Non-Gaussian time-dependent statistics of wind pressure processes on a roof structure

Huang, M.F.,Huang, Song,Feng, He,Lou, Wenjuan Techno-Press 2016 Wind and Structures, An International Journal (WAS Vol.23 No.4

Synchronous multi-pressure measurements were carried out with relatively long time duration for a double-layer reticulated shell roof model in the atmospheric boundary layer wind tunnel. Since the long roof is open at two ends for the storage of coal piles, three different testing cases were considered as the empty roof without coal piles (Case A), half coal piles inside (Case B) and full coal piles inside (Case C). Based on the wind tunnel test results, non-Gaussian time-dependent statistics of net wind pressure on the shell roof were quantified in terms of skewness and kurtosis. It was found that the direct statistical estimation of high-order moments and peak factors is quite sensitive to the duration of wind pressure time-history data. The maximum value of COVs (Coefficients of variations) of high-order moments is up to 1.05 for several measured pressure processes. The Mixture distribution models are proposed for better modeling the distribution of a parent pressure process. With the aid of mixture parent distribution models, the existing translated-peak-process (TPP) method has been revised and improved in the estimation of non-Gaussian peak factors. Finally, non-Gaussian peak factors of wind pressure, particularly for those observed hardening pressure process, were calculated by employing various state-of-the-art methods and compared to the direct statistical analysis of the measured long-duration wind pressure data. The estimated non-Gaussian peak factors for a hardening pressure process at the leading edge of the roof were varying from 3.6229, 3.3693 to 3.3416 corresponding to three different cases of A, B and C.

Characterization of Cucurbita maxima Fruit Metabolomic Profiling and Transcriptome to Reveal Fruit Quality and Ripening Gene Expression Patterns

He-Xun Huang,Ting Yu,Jun-Xing Li,Shu-Ping Qu,왕만만,Ting-Quan Wu,Yu-Juan Zhong 한국식물학회 2019 Journal of Plant Biology Vol.62 No.3

Pumpkin (Cucurbita maxima) fruit is the importantdietary source of carotenoid and is known for the goodflavour and texture due to the accumulation of sugar andstarch. However, lack of transcriptional information hindersour understanding of the molecular mechanisms underlyingfruit quality attributes and nutrition in C. maxima. To provideinsight into transcriptional regulation of fruit quality formationof C. maxima, quality analysis and high-throughput RNAsequencing of fruits at different developing stages werecharacterized. The quality analyses consist of dry mattervalues, percent soluble solids, carotenoid contents, and starchand sugar contents in seven stages of fruit development. Fruit transcriptome of C. maxima at five stages throughoutdevelopment was assembled to elucidate the molecularregulation of fruit development. Almost 18 billion nucleotidebases were sequenced in total, and 48,471 unigenes weredetected. A total of 32,397 (66.8%) unigenes were identifiedto be differentially expressed. We found there was a correlationbetween ripening-associated transcripts and metabolites andthe functions of regulating genes. KEGG analysis showedthere are multiple transcripts enriched in starch, sugar, carotenoid,plant hormone signal transduction and pectin pathways andseveral pathways regulating quality formation were identified. Candidate genes involving in sugar, starch, pectin, fruitsoftening and carotenoid metabolism in fruit were firstlyidentified for the species of C. maxima. Combining the sugar, starch and carotenoid accumulating patterns duringfruit development, a series of possible rate limiting geneswere identified. These findings will provide valuable informationfor further studies regarding fruit quality and development.

Three-dimensional Map Construction of Indoor Environment Based on RGB-D SLAM Scheme

Huang, He,Weng, FuZhou,Hu, Bo 한국측량학회 2019 한국측량학회지 Vol.37 No.2

RGB-D SLAM (Simultaneous Localization and Mapping) refers to the technology of using deep camera as a visual sensor for SLAM. In view of the disadvantages of high cost and indefinite scale in the construction of maps for laser sensors and traditional single and binocular cameras, a method for creating three-dimensional map of indoor environment with deep environment data combined with RGB-D SLAM scheme is studied. The method uses a mobile robot system equipped with a consumer-grade RGB-D sensor (Kinect) to acquire depth data, and then creates indoor three-dimensional point cloud maps in real time through key technologies such as positioning point generation, closed-loop detection, and map construction. The actual field experiment results show that the average error of the point cloud map created by the algorithm is 0.0045m, which ensures the stability of the construction using deep data and can accurately create real-time three-dimensional maps of indoor unknown environment.

Decreased Expression of LKB1 Correlates with Poor Prognosis in Hepatocellular Carcinoma Patients Undergoing Hepatectomy

Huang, Yue-Han,Chen, Zhen-Kun,Huang, Ka-Te,Li, Peng,He, Bin,Guo, Xu,Zhong, Jun-Qiao,Zhang, Qi-Yu,Shi, Hong-Qi,Song, Qi-Tong,Yu, Zheng-Ping,Shan, Yun-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Aim: To study any correlation of LKB1 expression with prognosis in hepatocellular carcinoma (HCC) cases. Methods: A total of 70 HCC patients and 20 primary intrahepatic stone patients in the first affiliated hospital of Wenzhou Medical College were enrolled in this study. LKB1 expression was detected by immunohistochemistry. Patients were followed-up and prognostic factors were evaluated. Result: LKB1 expression was decreased in the HCC samples. Loss of LKB1 expression in HCC was significantly related to histologic grade (P=0.010), vascular invasion (P=0.025) and TMN stage (P=0.011). Patients showing negative LKB1 expression had a significantly shorter disease-free and overall survival than those with positive expression (P = 0.001, P=0.000, respectively). Multivariate Cox regression analysis indicated that LKB1 expression level was an independent factor of survival (P = 0.033). Conclusion: HCC patients with decreased expression LKB1 have a poor prognosis. The loss of LKB1 expression is correlated with a lower survival rate.

Image Fusion and Evaluation by using Mapping Satellite-1 Data

He Huang,Yafei Hu,Yi Feng,Meng Zhang,DongSeob Song 한국측량학회 2013 한국측량학회지 Vol.31 No.6-2

Image Fusion and Evaluation by using Mapping Satellite-1 Data

He Huang,Yafei Hu,Yi Feng,Meng Zhang,송동섭 한국측량학회 2013 한국측량학회지 Vol.31 No.6

China’s Mapping Satellite-1, developed by the China Aerospace Science and Technology Corporation (CASC),was launched in three years ago. The data from Mapping Satellite-1 are able to use for efficient surveyingand geometric mapping application field. In this paper, we fuse the panchromatic and multispectral images ofChangchun area, which are obtained from the Mapping Satellite-1, the one that is the Chinese first transmissiontypethree-dimensional mapping satellite. The four traditional image fusion methods, which are HPF, Mod.IHS,Panshar and wavelet transform, were used to approach for effectively fusing Mapping Satellite-1 remote sensingdata. Subsequently we assess the results with some commonly used methods, which are known a subjectivequalitative evaluation and quantitative statistical analysis approach. Consequently, we found that the wavelettransform remote sensing image fusion is the optimal in the degree of distortion, the ability of performance ofdetails and image information availability among four methods. To further understand the optimal methods tofuse Mapping Satellite-1 images, an additional study is necessary.

Image Fusion and Evaluation by using Mapping Satellite-1 Data

Huang, He,Hu, Yafei,Feng, Yi,Zhang, Meng,Song, DongSeob Korean Society of Surveying 2013 한국측량학회지 Vol.31 No.6

China's Mapping Satellite-1, developed by the China Aerospace Science and Technology Corporation (CASC), was launched in three years ago. The data from Mapping Satellite-1 are able to use for efficient surveying and geometric mapping application field. In this paper, we fuse the panchromatic and multispectral images of Changchun area, which are obtained from the Mapping Satellite-1, the one that is the Chinese first transmission-type three-dimensional mapping satellite. The four traditional image fusion methods, which are HPF, Mod.IHS, Panshar and wavelet transform, were used to approach for effectively fusing Mapping Satellite-1 remote sensing data. Subsequently we assess the results with some commonly used methods, which are known a subjective qualitative evaluation and quantitative statistical analysis approach. Consequently, we found that the wavelet transform remote sensing image fusion is the optimal in the degree of distortion, the ability of performance of details and image information availability among four methods. To further understand the optimal methods to fuse Mapping Satellite-1 images, an additional study is necessary.

Energy Efficiency of Distributed Massive MIMO Systems

He, Chunlong,Yin, Jiajia,He, Yejun,Huang, Min,Zhao, Bo The Korea Institute of Information and Commucation 2016 Journal of communications and networks Vol.18 No.4

In this paper, we investigate energy efficiency (EE) of the traditional co-located and the distributed massive multiple-input multiple-output (MIMO) systems. First, we derive an approximate EE expression for both the idealistic and the realistic power consumption models. Then an optimal energy-efficient remote access unit (RAU) selection algorithm based on the distance between the mobile stations (MSs) and the RAUs are developed to maximize the EE for the downlink distributed massive MIMO systems under the realistic power consumption model. Numerical results show that the EE of the distributed massive MIMO systems is larger than the co-located massive MIMO systems under both the idealistic and realistic power consumption models, and the optimal EE can be obtained by the developed energy-efficient RAU selection algorithm.

Characteristics of the aerodynamic interference between two high-rise buildings of different height and identical square cross-section

Huang Dongmei,Zhu Xue,He Shiqing,He Xuhui,He Hua 한국풍공학회 2017 Wind and Structures, An International Journal (WAS Vol.24 No.5

In this work, wind tunnel tests of pressure measurements are carried out to assess the global aerodynamic interference factors, the local wind pressure interference factors, and the local lift spectra of an square high-rise building interfered by an identical cross-sections but lower height building arranged in various relative positions. The results show that, when the interfering building is located in an area of oblique upstream, the RMS of the along-wind, across-wind, and torsional aerodynamic forces on the test building increase significantly, and when it is located to a side, the mean across-wind and torsional aerodynamic forces increase; In addition, when the interfering building is located upstream or staggered upstream, the mean wind pressures on the sheltered windward side turn form positive to negative and with a maximum absolute value of up to 1.75 times, and the fluctuating wind pressures on the sheltered windward side and leading edge of the side increase significantly with decreasing spacing ratio (up to a maximum of 3.5 times). When it is located to a side, the mean and fluctuating wind pressures on the leading edge of inner side are significantly increased. The three-dimensional flow around a slightly-shorter disturbing building has a great effect on the average and fluctuating wind pressures on the windward or cross-wind faces. When the disturbing building is near to the test building, the vortex shedding peak in the lift spectra decreases and there are no obvious signs of periodicity, however, the energies of the high frequency components undergo an obvious increase.

The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs

Huang Bao,He Yongqing,Li Shengwen,Wei Xiaoan,Liu Junhui,Shan Zhi,Huang Yue,Chen Jiang,Zhao Fengdong 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

Calcipressin-1, also known as regulator of calcineurin 1 (RCAN1), can specifically bind calcineurin at or near the calcineurin A catalytic domain and downregulate calcineurin activity. However, whether RCAN1 affects the hypoxic intervertebral disc (IVD) phenotype through the calcineurin/NFAT signaling pathway remains unclear. First, we confirmed the characteristics of the degenerative nucleus pulposus (NP) by H&E, safranin O/fast green and Alcian blue staining, and detected increased RCAN1 levels in the degenerative NP by immunohistochemistry. Then, we demonstrated that the protein level of RCAN1.4 was higher than that of RCAN1.1 and progressively elevated from the control group to the Pfirrmann grade V group. In vitro, both hypoxia (1% O2) and overexpression of HIF-1α reduced the protein level of RCAN1.4 in rat NP cells in a dose- and time-dependent manner. We further found that miRNA-124, through a nondegradative pathway (without the proteasome or lysosome), suppressed the expression of RCAN1.4. As expected, calcineurin in NP cells was activated and primarily promoted nuclear translocation of NFATc1 under hypoxia or RCAN1.4 siRNA transfection. Furthermore, SOX9, type II collagen and MMP13 were elevated under hypoxia, RCAN1.4 siRNA transfection or NFATc1 overexpression. Using chromatin immunoprecipitation (ChIP) and a luciferase reporter assay (with mutation), we clarified that NFATc1 increasingly bound the SOX9 promotor region (bp −367~−357). Interaction of HIF-1α and NFATc1 promoted MMP13 transcription. Finally, we found that FK506 reversed hypoxia-induced activation of the calcineurin/NFAT signaling pathway in NP cells and an ex vivo model. Together, these findings show that the RCAN1.4-calcineurin/ NFAT signaling pathway has a vital role in the hypoxic phenotype of NP cells. RCAN1.4 might be a therapeutic target for degenerative disc diseases.