신농양에 동반된 척추 경막외 농양 1예

엄흥식,김준재,김현수,박영정,최상봉,박원도,김상현 인제대학교 2006 仁濟醫學 Vol.27 No.-

Spinal epidural abscess is an uncommon but readily diagnosable and treatable potential cause of paralysis and death. The incidence of spinal epidural abscess is approximately one to two cases per 10,000 hospital admissions in the United States. The symptoms of spinal epidural abscess are varied but include lower back pain, fever, local tenderness and neurological deficit, especially in such high risk groups as patients with diabetes, intravenous drug abuse, chronic renal failure, alcoholism, liver disease and immunocompromization. Infections of the epidural space originate from contiguous spread or via hematogenous routes from a distant source. Cutaneous sites of infection are the most common remote sources, especially in intravenous drug users. S. aureus accounts for most spinal epidural abscess infections, followed by streptococci and gram-negative anaerobes. We here report a case of spinal epidural abscess in renal abscess patient complaining of fever and back pain. A 71-year old female patient was admitted to epigastric pain and oliguria. She had been diagnosed as acute renal failure and treated with hydration. After third hospital days, she shows a persistent fever and drowsy mentality. Abdominal computed tomography demonstrated renal abscess. She was treated with intravenous antibiotics, third cephalosporin. Blood cultures and urinary culture revealed Escherichia, coli. After fourteenth hospital days, she developed back pain, muscle weakness and decreased sensation of lower extremities. Spine MRI demonstrated spinal epidural abscess with spinal cord compression. Surgical drainage with laminectomy was performed. After treatment of intravenous antibiotics and surgical drainage, she discharged with improved back pain and neurological symptom.

급성신부전, 막성 신병증과 간염이 합병된 제2기 매독1례

김현수,박영정,엄흥식,이활연,최상봉,김상현,박원도 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Syphilis is a systemic infectious disease infected by the spirochete Treponema pallidum. It shows variable clinical manifestations. Nephrotic syndrome from secondary syphilis is a rare complication in Korea. One letter was reported before in Korea. This report describes 64-year-old male patient with syphilis presented with feature of hepatitis, acute renal failure and nephrotic syndrome. A diagnosis of secondary syphilis was done by the serologic test for syphilis. After diagnosis of syphilis, we supposed that nephrotic syndrome and hepatitis were the complication of secondary syphilis and performed a kidney biopsy. A kidney biopsy revealed membranous nephropathy characterized by subepithelial deposits involving the glomerular basement membrane and effacement of epithelial foot-process on electron microscopy. The patient was treated with intramuscular benzathine penicillin 2.4 million units. Proteinuria, renal failure, hepatitis were resolved in 3 weeks after penicillin therapy.

수종의 골연하치주낭 치료법의 임상적 효과에 관한 연구

엄흥식(Um, Heung-Sik) 대한치과의사협회 1994 대한치과의사협회지 Vol.32 No.9

20대의 치주염 진행에 대한 2년간의 종적연구

엄흥식,Um, Heung-Sik 대한치주과학회 1998 Journal of Periodontal & Implant Science Vol.28 No.3

The purpose of this investigation was to examine the pattern of progression of periodontitis and the change in the extent and severity of the periodontal condition in young adults. Fourteen subjects with periodontitis, 11 males and 3 females in the age range 22-26, participated in the study. Following a baseline examination, the subjects were monitored for gingival index, probing pocket depth, gingival recession, probing attachment level and radiogrphic crestal bone height for 24 months without therapy. Re-examination were performed after 12 and 24 months. Gingival index, probing pocket depth, gingival recession and probing attachment level were assesed at 6 locations per tooth, and crestal bone height was assessed by subtraction radiography. The results from the follow-up examination revealed that the subjects underwent minor changes with respect to a series of different clinical parameters. The mean values of gingival index was improved, however, the mean values of probing pocket depth, gingival recession, probing attchment level and crestal bone height showed no significant change between baseline and the re-examination after 1 and 2 years.

Chlorhexidine을 이용한 치주낭 세척이 치주염에 이환된 치근내 침투세균에 미치는 영향

엄흥식,한수부,Um, Heung-Sik,Han, Soo-Boo 대한치주과학회 1989 Journal of Periodontal & Implant Science Vol.19 No.2

Porphyromonas gingivalis와 Tannerella forsythia의 응집반응

엄흥식,이석우,박재홍,Um, Heung-Sik,Lee, Seok-Woo,Park, Jae-Hong,Nauman, R.K. 대한치주과학회 2006 Journal of Periodontal & Implant Science Vol.36 No.1

Dental plaque, a biofilm consisting of more than 500 different bacterial species, is an etiological agent of human periodontal disease, It is therefore important to characterize interactions among periodontopathic microorganisms in order to understand the microbial pathogenesis of periodontal disease. Previous data have suggested a synergistic effect of tow major periodontal pathogens Porphyromonas gingivalis and Tannerella forsythia in the periodontal lesion. In the present study, to better understand interaction between P. gingivalis and T. forsythia, the coaggregation activity between these bacteria was characterized. The coaggregation activity was observed by a direct visual assay by mixing equal amount (1 ${\times}$ $10^9$)of T. forsythia and P. gingivaJis cells. It was found that the first aggregates began to appear after 5-10 min, and that the large aggregates completely settled within 1 h. Electron and epifluorescence microscopic studies confirmed cell-cell contact between two bacteria. The heat treatment of P. gingivalis completely blocked the activity, suggesting an involvement of a heat-labile component of P. gingivalis in the interaction. On the other hand, heat treatment of T. forsythia significantly increased the coaggregation activity; the aggregates began to appear immediately. The coaggregation activity was inhibited by addition of protease, however carbohydrates did not inhibit the activity, suggesting that coaggregation is a protein-protein interaction. The results of this study suggest that coaggregation between P. gingivalis and T. forsythia is a result of cell-cell physical contact, and that coaggregation is mediated by a heat-labile component of P. gingivalis and T. forsythia component that can be activated on heat treatment.

The effect of implant shape and bone preparation on primary stability

Moon, Sang-Hyun,Um, Heung-Sik,Lee, Jae-Kwan,Chang, Beom-Seok,Lee, Min-Ku Korean Academy of Periodontology 2010 Journal of Periodontal & Implant Science Vol.40 No.5

Purpose: The purpose of this study was to evaluate the effects of implant shape and bone preparation on the primary stability of the implants using resonance frequency analysis. Methods: Sixty bovine rib blocks were used for soft and hard bone models. Each rib block received two types of dental implant fixtures; a straight-screw type and tapered-screw type. Final drilling was done at three different depths for each implant type; 1 mm under-preparation, standard preparation, and 1 mm over-preparation. Immediately after fixture insertion, the implant stability quotient (ISQ) was measured for each implant. Results: Regardless of the bone type, the ISQ values of the straight-screw type and tapered-screw type implants were not significantly different (P>0.05). Depth of bone preparation had no significant effect on the ISQ value of straight-screw type implants (P>0.05). For the tapered-screw type implants, under-preparation significantly increased the ISQ value (P<0.05), whereas overpreparation significantly decreased the ISQ value (P<0.05). Conclusions: Within the limitations of this study, it is concluded that bone density seemed to have a prevailing effect over implant shape on primary stability. The primary stability of the tapered-screw type implants might be enhanced by delicate surgical techniques.

Controlled releasing properties of gelatin nanofabric device containing chlorhexidine

( Dae-ung Park ),( Heung-sik Um ),( Beom-seok Chang ),( Si-young Lee ),( Ki-yeon Yoo ),( Won-youl Choi ),( Jae-kwan Lee ) 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 2021 Oral Biology Research (Oral Biol Res) Vol.45 No.2

We aimed to evaluate the degradation and antimicrobial activity of novel chlorhexidine-containing gelatin nanofabric devices and their cytotoxicity in animals. The electro-spun device with a size of 3.4.0.4 mm³ was prepared by entrapping chlorhexidine gluconate (CHX) in a gelatin matrix. The devices were divided into three groups based on the CHX percentage (G1: 46%, G2: 50%, and G3: 54%), and the commercial product, PerioChip (CP), was used for the control group. We used an in vitro test for the degradation and antibacterial activity and investigated cytotoxicity using an in vivo test. Artificial saliva was used for the degradation test of chips and blood agar plates seeded with the oral bacteria Streptococcus sanguinis to address antibacterial activity. Furthermore, the devices were inserted between the skin and muscle of rat abdomens to evaluate infection and inflammatory reactions. We detected no obvious differences in the antibacterial or degradation test results between the test and control groups. In the histological analysis, the scaffold without CHX showed no signs of infection or inflammatory reaction. Both CHX-containing groups exhibited inflammation and necrosis in the muscle and skin, although the reaction in the test group was milder. In the degradation tests, antibacterial tests, and cytotoxic reactions in animal experiments, the electro-spun gelatin-based device showed similar results to those of the commercial device in the control group. Further studies on the quantitative analysis and clinical outcome evaluation of the electro-spun gelatin-based device in humans are necessary.

Phototoxic effect of blue light on the planktonic and biofilm state of anaerobic periodontal pathogens

Song, Hyun-Hwa,Lee, Jae-Kwan,Um, Heung-Sik,Chang, Beom-Seok,Lee, Si-Young,Lee, Min-Ku Korean Academy of Periodontology 2013 Journal of Periodontal & Implant Science Vol.43 No.2

Purpose: The purpose of this study was to compare the phototoxic effects of blue light exposure on periodontal pathogens in both planktonic and biofilm cultures. Methods: Strains of Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, and Porphyromonas gingivalis, in planktonic or biofilm states, were exposed to visible light at wavelengths of 400.520 nm. A quartz-tungsten-halogen lamp at a power density of $500mW/cm^2$ was used for the light source. Each sample was exposed to 15, 30, 60, 90, or 120 seconds of each bacterial strain in the planktonic or biofilm state. Confocal scanning laser microscopy (CSLM) was used to observe the distribution of live/dead bacterial cells in biofilms. After light exposure, the bacterial killing rates were calculated from colony forming unit (CFU) counts. Results: CLSM images that were obtained from biofilms showed a mixture of dead and live bacterial cells extending to a depth of $30-45{\mu}m$. Obvious differences in the live-to-dead bacterial cell ratio were found in P. gingivalis biofilm according to light exposure time. In the planktonic state, almost all bacteria were killed with 60 seconds of light exposure to F. nucleatum (99.1%) and with 15 seconds to P. gingivalis (100%). In the biofilm state, however, only the CFU of P. gingivalis demonstrated a decreasing tendency with increasing light exposure time, and there was a lower efficacy of phototoxicity to P. gingivalis as biofilm than in the planktonic state. Conclusions: Blue light exposure using a dental halogen curing unit is effective in reducing periodontal pathogens in the planktonic state. It is recommended that an adjunctive exogenous photosensitizer be used and that pathogens be exposed to visible light for clinical antimicrobial periodontal therapy.

Effect of the early exposure of cover screws on the survival rate of implants

( Kim Yong Gun ),( Lee Jae Kwan ),( Um Heung Sik ),( Chang Beom Seok ) 대한치주과학회 2006 대한치주과학회 학술대회자료집 Vol.2006 No.2