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- 저자 : ( Haojun Xu ) (검색결과 4 건)
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Chip Control Analysis in Low-Frequency Vibration-Assisted Drilling of Ti–6Al–4V Titanium Alloys
Haojun Yang,Yan Chen,Jiuhua Xu,Mathieu Ladonne,Julian Lonfier,Wenfeng Ding 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.4
In this study, control research of chip morphology and removal is conducted theoretically and experimentally on the basis ofthe low-frequency vibration-assisted drilling process of titanium alloy. The chip morphology prediction model is establishedon the basis of the modifi ed kinematic model, in which the shear angle variation, critical cutting thickness, and stiff ness ofa vibration generator system are considered. In terms of chip removal monitoring, a new monitoring method based on highspeed camera is proposed in this paper. And the reliability of the new method is verifi ed by comparing the signals obtainedby the power sensor and the force sensor. An empirical prediction model for chip removal is also established on the basis ofthe modifi ed kinematical model, the chip morphology prediction model, and the force balance analysis of fragmental chips. Validation experiments show that the mean error of chip radian, which can refl ect the diff erence between the predicted chipmorphology and the experimental one, is 6%. The mean error of the predicted chip removal index compared with the experimentalone is 10.4%. The results obtained show that chip removal can be controlled eff ectively by low rotation speed, smallchip radian, light chip weight, high minimum quantity lubrication cooling pressure, and high oscillation frequency. On thebasis of the prediction model of chip removal, the eff ects of drilling parameters on chip removal behavior are analyzed, andthe optimal drilling parameter combination with highest processing effi ciency is given.
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Bin Xu,Jingwen Xue,Jun Huang,Haojun Jin,Peng Shen,Qingjiang Sun 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.15 No.01
The doped quantum dots (QDs) that feature dual emission in one nanocrystal and long fluorescence lifetime have gained great interest in biosensing and bioimaging applications. In this work, we report the synthesis and functionalization of copper ion-doped indium phosphate (Cu:InP) QDs that exhibit simultaneous green InP emission and red Cu2+ emission. The oil-soluble QDs were synthesized by adsorbing Cu2+ onto InP core, followed by growing zinc selenide (ZnSe) shell via the successive ion layer adsorption reaction. During the synthesis, fluorescence ratiometry (and resultant multiple fluorescence colors) can be generated by changing either the dopant amount or the shell-growth time, but they act in a different manner: increasing the Cu2+ amount results in quenched InP emission and oppositely improved Cu2+ emission; the increase of shell-growth time leads to continuously improved Cu2+ emission relative to constant InP emission. Further, functionalization of the oil-soluble Cu:InP QDs with dihydrolipoic acid-polyethylene glycol (DHLA-PEG) via ligand exchange produces the water-soluble and biocompatible dual-emission QDs. The PEGylated Cu:InP QDs present desirable charge neutrality and excellent thermal stability and photostability, thereby holding high potential in a diversity of biomedical applications.
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Effects of Secondary Elements on Vortex-Induced Vibration of a Streamlined Box Girder
Xingyu Chen,Fang Qiu,Haojun Tang,Yongle Li,Xinyu Xu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.1
Box girders are aerodynamically favorable, and the paper presents a study on the vortex-induced vibration (VIV) of this girder type at large angles of attack. Taking a box girder as an example, the form of the guardrails and the position of the maintenance tracks were improved to increase the VIV performance. The aerodynamic mechanism was further investigated according to the change in flow field around the girder. Results showed that the VIV performance of the box girder at positive angles of attack is worse. Improving secondary elements is an effective way to increase the VIV performance. Adding four rectangle bars above the original guardrails could achieve the target by preventing the generation of the vortex and blocking its movement. Moving the maintenance tracks inwards with a reasonable distance could also achieve the target as the flow passes through the girder more smoothly. With the combination of the optimal form of the guardrails and the optimal position of the maintenance tracks, the VIV performance of the bridge is higher. The countermeasures provide reference for the inhibition of the VIV of box girders.
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( Qi Sun ),( Yao Fu ),( Xiaobing Chen ),( Lin Li ),( Hongyan Wu ),( Yixuan Liu ),( Haojun Xu ),( Guoren Zhou ),( Xiangshan Fan ),( Hongping Xia ) 대한소화기기능성질환·운동학회 2022 Gut and Liver Vol.16 No.6
Background/Aims: Epstein-Barr virus-associated gastric cancers (EBVaGCs) have unique molecular and clinicopathological characteristics. The cyclic GMP-AMP synthase-stimulator of interferon genes (STING) pathway is recently recognized as the critical innate immunity against pathogens and tumors. STING is also a master regulator in the cancer-immunity cycle and tar geting STING could synergize with existing immune-checkpoint therapies. However, the role of STING in GC, especially in EBVaGC, and its correlation with programmed death-ligand 1 (PD-L1) remain largely unclear. Methods: We collected 78 cases of EBVaGCs and 210 cases of EBV-negative GC (EBVnGC) from a total of 1,443 cases of GC analyzed by EBV-encoded small RNA in situ hybridization. We investigated STING and PD-L1 expression and their concomitant prognostic value in EBVaGCs and EBVnGCs using tissue microarray and immunohistochemistry. The effects of STING and PD-L1 expression on the overall survival of patients with EBVaGC or EBVnGC were assessed by univariate and multivariate analysis. Results: We found that both STING and PD-L1 exhibited significantly higher expression in the EBVaGCs than that in the EBVnGCs. The expression of STING was positively correlated with that of PD-L1 in EBVaGCs. Simultaneous negative expression of STING and PD-L1, and posi tive expression of STING were independent prognostic risk factors for EBVaGC and EBVnGC, respectively. Conclusions: This is the first prognostic retrospective study of STING and PD-L1 expression and the prognosis among EBVaGC and EBVnGC. The expression and prognostic value of STING and PD-L1 are different in the two types of GCs. STING and PD-L1 are promising prog nostic biomarkers and therapeutic targets for EBVaGC and EBVnGC. (Gut Liver 2022;16:875-891)
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