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- 저자 : ( Guo Ping Yang ) (검색결과 74 건)
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Yang-Yang Guo,Jian-Ping Zhou,Peng Liu 한국물리학회 2010 Current Applied Physics Vol.10 No.4
Dependence of magnetoelectric modulus and phasic difference on the bias magnetic field was studied in a magnetoelectric Pb(Zr, Ti)O3/Terfenol-D laminate composite. The shifts of both magnetoelectric resonant peak and phasic bounce under the bias magnetic field lead to a nonlinear relationship between them. The acoustic velocity of Terfenol-D has a nonlinear dependence on magnetic field, resulting in a similar relationship between the acoustic velocity of the composite and magnetic field. As a result, the magnetoelectric modulus and phase around the resonance frequency exhibit very sensitive dependences on the bias magnetic field.
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Guo, Wei,Jin, Xiao-Ju,Yu, Jun,Liu, Yang,Zhang, Jian-Ping,Yang, Da-Wei,Zhang, Lei,Guo, Jiang-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Objective: To investigate the effects of stellate ganglion block (SGB) on the peri-operative vasomotor cytokine content and intrapulmonary shunt in patients with esophagus cancer who underwent thoracotomy. Materials and Methods: Forty patients undergoing elective resection of esophageal cancer patients who had I~II American Society of Anesthesiologist (ASA) were randomly divided into total intravenous anesthesia group (group N, n=20) and total intravenous anesthesia combined with SGB group (group S, n=20, 0.12 mL/kg 1% lidocaine was used for SGB 10 min before induction). Heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary arterial pressure (MPAP) and continuous cardiac output (CCO) were continuously monitored. The blood from internal jugular vein was drawn respectively before induction ($T_0$), and 30 min ($T_1$), 60 min ($T_2$) and 120 min ($T_3$) after one-lung ventilation (OLV), and 30 min (T4) after two-lung ventilation. The contents of plasma endothelin (ET), nitric oxide (NO) and calcitonin gene-related peptide (CGRP) were detected with enzyme linked immunosorbent assay (ELISA). Meanwhile, arterial and mixed venous blood samples were collected for determination of blood gas and calculation of intrapulmonary shunt fraction (Qs/Qt). Results: During OLV, ET contents were increased significantly in two groups (P<0.05), and no significant difference was presented (P>0.05). NO content in group S was obviously higher than in group N at T3 (P<0.05), whereas CGRP content in group N was markedly lower than in group S at each time point (P<0.05). Qs/Qt was significantly increased in both groups after OLV, but there was no statistical significant regarding the Qs/Qt at each time point between two groups. Conclusions: Total intravenous anesthesia combined with SGB is conducive to regulation of perioperative vasomotor cytokines in thoracotomy, and has little effect on intrapulmonary shunt at the time of OLV.
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Jun-Cheng Guo,Yi-Jun Yang,Jin-Fang Zheng,Jian-Quan Zhang,Min Guo,Xiang Yang,Xiang-Ling Jiang,Li Xiang,You Li,Huang Ping,Liu Zhuo 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, but its molecular mechanisms are not yet well characterized. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, including that of HCC. However, the role of homeobox A11 antisense (HOXA11-AS) in determining HCC stem cell characteristics remains to be explained; hence, this study aimed to investigate the effects of HOXA11-AS on HCC stem cell characteristics. Initially, the expression patterns of HOXA11-AS and HOXA11 in HCC tissues, cells, and stem cells were determined. HCC stem cells, successfully sorted from Hep3B and Huh7 cells, were transfected with short hairpin or overexpression plasmids for HOXA11-AS or HOXA11 overexpression and depletion, with an aim to study the influences of these mediators on the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo. Additionally, the potential relationship and the regulatory mechanisms that link HOXA11-AS, HOXA11, and the Wnt signaling pathway were explored through treatment with Dickkopf-1 (a Wnt signaling pathway inhibitor). HCC stem cells showed high expression of HOXA11-AS and low expression of HOXA11. Both HOXA11-AS silencing and HOXA11 overexpression suppressed the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo, as evidenced by the decreased expression of cancer stem cell surface markers (CD133 and CD44) and stemness-related transcription factors (Nanog, Sox2, and Oct4). Moreover, silencing HOXA11-AS inactivated the Wnt signaling pathway by decreasing the methylation level of the HOXA11 promoter, thereby inhibiting HCC stem cell characteristics. Collectively, this study suggested that HOXA11-AS silencing exerts an antitumor effect, suppressing HCC development via Wnt signaling pathway inactivation by decreasing the methylation level of the HOXA11 promoter.
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Yang, Xiao-Ping,Han, Yue-Dong,Ye, Jian-Jun,Chen, Gang,Luo, Ying,Ma, Hong-Xia,Yu, Xue-Wen,Niu, Juan-Qin,Ren, Fang-Yuan,Guo, You-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Background: As a common and essential contrast medium at present, gadobenate dimeglumine has shown better performance than some other agents when applied to Breast Magnetic Resonance Imaging Screening (Breast MRI Screening). Nevertheless, reports on the diagnostic performance of these two mediums (gadobenate dimeglumine and gadopentetate dimeglumine) are not completely consistent. Objective: To assess the diagnostic value of gadobenate dimeglumine and gadopentetate dimeglumine for Breast MRI Screening in patients suffering from breast cancer and to provide more convinced evidence to guide clinical practice in terms of appropriate contrast agents. Data Sources and Review Methods: Original articles in English and Chinese published before January 2013 were selected from available databases (The Cochrane Library, PUBMED, EMBASE, Chinese Biomedical Literature Database, Chinese Scientific Journals Full-text Database, Chinese Journal Full-text). The criteria for inclusion and exclusion were based on the standard for diagnosis tests. Meta-Disc software (Version 1.4) was used for data analysis. Then, the area under curve (AUC) of SROC and the spearman rank correlation of sensitivity against (1-specificity) were calculated. Results: Total of 17 researches involving 1934 patients were included. The pooled sensitivity of gadobenate dimeglumine and gadopentetate dimeglumine were 0.99 (0.97, 1.00) and 0.93 (0.88, 1.00) respectively. The pooled specificity for these two contrast agents were 0.924 (0.902, 0.943) and 0.838 (0.817, 0.858) respectively, and the AUC of SROC curve were 0.9781 and 0.9215 respectively. Conclusions: Gadobenate dimeglumine can be regarded as a more effective and feasible contrast medium for Breast MRI Screening. At least 5% differences in diagnostic performance are usually considered as clinically relevant.
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Yang, Jinglei,Lin, Zhuang,Li, Ping,Guo, Zhiqun,Sun, Hanbing,Yang, Dongmei The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.-
The partial air cushion supported catamaran (PACSCAT) is a novel Surface Effect Ship (SES) and possesses distinctive resistance performance due to the presence of planing bottom. In this paper, the design of PACSCAT and air cushion system are described in detail. Model tests were carried out for Froude numbers ranging from 0.1 to 1.11, the focus is on the influence of air cushion system on resistance characteristics. Drag-reducing effect of air cushion system was proved by means of contrast tests in cuhionborne and non-cushionborne mode. Wave-making characteristics reflect that the PACSCAT would eventually enter planing regime, in which the air could just escape under the seals and the hull body could operate in a steady state. To acquire different air cushion pressure, air flow rate and leakage height were adjusted during tests. Experimental results show that the resistance performance in planing regime would decrease evidently as the increased air flow rate, however, the scheme with medium leakage height presents the best resistance performance in the hump region.
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NPC-IGCT Phase Module Clamp Circuit LRC Parameters Design considering FRD snappy Recovery
Yang Ju Zou,Jia Xi Hu,Zhen Yu Ma,Jian Ping Liu,Run Qing Guo,Zhi Xue Zhang 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
In this paper, a method for neutral point clamping-integrated gate commutated thyristor (NPCIGCT) phase module clamp circuit parameters design considering FRD snappy recovery is present. Based on the snappy recovery theory, and analysis of snappy recovery factors, the paper has shown decreasing current commutating slope can attenuated snappy recovery affect effectively. Then, the paper has shown that it is reasonable for decreasing di/dt by increasing inductance of NPC-IGCT phase module clamp circuit, based on the circuit working principle. Then, the new clamp circuit parameters design method which combine multi-objective optimization solution mathematical module of the circuit, fast recovery diode (FRD) snappy recovery, devices overvoltage and loss is shown in paper. A design example and its test results have demonstrated both IGCT and FRD characteristics have been guaranteed and ensuring safety and reliability of the NPC - IGCT phase module.
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Guo, Cheng-Xian,Yang, Guo-Ping,Pei, Qi,Yin, Ji-Ye,Tan, Hong-Yi,Yuan, Hong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: A number of association studies have been carried out to investigate the relationship between genetic polymorphisms in DNA repair genes and response to radiotherapy-based multimodality treatment of patients with rectal cancer. However, their conclusions were inconsistent. The objective of the present study was to assess the role of DNA repair gene genetic polymorphisms in predicting genetic biomarkers of the response in rectal cancer patients treated with neoadjuvant chemoradiation. Materials and Methods: Studies were retrieved by searching the PubMed database, Cochrane Library, Embase, and ISI Web of Knowledge. We conducted a meta-analysis to evaluate the association between genetic polymorphisms and the response in rectal cancer treated with neoadjuvant chemoradiation by checking odds ratios (ORs) and 95% confidence intervals (CIs). Results: Data were extracted from 5 clinical studies for this meta-analysis. The results showed that XRCC1 RS25487, XRCC1 RS179978, XRCC3 RS861539, ERCC1 RS11615 and ERCC2 RS13181 were not associated with the response in the radiotherapy-based multimodality treatment of patients with rectal cancer (p>0.05). Conclusions: This study shows that DNA repair gene common genetic polymorphisms are not significantly correlated with the radiotherapy-based multimodality treatment in rectal cancer patients.
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Yang, Dang-Wei,Ma, Zhan-Guo,Qi, Fu-Zhou,Gong, Peng,Liu, Dao-Ping,Zhao, Guo-Zhen,Zhang, Ray Ruichong Techno-Press 2017 Geomechanics & engineering Vol.13 No.2
This paper proposes gob-side entry retaining by roof break and filling in thick-layer soft rock conditions based on the thick-layer soft rock roof strata migration law and the demand for non-pillar gob-side entry retaining projects. The functional expressions of main roof subsidence are derived for three break roof direction conditions: lateral deflection toward the roadway, lateral deflection toward the gob and vertically to the roof. These are derived according to the load-bearing boundary conditions of the main roadway roof stratum. It is concluded that the break roof angle is an important factor influencing the stability of gob-side entry retaining surrounding rock. This paper studies the stress distribution characteristics and plastic damage scope of gob-side entry retaining integrated coal seams, as well as the roof strata migration law and the supporting stability of caving structure filled on the break roof layer at the break roof angles of $-5^{\circ}$, $0^{\circ}$, $5^{\circ}$, $10^{\circ}$ and $15^{\circ}$ are studied. The simulation results of numerical analysis indicate that, the stress concentration and plastic damage scope to the sides of gob-side entry retaining integrated coal at the break roof angle of $5^{\circ}$ are reduced and shearing stress concentration of the caving filling body has been eliminated. The disturbance of coal mining to the roadway roof and loss of carrying capacity are mitigated. Field tests have been carried out on air-return roadway 5203 with the break roof angle of $5^{\circ}$. The monitoring indicates that the break roof filling section and compaction section are located at 0-45 m and 45-75 m behind the working face, respectively. The section from 75-100 m tends to be stable.
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Yang, Jinglei,Lin, Zhuang,Li, Ping,Guo, Zhiqun,Sun, Hanbing,Yang, Dongmei The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.1
The partial air cushion supported catamaran (PACSCAT) is a novel Surface Effect Ship (SES) and possesses distinctive resistance performance due to the presence of planing bottom. In this paper, the design of PACSCAT and air cushion system are described in detail. Model tests were carried out for Froude numbers ranging from 0.1 to 1.11, the focus is on the influence of air cushion system on resistance characteristics. Drag-reducing effect of air cushion system was proved by means of contrast tests in cuhionborne and non-cushionborne mode. Wave-making characteristics reflect that the PACSCAT would eventually enter planing regime, in which the air could just escape under the seals and the hull body could operate in a steady state. To acquire different air cushion pressure, air flow rate and leakage height were adjusted during tests. Experimental results show that the resistance performance in planing regime would decrease evidently as the increased air flow rate, however, the scheme with medium leakage height presents the best resistance performance in the hump region.
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