous fingering is one of the widely known surface instability phenomena. This instability occurs on interface of two different fluids, when a less viscous fluid displaces a more viscous one. Unlike the methods that have caused this instability so far, such as direct injection of fluids, in this paper, we induce viscous fingering by electroconvective vortex in a single viscoplastic fluid and visualize it for the first time. For predicting this instability, we define a new dimensionless number Pe<SUP>*</SUP>, which is proportional to the strength of electroconvective vortex. We successfully clarify relationships between Pe<SUP>*</SUP> and the characteristics of fingering: propagation speed of fingering and frequency of occurring.